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The map label for this gene is uhpB [H]

Identifier: 15603204

GI number: 15603204

Start: 1531166

End: 1532731

Strand: Reverse

Name: uhpB [H]

Synonym: PM1339

Alternate gene names: 15603204

Gene position: 1532731-1531166 (Counterclockwise)

Preceding gene: 15603205

Following gene: 15603203

Centisome position: 67.9

GC content: 43.49

Gene sequence:

>1566_bases
ATGTGGAACTCACGAATTTCTTTCATCAAACATATTAACTTGAACAAGTTGTTCACCTTCATTTACAGTTGGTTTCTGCT
CACCTGTTCCTATTTCTGTTTATGGGGCGTGGCAGATTATTTGTTACATGACTCGCGCTTAGCCTTTCTCTTTTTGCCTT
TTGCATTGCGGCTTGGACTTTGTCTGCATCTTCGCCCCACATTGTGGTTGGCTCCACTGTTAGCCGAAATCAGCGTGCTC
CTGTTGGTTTCTTGGGCAGAACACAGTGCAGCTTACTTGCCCTTACTCTTATTAAGTGCGGTCAGTTTTCCCATCGTGTT
ATTTAGCCAATCCTATTATCAAGGCAAACAACGCTCCAAATTACGCCTACAAGGCATACTGGCATTGAGTATCAGCGTGC
TCAATGGATTGGTGCTTGTTTGTTTGGATGCCTCTTTTGCTTACACGATGCTAGTCAGTTTTACTGGTGCGTTATTGTTG
TTGCCGATGTGTTATTTATTACAAGATTTCTTATTTACACGGCAATGGATTCCACTTACTGCCAGCTTTATTCATCACCC
GATCGCCCTGCGCAGCAAACACATTGTGGTTTATACACTGTTATTAATCTTAAACATTCTGATCCAAACCTATCTGCCCG
ATGAGTTTAACCGCTTTAGCCTGTTCTTTTTAGCGATTCCGATTATTTTATTAGCCTATTATTATGGCTGGCAGGGCGCC
TTACTCGGCTCACTAATCAATAGTGTGGCATTAATTGCTTCCACACAGCACTTCTCCCATTTAGATCTGTCTGATTTACT
CCTATCTCTGTGTGCACAAACCATAACAGGAATTTTTCTAGGACTCGCTATTCAACATCAACGCGAGCTCAATCAGCATT
TAGGCATGGAGCTCATGCGTAACCGCGCTTTAACACAGCAATTGATCAGCAGTGAAGAAAGCATTCGCCAAGAAATTGCC
CGTGAATTACACGATCAAATCGGGCAAAACATTACCGCCATTCGCACCCAAGCCAGTATTCTGAAACGGCTCAATCCACA
CCCGCAAGAACAGAACAATGCCAATATGATCGAACACTTATCACTCAATATTTACGATACGGTCAAAGGACTATTAAACC
GCCTACGTCCTCGTGTATTAGATGACTTACCATTACCACAAGTCCTCCAAAATGTATTAGACGAATTAGGTTTAACGCAA
CAGCACATACACTGTCAGTTTGACTGGCATAATCCTCAACAATTGCACCTCGATCCGCGCTTAGAAATCACCCTTTACCG
CCTCTACCAAGAAGCCTTAAACAACATCATCAAGCATGCACAAGCCAGTCAAATTCACATTGCGATCCACATTGATCAGC
AGGTCATCTTATCGATTCAAGATAATGGCAAAGGCTTTGATATTCATCAGCCAGTGACAGGATTAGGGCTACGTGGTATG
CAAGAACGGGTTGCCTTACTCGGTGGCGAATTTCAGCTCTCCTCAAGCACGGCGAACATGCGTTCCTCTTCAATTCAACC
TTTGACACAAGGCACTTCCCTTGTGATCACTCTCCCTCGATTTTAA

Upstream 100 bases:

>100_bases
GGCTTAGATGCAAAAGAGATTGCTCAACAGCTGAATGTAAGCTTTAAAACAGTGCACGTGCATCGTGCTAATGCCATGAG
TAAGCTCAACCTAAAAAATA

Downstream 100 bases:

>100_bases
TGATGCCAATACAAAACTTTTCGCAAATTGACCGCACTTATCGCTACTGGCGCATTCACTTAATGATTGCCATGTACGTA
GGCTATGCCGGTTTTTACCT

Product: sensory histidine kinase UhpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MWNSRISFIKHINLNKLFTFIYSWFLLTCSYFCLWGVADYLLHDSRLAFLFLPFALRLGLCLHLRPTLWLAPLLAEISVL
LLVSWAEHSAAYLPLLLLSAVSFPIVLFSQSYYQGKQRSKLRLQGILALSISVLNGLVLVCLDASFAYTMLVSFTGALLL
LPMCYLLQDFLFTRQWIPLTASFIHHPIALRSKHIVVYTLLLILNILIQTYLPDEFNRFSLFFLAIPIILLAYYYGWQGA
LLGSLINSVALIASTQHFSHLDLSDLLLSLCAQTITGIFLGLAIQHQRELNQHLGMELMRNRALTQQLISSEESIRQEIA
RELHDQIGQNITAIRTQASILKRLNPHPQEQNNANMIEHLSLNIYDTVKGLLNRLRPRVLDDLPLPQVLQNVLDELGLTQ
QHIHCQFDWHNPQQLHLDPRLEITLYRLYQEALNNIIKHAQASQIHIAIHIDQQVILSIQDNGKGFDIHQPVTGLGLRGM
QERVALLGGEFQLSSSTANMRSSSIQPLTQGTSLVITLPRF

Sequences:

>Translated_521_residues
MWNSRISFIKHINLNKLFTFIYSWFLLTCSYFCLWGVADYLLHDSRLAFLFLPFALRLGLCLHLRPTLWLAPLLAEISVL
LLVSWAEHSAAYLPLLLLSAVSFPIVLFSQSYYQGKQRSKLRLQGILALSISVLNGLVLVCLDASFAYTMLVSFTGALLL
LPMCYLLQDFLFTRQWIPLTASFIHHPIALRSKHIVVYTLLLILNILIQTYLPDEFNRFSLFFLAIPIILLAYYYGWQGA
LLGSLINSVALIASTQHFSHLDLSDLLLSLCAQTITGIFLGLAIQHQRELNQHLGMELMRNRALTQQLISSEESIRQEIA
RELHDQIGQNITAIRTQASILKRLNPHPQEQNNANMIEHLSLNIYDTVKGLLNRLRPRVLDDLPLPQVLQNVLDELGLTQ
QHIHCQFDWHNPQQLHLDPRLEITLYRLYQEALNNIIKHAQASQIHIAIHIDQQVILSIQDNGKGFDIHQPVTGLGLRGM
QERVALLGGEFQLSSSTANMRSSSIQPLTQGTSLVITLPRF
>Mature_521_residues
MWNSRISFIKHINLNKLFTFIYSWFLLTCSYFCLWGVADYLLHDSRLAFLFLPFALRLGLCLHLRPTLWLAPLLAEISVL
LLVSWAEHSAAYLPLLLLSAVSFPIVLFSQSYYQGKQRSKLRLQGILALSISVLNGLVLVCLDASFAYTMLVSFTGALLL
LPMCYLLQDFLFTRQWIPLTASFIHHPIALRSKHIVVYTLLLILNILIQTYLPDEFNRFSLFFLAIPIILLAYYYGWQGA
LLGSLINSVALIASTQHFSHLDLSDLLLSLCAQTITGIFLGLAIQHQRELNQHLGMELMRNRALTQQLISSEESIRQEIA
RELHDQIGQNITAIRTQASILKRLNPHPQEQNNANMIEHLSLNIYDTVKGLLNRLRPRVLDDLPLPQVLQNVLDELGLTQ
QHIHCQFDWHNPQQLHLDPRLEITLYRLYQEALNNIIKHAQASQIHIAIHIDQQVILSIQDNGKGFDIHQPVTGLGLRGM
QERVALLGGEFQLSSSTANMRSSSIQPLTQGTSLVITLPRF

Specific function: Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=486, Percent_Identity=39.7119341563786, Blast_Score=288, Evalue=7e-79,
Organism=Escherichia coli, GI1788812, Length=212, Percent_Identity=33.4905660377358, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR007895
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; PF05231 MASE1 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59314; Mature: 59314

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWNSRISFIKHINLNKLFTFIYSWFLLTCSYFCLWGVADYLLHDSRLAFLFLPFALRLGL
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
CLHLRPTLWLAPLLAEISVLLLVSWAEHSAAYLPLLLLSAVSFPIVLFSQSYYQGKQRSK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHH
LRLQGILALSISVLNGLVLVCLDASFAYTMLVSFTGALLLLPMCYLLQDFLFTRQWIPLT
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ASFIHHPIALRSKHIVVYTLLLILNILIQTYLPDEFNRFSLFFLAIPIILLAYYYGWQGA
HHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHH
LLGSLINSVALIASTQHFSHLDLSDLLLSLCAQTITGIFLGLAIQHQRELNQHLGMELMR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRALTQQLISSEESIRQEIARELHDQIGQNITAIRTQASILKRLNPHPQEQNNANMIEHL
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
SLNIYDTVKGLLNRLRPRVLDDLPLPQVLQNVLDELGLTQQHIHCQFDWHNPQQLHLDPR
HCHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCEEECCCC
LEITLYRLYQEALNNIIKHAQASQIHIAIHIDQQVILSIQDNGKGFDIHQPVTGLGLRGM
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEEECCCCCCCCCCCCHHCCCCCH
QERVALLGGEFQLSSSTANMRSSSIQPLTQGTSLVITLPRF
HHHHHHHCCCEEECCCHHHHHHCCCCHHCCCCEEEEECCCC
>Mature Secondary Structure
MWNSRISFIKHINLNKLFTFIYSWFLLTCSYFCLWGVADYLLHDSRLAFLFLPFALRLGL
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
CLHLRPTLWLAPLLAEISVLLLVSWAEHSAAYLPLLLLSAVSFPIVLFSQSYYQGKQRSK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHH
LRLQGILALSISVLNGLVLVCLDASFAYTMLVSFTGALLLLPMCYLLQDFLFTRQWIPLT
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ASFIHHPIALRSKHIVVYTLLLILNILIQTYLPDEFNRFSLFFLAIPIILLAYYYGWQGA
HHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHH
LLGSLINSVALIASTQHFSHLDLSDLLLSLCAQTITGIFLGLAIQHQRELNQHLGMELMR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRALTQQLISSEESIRQEIARELHDQIGQNITAIRTQASILKRLNPHPQEQNNANMIEHL
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
SLNIYDTVKGLLNRLRPRVLDDLPLPQVLQNVLDELGLTQQHIHCQFDWHNPQQLHLDPR
HCHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCEEECCCC
LEITLYRLYQEALNNIIKHAQASQIHIAIHIDQQVILSIQDNGKGFDIHQPVTGLGLRGM
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEEECCCCCCCCCCCCHHCCCCCH
QERVALLGGEFQLSSSTANMRSSSIQPLTQGTSLVITLPRF
HHHHHHHCCCEEECCCHHHHHHCCCCHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3301805; 1569007; 7686882; 9278503 [H]