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The map label for this gene is uhpT [H]

Identifier: 15603206

GI number: 15603206

Start: 1533364

End: 1534743

Strand: Reverse

Name: uhpT [H]

Synonym: PM1341

Alternate gene names: 15603206

Gene position: 1534743-1533364 (Counterclockwise)

Preceding gene: 15603207

Following gene: 15603205

Centisome position: 67.98

GC content: 41.09

Gene sequence:

>1380_bases
ATGCTTAGCTTTTTACAAGAAGTTAGAAAACCGACGCTGGAACTGCCAGTGGAAGAACGTCGTAAACTGTGGTTTAAACC
CTTTATGCAATCTTATTTGGTGGTATTCATCGGTTATATGGCGATGTATTTAATTCGCAAAAATTTCAACATCGCACAAA
ATGATTTAATCGAAACCTATGGATTAAGCAAAACCCAGCTCGGTATGATTGGCTTAGGCTTTTCCATTACTTACGGTGTC
GGCAAAACGTTAGTCTCTTATTATGCGGATGGCAAAAACACGAAACAATTCGTACCGTTTATGCTGATTTTATCTGCCAT
TTGTATGCTCGGTTTTAGTGCCAGTATGGGTGGTGGCAGTGTCAGTTTATTCTTAATGATCGCCTTTTATGCGTTAAGCG
GTTTTTTCCAAAGTACAGGTGGTCCTTCAAGCTACTCCACTATCACTAAATGGACTCCACGTAATAAACGCGGCACCTAT
TTAGGTTTTTGGAATTTATCTCACAATGTGGGTGGGGCTGCCGCGGCGGCTGTTGCCTTATTCGGCGCCAATGTGTTCTT
TAATGGGCATGTGATCGGGATGTTCGTGTTCCCGTCAATCATTGCCTTAATTATTGGTTTCTGGGGCTTGCGTTATGGTA
GTGATTCACCAGAAGCTTATGGTTTAGGAAAAGCAGAAGAATTATTTGGTGAGCCATTAAGTGAAGAAGATTTAGCGACT
GAACAAAATCAATTAACCAAATGGCAAACTTTCGTACAGTATATTTTGAAAAATAAGGTGATTTGGCTGTTATGTTTTGC
CAATATTTTCCTGTATATCGTGCGGATTGGGATCGACCAATGGTCACCGGTTTATGCTTACCAAGAATTAGGCTTTTCTA
AAGACGCTGCGATTTCAGGTTTTGCCTTATTTGAAGTAGGGGCGTTAGTTGGTACATTCTTATGGGGCTATTTATCCGAT
TTAGCCAATGGTCGCCGTGGCTTAACCGCTTGTGTGGCGTTAATTCTGATTGTCTTTACTTTAGAATTTTATCAATTCGC
TACTAACGAAGTCATGTATTTATGTGCCTTGTTTGTATTAGGTTTCTTGGTGTTTGGTCCACAATTATTAATTGGGGTGG
CGGCTGTGGGCTTTGTACCGAAAAAAGCCATTAGTGTGGCAGATGGTGTAAAAGGCACTTTTGCTTACCTTATCGGTGAT
AGCTTCGCTAAATTAGGCTTAGGCATGATTGCAGATGGTACAGCAATCTTTGGTTTAACGGGTTGGGCAGGCACTTTTGC
CGCACTCAATATCTCTGCAATCGTTTGCATGGTATTACTTGCCTTTGTTGCCATTGCAGAAGAGAAGAAAATCCGTAAAA
TAAAGGCTCAAGCCAGATAA

Upstream 100 bases:

>100_bases
CTAAGGATTATTCCTAGATCAATTAAAGCATCTTCTCACGCCAGCAGAACGTGATTTTCTTATAGTGACAACAATATTTT
TTTATTTAATGAGGTAAAGC

Downstream 100 bases:

>100_bases
ACAGGTAAATAACATGACACAAAAGTGCGGTTAAATTGACCGCACTTTTTCATTTTTGAGGATAATAAAGATGATTAAAG
TAGCGTTGATCGATGATCAT

Product: sugar phosphate antiporter

Products: Proton [Cytoplasm]; glucose-6-phosphate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MLSFLQEVRKPTLELPVEERRKLWFKPFMQSYLVVFIGYMAMYLIRKNFNIAQNDLIETYGLSKTQLGMIGLGFSITYGV
GKTLVSYYADGKNTKQFVPFMLILSAICMLGFSASMGGGSVSLFLMIAFYALSGFFQSTGGPSSYSTITKWTPRNKRGTY
LGFWNLSHNVGGAAAAAVALFGANVFFNGHVIGMFVFPSIIALIIGFWGLRYGSDSPEAYGLGKAEELFGEPLSEEDLAT
EQNQLTKWQTFVQYILKNKVIWLLCFANIFLYIVRIGIDQWSPVYAYQELGFSKDAAISGFALFEVGALVGTFLWGYLSD
LANGRRGLTACVALILIVFTLEFYQFATNEVMYLCALFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGD
SFAKLGLGMIADGTAIFGLTGWAGTFAALNISAIVCMVLLAFVAIAEEKKIRKIKAQAR

Sequences:

>Translated_459_residues
MLSFLQEVRKPTLELPVEERRKLWFKPFMQSYLVVFIGYMAMYLIRKNFNIAQNDLIETYGLSKTQLGMIGLGFSITYGV
GKTLVSYYADGKNTKQFVPFMLILSAICMLGFSASMGGGSVSLFLMIAFYALSGFFQSTGGPSSYSTITKWTPRNKRGTY
LGFWNLSHNVGGAAAAAVALFGANVFFNGHVIGMFVFPSIIALIIGFWGLRYGSDSPEAYGLGKAEELFGEPLSEEDLAT
EQNQLTKWQTFVQYILKNKVIWLLCFANIFLYIVRIGIDQWSPVYAYQELGFSKDAAISGFALFEVGALVGTFLWGYLSD
LANGRRGLTACVALILIVFTLEFYQFATNEVMYLCALFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGD
SFAKLGLGMIADGTAIFGLTGWAGTFAALNISAIVCMVLLAFVAIAEEKKIRKIKAQAR
>Mature_459_residues
MLSFLQEVRKPTLELPVEERRKLWFKPFMQSYLVVFIGYMAMYLIRKNFNIAQNDLIETYGLSKTQLGMIGLGFSITYGV
GKTLVSYYADGKNTKQFVPFMLILSAICMLGFSASMGGGSVSLFLMIAFYALSGFFQSTGGPSSYSTITKWTPRNKRGTY
LGFWNLSHNVGGAAAAAVALFGANVFFNGHVIGMFVFPSIIALIIGFWGLRYGSDSPEAYGLGKAEELFGEPLSEEDLAT
EQNQLTKWQTFVQYILKNKVIWLLCFANIFLYIVRIGIDQWSPVYAYQELGFSKDAAISGFALFEVGALVGTFLWGYLSD
LANGRRGLTACVALILIVFTLEFYQFATNEVMYLCALFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGD
SFAKLGLGMIADGTAIFGLTGWAGTFAALNISAIVCMVLLAFVAIAEEKKIRKIKAQAR

Specific function: Transport protein for sugar phosphate uptake [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=391, Percent_Identity=23.7851662404092, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI4503847, Length=391, Percent_Identity=23.7851662404092, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI256219483, Length=391, Percent_Identity=23.7851662404092, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI256219543, Length=413, Percent_Identity=23.728813559322, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI2367259, Length=455, Percent_Identity=81.7582417582418, Blast_Score=744, Evalue=0.0,
Organism=Escherichia coli, GI1788573, Length=452, Percent_Identity=32.7433628318584, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082310, Length=463, Percent_Identity=32.3974082073434, Blast_Score=192, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17542316, Length=371, Percent_Identity=23.4501347708895, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI133930953, Length=452, Percent_Identity=21.4601769911504, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI133901854, Length=462, Percent_Identity=23.3766233766234, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI133901856, Length=462, Percent_Identity=23.3766233766234, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24656866, Length=513, Percent_Identity=21.4424951267057, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45550478, Length=513, Percent_Identity=21.4424951267057, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24656861, Length=513, Percent_Identity=21.4424951267057, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50321; Mature: 50321

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFLQEVRKPTLELPVEERRKLWFKPFMQSYLVVFIGYMAMYLIRKNFNIAQNDLIETY
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
GLSKTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFVPFMLILSAICMLGFSASMGGGS
CCCHHHHCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCH
VSLFLMIAFYALSGFFQSTGGPSSYSTITKWTPRNKRGTYLGFWNLSHNVGGAAAAAVAL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCEEEEECCCCCCCHHHHHHHHH
FGANVFFNGHVIGMFVFPSIIALIIGFWGLRYGSDSPEAYGLGKAEELFGEPLSEEDLAT
HHCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHH
EQNQLTKWQTFVQYILKNKVIWLLCFANIFLYIVRIGIDQWSPVYAYQELGFSKDAAISG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHCH
FALFEVGALVGTFLWGYLSDLANGRRGLTACVALILIVFTLEFYQFATNEVMYLCALFVL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGDSFAKLGLGMIADGTAIFGLT
HHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEECCCEEEEEC
GWAGTFAALNISAIVCMVLLAFVAIAEEKKIRKIKAQAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSFLQEVRKPTLELPVEERRKLWFKPFMQSYLVVFIGYMAMYLIRKNFNIAQNDLIETY
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
GLSKTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFVPFMLILSAICMLGFSASMGGGS
CCCHHHHCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCH
VSLFLMIAFYALSGFFQSTGGPSSYSTITKWTPRNKRGTYLGFWNLSHNVGGAAAAAVAL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCEEEEECCCCCCCHHHHHHHHH
FGANVFFNGHVIGMFVFPSIIALIIGFWGLRYGSDSPEAYGLGKAEELFGEPLSEEDLAT
HHCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHH
EQNQLTKWQTFVQYILKNKVIWLLCFANIFLYIVRIGIDQWSPVYAYQELGFSKDAAISG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHCH
FALFEVGALVGTFLWGYLSDLANGRRGLTACVALILIVFTLEFYQFATNEVMYLCALFVL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGDSFAKLGLGMIADGTAIFGLT
HHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEECCCEEEEEC
GWAGTFAALNISAIVCMVLLAFVAIAEEKKIRKIKAQAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; glucose-6-phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + glucose-6-phosphate [Periplasm] = Proton [Cytoplasm] + glucose-6-phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]