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The map label for this gene is fabB [H]

Identifier: 15602204

GI number: 15602204

Start: 399151

End: 400371

Strand: Direct

Name: fabB [H]

Synonym: PM0339

Alternate gene names: 15602204

Gene position: 399151-400371 (Clockwise)

Preceding gene: 15602200

Following gene: 15602207

Centisome position: 17.68

GC content: 43.98

Gene sequence:

>1221_bases
ATGAAAAGAGCGGTTATTACTGGGTTTGGTATTATTTCGAGTATTGGCAACAATAAAGACGAAGTATTAGCATCGTTAAA
AGCTGGCAAATCAGGTATCGAAGTGATGCCCGAGTTTGTTGAGATTGGCATGCGTAGTCATGTGGCCGGCACGGTTAAAT
TAAATCCAAGTGAGCTGATTGATCGTAAAATATATCGTTTTATGGGGGATGCGGCAGCTTATGCTTATCTTTCGATGAAA
GAGGCGATTGAAGATGCAGGTTTGACAGAAGATCAAGTATCGAACGATCGTACTGGCTTGGTGATTGGTGCGGGAACTGG
TTCAGCCCATAACCAATTAATCGCCTGTGATGCGGTGCGTGGTCCTCGTGGTGTGAAAGCGGTAGGACCTTATGCGGTCA
CTAAAACGATGGCATCCAGTGTTTCAGCTTGTTTAGCAACACCTTACAAAATTCGTGGTGTGAACTACAGTATTAGTTCA
GCTTGTGCAACATCAGCCCATTGTATTGGTCATGCGCTTGAGTTAATTCAATTAGGTAAACAAGATATTGTGTTTGCGGG
TGGCGCAGAAGAATTATCTTGGGAATGTGCAACTGAGTTTGATGCGATGGGTGCGGTATCGACAAAATACAACGATACCC
CAGAAAAAGCGTCACGCGCTTATGATGCGAACCGTGATGGTTTCGTCATCGCAGGTGGTGGTGCAGTGGTTGTTGTTGAA
GAATTAGAGCATGCTCTTGCACGTGGTGCGAAAATTTATGCTGAAATCGTTGGCTATGGCGCTACATCAGACGGTTATGA
CATGGTGGCGCCAAGTGGTGAAGGCGCGGAGCGTTGTATGAGACAAGCCATGGCGACGGTTGATACACCAATTGATTACA
TTAACGTCCATGGTACTTCTACACCAGTAGGAGATGTGAAAGAGTTAGGTGCGATTAAAAATGTTTTTGGTGATAAAGTG
CCAGCTATCTCATCAACGAAATCGATGACCGGTCACTCTTTAGGTGCAGCGGGTGCGCACGAAGCGATTTACACGTTATT
AATGTTAGACAATGATTTTATTGCGCCAAGTATCAATATCGAAACTCTCGATGAGAATGCAAAAGGCTGTAACATTGTGA
CCGAAACTGTTGAAAATGCCGGCTTGAAAACTGTGATGTCAAATAGCTTTGGTTTTGGTGGAACAAACGCAGCGTTAATT
TTCAAAAAGTATCAAGCATAA

Upstream 100 bases:

>100_bases
CTGGTCGAACGATCAAATTAGCACTTGAAATGTTAACGTTTGCTCGTTATTTTATCGACCATATTTTTCACAATTTTGAA
TAATTGATAAGGAATACTCC

Downstream 100 bases:

>100_bases
TGGCGTAAAATGACTTGAGATTTAAAGGAAAGCGGTGAGTCTTTTATAGCGTCACCGCTTTTTTTTAGGTTAGTAGATGA
TGGACATTGTTCTGTATTAA

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MKRAVITGFGIISSIGNNKDEVLASLKAGKSGIEVMPEFVEIGMRSHVAGTVKLNPSELIDRKIYRFMGDAAAYAYLSMK
EAIEDAGLTEDQVSNDRTGLVIGAGTGSAHNQLIACDAVRGPRGVKAVGPYAVTKTMASSVSACLATPYKIRGVNYSISS
ACATSAHCIGHALELIQLGKQDIVFAGGAEELSWECATEFDAMGAVSTKYNDTPEKASRAYDANRDGFVIAGGGAVVVVE
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMRQAMATVDTPIDYINVHGTSTPVGDVKELGAIKNVFGDKV
PAISSTKSMTGHSLGAAGAHEAIYTLLMLDNDFIAPSINIETLDENAKGCNIVTETVENAGLKTVMSNSFGFGGTNAALI
FKKYQA

Sequences:

>Translated_406_residues
MKRAVITGFGIISSIGNNKDEVLASLKAGKSGIEVMPEFVEIGMRSHVAGTVKLNPSELIDRKIYRFMGDAAAYAYLSMK
EAIEDAGLTEDQVSNDRTGLVIGAGTGSAHNQLIACDAVRGPRGVKAVGPYAVTKTMASSVSACLATPYKIRGVNYSISS
ACATSAHCIGHALELIQLGKQDIVFAGGAEELSWECATEFDAMGAVSTKYNDTPEKASRAYDANRDGFVIAGGGAVVVVE
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMRQAMATVDTPIDYINVHGTSTPVGDVKELGAIKNVFGDKV
PAISSTKSMTGHSLGAAGAHEAIYTLLMLDNDFIAPSINIETLDENAKGCNIVTETVENAGLKTVMSNSFGFGGTNAALI
FKKYQA
>Mature_406_residues
MKRAVITGFGIISSIGNNKDEVLASLKAGKSGIEVMPEFVEIGMRSHVAGTVKLNPSELIDRKIYRFMGDAAAYAYLSMK
EAIEDAGLTEDQVSNDRTGLVIGAGTGSAHNQLIACDAVRGPRGVKAVGPYAVTKTMASSVSACLATPYKIRGVNYSISS
ACATSAHCIGHALELIQLGKQDIVFAGGAEELSWECATEFDAMGAVSTKYNDTPEKASRAYDANRDGFVIAGGGAVVVVE
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMRQAMATVDTPIDYINVHGTSTPVGDVKELGAIKNVFGDKV
PAISSTKSMTGHSLGAAGAHEAIYTLLMLDNDFIAPSINIETLDENAKGCNIVTETVENAGLKTVMSNSFGFGGTNAALI
FKKYQA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=34.1346153846154, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI41872631, Length=337, Percent_Identity=27.5964391691395, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI223972627, Length=136, Percent_Identity=43.3823529411765, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1788663, Length=406, Percent_Identity=73.8916256157635, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1787337, Length=416, Percent_Identity=40.1442307692308, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71983541, Length=420, Percent_Identity=35.7142857142857, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=41.1320754716981, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI212642053, Length=353, Percent_Identity=27.1954674220963, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=330, Percent_Identity=27.5757575757576, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=31.685393258427, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24644341, Length=424, Percent_Identity=36.5566037735849, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI221330659, Length=338, Percent_Identity=27.5147928994083, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19920632, Length=338, Percent_Identity=27.5147928994083, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24581345, Length=340, Percent_Identity=23.5294117647059, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42492; Mature: 42492

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAVITGFGIISSIGNNKDEVLASLKAGKSGIEVMPEFVEIGMRSHVAGTVKLNPSELI
CCCEEEEHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCHHHCCEEEEEECHHHHH
DRKIYRFMGDAAAYAYLSMKEAIEDAGLTEDQVSNDRTGLVIGAGTGSAHNQLIACDAVR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCCCCCCCEEEEECCC
GPRGVKAVGPYAVTKTMASSVSACLATPYKIRGVNYSISSACATSAHCIGHALELIQLGK
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCC
QDIVFAGGAEELSWECATEFDAMGAVSTKYNDTPEKASRAYDANRDGFVIAGGGAVVVVE
CCEEEECCCHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCEEEEHH
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMRQAMATVDTPIDYINVHGTS
HHHHHHHCCHHEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
TPVGDVKELGAIKNVFGDKVPAISSTKSMTGHSLGAAGAHEAIYTLLMLDNDFIAPSINI
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCCCCCCCEE
ETLDENAKGCNIVTETVENAGLKTVMSNSFGFGGTNAALIFKKYQA
EECCCCCCCCHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MKRAVITGFGIISSIGNNKDEVLASLKAGKSGIEVMPEFVEIGMRSHVAGTVKLNPSELI
CCCEEEEHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCHHHCCEEEEEECHHHHH
DRKIYRFMGDAAAYAYLSMKEAIEDAGLTEDQVSNDRTGLVIGAGTGSAHNQLIACDAVR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCCCCCCCEEEEECCC
GPRGVKAVGPYAVTKTMASSVSACLATPYKIRGVNYSISSACATSAHCIGHALELIQLGK
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCC
QDIVFAGGAEELSWECATEFDAMGAVSTKYNDTPEKASRAYDANRDGFVIAGGGAVVVVE
CCEEEECCCHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCEEEEHH
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMRQAMATVDTPIDYINVHGTS
HHHHHHHCCHHEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
TPVGDVKELGAIKNVFGDKVPAISSTKSMTGHSLGAAGAHEAIYTLLMLDNDFIAPSINI
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCCCCCCCEE
ETLDENAKGCNIVTETVENAGLKTVMSNSFGFGGTNAALIFKKYQA
EECCCCCCCCHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]