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The map label for this gene is alr

Identifier: 15672826

GI number: 15672826

Start: 861791

End: 862894

Strand: Direct

Name: alr

Synonym: L0103

Alternate gene names: 15672826

Gene position: 861791-862894 (Clockwise)

Preceding gene: 15672825

Following gene: 15672827

Centisome position: 36.43

GC content: 37.23

Gene sequence:

>1104_bases
ATGAAAACTTCTCCACATCGCAATACGTCAGCCATTGTTGACTTAAAGGCGATTAGAAATAATATTGAAAAATTTAAAAA
ACATATTCACCCTAATGCGGAAATTTGGCCAGCAGTGAAAGCAGATGCTTATGGTCATGGCTCGGTTGAGGTTTCTAAAG
CGGTGAGCGATTTGGTAGGCGGTTTTTGTGTATCAAACCTTGATGAGGCAATTGAATTACGGAATCATTTGGTAACTAAA
CCGATTTTAGTTTTATCAGGAATTGTTCCAGAAGATGTTGATATTGCAGCTGCTCTTAATATCAGTCTTACTGCCCCAAG
TTTAGAATGGTTAAAATTGGTTGTTCAAGAAGAAGCAGAACTTTCAGATTTAAAAATTCATATTGGTGTAGATTCTGGTA
TGGGTCGGATTGGGATTCGGGATGTTGAAGAAGCAAATCAGATGATTGAACTTGCTGATAAATATGCGATTAATTTTGAA
GGGATTTTCACTCACTTTGCGACCGCCGATATGGCTGATGATACAAAATTTAAAGATCAACAGGCAAGATTTAACAAAAT
TATGGCCGGATTATCACGTAAACCAAAATTTGTTCACTCAACTAATACGGCCGCCGCTTTATGGCATAAGGAACAGGTTC
AAGCTATTGAACGCTTAGGTATTTCAATGTACGGCTTGAATCCAAGTGGTAAAACTTTGGAACTTCCTTTTGAAATCGAA
CCTGCTCTCTCTTTAGTTTCTGAATTGACTCATATTAAAAAAATAGCCGCAGGCGAAACAGTTGGTTACGGTGCAACTTA
TGAAACAAGTGAAGAAACATGGATTGGAACCGTTCCAATTGGTTATGCTGATGGTTGGACTCGTCAAATGCAAGGCTTCA
AAGTACTGGTAAATGGAGAATTTTGTGAGATTGTTGGTCGAGTTTGTATGGATCAAATGATGATAAAACTTGATAAATCT
TATCCTCTAGGAACAAAAGTTACCCTGATTGGTCGTGATAAGACTAATGAAATCACGACGACAGATGTTGCTGATTGGCG
TGGAACGATAAATTATGAAGTGCTTTGTTTACTTTCTGATAGAATCAAACGAATTTATAAATAA

Upstream 100 bases:

>100_bases
CTATCTCGCATAGTAATTTAGAAGCTGTTGCTTTTGTTGTTTTGGAAAAGAATTAAGAAGTAATAAAAATTTTTGCTTAA
ACTAGAGGAAGGTTTAAAAG

Downstream 100 bases:

>100_bases
AATGAATTAATTCCTAATTTTTTCCTCATGATACCCTTTACAAATTGTCTTTTTATGGTAAAATATAATTAAGATATAAA
TGAGAAAGCCATAAGAAAAA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKTSPHRNTSAIVDLKAIRNNIEKFKKHIHPNAEIWPAVKADAYGHGSVEVSKAVSDLVGGFCVSNLDEAIELRNHLVTK
PILVLSGIVPEDVDIAAALNISLTAPSLEWLKLVVQEEAELSDLKIHIGVDSGMGRIGIRDVEEANQMIELADKYAINFE
GIFTHFATADMADDTKFKDQQARFNKIMAGLSRKPKFVHSTNTAAALWHKEQVQAIERLGISMYGLNPSGKTLELPFEIE
PALSLVSELTHIKKIAAGETVGYGATYETSEETWIGTVPIGYADGWTRQMQGFKVLVNGEFCEIVGRVCMDQMMIKLDKS
YPLGTKVTLIGRDKTNEITTTDVADWRGTINYEVLCLLSDRIKRIYK

Sequences:

>Translated_367_residues
MKTSPHRNTSAIVDLKAIRNNIEKFKKHIHPNAEIWPAVKADAYGHGSVEVSKAVSDLVGGFCVSNLDEAIELRNHLVTK
PILVLSGIVPEDVDIAAALNISLTAPSLEWLKLVVQEEAELSDLKIHIGVDSGMGRIGIRDVEEANQMIELADKYAINFE
GIFTHFATADMADDTKFKDQQARFNKIMAGLSRKPKFVHSTNTAAALWHKEQVQAIERLGISMYGLNPSGKTLELPFEIE
PALSLVSELTHIKKIAAGETVGYGATYETSEETWIGTVPIGYADGWTRQMQGFKVLVNGEFCEIVGRVCMDQMMIKLDKS
YPLGTKVTLIGRDKTNEITTTDVADWRGTINYEVLCLLSDRIKRIYK
>Mature_367_residues
MKTSPHRNTSAIVDLKAIRNNIEKFKKHIHPNAEIWPAVKADAYGHGSVEVSKAVSDLVGGFCVSNLDEAIELRNHLVTK
PILVLSGIVPEDVDIAAALNISLTAPSLEWLKLVVQEEAELSDLKIHIGVDSGMGRIGIRDVEEANQMIELADKYAINFE
GIFTHFATADMADDTKFKDQQARFNKIMAGLSRKPKFVHSTNTAAALWHKEQVQAIERLGISMYGLNPSGKTLELPFEIE
PALSLVSELTHIKKIAAGETVGYGATYETSEETWIGTVPIGYADGWTRQMQGFKVLVNGEFCEIVGRVCMDQMMIKLDKS
YPLGTKVTLIGRDKTNEITTTDVADWRGTINYEVLCLLSDRIKRIYK

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=361, Percent_Identity=32.9639889196676, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1790487, Length=371, Percent_Identity=30.188679245283, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_LACLA (Q9CH94)

Other databases:

- EMBL:   AE005176
- PIR:   D86730
- RefSeq:   NP_267000.1
- ProteinModelPortal:   Q9CH94
- SMR:   Q9CH94
- GeneID:   1114472
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0103
- NMPDR:   fig|272623.1.peg.864
- HOGENOM:   HBG712172
- OMA:   TRKEDAN
- ProtClustDB:   PRK00053
- BioCyc:   LLAC272623:L0103-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 40689; Mature: 40689

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 40-40 ACT_SITE 263-263

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSPHRNTSAIVDLKAIRNNIEKFKKHIHPNAEIWPAVKADAYGHGSVEVSKAVSDLVG
CCCCCCCCCHHEEEHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCEEHHHHHHHHHH
GFCVSNLDEAIELRNHLVTKPILVLSGIVPEDVDIAAALNISLTAPSLEWLKLVVQEEAE
HHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCC
LSDLKIHIGVDSGMGRIGIRDVEEANQMIELADKYAINFEGIFTHFATADMADDTKFKDQ
CCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCCCCCCCHH
QARFNKIMAGLSRKPKFVHSTNTAAALWHKEQVQAIERLGISMYGLNPSGKTLELPFEIE
HHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECEECC
PALSLVSELTHIKKIAAGETVGYGATYETSEETWIGTVPIGYADGWTRQMQGFKVLVNGE
HHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCEEEEECCCCCCCHHHHCCCCEEEECCH
FCEIVGRVCMDQMMIKLDKSYPLGTKVTLIGRDKTNEITTTDVADWRGTINYEVLCLLSD
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEEEEEEEHH
RIKRIYK
HHHHHCC
>Mature Secondary Structure
MKTSPHRNTSAIVDLKAIRNNIEKFKKHIHPNAEIWPAVKADAYGHGSVEVSKAVSDLVG
CCCCCCCCCHHEEEHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCEEHHHHHHHHHH
GFCVSNLDEAIELRNHLVTKPILVLSGIVPEDVDIAAALNISLTAPSLEWLKLVVQEEAE
HHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCC
LSDLKIHIGVDSGMGRIGIRDVEEANQMIELADKYAINFEGIFTHFATADMADDTKFKDQ
CCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCCCCCCCHH
QARFNKIMAGLSRKPKFVHSTNTAAALWHKEQVQAIERLGISMYGLNPSGKTLELPFEIE
HHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECEECC
PALSLVSELTHIKKIAAGETVGYGATYETSEETWIGTVPIGYADGWTRQMQGFKVLVNGE
HHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCEEEEECCCCCCCHHHHCCCCEEEECCH
FCEIVGRVCMDQMMIKLDKSYPLGTKVTLIGRDKTNEITTTDVADWRGTINYEVLCLLSD
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEEEEEEEHH
RIKRIYK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471