Click here to switch to the map view.

The map label for this gene is trxA1_2

Identifier: 16120325

GI number: 16120325

Start: 342611

End: 342970

Strand: Reverse

Name: trxA1_2

Synonym: VNG6453G

Alternate gene names: 16120325

Gene position: 342970-342611 (Counterclockwise)

Preceding gene: 16120326

Following gene: 16120324

Centisome position: 93.86

GC content: 63.89

Gene sequence:

>360_bases
ATGGCAACCGATACTGCAGCCACGACTGGCACCGCATCGCCTGACGAACCGCTTTACGTGAACGGCCAGACAGAGCTCGA
CGACGTCACCAGCGACAACGACGTCGTGCTCGCGGACTTCTACGCCGACTGGTGTGGCCCCTGCCAGATGCTCGAACCCG
TCGTCGAGACGCTCGCCGAGCAGACCGACGCGGCCGTCGCGAAAATCGACGTCGACGAGAATCAAGCCCTCGCCAGCGCG
TACGGCGTGCGCGGCGTCCCCACGCTCGTTCTCTTCGCGGACGGCGAGCAAGTCGAGGAAGTCGTCGGCCTTCAGGATGA
AGACGCGCTCAAGGACCTCATCGAGAGCTACACCGAGTAA

Upstream 100 bases:

>100_bases
TAGCGGCGAGCGGTTACGGTGTGGTAGGTGAGTTACCGACCAGTAGTATTGTGTGGCACGTCCAAAACTCTTAACTTCTA
TACCCGCCTACTACCGTGTG

Downstream 100 bases:

>100_bases
ATGACTGAGGACAGCCACGACCTAGTCATCGCCGGGTCGGGAATCGCCGGCCTCTCGGCAGCGGTCTACGCAGCGCGTGC
CGACCTCGAACCCCTCGTCT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 119; Mature: 118

Protein sequence:

>119_residues
MATDTAATTGTASPDEPLYVNGQTELDDVTSDNDVVLADFYADWCGPCQMLEPVVETLAEQTDAAVAKIDVDENQALASA
YGVRGVPTLVLFADGEQVEEVVGLQDEDALKDLIESYTE

Sequences:

>Translated_119_residues
MATDTAATTGTASPDEPLYVNGQTELDDVTSDNDVVLADFYADWCGPCQMLEPVVETLAEQTDAAVAKIDVDENQALASA
YGVRGVPTLVLFADGEQVEEVVGLQDEDALKDLIESYTE
>Mature_118_residues
ATDTAATTGTASPDEPLYVNGQTELDDVTSDNDVVLADFYADWCGPCQMLEPVVETLAEQTDAAVAKIDVDENQALASAY
GVRGVPTLVLFADGEQVEEVVGLQDEDALKDLIESYTE

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=36.9565217391304, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI42794771, Length=99, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=1e-12,
Organism=Homo sapiens, GI224493972, Length=99, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI5031973, Length=75, Percent_Identity=44, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI87082331, Length=91, Percent_Identity=39.5604395604396, Blast_Score=86, Evalue=8e-19,
Organism=Escherichia coli, GI1788936, Length=104, Percent_Identity=32.6923076923077, Blast_Score=69, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=105, Percent_Identity=36.1904761904762, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=82, Percent_Identity=42.6829268292683, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554386, Length=96, Percent_Identity=37.5, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=83, Percent_Identity=39.7590361445783, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=83, Percent_Identity=32.5301204819277, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=110, Percent_Identity=31.8181818181818, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=83, Percent_Identity=32.5301204819277, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=89, Percent_Identity=42.6966292134831, Blast_Score=77, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=81, Percent_Identity=43.2098765432099, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=94, Percent_Identity=37.2340425531915, Blast_Score=71, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17530795, Length=86, Percent_Identity=37.2093023255814, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24639826, Length=102, Percent_Identity=36.2745098039216, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573567, Length=90, Percent_Identity=37.7777777777778, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17648013, Length=84, Percent_Identity=38.0952380952381, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583090, Length=84, Percent_Identity=38.0952380952381, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358065, Length=104, Percent_Identity=38.4615384615385, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24639068, Length=101, Percent_Identity=33.6633663366337, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12690; Mature: 12559

Theoretical pI: Translated: 3.18; Mature: 3.18

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDTAATTGTASPDEPLYVNGQTELDDVTSDNDVVLADFYADWCGPCQMLEPVVETLAE
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECHHHHCCHHHHHHHHHHHHHH
QTDAAVAKIDVDENQALASAYGVRGVPTLVLFADGEQVEEVVGLQDEDALKDLIESYTE
HHCCEEEEEECCCCHHHHHHCCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ATDTAATTGTASPDEPLYVNGQTELDDVTSDNDVVLADFYADWCGPCQMLEPVVETLAE
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECHHHHCCHHHHHHHHHHHHHH
QTDAAVAKIDVDENQALASAYGVRGVPTLVLFADGEQVEEVVGLQDEDALKDLIESYTE
HHCCEEEEEECCCCHHHHHHCCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8936321; 12682364 [H]