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The map label for this gene is atoC

Identifier: 15836118

GI number: 15836118

Start: 675347

End: 676507

Strand: Direct

Name: atoC

Synonym: CPj0586

Alternate gene names: 15836118

Gene position: 675347-676507 (Clockwise)

Preceding gene: 15836116

Following gene: 15836119

Centisome position: 55.06

GC content: 44.62

Gene sequence:

>1161_bases
ATGGCGATTAAAAATATACTTGTTGTTGATGACGAGCCCCTACTCAGAGATTTCCTCTCGGAACTTCTTACCTCACAGGG
ATTCATCCCAGACACTGCTGAAAACTTAAGAAATGCTCTCCAAATGATCCGAAGTCGAGACTATGACCTTGTCATCTCAG
ACATGAGTATGCCTGACGGCTCTGGTCTTGATTTAATCAAAATTATAAAGCAAAGCTCCCCCCACACGCCCGTCCTTGTA
GTCACTGCTTACGGAAGCATAGAGAACGCCGTAGAGGCTATGCACCAAGGGGCATTCAACTACTTAACAAAACCTTTTTC
TTCTGAAGCACTTTTTGCCTTTATCTCTAAAGCTGAAGAACTTAAGAACCTAGTCCATGAGAATCTCTTTCTACATTCTC
AGACAACACCAGATTCACACCCTCTGATTGCAGAAAGCAAGGCTATGAAAGATCTTCTTGCCATAGCAAAAAAAGCAGCT
TCAAGCTCAGCAAATATATTCATTCACGGAGAATCGGGATGCGGAAAGGAAGTCCTCTCCTTTTTTATCCACCACAACTC
TCCTCGAGCCAACCACCCCTATATTAAAGTTAACTGCGCAGCAATTCCTGAAACTCTCTTAGAATCAGAACTTTTTGGCC
ATGAAAAGGGAGCATTTACAGGAGCAACTACAAAGAAGGCAGGACGTTTTGAACTTGCCCATAAAGGAACCCTCTTATTA
GATGAAATCACCGAAGTCCCAGTAAACCTTCAAGCAAAACTCCTGAGAGCTATCCAAGAAAAAGAAATCGAACACCTTGG
AGGAACCAAGACCCTCTCCGTAGATGTTCGCATCTTAGCGACCTCAAACCGAAAGCTTAAAGAAGCTATCGATGATAAAA
GCTTCCGACAAGATCTGTATTACCGGTTGAATGTCATCCCTCTACACCTCCCCCCTCTAAGAGACCGACAGGACGACATC
CTCCCTCTGGCGAACTACTTCCTAAATAAGTTCTGCCGCATGAACAATACTCCTCTGAAAACCCTCTCTCCTAAAGCTCA
AGAGCTCCTCCTTAACTACCCCTGGCCAGGCAATATTCGAGAGCTCTCCAATGTTCTGGAACGTGTGGTTATCCTAGAGA
ACACCTCCCTACTCACCGAAGACATGCTCGCTTTAGCTTGA

Upstream 100 bases:

>100_bases
TTGATAATATTTTTTAAATTCTTTCTATTAAATTGAAAGTTTTGCTTCATTTTTCAAGATTTAGTAAAAAGAAAAAATGA
ATCCATCCAGGGGAGAGAAC

Downstream 100 bases:

>100_bases
TCTCCTCTAGGGGTTTTTCTTGTTTTTCTCAATAGCATCTGGTAAGCTGATTTGCTTTAATCTCTGTATTCTTTTAAGCA
CCGATAGCTCAATTGGATAG

Product: 2-component regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MAIKNILVVDDEPLLRDFLSELLTSQGFIPDTAENLRNALQMIRSRDYDLVISDMSMPDGSGLDLIKIIKQSSPHTPVLV
VTAYGSIENAVEAMHQGAFNYLTKPFSSEALFAFISKAEELKNLVHENLFLHSQTTPDSHPLIAESKAMKDLLAIAKKAA
SSSANIFIHGESGCGKEVLSFFIHHNSPRANHPYIKVNCAAIPETLLESELFGHEKGAFTGATTKKAGRFELAHKGTLLL
DEITEVPVNLQAKLLRAIQEKEIEHLGGTKTLSVDVRILATSNRKLKEAIDDKSFRQDLYYRLNVIPLHLPPLRDRQDDI
LPLANYFLNKFCRMNNTPLKTLSPKAQELLLNYPWPGNIRELSNVLERVVILENTSLLTEDMLALA

Sequences:

>Translated_386_residues
MAIKNILVVDDEPLLRDFLSELLTSQGFIPDTAENLRNALQMIRSRDYDLVISDMSMPDGSGLDLIKIIKQSSPHTPVLV
VTAYGSIENAVEAMHQGAFNYLTKPFSSEALFAFISKAEELKNLVHENLFLHSQTTPDSHPLIAESKAMKDLLAIAKKAA
SSSANIFIHGESGCGKEVLSFFIHHNSPRANHPYIKVNCAAIPETLLESELFGHEKGAFTGATTKKAGRFELAHKGTLLL
DEITEVPVNLQAKLLRAIQEKEIEHLGGTKTLSVDVRILATSNRKLKEAIDDKSFRQDLYYRLNVIPLHLPPLRDRQDDI
LPLANYFLNKFCRMNNTPLKTLSPKAQELLLNYPWPGNIRELSNVLERVVILENTSLLTEDMLALA
>Mature_385_residues
AIKNILVVDDEPLLRDFLSELLTSQGFIPDTAENLRNALQMIRSRDYDLVISDMSMPDGSGLDLIKIIKQSSPHTPVLVV
TAYGSIENAVEAMHQGAFNYLTKPFSSEALFAFISKAEELKNLVHENLFLHSQTTPDSHPLIAESKAMKDLLAIAKKAAS
SSANIFIHGESGCGKEVLSFFIHHNSPRANHPYIKVNCAAIPETLLESELFGHEKGAFTGATTKKAGRFELAHKGTLLLD
EITEVPVNLQAKLLRAIQEKEIEHLGGTKTLSVDVRILATSNRKLKEAIDDKSFRQDLYYRLNVIPLHLPPLRDRQDDIL
PLANYFLNKFCRMNNTPLKTLSPKAQELLLNYPWPGNIRELSNVLERVVILENTSLLTEDMLALA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=384, Percent_Identity=48.1770833333333, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1790437, Length=385, Percent_Identity=43.8961038961039, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1790299, Length=378, Percent_Identity=40.2116402116402, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1788905, Length=387, Percent_Identity=39.5348837209302, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI87082117, Length=231, Percent_Identity=53.2467532467532, Blast_Score=264, Evalue=7e-72,
Organism=Escherichia coli, GI1789087, Length=260, Percent_Identity=47.6923076923077, Blast_Score=244, Evalue=8e-66,
Organism=Escherichia coli, GI1789233, Length=235, Percent_Identity=48.0851063829787, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI87082152, Length=236, Percent_Identity=47.0338983050847, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1786524, Length=260, Percent_Identity=42.3076923076923, Blast_Score=207, Evalue=8e-55,
Organism=Escherichia coli, GI87081872, Length=236, Percent_Identity=44.9152542372881, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI1787583, Length=274, Percent_Identity=38.3211678832117, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1789828, Length=238, Percent_Identity=33.6134453781513, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87081858, Length=292, Percent_Identity=31.8493150684932, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786784, Length=108, Percent_Identity=37.037037037037, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786911, Length=153, Percent_Identity=35.2941176470588, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786599, Length=114, Percent_Identity=37.719298245614, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788191, Length=108, Percent_Identity=38.8888888888889, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790552, Length=110, Percent_Identity=34.5454545454545, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787375, Length=130, Percent_Identity=33.8461538461538, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082012, Length=110, Percent_Identity=29.0909090909091, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789402, Length=103, Percent_Identity=32.0388349514563, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789809, Length=111, Percent_Identity=31.5315315315315, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 43072; Mature: 42941

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKNILVVDDEPLLRDFLSELLTSQGFIPDTAENLRNALQMIRSRDYDLVISDMSMPDG
CCCCCEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
SGLDLIKIIKQSSPHTPVLVVTAYGSIENAVEAMHQGAFNYLTKPFSSEALFAFISKAEE
CCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LKNLVHENLFLHSQTTPDSHPLIAESKAMKDLLAIAKKAASSSANIFIHGESGCGKEVLS
HHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
FFIHHNSPRANHPYIKVNCAAIPETLLESELFGHEKGAFTGATTKKAGRFELAHKGTLLL
HHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCEEE
DEITEVPVNLQAKLLRAIQEKEIEHLGGTKTLSVDVRILATSNRKLKEAIDDKSFRQDLY
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHHCHHHHHHHHH
YRLNVIPLHLPPLRDRQDDILPLANYFLNKFCRMNNTPLKTLSPKAQELLLNYPWPGNIR
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEECCCCCCHH
ELSNVLERVVILENTSLLTEDMLALA
HHHHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
AIKNILVVDDEPLLRDFLSELLTSQGFIPDTAENLRNALQMIRSRDYDLVISDMSMPDG
CCCCEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
SGLDLIKIIKQSSPHTPVLVVTAYGSIENAVEAMHQGAFNYLTKPFSSEALFAFISKAEE
CCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LKNLVHENLFLHSQTTPDSHPLIAESKAMKDLLAIAKKAASSSANIFIHGESGCGKEVLS
HHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
FFIHHNSPRANHPYIKVNCAAIPETLLESELFGHEKGAFTGATTKKAGRFELAHKGTLLL
HHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCEEE
DEITEVPVNLQAKLLRAIQEKEIEHLGGTKTLSVDVRILATSNRKLKEAIDDKSFRQDLY
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHHCHHHHHHHHH
YRLNVIPLHLPPLRDRQDDILPLANYFLNKFCRMNNTPLKTLSPKAQELLLNYPWPGNIR
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEECCCCCCHH
ELSNVLERVVILENTSLLTEDMLALA
HHHHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]