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The map label for this gene is atoS

Identifier: 15836116

GI number: 15836116

Start: 672028

End: 673122

Strand: Direct

Name: atoS

Synonym: CPj0584

Alternate gene names: 15836116

Gene position: 672028-673122 (Clockwise)

Preceding gene: 15836115

Following gene: 15836118

Centisome position: 54.79

GC content: 42.47

Gene sequence:

>1095_bases
ATGAACGTCCCTGATTCCAAGAACCTCCATCCTCCTGCATACGAACTCCTAGAGATCAAGGCTCGCATCACACAATCTTA
TAAAGAAGCGAGTGCTATACTGACAGCGATTCCTGATGGTATCCTATTACTTTCTGAAACAGGACACTTTCTTATCTGCA
ATTCACAAGCACGTGAAATTCTAGGAATTGATGAAAATCTAGAAATTCTTAATAGATCCTTTACCGATGTTCTCCCCGAT
ACGTGTCTTGGATTTTCTATTCAAGAGGCTCTTGAATCTCTAAAAGTCCCTAAAACTCTTAGACTCTCTCTCTGTAAAGA
ATCTAAAGAAAAAGAAGTGGAACTCTTCATCCGTAAAAACGAGATCAGTGGATACCTGTTTATCCAAATCCGCGATCGGT
CCGACTATAAACAACTAGAAAACGCTATAGAAAGATATAGAAATATCGCAGAACTTGGGAAAATGACGGCTACCCTAGCT
CACGAAATCCGCAATCCGCTAAGTGGAATCGTTGGATTTGCCTCTATCCTAAAGAAAGAGATTTCCTCTCCTCGCCACCA
ACGAATGCTCTCCTCAATCATCTCCGGCACAAGGTCTCTAAATAACCTTGTCTCTTCTATGTTAGAATATACAAAATCAC
AACCGTTGAACCTAAAGATTATAAATTTACAAGACTTCTTCTCTTCTCTTATCCCTCTGCTCTCCGTCTCTTTCCCGAAT
TGCAAGTTTGTAAGAGAGGGCGCACAACCTCTATTCAGATCTATAGATCCTGATCGGATGAACAGTGTCGTTTGGAACCT
AGTGAAAAATGCTGTAGAAACAGGGAACTCTCCGATCACTCTGACCCTGCATACATCGGGAGACATCTCGGTAACGAACC
CCGGAACGATTCCTTCCGAGATCATGGACAAGCTCTTCACTCCATTCTTCACAACAAAGAGAGAGGGAAATGGTTTGGGA
CTTGCTGAAGCTCAAAAAATTATAAGACTCCATGGAGGAGATATCCAATTAAAAACAAGCGACTCCGCCGTTAGCTTCTT
CATAATCATCCCCGAACTTCTAGCGGCCCTACCCAAAGAAAGAGCCGCTAGCTAG

Upstream 100 bases:

>100_bases
GATATCCAAGAAGAGCTGGAAGAAATCCGTGATGTTATTATTCGTATTCTAGATACGGATAAACGCAACTATGCACAGAA
AAAAAAGGAATTTGGTATTT

Downstream 100 bases:

>100_bases
AACGCGTTCTTGAATCTTCAAGACCACTTAGGGTTCTCAAAGATCATCTACGATGTTTTCTTATCCTTGAAATTGCTCTT
GCTCTAGTCTTTCAACCTCC

Product: 2-component sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MNVPDSKNLHPPAYELLEIKARITQSYKEASAILTAIPDGILLLSETGHFLICNSQAREILGIDENLEILNRSFTDVLPD
TCLGFSIQEALESLKVPKTLRLSLCKESKEKEVELFIRKNEISGYLFIQIRDRSDYKQLENAIERYRNIAELGKMTATLA
HEIRNPLSGIVGFASILKKEISSPRHQRMLSSIISGTRSLNNLVSSMLEYTKSQPLNLKIINLQDFFSSLIPLLSVSFPN
CKFVREGAQPLFRSIDPDRMNSVVWNLVKNAVETGNSPITLTLHTSGDISVTNPGTIPSEIMDKLFTPFFTTKREGNGLG
LAEAQKIIRLHGGDIQLKTSDSAVSFFIIIPELLAALPKERAAS

Sequences:

>Translated_364_residues
MNVPDSKNLHPPAYELLEIKARITQSYKEASAILTAIPDGILLLSETGHFLICNSQAREILGIDENLEILNRSFTDVLPD
TCLGFSIQEALESLKVPKTLRLSLCKESKEKEVELFIRKNEISGYLFIQIRDRSDYKQLENAIERYRNIAELGKMTATLA
HEIRNPLSGIVGFASILKKEISSPRHQRMLSSIISGTRSLNNLVSSMLEYTKSQPLNLKIINLQDFFSSLIPLLSVSFPN
CKFVREGAQPLFRSIDPDRMNSVVWNLVKNAVETGNSPITLTLHTSGDISVTNPGTIPSEIMDKLFTPFFTTKREGNGLG
LAEAQKIIRLHGGDIQLKTSDSAVSFFIIIPELLAALPKERAAS
>Mature_364_residues
MNVPDSKNLHPPAYELLEIKARITQSYKEASAILTAIPDGILLLSETGHFLICNSQAREILGIDENLEILNRSFTDVLPD
TCLGFSIQEALESLKVPKTLRLSLCKESKEKEVELFIRKNEISGYLFIQIRDRSDYKQLENAIERYRNIAELGKMTATLA
HEIRNPLSGIVGFASILKKEISSPRHQRMLSSIISGTRSLNNLVSSMLEYTKSQPLNLKIINLQDFFSSLIPLLSVSFPN
CKFVREGAQPLFRSIDPDRMNSVVWNLVKNAVETGNSPITLTLHTSGDISVTNPGTIPSEIMDKLFTPFFTTKREGNGLG
LAEAQKIIRLHGGDIQLKTSDSAVSFFIIIPELLAALPKERAAS

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788549, Length=336, Percent_Identity=26.4880952380952, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1790300, Length=353, Percent_Identity=23.5127478753541, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI48994928, Length=242, Percent_Identity=28.099173553719, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI145693157, Length=256, Percent_Identity=26.5625, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40526; Mature: 40526

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVPDSKNLHPPAYELLEIKARITQSYKEASAILTAIPDGILLLSETGHFLICNSQAREI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHH
LGIDENLEILNRSFTDVLPDTCLGFSIQEALESLKVPKTLRLSLCKESKEKEVELFIRKN
HCCCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEC
EISGYLFIQIRDRSDYKQLENAIERYRNIAELGKMTATLAHEIRNPLSGIVGFASILKKE
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISSPRHQRMLSSIISGTRSLNNLVSSMLEYTKSQPLNLKIINLQDFFSSLIPLLSVSFPN
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCC
CKFVREGAQPLFRSIDPDRMNSVVWNLVKNAVETGNSPITLTLHTSGDISVTNPGTIPSE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCHHH
IMDKLFTPFFTTKREGNGLGLAEAQKIIRLHGGDIQLKTSDSAVSFFIIIPELLAALPKE
HHHHHHCCHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHCCHH
RAAS
HCCC
>Mature Secondary Structure
MNVPDSKNLHPPAYELLEIKARITQSYKEASAILTAIPDGILLLSETGHFLICNSQAREI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHH
LGIDENLEILNRSFTDVLPDTCLGFSIQEALESLKVPKTLRLSLCKESKEKEVELFIRKN
HCCCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEC
EISGYLFIQIRDRSDYKQLENAIERYRNIAELGKMTATLAHEIRNPLSGIVGFASILKKE
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISSPRHQRMLSSIISGTRSLNNLVSSMLEYTKSQPLNLKIINLQDFFSSLIPLLSVSFPN
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCC
CKFVREGAQPLFRSIDPDRMNSVVWNLVKNAVETGNSPITLTLHTSGDISVTNPGTIPSE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCHHH
IMDKLFTPFFTTKREGNGLGLAEAQKIIRLHGGDIQLKTSDSAVSFFIIIPELLAALPKE
HHHHHHCCHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHCCHH
RAAS
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]