Click here to switch to the map view.

The map label for this gene is clpC

Identifier: 15835970

GI number: 15835970

Start: 481526

End: 484063

Strand: Direct

Name: clpC

Synonym: CPj0437

Alternate gene names: 15835970

Gene position: 481526-484063 (Clockwise)

Preceding gene: 15835963

Following gene: 15835972

Centisome position: 39.26

GC content: 43.74

Gene sequence:

>2538_bases
ATGTTTGAGACGTTCACTAATAGAGCAAAACAAGTCATTAAACTGGCGAAAAAGGAGGCTCAGCGTTTAAATCATAACTA
CCTGGGTACTGAGCACATCCTGCTTGGTCTTCTCAAACTTGGTCAAGGGGTAGCTGTTAATGTATTACGCAACCTCGGTA
TAGATTTTGATACGGCACGGCAAGAGGTGGAACGCCTGATTGGTTATGGTCCAGAAATTCAAGTCTACGGAGACCCTGCC
CTTACAGGAAGAGTAAAAAAATCTTTTGAATCAGCAAATGAAGAGGCCAGCCTTTTAGAGCACAATTATGTCGGGACGGA
GCATTTACTCTTAGGGATCCTACATCAATCAGATAGTGTCGCTCTTCAGGTATTAGAAAACTTACATATCGATCCAAGAG
AGGTTCGTAAGGAAATTCTTAAAGAATTAGAGACCTTCAATCTACAACTTCCTCCTTCGTCGTCGTCTTCTTCCTCATCC
TCTCGAAGCAACCCTTCATCTTCAAAATCTCCTTTAGGTCATAGCTTAGGTTCTGACAAAAACGAAAAGCTTTCTGCTCT
GAAAGCATATGGTTATGATTTAACGGAGATGGTCCGAGAGTCTAAGCTCGATCCTGTCATTGGTCGTTCTTCAGAAGTCG
AACGGTTGATTTTGATTCTTTGCCGAAGAAGAAAAAACAATCCTGTACTTATTGGAGAAGCTGGAGTTGGTAAGACTGCA
ATTGTTGAGGGTCTGGCTCAAAAAATCATTCTGAATGAGGTTCCTGATGCCTTACGGAAAAAGCGACTGATTACTCTAGA
TCTAGCATTAATGATTGCTGGAACAAAATATCGAGGGCAATTTGAGGAACGGATCAAAGCTGTCATGGATGAAGTTCGCA
AGCATGGAAACATCTTGCTCTTCATTGACGAGCTCCACACGATTGTAGGAGCAGGAGCAGCTGAAGGTGCTATCGATGCT
TCAAACATTTTAAAACCTGCGTTAGCGCGAGGTGAAATTCAGTGTATTGGAGCAACTACGATAGATGAGTATCGCAAGCA
CATAGAAAAAGACGCAGCTTTAGAACGTCGTTTCCAAAAAATCGTGGTTCACCCTCCTAGTGTAGATGAGACTATTGAGA
TTTTACGTGGCCTCAAGAAAAAGTATGAAGAACATCACAATGTCTTCATTACTGAAGAAGCTTTAAAAGCAGCTGCGACT
CTTTCTGATCAATATGTTCATGGACGTTTCCTCCCTGATAAAGCAATAGATCTTTTAGATGAAGCTGGGGCTCGTGTCCG
TGTGAATACAATGGGTCAGCCTACAGATTTAATGAAGCTAGAGGCTGAAATCGAAAATACAAAATTGGCCAAAGAGCAGG
CCATTGGAACTCAAGAATACGAAAAAGCTGCAGGTTTACGTGATGAAGAGAAAAAACTTCGCGAACGTCTGCAAAGTATG
AAACAGGAATGGGAAAATCATAAAGAAGAGCACCAAGTTCCTGTAGATGAAGAAGCAGTCGCTCAGGTAGTTTCTCTACA
AACAGGAATTCCCTCAGCAAGGCTCACAGAAGCTGAAAGTGAGAAGCTTCTGAAGTTAGAAGACACGTTAAGAAGAAAAG
TCATTGGTCAAAATGATGCCGTTACCAGCATTTGCCGTGCCATCCGACGTTCTCGAACAGGGATCAAAGATCCTAACCGA
CCTACGGGCTCCTTCCTATTCCTTGGGCCTACCGGTGTAGGGAAAAGCCTGCTCGCCCAACAAATTGCTATAGAGATGTT
CGGTGGTGAAGACGCTCTGATTCAGGTAGACATGTCAGAGTACATGGAGAAATTTGCTGCTACCAAGATGATGGGATCAC
CTCCAGGATATGTAGGTCATGAAGAAGGGGGCCACCTTACGGAACAGGTACGTCGCCGTCCTTACTGCGTTGTTCTCTTT
GATGAGATAGAAAAGGCACACCCAGACATTATGGACCTGATGTTGCAAATTTTAGAGCAAGGACGTCTTACTGATTCTTT
TGGTCGCAAAGTGGATTTCCGTCATGCCATTATTATCATGACCTCCAATTTGGGAGCTGATCTCATTCGTAAAAGCGGAG
AAATTGGTTTTGGCTTGAAGTCCCATATGGACTATAAGGTCATCCAAGAGAAAATCGAACATGCTATGAAGAAACACTTA
AAGCCTGAGTTCATTAACCGTTTGGATGAAAGTGTGATTTTCCGTCCCCTCGAGAAAGAATCTCTATCGGAGATCATCCA
TTTAGAGATCAACAAACTGGACTCGAGACTGAAAAACTACCAAATGGCTTTGAACATCCCAGACTCTGTGATTTCCTTCC
TAGTAACGAAGGGGCATTCTCCAGAAATGGGAGCACGTCCTCTACGCCGTGTCATTGAGCAGTACCTTGAAGATCCTCTA
GCGGAGCTCTTGCTTAAAGAGTCCTGCCGTCAAGAAGCTCGCAAGCTACGAGCAACCTTGGTTGAAAATCGCGTTGCCTT
TGAAAGGGAAGAAGAGGAGCAGGAAGCTGCTCTCCCTAGCCCTCACTTGGAATCATAG

Upstream 100 bases:

>100_bases
GAATTTTACCAAATTTGCTGGGTTAGAGCGAAGAGTTGCATCATTATTTTAAATTTCGTATATGCTTAAGGAAAGTTCTA
CCCCTGTCTTTTAGGTTTTT

Downstream 100 bases:

>100_bases
GAACGTCGATAACTCCACTACCAAGGCAGGTATCTCCTTGATAAAACGCTATTGTTTGTCCTGGAGTTACCGCCTTGACG
GGTTGTGAAAATCGCACCTT

Product: ClpC protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 845; Mature: 845

Protein sequence:

>845_residues
MFETFTNRAKQVIKLAKKEAQRLNHNYLGTEHILLGLLKLGQGVAVNVLRNLGIDFDTARQEVERLIGYGPEIQVYGDPA
LTGRVKKSFESANEEASLLEHNYVGTEHLLLGILHQSDSVALQVLENLHIDPREVRKEILKELETFNLQLPPSSSSSSSS
SRSNPSSSKSPLGHSLGSDKNEKLSALKAYGYDLTEMVRESKLDPVIGRSSEVERLILILCRRRKNNPVLIGEAGVGKTA
IVEGLAQKIILNEVPDALRKKRLITLDLALMIAGTKYRGQFEERIKAVMDEVRKHGNILLFIDELHTIVGAGAAEGAIDA
SNILKPALARGEIQCIGATTIDEYRKHIEKDAALERRFQKIVVHPPSVDETIEILRGLKKKYEEHHNVFITEEALKAAAT
LSDQYVHGRFLPDKAIDLLDEAGARVRVNTMGQPTDLMKLEAEIENTKLAKEQAIGTQEYEKAAGLRDEEKKLRERLQSM
KQEWENHKEEHQVPVDEEAVAQVVSLQTGIPSARLTEAESEKLLKLEDTLRRKVIGQNDAVTSICRAIRRSRTGIKDPNR
PTGSFLFLGPTGVGKSLLAQQIAIEMFGGEDALIQVDMSEYMEKFAATKMMGSPPGYVGHEEGGHLTEQVRRRPYCVVLF
DEIEKAHPDIMDLMLQILEQGRLTDSFGRKVDFRHAIIIMTSNLGADLIRKSGEIGFGLKSHMDYKVIQEKIEHAMKKHL
KPEFINRLDESVIFRPLEKESLSEIIHLEINKLDSRLKNYQMALNIPDSVISFLVTKGHSPEMGARPLRRVIEQYLEDPL
AELLLKESCRQEARKLRATLVENRVAFEREEEEQEAALPSPHLES

Sequences:

>Translated_845_residues
MFETFTNRAKQVIKLAKKEAQRLNHNYLGTEHILLGLLKLGQGVAVNVLRNLGIDFDTARQEVERLIGYGPEIQVYGDPA
LTGRVKKSFESANEEASLLEHNYVGTEHLLLGILHQSDSVALQVLENLHIDPREVRKEILKELETFNLQLPPSSSSSSSS
SRSNPSSSKSPLGHSLGSDKNEKLSALKAYGYDLTEMVRESKLDPVIGRSSEVERLILILCRRRKNNPVLIGEAGVGKTA
IVEGLAQKIILNEVPDALRKKRLITLDLALMIAGTKYRGQFEERIKAVMDEVRKHGNILLFIDELHTIVGAGAAEGAIDA
SNILKPALARGEIQCIGATTIDEYRKHIEKDAALERRFQKIVVHPPSVDETIEILRGLKKKYEEHHNVFITEEALKAAAT
LSDQYVHGRFLPDKAIDLLDEAGARVRVNTMGQPTDLMKLEAEIENTKLAKEQAIGTQEYEKAAGLRDEEKKLRERLQSM
KQEWENHKEEHQVPVDEEAVAQVVSLQTGIPSARLTEAESEKLLKLEDTLRRKVIGQNDAVTSICRAIRRSRTGIKDPNR
PTGSFLFLGPTGVGKSLLAQQIAIEMFGGEDALIQVDMSEYMEKFAATKMMGSPPGYVGHEEGGHLTEQVRRRPYCVVLF
DEIEKAHPDIMDLMLQILEQGRLTDSFGRKVDFRHAIIIMTSNLGADLIRKSGEIGFGLKSHMDYKVIQEKIEHAMKKHL
KPEFINRLDESVIFRPLEKESLSEIIHLEINKLDSRLKNYQMALNIPDSVISFLVTKGHSPEMGARPLRRVIEQYLEDPL
AELLLKESCRQEARKLRATLVENRVAFEREEEEQEAALPSPHLES
>Mature_845_residues
MFETFTNRAKQVIKLAKKEAQRLNHNYLGTEHILLGLLKLGQGVAVNVLRNLGIDFDTARQEVERLIGYGPEIQVYGDPA
LTGRVKKSFESANEEASLLEHNYVGTEHLLLGILHQSDSVALQVLENLHIDPREVRKEILKELETFNLQLPPSSSSSSSS
SRSNPSSSKSPLGHSLGSDKNEKLSALKAYGYDLTEMVRESKLDPVIGRSSEVERLILILCRRRKNNPVLIGEAGVGKTA
IVEGLAQKIILNEVPDALRKKRLITLDLALMIAGTKYRGQFEERIKAVMDEVRKHGNILLFIDELHTIVGAGAAEGAIDA
SNILKPALARGEIQCIGATTIDEYRKHIEKDAALERRFQKIVVHPPSVDETIEILRGLKKKYEEHHNVFITEEALKAAAT
LSDQYVHGRFLPDKAIDLLDEAGARVRVNTMGQPTDLMKLEAEIENTKLAKEQAIGTQEYEKAAGLRDEEKKLRERLQSM
KQEWENHKEEHQVPVDEEAVAQVVSLQTGIPSARLTEAESEKLLKLEDTLRRKVIGQNDAVTSICRAIRRSRTGIKDPNR
PTGSFLFLGPTGVGKSLLAQQIAIEMFGGEDALIQVDMSEYMEKFAATKMMGSPPGYVGHEEGGHLTEQVRRRPYCVVLF
DEIEKAHPDIMDLMLQILEQGRLTDSFGRKVDFRHAIIIMTSNLGADLIRKSGEIGFGLKSHMDYKVIQEKIEHAMKKHL
KPEFINRLDESVIFRPLEKESLSEIIHLEINKLDSRLKNYQMALNIPDSVISFLVTKGHSPEMGARPLRRVIEQYLEDPL
AELLLKESCRQEARKLRATLVENRVAFEREEEEQEAALPSPHLES

Specific function: Part Of A Stress-Induced Multi-Chaperone System, It Is Involved In The Recovery Of The Cell From Heat-Induced Damage, In Cooperation With Dnak, Dnaj And Grpe. Acts Before Dnak, In The Processing Of Protein Aggregates. Protein Binding Stimulates The Atpase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=345, Percent_Identity=33.9130434782609, Blast_Score=188, Evalue=2e-47,
Organism=Escherichia coli, GI1788943, Length=869, Percent_Identity=41.1967779056387, Blast_Score=637, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=806, Percent_Identity=35.1116625310174, Blast_Score=466, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6320464, Length=743, Percent_Identity=40.9152086137281, Blast_Score=559, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6323002, Length=889, Percent_Identity=36.4454443194601, Blast_Score=506, Evalue=1e-144,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 94955; Mature: 94955

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFETFTNRAKQVIKLAKKEAQRLNHNYLGTEHILLGLLKLGQGVAVNVLRNLGIDFDTAR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHH
QEVERLIGYGPEIQVYGDPALTGRVKKSFESANEEASLLEHNYVGTEHLLLGILHQSDSV
HHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCHHH
ALQVLENLHIDPREVRKEILKELETFNLQLPPSSSSSSSSSRSNPSSSKSPLGHSLGSDK
HHHHHHHCCCCHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NEKLSALKAYGYDLTEMVRESKLDPVIGRSSEVERLILILCRRRKNNPVLIGEAGVGKTA
HHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHH
IVEGLAQKIILNEVPDALRKKRLITLDLALMIAGTKYRGQFEERIKAVMDEVRKHGNILL
HHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEE
FIDELHTIVGAGAAEGAIDASNILKPALARGEIQCIGATTIDEYRKHIEKDAALERRFQK
EHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
IVVHPPSVDETIEILRGLKKKYEEHHNVFITEEALKAAATLSDQYVHGRFLPDKAIDLLD
HCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
EAGARVRVNTMGQPTDLMKLEAEIENTKLAKEQAIGTQEYEKAAGLRDEEKKLRERLQSM
HCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHH
KQEWENHKEEHQVPVDEEAVAQVVSLQTGIPSARLTEAESEKLLKLEDTLRRKVIGQNDA
HHHHHCCHHHCCCCCCHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCCHH
VTSICRAIRRSRTGIKDPNRPTGSFLFLGPTGVGKSLLAQQIAIEMFGGEDALIQVDMSE
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHH
YMEKFAATKMMGSPPGYVGHEEGGHLTEQVRRRPYCVVLFDEIEKAHPDIMDLMLQILEQ
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEHHHHHHHCCHHHHHHHHHHHC
GRLTDSFGRKVDFRHAIIIMTSNLGADLIRKSGEIGFGLKSHMDYKVIQEKIEHAMKKHL
CCCCHHHCCCCCCCEEEEEEECCCCHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHCC
KPEFINRLDESVIFRPLEKESLSEIIHLEINKLDSRLKNYQMALNIPDSVISFLVTKGHS
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHCCCC
PEMGARPLRRVIEQYLEDPLAELLLKESCRQEARKLRATLVENRVAFEREEEEQEAALPS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PHLES
CCCCC
>Mature Secondary Structure
MFETFTNRAKQVIKLAKKEAQRLNHNYLGTEHILLGLLKLGQGVAVNVLRNLGIDFDTAR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHH
QEVERLIGYGPEIQVYGDPALTGRVKKSFESANEEASLLEHNYVGTEHLLLGILHQSDSV
HHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCHHH
ALQVLENLHIDPREVRKEILKELETFNLQLPPSSSSSSSSSRSNPSSSKSPLGHSLGSDK
HHHHHHHCCCCHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NEKLSALKAYGYDLTEMVRESKLDPVIGRSSEVERLILILCRRRKNNPVLIGEAGVGKTA
HHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHH
IVEGLAQKIILNEVPDALRKKRLITLDLALMIAGTKYRGQFEERIKAVMDEVRKHGNILL
HHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEE
FIDELHTIVGAGAAEGAIDASNILKPALARGEIQCIGATTIDEYRKHIEKDAALERRFQK
EHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
IVVHPPSVDETIEILRGLKKKYEEHHNVFITEEALKAAATLSDQYVHGRFLPDKAIDLLD
HCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
EAGARVRVNTMGQPTDLMKLEAEIENTKLAKEQAIGTQEYEKAAGLRDEEKKLRERLQSM
HCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHH
KQEWENHKEEHQVPVDEEAVAQVVSLQTGIPSARLTEAESEKLLKLEDTLRRKVIGQNDA
HHHHHCCHHHCCCCCCHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCCHH
VTSICRAIRRSRTGIKDPNRPTGSFLFLGPTGVGKSLLAQQIAIEMFGGEDALIQVDMSE
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHH
YMEKFAATKMMGSPPGYVGHEEGGHLTEQVRRRPYCVVLFDEIEKAHPDIMDLMLQILEQ
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEHHHHHHHCCHHHHHHHHHHHC
GRLTDSFGRKVDFRHAIIIMTSNLGADLIRKSGEIGFGLKSHMDYKVIQEKIEHAMKKHL
CCCCHHHCCCCCCCEEEEEEECCCCHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHCC
KPEFINRLDESVIFRPLEKESLSEIIHLEINKLDSRLKNYQMALNIPDSVISFLVTKGHS
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHCCCC
PEMGARPLRRVIEQYLEDPLAELLLKESCRQEARKLRATLVENRVAFEREEEEQEAALPS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PHLES
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]