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The map label for this gene is pdhA

Identifier: 15835839

GI number: 15835839

Start: 342755

End: 343783

Strand: Direct

Name: pdhA

Synonym: CPj0304

Alternate gene names: 15835839

Gene position: 342755-343783 (Clockwise)

Preceding gene: 15835837

Following gene: 15835840

Centisome position: 27.94

GC content: 42.37

Gene sequence:

>1029_bases
ATGGATAGTTCAGCACCTTATAATATAGCTTCTCAGGGCACAGAGAAATCCACAGTAGAAAGGATCTTAGACCTTTACGG
GCCCGCTTCCTGTATTAAATTTTTAAAACAGATGGTTCTGATTCGTGAATTCGAAGCCCGAGGAGAAGAAGCCTATCTAG
AAGGGCTAGTGGGTGGATTTTACCACTCTTACGCTGGCCAAGAAGCTGTAGCAACTGCTGCAATCGCAAACACAGGACTA
GATCCCTGGGTGTTCTCTTCATACCGCTGCCACGCACTTGCGATTCTTCTCAACATTCCCCTTCAAGAAATTGCTGCTGA
ACTTTTAGGGAAAGAAACTGGATGCGCTTTAGGTCGTGGAGGATCCATGCATATGTGTGGGCCTAATTTCCCTGGAGGAT
TTGGTATTGTCGGAGGACAAATTCCCCTCGCAGCTGGAGCCGCATTTACCATCAAATATCAAGAACAAAAAAATAGAGTT
TCTCTATGCTTTATCGGAGATGGTGCGGTAGCTCAAGGTGTATTCCATGAAACTCTGAACTTTGTTTCTCTTCACCAACT
CCCTCTAATGCTTATTATTGAAAATAACGGCTGGAGTATGGGAACGTCATTAAATCGTGCTGTTGCAAAACAGCCCATAG
CAGAGTCTCAAGGAAGTTCCTACGATATCCGTGCAGTCACAGTCAATGGTTTTGATCTATTTAACTCTCTTTTAGGATTT
AGAGAGGCTTATCGCTATATGGTTGATACCGAATCTCCGGTTTTAGTTGAGTGTCTCTGCTCCCGATTTCGAGGGCATTC
TATATCAGATCCTAATTTATATAGATCGAAAGAAGAAATGCAGTGTTTATTTAAAAAAGATCCTATTGTCCTAGCTAAAG
ATTGGCTAATTCGATTAGAGGTTCTGACTGAAGAGGAATTTCAAAATATACGCCAAGAATGCAAAACTGCTGTTTTAGAA
GCGTTCTCTAACGCAAAACTCTCATCAGATCCATCCGTCACCACATTAGAGGAAGGAGTCTATGCCTAA

Upstream 100 bases:

>100_bases
CTTAATTATTTTTTCTTCGGATAGCCCTTGTCTTTTGAAACCTAGGCTCCTATAATGAGATCAAAAACCGCTCCCGAAGC
GTCTCCCTTATAAAAAAGTT

Downstream 100 bases:

>100_bases
ACATAAAACATTAGAAATTCGAGAAGCTCTCCGAGAAGCAATTGACGAAGAGATGTCTCGCGATCCTAATGTCTGTATTC
TTGGTGAAGAGGTTGGTGAC

Product: pyruvate dehydrogenase alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MDSSAPYNIASQGTEKSTVERILDLYGPASCIKFLKQMVLIREFEARGEEAYLEGLVGGFYHSYAGQEAVATAAIANTGL
DPWVFSSYRCHALAILLNIPLQEIAAELLGKETGCALGRGGSMHMCGPNFPGGFGIVGGQIPLAAGAAFTIKYQEQKNRV
SLCFIGDGAVAQGVFHETLNFVSLHQLPLMLIIENNGWSMGTSLNRAVAKQPIAESQGSSYDIRAVTVNGFDLFNSLLGF
REAYRYMVDTESPVLVECLCSRFRGHSISDPNLYRSKEEMQCLFKKDPIVLAKDWLIRLEVLTEEEFQNIRQECKTAVLE
AFSNAKLSSDPSVTTLEEGVYA

Sequences:

>Translated_342_residues
MDSSAPYNIASQGTEKSTVERILDLYGPASCIKFLKQMVLIREFEARGEEAYLEGLVGGFYHSYAGQEAVATAAIANTGL
DPWVFSSYRCHALAILLNIPLQEIAAELLGKETGCALGRGGSMHMCGPNFPGGFGIVGGQIPLAAGAAFTIKYQEQKNRV
SLCFIGDGAVAQGVFHETLNFVSLHQLPLMLIIENNGWSMGTSLNRAVAKQPIAESQGSSYDIRAVTVNGFDLFNSLLGF
REAYRYMVDTESPVLVECLCSRFRGHSISDPNLYRSKEEMQCLFKKDPIVLAKDWLIRLEVLTEEEFQNIRQECKTAVLE
AFSNAKLSSDPSVTTLEEGVYA
>Mature_342_residues
MDSSAPYNIASQGTEKSTVERILDLYGPASCIKFLKQMVLIREFEARGEEAYLEGLVGGFYHSYAGQEAVATAAIANTGL
DPWVFSSYRCHALAILLNIPLQEIAAELLGKETGCALGRGGSMHMCGPNFPGGFGIVGGQIPLAAGAAFTIKYQEQKNRV
SLCFIGDGAVAQGVFHETLNFVSLHQLPLMLIIENNGWSMGTSLNRAVAKQPIAESQGSSYDIRAVTVNGFDLFNSLLGF
REAYRYMVDTESPVLVECLCSRFRGHSISDPNLYRSKEEMQCLFKKDPIVLAKDWLIRLEVLTEEEFQNIRQECKTAVLE
AFSNAKLSSDPSVTTLEEGVYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=316, Percent_Identity=35.126582278481, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI4505685, Length=313, Percent_Identity=35.4632587859425, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI291084742, Length=313, Percent_Identity=35.4632587859425, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI291084744, Length=320, Percent_Identity=34.6875, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI291084757, Length=313, Percent_Identity=30.9904153354633, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI11386135, Length=319, Percent_Identity=29.4670846394984, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI258645172, Length=319, Percent_Identity=29.4670846394984, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17536047, Length=298, Percent_Identity=38.5906040268456, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI32564172, Length=297, Percent_Identity=38.7205387205387, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI86563357, Length=316, Percent_Identity=26.2658227848101, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI86563355, Length=316, Percent_Identity=26.2658227848101, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=319, Percent_Identity=35.1097178683386, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24639744, Length=356, Percent_Identity=35.6741573033708, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI28571106, Length=356, Percent_Identity=35.6741573033708, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24639740, Length=356, Percent_Identity=35.6741573033708, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24639748, Length=311, Percent_Identity=37.2990353697749, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24639746, Length=307, Percent_Identity=36.8078175895765, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21355903, Length=318, Percent_Identity=25.1572327044025, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37466; Mature: 37466

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSSAPYNIASQGTEKSTVERILDLYGPASCIKFLKQMVLIREFEARGEEAYLEGLVGGF
CCCCCCCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
YHSYAGQEAVATAAIANTGLDPWVFSSYRCHALAILLNIPLQEIAAELLGKETGCALGRG
HHHHCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
GSMHMCGPNFPGGFGIVGGQIPLAAGAAFTIKYQEQKNRVSLCFIGDGAVAQGVFHETLN
CCEEECCCCCCCCCEEECCCCCEECCCEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHH
FVSLHQLPLMLIIENNGWSMGTSLNRAVAKQPIAESQGSSYDIRAVTVNGFDLFNSLLGF
HHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCHHCCCCCEEEEEEEECCHHHHHHHHHH
REAYRYMVDTESPVLVECLCSRFRGHSISDPNLYRSKEEMQCLFKKDPIVLAKDWLIRLE
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHCCCCEEEECCCEEEEH
VLTEEEFQNIRQECKTAVLEAFSNAKLSSDPSVTTLEEGVYA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHCCCCC
>Mature Secondary Structure
MDSSAPYNIASQGTEKSTVERILDLYGPASCIKFLKQMVLIREFEARGEEAYLEGLVGGF
CCCCCCCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
YHSYAGQEAVATAAIANTGLDPWVFSSYRCHALAILLNIPLQEIAAELLGKETGCALGRG
HHHHCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
GSMHMCGPNFPGGFGIVGGQIPLAAGAAFTIKYQEQKNRVSLCFIGDGAVAQGVFHETLN
CCEEECCCCCCCCCEEECCCCCEECCCEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHH
FVSLHQLPLMLIIENNGWSMGTSLNRAVAKQPIAESQGSSYDIRAVTVNGFDLFNSLLGF
HHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCHHCCCCCEEEEEEEECCHHHHHHHHHH
REAYRYMVDTESPVLVECLCSRFRGHSISDPNLYRSKEEMQCLFKKDPIVLAKDWLIRLE
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHCCCCEEEECCCEEEEH
VLTEEEFQNIRQECKTAVLEAFSNAKLSSDPSVTTLEEGVYA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA