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The map label for this gene is lpxD

Identifier: 15835837

GI number: 15835837

Start: 340409

End: 341491

Strand: Direct

Name: lpxD

Synonym: CPj0302

Alternate gene names: 15835837

Gene position: 340409-341491 (Clockwise)

Preceding gene: 15835836

Following gene: 15835839

Centisome position: 27.75

GC content: 40.54

Gene sequence:

>1083_bases
ATGTCCGAAGCACCAGTCTACACTCTTAAACAGTTAGCTGAGCTACTACAAGTCGAAGTTCAAGGAAATATAGAAACTCC
TATTTCAGGTGTTGAAGATATTAGTCAGGCGCAACCTCACCATATTGCTTTTTTAGATAATGAGAAATACTCTAGCTTTC
TAAAAAACACCAAAGCTGGTGCTATTATTTTATCTAGATCTCAGGCAATGCAACATGCCCACCTAAAGAAAAACTTTCTT
ATTACCAATGAATCCCCTTCTCTAACATTTCAAAAGTGCATAGAGTTGTTTATTGAACCCGTAACATCAGGGTTTCCTGG
TATTCATCCTACTGCAGTGATTCATCCTACTGCACGTATTGAGAAAAATGTAACCATAGAACCTTACGTTGTCATTAGTC
AACATGCCCATATCGGCTCTGACACATACATCGGAGCTGGAAGTGTCATTGGAGCTCACAGCGTTCTAGGTGCTAACTGT
CTGATTCACCCTAAGGTGGTGATTCGAGAAAGAGTCCTCATGGGAAACCGTGTAGTTGTTCAACCTGGAGCTGTTTTAGG
ATCCTGTGGTTTTGGTTATATTACAAATGCTTTTGGTCATCACAAACCTTTAAAGCATCTAGGCTATGTGATTGTAGGTG
ATGATGTAGAAATCGGAGCCAACACTACGATAGATCGTGGTCGATTCAAGAACACCGTGATCCATGAAGGAACTAAAATA
GATAACCAAGTACAAGTAGCTCATCACGTAGAAATTGGAAAGCATAGTATTATTGTTGCCCAAGCAGGCATTGCAGGTTC
TACAAAAATTGGTGAACATGTCATCATTGGAGGGCAAACCGGAATTACTGGGCATATTTCTATTGCAGACCATGTGATCA
TGATTGCTCAAACTGGAGTCACAAAATCTATCACCTCTCCAGGCATTTATGGAGGCGCTCCAGCACGACCTTATCAAGAA
ACACATCGGTTGATTGCTAAAATTCGGAACCTTCCTAAAACTGAAGAAAGACTAAGTAAGTTAGAAAAACAAGTAAGAGA
TCTATCGACTCCCAGCCTTGCTGAGATTCCTTCAGAGATCTAA

Upstream 100 bases:

>100_bases
CTTAGCAATAGCACCTGGGACTGATAAAACAACCGAAATTATTGCTATTCTTAACGAATCTTTCAAAAAACAAAACTAGT
CCAAGTTTAAGGAGTTTTCT

Downstream 100 bases:

>100_bases
AATTCTATTTATTTTATTAGTTTTGAAATCAAAAAAAAGACCAAATAATTAAATATATAAAGAACGTACTCTTCTTTTTA
TCATGAGAATTTTCATGATA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSEAPVYTLKQLAELLQVEVQGNIETPISGVEDISQAQPHHIAFLDNEKYSSFLKNTKAGAIILSRSQAMQHAHLKKNFL
ITNESPSLTFQKCIELFIEPVTSGFPGIHPTAVIHPTARIEKNVTIEPYVVISQHAHIGSDTYIGAGSVIGAHSVLGANC
LIHPKVVIRERVLMGNRVVVQPGAVLGSCGFGYITNAFGHHKPLKHLGYVIVGDDVEIGANTTIDRGRFKNTVIHEGTKI
DNQVQVAHHVEIGKHSIIVAQAGIAGSTKIGEHVIIGGQTGITGHISIADHVIMIAQTGVTKSITSPGIYGGAPARPYQE
THRLIAKIRNLPKTEERLSKLEKQVRDLSTPSLAEIPSEI

Sequences:

>Translated_360_residues
MSEAPVYTLKQLAELLQVEVQGNIETPISGVEDISQAQPHHIAFLDNEKYSSFLKNTKAGAIILSRSQAMQHAHLKKNFL
ITNESPSLTFQKCIELFIEPVTSGFPGIHPTAVIHPTARIEKNVTIEPYVVISQHAHIGSDTYIGAGSVIGAHSVLGANC
LIHPKVVIRERVLMGNRVVVQPGAVLGSCGFGYITNAFGHHKPLKHLGYVIVGDDVEIGANTTIDRGRFKNTVIHEGTKI
DNQVQVAHHVEIGKHSIIVAQAGIAGSTKIGEHVIIGGQTGITGHISIADHVIMIAQTGVTKSITSPGIYGGAPARPYQE
THRLIAKIRNLPKTEERLSKLEKQVRDLSTPSLAEIPSEI
>Mature_359_residues
SEAPVYTLKQLAELLQVEVQGNIETPISGVEDISQAQPHHIAFLDNEKYSSFLKNTKAGAIILSRSQAMQHAHLKKNFLI
TNESPSLTFQKCIELFIEPVTSGFPGIHPTAVIHPTARIEKNVTIEPYVVISQHAHIGSDTYIGAGSVIGAHSVLGANCL
IHPKVVIRERVLMGNRVVVQPGAVLGSCGFGYITNAFGHHKPLKHLGYVIVGDDVEIGANTTIDRGRFKNTVIHEGTKID
NQVQVAHHVEIGKHSIIVAQAGIAGSTKIGEHVIIGGQTGITGHISIADHVIMIAQTGVTKSITSPGIYGGAPARPYQET
HRLIAKIRNLPKTEERLSKLEKQVRDLSTPSLAEIPSEI

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=342, Percent_Identity=34.7953216374269, Blast_Score=203, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_CHLPN (Q9Z8N6)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   F72094
- PIR:   F86528
- RefSeq:   NP_224507.1
- RefSeq:   NP_300361.1
- RefSeq:   NP_445004.1
- RefSeq:   NP_876587.1
- ProteinModelPortal:   Q9Z8N6
- SMR:   Q9Z8N6
- PHCI-2DPAGE:   Q9Z8N6
- GeneID:   1466994
- GeneID:   894718
- GeneID:   919085
- GeneID:   962794
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0456
- KEGG:   cpn:CPn0302
- KEGG:   cpt:CpB0311
- TIGR:   CP_0456
- HOGENOM:   HBG469615
- OMA:   AKIMKSA
- PhylomeDB:   Q9Z8N6
- ProtClustDB:   PRK00892
- BioCyc:   CPNE115711:CP_0456-MONOMER
- BioCyc:   CPNE115713:CPN0302-MONOMER
- BioCyc:   CPNE138677:CPJ0302-MONOMER
- BioCyc:   CPNE182082:CPB0311-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 38847; Mature: 38716

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAPVYTLKQLAELLQVEVQGNIETPISGVEDISQAQPHHIAFLDNEKYSSFLKNTKAG
CCCCCHHHHHHHHHHHEEHCCCCCCCCCCCHHHHHHCCCCEEEEEECHHHHHHHHCCCCC
AIILSRSQAMQHAHLKKNFLITNESPSLTFQKCIELFIEPVTSGFPGIHPTAVIHPTARI
EEEEEHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHH
EKNVTIEPYVVISQHAHIGSDTYIGAGSVIGAHSVLGANCLIHPKVVIRERVLMGNRVVV
CCCCEECEEEEEECCCCCCCCCEECCCCHHHHHHHHCCCEEECCHHHHHHHHHCCCEEEE
QPGAVLGSCGFGYITNAFGHHKPLKHLGYVIVGDDVEIGANTTIDRGRFKNTVIHEGTKI
ECCCEEECCCCHHHHHHHCCCCCHHHCCEEEECCCEEECCCCCCCCCCCCCCEEECCCCC
DNQVQVAHHVEIGKHSIIVAQAGIAGSTKIGEHVIIGGQTGITGHISIADHVIMIAQTGV
CCEEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCEEEEEHHCEEEEEEECCC
TKSITSPGIYGGAPARPYQETHRLIAKIRNLPKTEERLSKLEKQVRDLSTPSLAEIPSEI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCC
>Mature Secondary Structure 
SEAPVYTLKQLAELLQVEVQGNIETPISGVEDISQAQPHHIAFLDNEKYSSFLKNTKAG
CCCCHHHHHHHHHHHEEHCCCCCCCCCCCHHHHHHCCCCEEEEEECHHHHHHHHCCCCC
AIILSRSQAMQHAHLKKNFLITNESPSLTFQKCIELFIEPVTSGFPGIHPTAVIHPTARI
EEEEEHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHH
EKNVTIEPYVVISQHAHIGSDTYIGAGSVIGAHSVLGANCLIHPKVVIRERVLMGNRVVV
CCCCEECEEEEEECCCCCCCCCEECCCCHHHHHHHHCCCEEECCHHHHHHHHHCCCEEEE
QPGAVLGSCGFGYITNAFGHHKPLKHLGYVIVGDDVEIGANTTIDRGRFKNTVIHEGTKI
ECCCEEECCCCHHHHHHHCCCCCHHHCCEEEECCCEEECCCCCCCCCCCCCCEEECCCCC
DNQVQVAHHVEIGKHSIIVAQAGIAGSTKIGEHVIIGGQTGITGHISIADHVIMIAQTGV
CCEEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCEEEEEHHCEEEEEEECCC
TKSITSPGIYGGAPARPYQETHRLIAKIRNLPKTEERLSKLEKQVRDLSTPSLAEIPSEI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362