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The map label for this gene is adk

Identifier: 15835779

GI number: 15835779

Start: 280540

End: 281181

Strand: Direct

Name: adk

Synonym: CPj0244

Alternate gene names: 15835779

Gene position: 280540-281181 (Clockwise)

Preceding gene: 15835774

Following gene: 15835780

Centisome position: 22.87

GC content: 40.97

Gene sequence:

>642_bases
GTGACTAAGGGCTCTGTTTTTATTATTATGGGGCCTCCAGGCTCAGGCAAAGGAACCCAATCTCAATATCTTGCCAATAG
AATAGGCTTACCCCACATCAGTACTGGGGATTTATTAAGAGCGATTATTCGAGAAGGAACTCCTAATGGATTGAAGGCTA
AAGCCTACCTAGATAAGGGTGCTTTTGTTCCTAGTGATTTTGTATGGGAAATACTGAAAGAAAAACTGCAAAGCCAAGCC
TGCTCTAAAGGATGCATTATCGATGGGTTCCCGAGAACCTTAGATCAGGCGCATCTTCTGGATAGTTTTCTTATGGACGT
CCATTCTAACTACACGGTGATTTTCCTAGAGATTTCTGAAGACGAGATCTTAAAAAGAGTGTGTTCAAGATTTCTTTGCC
CCTCCTGTTCGCGTATCTACAACACAAGTCAGGGACATACCGAATGTCCAGACTGTCATGTGCCTTTGATACGGCGTTCT
GACGATACCCCGGAAATCATTAAAGAAAGATTAACAAAATATCAAGAACGCACAGCTCCTGTTATTGCCTATTATGACAG
CTTAGGGAAGCTATGTAGGGTTTCTTCTGAAAACAAAGAGGATCTTGTTTTTGAAGACATTTTGAAATGCATTTATAAAT
AG

Upstream 100 bases:

>100_bases
AGGAAAAGTCTCTCTGTTTTACCCCATGTCGTACGAAAAGTATTGTTAAGTTTCCCTGATTTTAGGGGTAATGGTGACGT
CAATTTAAGGAGCATTCGAA

Downstream 100 bases:

>100_bases
TTTTTCTTCCTTCCAAAGAAAAGTACCGAATTCACCCGAAAAAAATTCACTCAGAACCTTGTCTTAAACTTGTCAGAAGG
AAATTATGAAACACTACCTA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MTKGSVFIIMGPPGSGKGTQSQYLANRIGLPHISTGDLLRAIIREGTPNGLKAKAYLDKGAFVPSDFVWEILKEKLQSQA
CSKGCIIDGFPRTLDQAHLLDSFLMDVHSNYTVIFLEISEDEILKRVCSRFLCPSCSRIYNTSQGHTECPDCHVPLIRRS
DDTPEIIKERLTKYQERTAPVIAYYDSLGKLCRVSSENKEDLVFEDILKCIYK

Sequences:

>Translated_213_residues
MTKGSVFIIMGPPGSGKGTQSQYLANRIGLPHISTGDLLRAIIREGTPNGLKAKAYLDKGAFVPSDFVWEILKEKLQSQA
CSKGCIIDGFPRTLDQAHLLDSFLMDVHSNYTVIFLEISEDEILKRVCSRFLCPSCSRIYNTSQGHTECPDCHVPLIRRS
DDTPEIIKERLTKYQERTAPVIAYYDSLGKLCRVSSENKEDLVFEDILKCIYK
>Mature_212_residues
TKGSVFIIMGPPGSGKGTQSQYLANRIGLPHISTGDLLRAIIREGTPNGLKAKAYLDKGAFVPSDFVWEILKEKLQSQAC
SKGCIIDGFPRTLDQAHLLDSFLMDVHSNYTVIFLEISEDEILKRVCSRFLCPSCSRIYNTSQGHTECPDCHVPLIRRSD
DTPEIIKERLTKYQERTAPVIAYYDSLGKLCRVSSENKEDLVFEDILKCIYK

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=216, Percent_Identity=35.1851851851852, Blast_Score=140, Evalue=7e-34,
Organism=Homo sapiens, GI4502013, Length=216, Percent_Identity=35.1851851851852, Blast_Score=140, Evalue=7e-34,
Organism=Homo sapiens, GI19923437, Length=189, Percent_Identity=37.5661375661376, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI310110345, Length=196, Percent_Identity=35.7142857142857, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI53832003, Length=196, Percent_Identity=35.7142857142857, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI8051579, Length=196, Percent_Identity=35.7142857142857, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI53832001, Length=196, Percent_Identity=35.7142857142857, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI4502011, Length=208, Percent_Identity=30.2884615384615, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI28144897, Length=205, Percent_Identity=31.219512195122, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI28144899, Length=205, Percent_Identity=31.219512195122, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI22749187, Length=181, Percent_Identity=27.6243093922652, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=26.027397260274, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1786680, Length=183, Percent_Identity=34.9726775956284, Blast_Score=126, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17552384, Length=194, Percent_Identity=36.5979381443299, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=210, Percent_Identity=33.8095238095238, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17533833, Length=206, Percent_Identity=29.6116504854369, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=206, Percent_Identity=29.126213592233, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=214, Percent_Identity=26.6355140186916, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=33.8028169014084, Blast_Score=135, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6321018, Length=205, Percent_Identity=33.6585365853659, Blast_Score=111, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6322828, Length=210, Percent_Identity=31.9047619047619, Blast_Score=98, Evalue=8e-22,
Organism=Drosophila melanogaster, GI22026816, Length=205, Percent_Identity=36.5853658536585, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=33.1658291457286, Blast_Score=113, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=33.1658291457286, Blast_Score=113, Evalue=7e-26,
Organism=Drosophila melanogaster, GI17647141, Length=207, Percent_Identity=26.0869565217391, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24663208, Length=207, Percent_Identity=26.0869565217391, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221459597, Length=210, Percent_Identity=26.1904761904762, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356893, Length=210, Percent_Identity=26.1904761904762, Blast_Score=85, Evalue=3e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CHLPN (Q9Z8U0)

Other databases:

- EMBL:   AB022016
- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   D86521
- PIR:   H72100
- RefSeq:   NP_224453.1
- RefSeq:   NP_300303.1
- RefSeq:   NP_445062.1
- RefSeq:   NP_876527.1
- ProteinModelPortal:   Q9Z8U0
- SMR:   Q9Z8U0
- GeneID:   1466934
- GeneID:   895175
- GeneID:   919023
- GeneID:   962784
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0518
- KEGG:   cpn:CPn0244
- KEGG:   cpt:CpB0251
- TIGR:   CP_0518
- HOGENOM:   HBG630208
- OMA:   FQSILAC
- ProtClustDB:   PRK00279
- BioCyc:   CPNE115711:CP_0518-MONOMER
- BioCyc:   CPNE115713:CPN0244-MONOMER
- BioCyc:   CPNE138677:CPJ0244-MONOMER
- BioCyc:   CPNE182082:CPB0251-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23953; Mature: 23822

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKGSVFIIMGPPGSGKGTQSQYLANRIGLPHISTGDLLRAIIREGTPNGLKAKAYLDKG
CCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEHEECCCC
AFVPSDFVWEILKEKLQSQACSKGCIIDGFPRTLDQAHLLDSFLMDVHSNYTVIFLEISE
CCCCHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECH
DEILKRVCSRFLCPSCSRIYNTSQGHTECPDCHVPLIRRSDDTPEIIKERLTKYQERTAP
HHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCC
VIAYYDSLGKLCRVSSENKEDLVFEDILKCIYK
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TKGSVFIIMGPPGSGKGTQSQYLANRIGLPHISTGDLLRAIIREGTPNGLKAKAYLDKG
CCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEHEECCCC
AFVPSDFVWEILKEKLQSQACSKGCIIDGFPRTLDQAHLLDSFLMDVHSNYTVIFLEISE
CCCCHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECH
DEILKRVCSRFLCPSCSRIYNTSQGHTECPDCHVPLIRRSDDTPEIIKERLTKYQERTAP
HHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCC
VIAYYDSLGKLCRVSSENKEDLVFEDILKCIYK
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362