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The map label for this gene is hemK

Identifier: 15835650

GI number: 15835650

Start: 146109

End: 146975

Strand: Direct

Name: hemK

Synonym: CPj0114

Alternate gene names: 15835650

Gene position: 146109-146975 (Clockwise)

Preceding gene: 15835649

Following gene: 15835651

Centisome position: 11.91

GC content: 41.64

Gene sequence:

>867_bases
ATGGAAATTAAAAAGGCGATTCAAGAGGGAACCGCTTACCTAGATTATTATGGGGTGCCTCTTTCTGATTGCGAAGCCCT
GTATATTCTCATGGATTTATTAGAAGTCAGTTCAAGGGCAAAGTTATTCGATCTTGTTGGAATTAGCGAAACGATGCTTA
TGGAGTATCGAAAGAGGCTAGCTTTAAGGGGGCAACGGTGTCCTACTGCATATCTCAATGGTGCCGTGAGTTTTTTGGGA
TTAAGATTGAGAGTGGATTCTAGGGTTTTAATTCCCAGGACAGAGACTGAGCTGCTTGCTGAGTATATTATCAACTATCT
TTTATCTCATTCTGAGATTCAAACTTTTTATGATATTTGTTGTGGTAGCGGGTGTTTAGGGCTAGCTATCAAGAAATCCT
GTCCTCATGTGGAAGTGGTGCTTTCAGATGTTTGTCCGCAAGCAGTTGCCGTCGCAAATGAAAATGCTAAAAGTAATGGT
TTGGATGTAAAGATTCTTCTAGGCGATTTGTCAGCCCCCTACACTCGTCCTGCAGATGCTTTTGTTTGTAATCCCCCCTA
TTTGTCTTTTAATGAAATTATTCATATAGATCCCGAAGTGCGTTGTTACGAGCCTTGGAAGGCTCTTGTTGGAGGTTCTA
CGGGTTTGGAGTTTTATCAGCGTATCGCCCAAGAATTGCCTAAGATTGTAACTTCTACAGGAGTCGGTTGGTTGGAGATT
GGATCCAGTCAAGGAGAAAGTATAAAGAATATTTTTTCGAAGCACGGAATTTATGGCCGTCTCCATCAAGATTTGTCTGG
ACGCGATAGAATTTTTTTTCTTGAAATGGATGGGAGAGATCCTGTATCCTCGGGGGCTTATTCTTGA

Upstream 100 bases:

>100_bases
ATCGGATTAACTTTATATAACTTAGATAAAGTTATGGAAGGAGACCTAGATCCAATTACGACTGCAATGGTGAGTCATGC
CTACCACCAGTTACTCGAAC

Downstream 100 bases:

>100_bases
TTTTTTCTGGATAAATGATTAATTCTTTATCGCAAAAGCTATCTTCTATTTTTTCTTTTTTGGTTTCTTCTCGTAGAATT
AATGAAGAAAATATTTCCGA

Product: N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase

Products: NA

Alternate protein names: M.AaoHemKP [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MEIKKAIQEGTAYLDYYGVPLSDCEALYILMDLLEVSSRAKLFDLVGISETMLMEYRKRLALRGQRCPTAYLNGAVSFLG
LRLRVDSRVLIPRTETELLAEYIINYLLSHSEIQTFYDICCGSGCLGLAIKKSCPHVEVVLSDVCPQAVAVANENAKSNG
LDVKILLGDLSAPYTRPADAFVCNPPYLSFNEIIHIDPEVRCYEPWKALVGGSTGLEFYQRIAQELPKIVTSTGVGWLEI
GSSQGESIKNIFSKHGIYGRLHQDLSGRDRIFFLEMDGRDPVSSGAYS

Sequences:

>Translated_288_residues
MEIKKAIQEGTAYLDYYGVPLSDCEALYILMDLLEVSSRAKLFDLVGISETMLMEYRKRLALRGQRCPTAYLNGAVSFLG
LRLRVDSRVLIPRTETELLAEYIINYLLSHSEIQTFYDICCGSGCLGLAIKKSCPHVEVVLSDVCPQAVAVANENAKSNG
LDVKILLGDLSAPYTRPADAFVCNPPYLSFNEIIHIDPEVRCYEPWKALVGGSTGLEFYQRIAQELPKIVTSTGVGWLEI
GSSQGESIKNIFSKHGIYGRLHQDLSGRDRIFFLEMDGRDPVSSGAYS
>Mature_288_residues
MEIKKAIQEGTAYLDYYGVPLSDCEALYILMDLLEVSSRAKLFDLVGISETMLMEYRKRLALRGQRCPTAYLNGAVSFLG
LRLRVDSRVLIPRTETELLAEYIINYLLSHSEIQTFYDICCGSGCLGLAIKKSCPHVEVVLSDVCPQAVAVANENAKSNG
LDVKILLGDLSAPYTRPADAFVCNPPYLSFNEIIHIDPEVRCYEPWKALVGGSTGLEFYQRIAQELPKIVTSTGVGWLEI
GSSQGESIKNIFSKHGIYGRLHQDLSGRDRIFFLEMDGRDPVSSGAYS

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=293, Percent_Identity=26.2798634812287, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI87082085, Length=224, Percent_Identity=31.25, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787463, Length=259, Percent_Identity=29.3436293436293, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24582226, Length=228, Percent_Identity=27.1929824561404, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 31963; Mature: 31963

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKKAIQEGTAYLDYYGVPLSDCEALYILMDLLEVSSRAKLFDLVGISETMLMEYRKRL
CCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ALRGQRCPTAYLNGAVSFLGLRLRVDSRVLIPRTETELLAEYIINYLLSHSEIQTFYDIC
HHCCCCCCHHHHHHHHHHHEEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CGSGCLGLAIKKSCPHVEVVLSDVCPQAVAVANENAKSNGLDVKILLGDLSAPYTRPADA
HCCCCHHHEECCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCC
FVCNPPYLSFNEIIHIDPEVRCYEPWKALVGGSTGLEFYQRIAQELPKIVTSTGVGWLEI
EEECCCCCCCCCEEEECCCCEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
GSSQGESIKNIFSKHGIYGRLHQDLSGRDRIFFLEMDGRDPVSSGAYS
CCCCCHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MEIKKAIQEGTAYLDYYGVPLSDCEALYILMDLLEVSSRAKLFDLVGISETMLMEYRKRL
CCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ALRGQRCPTAYLNGAVSFLGLRLRVDSRVLIPRTETELLAEYIINYLLSHSEIQTFYDIC
HHCCCCCCHHHHHHHHHHHEEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CGSGCLGLAIKKSCPHVEVVLSDVCPQAVAVANENAKSNGLDVKILLGDLSAPYTRPADA
HCCCCHHHEECCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCC
FVCNPPYLSFNEIIHIDPEVRCYEPWKALVGGSTGLEFYQRIAQELPKIVTSTGVGWLEI
EEECCCCCCCCCEEEECCCCEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
GSSQGESIKNIFSKHGIYGRLHQDLSGRDRIFFLEMDGRDPVSSGAYS
CCCCCHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]