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The map label for this gene is tcyP [H]

Identifier: 15595074

GI number: 15595074

Start: 768079

End: 769470

Strand: Reverse

Name: tcyP [H]

Synonym: BB0729

Alternate gene names: 15595074

Gene position: 769470-768079 (Counterclockwise)

Preceding gene: 15595075

Following gene: 15595073

Centisome position: 84.49

GC content: 32.69

Gene sequence:

>1392_bases
ATGGATAAAATAAGTATATTATATACATTAATCAATATTATAATAATGCTTATTCTAATAAGCATAGTTTATCTTTGTAA
AAGAAAAAATGTTTCTTTTACAAAAAGAGTGTTTATAGCGTTAGCAATCGGAATAGTATTTGGAATGACCATTCAATATT
TTTATGGAACAAATTCAGAAATAACAAACGAAACTATAAATTGGATAAGTATTTTGGGCGATGGATACGTAAGGCTCCTT
AAAATGATTATAATCCCCTTAATAATAACATCAATAATCTCTGCAATAATAAAACTAACCAATAGTAAAGATGTTGGGAA
AATGAGCCTACTTGTAATATTAACACTAGTATTTACAGCAGGTATTGCTGCCATAATTGGCATTTTCACTGCTTTAGCAT
TGGGATTAACAGCCGAAGGACTACAAGCGGGAACCATCGAAATTTTACAAAGTGAAAAATTGCAAAAAGGCCTTGAAATA
TTAAATCAAACAACAATCACAAAAAAAATCACAGATCTTATTCCACAAAATATATTTGAAGATTTTGCAGGGCTTAGAAA
AAACTCAACCATCGGGGTCGTGATATTTTCAGCTATCATAGGAATAGCCGCCCTTAAAACATCTATCAAAAAGCCAGAAT
CAATAGAATTTTTTAAAAAAATAATATTAACACTCCAAGACATAATATTAGGTGTAGTAACTTTGATTTTAAAACTAACG
CCTTATGCTATATTAGCTTTAATGACAAAAATTACAGCAACCAGCGAAATCAAAAGCATAATAAAGCTTGGAGAATTTGT
AATTGCTTCCTACATTGCCATAGGTCTTACATTTCTTATGCATATGACATTAATTGCAATAAATAAATTAAACCCAATTA
CTTTTATAAAAAAAATATTCCCAGCACTATCATTTGCATTCATATCTAGGTCGAGTGCTGCAACCATACCCATTAATATA
GAAATTCAAACTAAAAATCTGGGAGTAAGCGAAGGAATAGCAAATTTATCAAGCTCCTTTGGAACATCAATTGGGCAAAA
TGGTTGTGCAGCACTACACCCCGCTATGCTTGCAATAATGATAGCACCAACTCAGGGAATAAACCCCACAGATATTTCAT
TTATACTCACACTTATTGGATTAATAATAATAACTTCATTTGGAGCTGCTGGCGCTGGTGGAGGCGCAACAACAGCCTCA
CTAATGGTGCTCTCAGCAATGAACTTTCCAGTGGGATTGGTAGGACTTGTAATATCTGTTGAGCCTATAATTGACATGGG
AAGAACAGCTGTTAATGTAGGCGGCTCAATGCTTGCAGGCGTTATATCTGCTAAACAGCTCAAACAATTCAACCATAATA
TATACAACCAAAAAGAGCTTGTAAACAAATAA

Upstream 100 bases:

>100_bases
AAAAAAATTCTAAAAAAATTTTAAAACAAGATTAATTAATTTTTGAATATACCCCCTTAAGTTTAAAAAAGAATGCACTA
AGCTTATATAAGAGGTAATA

Downstream 100 bases:

>100_bases
ATAGGAAAACAATGATGAAAATAATAATTATTGGGGGCACATCAGCAGGAACTAGTGCCGCAGCTAAAGCAAACCGCTTA
AACAAAAAGCTAGACATTAC

Product: glutamate transporter

Products: NA

Alternate protein names: Transporter of cystine tcyP [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MDKISILYTLINIIIMLILISIVYLCKRKNVSFTKRVFIALAIGIVFGMTIQYFYGTNSEITNETINWISILGDGYVRLL
KMIIIPLIITSIISAIIKLTNSKDVGKMSLLVILTLVFTAGIAAIIGIFTALALGLTAEGLQAGTIEILQSEKLQKGLEI
LNQTTITKKITDLIPQNIFEDFAGLRKNSTIGVVIFSAIIGIAALKTSIKKPESIEFFKKIILTLQDIILGVVTLILKLT
PYAILALMTKITATSEIKSIIKLGEFVIASYIAIGLTFLMHMTLIAINKLNPITFIKKIFPALSFAFISRSSAATIPINI
EIQTKNLGVSEGIANLSSSFGTSIGQNGCAALHPAMLAIMIAPTQGINPTDISFILTLIGLIIITSFGAAGAGGGATTAS
LMVLSAMNFPVGLVGLVISVEPIIDMGRTAVNVGGSMLAGVISAKQLKQFNHNIYNQKELVNK

Sequences:

>Translated_463_residues
MDKISILYTLINIIIMLILISIVYLCKRKNVSFTKRVFIALAIGIVFGMTIQYFYGTNSEITNETINWISILGDGYVRLL
KMIIIPLIITSIISAIIKLTNSKDVGKMSLLVILTLVFTAGIAAIIGIFTALALGLTAEGLQAGTIEILQSEKLQKGLEI
LNQTTITKKITDLIPQNIFEDFAGLRKNSTIGVVIFSAIIGIAALKTSIKKPESIEFFKKIILTLQDIILGVVTLILKLT
PYAILALMTKITATSEIKSIIKLGEFVIASYIAIGLTFLMHMTLIAINKLNPITFIKKIFPALSFAFISRSSAATIPINI
EIQTKNLGVSEGIANLSSSFGTSIGQNGCAALHPAMLAIMIAPTQGINPTDISFILTLIGLIIITSFGAAGAGGGATTAS
LMVLSAMNFPVGLVGLVISVEPIIDMGRTAVNVGGSMLAGVISAKQLKQFNHNIYNQKELVNK
>Mature_463_residues
MDKISILYTLINIIIMLILISIVYLCKRKNVSFTKRVFIALAIGIVFGMTIQYFYGTNSEITNETINWISILGDGYVRLL
KMIIIPLIITSIISAIIKLTNSKDVGKMSLLVILTLVFTAGIAAIIGIFTALALGLTAEGLQAGTIEILQSEKLQKGLEI
LNQTTITKKITDLIPQNIFEDFAGLRKNSTIGVVIFSAIIGIAALKTSIKKPESIEFFKKIILTLQDIILGVVTLILKLT
PYAILALMTKITATSEIKSIIKLGEFVIASYIAIGLTFLMHMTLIAINKLNPITFIKKIFPALSFAFISRSSAATIPINI
EIQTKNLGVSEGIANLSSSFGTSIGQNGCAALHPAMLAIMIAPTQGINPTDISFILTLIGLIIITSFGAAGAGGGATTAS
LMVLSAMNFPVGLVGLVISVEPIIDMGRTAVNVGGSMLAGVISAKQLKQFNHNIYNQKELVNK

Specific function: Mediates uptake of L-cystine, the oxidized form of L- cysteine [H]

COG id: COG1823

COG function: function code R; Predicted Na+/dicarboxylate symporter

Gene ontology:

Cell location: Membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI194239697, Length=494, Percent_Identity=23.6842105263158, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI40254478, Length=498, Percent_Identity=24.6987951807229, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI21314632, Length=447, Percent_Identity=24.1610738255034, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI223468564, Length=252, Percent_Identity=26.5873015873016, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI223468566, Length=252, Percent_Identity=26.5873015873016, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI66773030, Length=304, Percent_Identity=26.6447368421053, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI5032093, Length=252, Percent_Identity=26.5873015873016, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI169790839, Length=282, Percent_Identity=27.3049645390071, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788024, Length=449, Percent_Identity=45.43429844098, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1790514, Length=449, Percent_Identity=24.9443207126949, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789947, Length=427, Percent_Identity=24.824355971897, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=427, Percent_Identity=26.463700234192, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71983106, Length=427, Percent_Identity=26.463700234192, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI193206505, Length=464, Percent_Identity=23.7068965517241, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI193206654, Length=466, Percent_Identity=23.6051502145923, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17537407, Length=444, Percent_Identity=24.5495495495495, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17541374, Length=432, Percent_Identity=23.8425925925926, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71996953, Length=477, Percent_Identity=24.5283018867925, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583025, Length=437, Percent_Identity=25.858123569794, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137668, Length=437, Percent_Identity=25.858123569794, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583023, Length=437, Percent_Identity=25.858123569794, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 49622; Mature: 49622

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKISILYTLINIIIMLILISIVYLCKRKNVSFTKRVFIALAIGIVFGMTIQYFYGTNSE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ITNETINWISILGDGYVRLLKMIIIPLIITSIISAIIKLTNSKDVGKMSLLVILTLVFTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GIAAIIGIFTALALGLTAEGLQAGTIEILQSEKLQKGLEILNQTTITKKITDLIPQNIFE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFAGLRKNSTIGVVIFSAIIGIAALKTSIKKPESIEFFKKIILTLQDIILGVVTLILKLT
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PYAILALMTKITATSEIKSIIKLGEFVIASYIAIGLTFLMHMTLIAINKLNPITFIKKIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
PALSFAFISRSSAATIPINIEIQTKNLGVSEGIANLSSSFGTSIGQNGCAALHPAMLAIM
HHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IAPTQGINPTDISFILTLIGLIIITSFGAAGAGGGATTASLMVLSAMNFPVGLVGLVISV
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
EPIIDMGRTAVNVGGSMLAGVISAKQLKQFNHNIYNQKELVNK
HHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCC
>Mature Secondary Structure
MDKISILYTLINIIIMLILISIVYLCKRKNVSFTKRVFIALAIGIVFGMTIQYFYGTNSE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ITNETINWISILGDGYVRLLKMIIIPLIITSIISAIIKLTNSKDVGKMSLLVILTLVFTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GIAAIIGIFTALALGLTAEGLQAGTIEILQSEKLQKGLEILNQTTITKKITDLIPQNIFE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFAGLRKNSTIGVVIFSAIIGIAALKTSIKKPESIEFFKKIILTLQDIILGVVTLILKLT
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PYAILALMTKITATSEIKSIIKLGEFVIASYIAIGLTFLMHMTLIAINKLNPITFIKKIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
PALSFAFISRSSAATIPINIEIQTKNLGVSEGIANLSSSFGTSIGQNGCAALHPAMLAIM
HHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IAPTQGINPTDISFILTLIGLIIITSFGAAGAGGGATTASLMVLSAMNFPVGLVGLVISV
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
EPIIDMGRTAVNVGGSMLAGVISAKQLKQFNHNIYNQKELVNK
HHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA