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The map label for this gene is pgi

Identifier: 15595075

GI number: 15595075

Start: 769547

End: 771145

Strand: Reverse

Name: pgi

Synonym: BB0730

Alternate gene names: 15595075

Gene position: 771145-769547 (Counterclockwise)

Preceding gene: 15595076

Following gene: 15595074

Centisome position: 84.67

GC content: 29.02

Gene sequence:

>1599_bases
GTGTTTATGTTAAATTACAAAAATCTTAATGAACTTGAAAATTTTAAAATCCTTGAAGGTATTGCTCCAGAAGTGCTCAA
AACGGCATTAACTGGAAAAAGGATAAAAGAATACGACATTACAATAGAAGGAGATAGTGTACATTATAACTATGCTTCAA
AACAAATTAATGAAACCCACCTTAAAATTTTTCAAAATTTAAGCGATGAAGCAAATTTAATAGAAAAATATAAAGAAGTG
CTTGATGGGGAAAAGATCAATATTAGTGAAAATAGAAAAGTCCTGCATCACCTTACAAGAGGGCAAATTGGTAAGGACGT
AATAGAAGACAATAAAGAAAATATGAGAGAGTTTTTCCAATCAGAACTTGAAAAAATATATAATTTTGCAAAGCAAATTC
ATTCTGGGAACATTAAAAGTTCAAATGGCAAAAAGTTTAAAAATGTAGTTCAAATAGGAATTGGTGGATCTAGCCTGGGG
CCAAAAGCTCTTTACAGCTCAATAAAAAATTATGCAAAAAAACACAATCTAGCCCTAATGAATGGTTATTTTATTTCAAA
CATTGATCCAGACGAATCAGAAGAAGTATTAAGCAGCATTAATGTTGATGAAACGCTTTTTATTATTGTCTCAAAAAGTG
GAAATACATTAGAAACTAAAGCTAATATGCAATTCTTAATAAACAAATTAAAATTAAATGGCATAAAAGAATATAAAAAA
CAAATGGTCATTATAACACTAAAAGATAGCATGTTGGCAATAGAAGAAAAAGGATATCTTGAATATTTCTTCATGCATGA
CTCAATAGGTGGAAGATTTTCTCCAACATCAGCAGTTGGACTTACACTACTTACTCTTTGCTTCACAGAAAAAGTTGCAA
AAGAAATTCTAAAAGGAGCCAATGAGGCTGACAAAAAATCATTAAACAAAAACGTAAAAGACAATGCATCTCTCTTGGCA
GCACTAATTAGCATATATGAAAGAAATGTTCTAAATTACAGTAGCAACTGCATCATTGCTTATTCTAAAGCAATGGAAAA
TTTTTATCTTCATTTACAACAACTTGAAATGGAGAGTAATGGAAAAAGTGTAAACAGATTTAATGAAACAATAAACTACA
AAACTGTAAGAATAATTTGGGGAGGCATTGGAACAGATGTTCAACACTCATTCTTTCAAATGCTTCACCAAGGAACGGAT
ATAGTTCCAATGGATTTCATAGGTTTTAATGAAACACAACTTAAAGAAGATGTAATATCTGATAACAGCTCAAGCAATGA
TAAATTAAAAGCAAATTTAATAGCCCAAATAATAGCATTTTCAAAAGGTAAAGAAAATAGCAATAAAAATAAAAATTTCC
AAGGCGAGAGACCTTCTGCACTAATATATTCAAAAGAATTAACACCTTATGCAATAGGAGCAATACTCTCCCATTATGAA
AATAAAGTAATGTTTGAGGGATTTTTATTAAATATAAACTCATTCGACCAAGAAGGAGTTCAGCTAGGAAAAATTATTGC
AAATCAAATTTTAAAAAATGACAATTTTAAAGATGAAGTAATAGAATCTTATTCTAAAAAAATTCTAAAAAAATTTTAA

Upstream 100 bases:

>100_bases
GAAAGCAATATAATAATAAGATTCCTTAAATTTATTATCTTAAAAATTAAAAACATGTGTAAAATAAGAAATAGAAAAAT
TTAAATCATAATAAAGAGGT

Downstream 100 bases:

>100_bases
AACAAGATTAATTAATTTTTGAATATACCCCCTTAAGTTTAAAAAAGAATGCACTAAGCTTATATAAGAGGTAATAATGG
ATAAAATAAGTATATTATAT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MFMLNYKNLNELENFKILEGIAPEVLKTALTGKRIKEYDITIEGDSVHYNYASKQINETHLKIFQNLSDEANLIEKYKEV
LDGEKINISENRKVLHHLTRGQIGKDVIEDNKENMREFFQSELEKIYNFAKQIHSGNIKSSNGKKFKNVVQIGIGGSSLG
PKALYSSIKNYAKKHNLALMNGYFISNIDPDESEEVLSSINVDETLFIIVSKSGNTLETKANMQFLINKLKLNGIKEYKK
QMVIITLKDSMLAIEEKGYLEYFFMHDSIGGRFSPTSAVGLTLLTLCFTEKVAKEILKGANEADKKSLNKNVKDNASLLA
ALISIYERNVLNYSSNCIIAYSKAMENFYLHLQQLEMESNGKSVNRFNETINYKTVRIIWGGIGTDVQHSFFQMLHQGTD
IVPMDFIGFNETQLKEDVISDNSSSNDKLKANLIAQIIAFSKGKENSNKNKNFQGERPSALIYSKELTPYAIGAILSHYE
NKVMFEGFLLNINSFDQEGVQLGKIIANQILKNDNFKDEVIESYSKKILKKF

Sequences:

>Translated_532_residues
MFMLNYKNLNELENFKILEGIAPEVLKTALTGKRIKEYDITIEGDSVHYNYASKQINETHLKIFQNLSDEANLIEKYKEV
LDGEKINISENRKVLHHLTRGQIGKDVIEDNKENMREFFQSELEKIYNFAKQIHSGNIKSSNGKKFKNVVQIGIGGSSLG
PKALYSSIKNYAKKHNLALMNGYFISNIDPDESEEVLSSINVDETLFIIVSKSGNTLETKANMQFLINKLKLNGIKEYKK
QMVIITLKDSMLAIEEKGYLEYFFMHDSIGGRFSPTSAVGLTLLTLCFTEKVAKEILKGANEADKKSLNKNVKDNASLLA
ALISIYERNVLNYSSNCIIAYSKAMENFYLHLQQLEMESNGKSVNRFNETINYKTVRIIWGGIGTDVQHSFFQMLHQGTD
IVPMDFIGFNETQLKEDVISDNSSSNDKLKANLIAQIIAFSKGKENSNKNKNFQGERPSALIYSKELTPYAIGAILSHYE
NKVMFEGFLLNINSFDQEGVQLGKIIANQILKNDNFKDEVIESYSKKILKKF
>Mature_532_residues
MFMLNYKNLNELENFKILEGIAPEVLKTALTGKRIKEYDITIEGDSVHYNYASKQINETHLKIFQNLSDEANLIEKYKEV
LDGEKINISENRKVLHHLTRGQIGKDVIEDNKENMREFFQSELEKIYNFAKQIHSGNIKSSNGKKFKNVVQIGIGGSSLG
PKALYSSIKNYAKKHNLALMNGYFISNIDPDESEEVLSSINVDETLFIIVSKSGNTLETKANMQFLINKLKLNGIKEYKK
QMVIITLKDSMLAIEEKGYLEYFFMHDSIGGRFSPTSAVGLTLLTLCFTEKVAKEILKGANEADKKSLNKNVKDNASLLA
ALISIYERNVLNYSSNCIIAYSKAMENFYLHLQQLEMESNGKSVNRFNETINYKTVRIIWGGIGTDVQHSFFQMLHQGTD
IVPMDFIGFNETQLKEDVISDNSSSNDKLKANLIAQIIAFSKGKENSNKNKNFQGERPSALIYSKELTPYAIGAILSHYE
NKVMFEGFLLNINSFDQEGVQLGKIIANQILKNDNFKDEVIESYSKKILKKF

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=506, Percent_Identity=29.6442687747036, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI296080693, Length=506, Percent_Identity=27.6679841897233, Blast_Score=198, Evalue=9e-51,
Organism=Escherichia coli, GI1790457, Length=529, Percent_Identity=34.9716446124764, Blast_Score=275, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI71996708, Length=494, Percent_Identity=31.1740890688259, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71996703, Length=494, Percent_Identity=31.1740890688259, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6319673, Length=488, Percent_Identity=32.7868852459016, Blast_Score=241, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24651916, Length=503, Percent_Identity=30.6163021868787, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24651914, Length=503, Percent_Identity=30.6163021868787, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI17737445, Length=503, Percent_Identity=30.6163021868787, Blast_Score=235, Evalue=5e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_BORBU (O51672)

Other databases:

- EMBL:   AE000783
- PIR:   A70191
- RefSeq:   NP_212864.1
- ProteinModelPortal:   O51672
- EnsemblBacteria:   EBBORT00000008374
- GeneID:   1195584
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0730
- NMPDR:   fig|224326.1.peg.1114
- TIGR:   BB_0730
- GeneTree:   EBGT00050000006954
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK14095
- BioCyc:   BBUR224326:BB_0730-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 60400; Mature: 60400

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 358-358 ACT_SITE 389-389 ACT_SITE 504-504

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMLNYKNLNELENFKILEGIAPEVLKTALTGKRIKEYDITIEGDSVHYNYASKQINETH
CEEECCCCCHHHHCHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCEEEEHHHHHHHHHH
LKIFQNLSDEANLIEKYKEVLDGEKINISENRKVLHHLTRGQIGKDVIEDNKENMREFFQ
HHHHHCCCHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHH
SELEKIYNFAKQIHSGNIKSSNGKKFKNVVQIGIGGSSLGPKALYSSIKNYAKKHNLALM
HHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEE
NGYFISNIDPDESEEVLSSINVDETLFIIVSKSGNTLETKANMQFLINKLKLNGIKEYKK
ECEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHCCHHHHCC
QMVIITLKDSMLAIEEKGYLEYFFMHDSIGGRFSPTSAVGLTLLTLCFTEKVAKEILKGA
CEEEEEECCCEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
NEADKKSLNKNVKDNASLLAALISIYERNVLNYSSNCIIAYSKAMENFYLHLQQLEMESN
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCC
GKSVNRFNETINYKTVRIIWGGIGTDVQHSFFQMLHQGTDIVPMDFIGFNETQLKEDVIS
CCHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHC
DNSSSNDKLKANLIAQIIAFSKGKENSNKNKNFQGERPSALIYSKELTPYAIGAILSHYE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHC
NKVMFEGFLLNINSFDQEGVQLGKIIANQILKNDNFKDEVIESYSKKILKKF
CCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFMLNYKNLNELENFKILEGIAPEVLKTALTGKRIKEYDITIEGDSVHYNYASKQINETH
CEEECCCCCHHHHCHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCEEEEHHHHHHHHHH
LKIFQNLSDEANLIEKYKEVLDGEKINISENRKVLHHLTRGQIGKDVIEDNKENMREFFQ
HHHHHCCCHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHH
SELEKIYNFAKQIHSGNIKSSNGKKFKNVVQIGIGGSSLGPKALYSSIKNYAKKHNLALM
HHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEE
NGYFISNIDPDESEEVLSSINVDETLFIIVSKSGNTLETKANMQFLINKLKLNGIKEYKK
ECEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHCCHHHHCC
QMVIITLKDSMLAIEEKGYLEYFFMHDSIGGRFSPTSAVGLTLLTLCFTEKVAKEILKGA
CEEEEEECCCEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
NEADKKSLNKNVKDNASLLAALISIYERNVLNYSSNCIIAYSKAMENFYLHLQQLEMESN
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCC
GKSVNRFNETINYKTVRIIWGGIGTDVQHSFFQMLHQGTDIVPMDFIGFNETQLKEDVIS
CCHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHC
DNSSSNDKLKANLIAQIIAFSKGKENSNKNKNFQGERPSALIYSKELTPYAIGAILSHYE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHC
NKVMFEGFLLNINSFDQEGVQLGKIIANQILKNDNFKDEVIESYSKKILKKF
CCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685