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The map label for this gene is tcyA

Identifier: 255767112

GI number: 255767112

Start: 410656

End: 411462

Strand: Reverse

Name: tcyA

Synonym: BSU03610

Alternate gene names: 255767112

Gene position: 411462-410656 (Counterclockwise)

Preceding gene: 16077430

Following gene: 16077428

Centisome position: 9.76

GC content: 41.51

Gene sequence:

>807_bases
ATGAAAAAAGCATTATTGGCTTTATTCATGGTCGTAAGTATTGCAGCTCTTGCAGCTTGCGGAGCAGGAAATGACAATCA
GTCAAAAGATAATGCCAAAGATGGCGATCTTTGGGCTTCAATTAAGAAAAAAGGTGTGCTCACAGTCGGAACGGAAGGAA
CATATGAGCCGTTCACTTACCACGACAAAGACACTGATAAACTGACTGGCTATGATGTCGAAGTTATCACAGAAGTCGCA
AAACGCCTCGGGCTTAAAGTCGACTTTAAGGAAACACAATGGGACAGTATGTTTGCCGGCCTGAATTCCAAACGGTTTGA
CGTTGTTGCCAACCAAGTCGGAAAAACAGATCGTGAAGACAAATATGATTTCTCAGATAAATACACAACATCAAGAGCCG
TTGTCGTAACGAAAAAAGACAACAACGATATTAAGTCTGAAGCAGATGTAAAAGGAAAAACGTCAGCTCAATCACTGACA
AGCAACTACAACAAATTAGCTACAAATGCCGGCGCTAAAGTAGAAGGCGTTGAAGGCATGGCGCAGGCCCTTCAAATGAT
CCAGCAAGGCCGCGTCGATATGACATACAACGATAAGCTTGCCGTATTGAACTACTTAAAAACATCTGGCAATAAAAACG
TGAAAATCGCGTTTGAAACAGGTGAGCCTCAGTCAACATATTTCACGTTCCGTAAAGGAAGCGGCGAGGTTGTTGATCAA
GTCAACAAAGCATTAAAAGAAATGAAAGAGGACGGGACTCTTTCTAAAATTTCTAAAAAATGGTTCGGCGAAGATGTTTC
TAAATAA

Upstream 100 bases:

>100_bases
GAAAACCAAATACTTGACTCATACTAAAAAAAAGTTATCCTTTAGATTTGTAAGCTAATTTTTTATTTCAATAAAATCAA
CCAGAAAAGTGGGGAATAAG

Downstream 100 bases:

>100_bases
TCTGCCGGCATTGACGCTTGGCACGGCGATCCCGTGGGATCTGGTGCAGCAGTCATTCTGGCCGATACTTTCAGGGGGAA
TCTACTATACGATTCCCCTT

Product: cystine ABC transporter substrate-binding lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKGVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVA
KRLGLKVDFKETQWDSMFAGLNSKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT
SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAFETGEPQSTYFTFRKGSGEVVDQ
VNKALKEMKEDGTLSKISKKWFGEDVSK

Sequences:

>Translated_268_residues
MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKGVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVA
KRLGLKVDFKETQWDSMFAGLNSKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT
SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAFETGEPQSTYFTFRKGSGEVVDQ
VNKALKEMKEDGTLSKISKKWFGEDVSK
>Mature_268_residues
MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKGVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVA
KRLGLKVDFKETQWDSMFAGLNSKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT
SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAFETGEPQSTYFTFRKGSGEVVDQ
VNKALKEMKEDGTLSKISKKWFGEDVSK

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import

COG id: COG0834

COG function: function code ET; ABC-type amino acid transport/signal transduction systems, periplasmic component/domain

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 3 family

Homologues:

Organism=Escherichia coli, GI1788228, Length=271, Percent_Identity=38.3763837638376, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1787031, Length=220, Percent_Identity=34.0909090909091, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787085, Length=228, Percent_Identity=27.1929824561404, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788648, Length=233, Percent_Identity=27.4678111587983, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1788649, Length=275, Percent_Identity=25.8181818181818, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1787088, Length=230, Percent_Identity=25.2173913043478, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 1920 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1060 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 80 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TCYA_BACSU (P42199)

Other databases:

- EMBL:   X77636
- EMBL:   D50453
- EMBL:   AL009126
- PIR:   E69761
- RefSeq:   NP_388243.2
- ProteinModelPortal:   P42199
- SMR:   P42199
- EnsemblBacteria:   EBBACT00000003518
- GeneID:   938298
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU03610
- NMPDR:   fig|224308.1.peg.362
- GenoList:   BSU03610
- GeneTree:   EBGT00050000000372
- HOGENOM:   HBG698334
- ProtClustDB:   CLSK886685
- BioCyc:   BSUB:BSU03610-MONOMER
- InterPro:   IPR001638
- InterPro:   IPR018313
- SMART:   SM00062

Pfam domain/function: PF00497 SBP_bac_3

EC number: NA

Molecular weight: Translated: 29515; Mature: 29515

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS51257 PROKAR_LIPOPROTEIN; PS01039 SBP_BACTERIAL_3; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKGVLTVGTEGTYEPFTY
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCEE
HDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLNSKRFDVVANQVGKTDRED
CCCCCCCCCCCHHHHHHHHHHHHCCEECCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCC
KYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLTSNYNKLATNAGAKVEGVEGM
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
AQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAFETGEPQSTYFTFRKGSGEVVDQ
HHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCCHHHHH
VNKALKEMKEDGTLSKISKKWFGEDVSK
HHHHHHHHHHCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKGVLTVGTEGTYEPFTY
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCEE
HDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLNSKRFDVVANQVGKTDRED
CCCCCCCCCCCHHHHHHHHHHHHCCEECCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCC
KYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLTSNYNKLATNAGAKVEGVEGM
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
AQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAFETGEPQSTYFTFRKGSGEVVDQ
HHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCCHHHHH
VNKALKEMKEDGTLSKISKKWFGEDVSK
HHHHHHHHHHCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377