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The map label for this gene is tcyB

Identifier: 16077428

GI number: 16077428

Start: 409965

End: 410669

Strand: Reverse

Name: tcyB

Synonym: BSU03600

Alternate gene names: 16077428

Gene position: 410669-409965 (Counterclockwise)

Preceding gene: 255767112

Following gene: 255767111

Centisome position: 9.74

GC content: 47.38

Gene sequence:

>705_bases
ATGTTTCTAAATAATCTGCCGGCATTGACGCTTGGCACGGCGATCCCGTGGGATCTGGTGCAGCAGTCATTCTGGCCGAT
ACTTTCAGGGGGAATCTACTATACGATTCCCCTTACGATTCTTTCCTTTATATTCGGAATGATCCTGGCGCTGATTACGG
CGCTTGCCAGAATGTCGAAAGTGAGACCTTTGAGATGGGTGTTCAGCGTATACGTATCCGCAATACGCGGCACTCCTCTT
CTCGTTCAATTGTTCATCATTTTCTATCTGTTCCCGGCCTTTAACGTCACATTAGATCCATTTCCAAGCGCAGTTATCGC
CTTTTCATTAAACGTCGGCGCCTATGCATCTGAAATCATTCGGGCATCTATTTTATCCGTGCCGAAAGGGCAATGGGAAG
CCGGCTACACAATTGGCATGACACATCAAAAAACGCTGTTCCGCGTCATTTTGCCGCAGGCGTTTCGTGTGTCGATCCCG
CCATTATCCAATACCTTTATCAGCCTGATTAAAGATACATCCCTCGCCTCTCAAATTCTGGTCGCTGAGCTGTTCAGAAA
AGCCCAGGAAATCGGCGCGCGGAATCTTGATCAAATTTTAGTGATCTATATTGAAGCAGCCTTTATTTATTGGATTATCT
GCTTCCTGCTCTCACTCGTCCAGCATGTCATCGAACGGCGTCTTGACCGCTACGTGGCCAAATAA

Upstream 100 bases:

>100_bases
AAAGGAAGCGGCGAGGTTGTTGATCAAGTCAACAAAGCATTAAAAGAAATGAAAGAGGACGGGACTCTTTCTAAAATTTC
TAAAAAATGGTTCGGCGAAG

Downstream 100 bases:

>100_bases
GGAGGTTCCGAGTATGCTTACCGTTAAAGGATTAAACAAATCATTCGGTGAAAATGAAATTTTAAAAAAGATAGATATGA
AGATTGAAAAAGGAAAAGTC

Product: cystine ABC transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFIFGMILALITALARMSKVRPLRWVFSVYVSAIRGTPL
LVQLFIIFYLFPAFNVTLDPFPSAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP
PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQHVIERRLDRYVAK

Sequences:

>Translated_234_residues
MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFIFGMILALITALARMSKVRPLRWVFSVYVSAIRGTPL
LVQLFIIFYLFPAFNVTLDPFPSAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP
PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQHVIERRLDRYVAK
>Mature_234_residues
MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFIFGMILALITALARMSKVRPLRWVFSVYVSAIRGTPL
LVQLFIIFYLFPAFNVTLDPFPSAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP
PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQHVIERRLDRYVAK

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable)

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain

Homologues:

Organism=Escherichia coli, GI1788226, Length=205, Percent_Identity=52.1951219512195, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1787030, Length=206, Percent_Identity=40.2912621359223, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1786873, Length=210, Percent_Identity=36.6666666666667, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1787086, Length=215, Percent_Identity=33.4883720930233, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787087, Length=234, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI87082239, Length=205, Percent_Identity=32.6829268292683, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1788645, Length=212, Percent_Identity=31.6037735849057, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1788646, Length=216, Percent_Identity=28.7037037037037, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786874, Length=211, Percent_Identity=27.0142180094787, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI48994930, Length=206, Percent_Identity=30.5825242718447, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TCYB_BACSU (P42200)

Other databases:

- EMBL:   X77636
- EMBL:   D50453
- EMBL:   AL009126
- PIR:   I40451
- RefSeq:   NP_388242.1
- ProteinModelPortal:   P42200
- EnsemblBacteria:   EBBACT00000003813
- GeneID:   938301
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU03600
- NMPDR:   fig|224308.1.peg.361
- GenoList:   BSU03600
- GeneTree:   EBGT00070000031800
- HOGENOM:   HBG704821
- OMA:   IISFTIG
- PhylomeDB:   P42200
- ProtClustDB:   CLSK886684
- BioCyc:   BSUB:BSU03600-MONOMER
- InterPro:   IPR010065
- InterPro:   IPR000515
- TIGRFAMs:   TIGR01726

Pfam domain/function: PF00528 BPD_transp_1

EC number: NA

Molecular weight: Translated: 26389; Mature: 26389

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xcc304a0)-; HASH(0xcf281a8)-; HASH(0xcb6d038)-; HASH(0xc90a890)-; HASH(0xc7f8c94)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFIFGMILALITALARMSK
CCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
VRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFPSAVIAFSLNVGAYASEII
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHEECCHHHHHHHHH
RASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIPPLSNTFISLIKDTSLASQIL
HHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHH
VAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQHVIERRLDRYVAK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFIFGMILALITALARMSK
CCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
VRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFPSAVIAFSLNVGAYASEII
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHEECCHHHHHHHHH
RASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIPPLSNTFISLIKDTSLASQIL
HHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHH
VAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQHVIERRLDRYVAK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377