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The map label for this gene is hisB

Identifier: 16080543

GI number: 16080543

Start: 3585690

End: 3586274

Strand: Reverse

Name: hisB

Synonym: BSU34900

Alternate gene names: 16080543

Gene position: 3586274-3585690 (Counterclockwise)

Preceding gene: 16080544

Following gene: 16080542

Centisome position: 85.07

GC content: 46.5

Gene sequence:

>585_bases
ATGAGAAAAGCGGAACGCGTCAGGAAAACAAACGAAACAGATATTGAGCTGGCATTTACAATAGACGGCGGAGGACAAGC
GGATATTAAAACAGATGTGCCGTTTATGACACATATGTTGGATTTATTCACGAAACACGGCCAATTTGATCTTTCCATTA
ACGCAAAAGGCGATGTTGATATAGATGATCACCACACGACTGAAGATATCGGCATCTGCTTAGGGCAGGCGCTGCTCGAA
GCGTTGGGCGATAAAAAAGGAATCAAACGCTACGGATCGGCGTTTGTGCCGATGGATGAGGCACTTGCTCAAGTTGTGAT
TGATTTAAGCAACCGGCCGCACTTAGAAATGCGCGCTGATTTCCCGGCTGCTAAAGTCGGAACTTTCGATACGGAGCTTG
TACATGAATTTTTGTGGAAGCTGGCGCTCGAAGCTCGAATGAACCTGCACGTCATCGTTCATTATGGAACAAATACCCAC
CACATGATTGAAGCCGTTTTTAAAGCACTGGGACGTGCGCTTGATGAAGCGACAACGATCGATCCGCGAGTTAAAGGAAT
ACCGTCAACGAAAGGGATGCTGTAA

Upstream 100 bases:

>100_bases
CCTTTGAAGAACATGCCGAAAGCATCGCGGCTTTTGCCAGACTGGAAGGGTTAGAAGCCCATGCCAGATCAATTGAAGCG
AGAGAACGGAGGATTTCTAA

Downstream 100 bases:

>100_bases
ATGATCGGCGTGATAGATTACGGAATGGGGAATTTATACAGTGTCTCAAAGGCGCTTGAACGTGTCGGCGTGCCGTATTT
TGTTTCTGAAAAGCCGGAGG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFTKHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLE
ALGDKKGIKRYGSAFVPMDEALAQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH
HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML

Sequences:

>Translated_194_residues
MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFTKHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLE
ALGDKKGIKRYGSAFVPMDEALAQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH
HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML
>Mature_194_residues
MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFTKHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLE
ALGDKKGIKRYGSAFVPMDEALAQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH
HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=46.6666666666667, Blast_Score=167, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324776, Length=217, Percent_Identity=40.5529953917051, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_BACSU (O34683)

Other databases:

- EMBL:   AF017113
- EMBL:   AL009126
- PIR:   G69640
- RefSeq:   NP_391370.1
- ProteinModelPortal:   O34683
- SMR:   O34683
- EnsemblBacteria:   EBBACT00000003576
- GeneID:   936560
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU34900
- NMPDR:   fig|224308.1.peg.3496
- GenoList:   BSU34900
- GeneTree:   EBGT00050000001667
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   O34683
- ProtClustDB:   PRK00951
- BioCyc:   BSUB:BSU34900-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21549; Mature: 21549

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFTKHGQFDLSINAKGDVD
CCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCC
IDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEALAQVVIDLSNRPHLEMRAD
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEECC
FPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTHHMIEAVFKALGRALDEATTI
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
DPRVKGIPSTKGML
CCCCCCCCCCCCCC
>Mature Secondary Structure
MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFTKHGQFDLSINAKGDVD
CCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCC
IDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEALAQVVIDLSNRPHLEMRAD
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEECC
FPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTHHMIEAVFKALGRALDEATTI
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
DPRVKGIPSTKGML
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377