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The map label for this gene is hisD

Identifier: 16080544

GI number: 16080544

Start: 3586271

End: 3587554

Strand: Reverse

Name: hisD

Synonym: BSU34910

Alternate gene names: 16080544

Gene position: 3587554-3586271 (Counterclockwise)

Preceding gene: 16080545

Following gene: 16080543

Centisome position: 85.1

GC content: 49.38

Gene sequence:

>1284_bases
ATGAAGATCAAAACCATCAGCGGAGCGGAACGGCTTTCTCTCAAGCGTTCCATCGATGCCGGAACGGAAGAGCAAAGAAA
GACGGTCCGGTCCATTATTGAAGATGTTAAAGCAAACGGTGATCAGGCGGTTCGCAGCTACACGGCGAAATTTGACTGCA
TCGAAATAGACAGCCCGCTGGTCACAAAAGAAGAATTTGAGGAGGCATACACCTCACTGGATTCACGTCTTCTTCAGGTG
ATTAGGCAGGCAATCGAAAATATTAGGGAATATCACGAAAGACAGCTGCAATCCTCCTGGTTTTATCACAGAAAGGACGG
CACAATGCTGGGGCAGAAAGTGACGGCGCTGGATTCCGCCGGTGTATATGTGCCGGGGGGAACGGCCGCATATCCTTCAT
CTGTTTTGATGAATGTGATTCCGGCGCTCGTAGCGGGCGTTGAAAGAATCGTTCTCGTCACGCCTCCGGGAAAAGACGGT
CTGCTGTCTCCTGGAGTTTTGGTTGCTGCAGCCGAGCTGGGCATAAAAGACATTTACAAAATGGGCGGCGCTCAGGCGAT
TGCGGCGTTAGCATACGGAACAGAAACCATTGAGCCGGTGGATAAAATCACGGGTCCGGGCAACATTTATGTCGCGCTTG
CCAAACGAGAAGTGTTCGGCGATGTCGATATCGATATGATTGCCGGACCGAGTGAAATCGTCGTGCTGGCTGATGAAACA
GCGATTCCGAGCGAAATTGCAGCCGATCTGCTGTCACAGGCGGAACACGATAAGCTTAGCTCATGTGTGTTTGTCACAGA
TTCCATGGCGCTGGCCGAGACGGTTTCAGCCGAGGTGAATAAGCAGCTGGAAACCTTGCCGCGAAGAGAAATAGCGGAAG
CTTCAGTGAGAGATTACGGTTGTATATATGTGGCGGAAACAATGGTAGAAGCGATTGAGACTGTCAATACACTCGCGCCA
GAGCATTTAGAAATCATAACACAGTCTCCGGAAGCTTTGCTTGGCAGTATCAAACATGCGGGTGCAATTTTCTTAGGCAG
ATACAGCCCTGAGCCTGTCGGTGATTATTTTGCCGGACCGAACCATGTGCTTCCGACAAACGGAACAGCCAGATTTTCAA
GTCCATTAAACGTAACTGATTTTCAAAAGAAATCGAGCATTATTTCTTACAGTCAATCAGCCTTTGAAGAACATGCCGAA
AGCATCGCGGCTTTTGCCAGACTGGAAGGGTTAGAAGCCCATGCCAGATCAATTGAAGCGAGAGAACGGAGGATTTCTAA
ATGA

Upstream 100 bases:

>100_bases
CTCGCTTTATTGTCAACCCGGTAAGCTATCGCATGAAAGACGATGTGATTGACGAAATGGCATCCCGCCTATCTCTCGTT
GTGGAAGGAGAGACGGCAAA

Downstream 100 bases:

>100_bases
GAAAAGCGGAACGCGTCAGGAAAACAAACGAAACAGATATTGAGCTGGCATTTACAATAGACGGCGGAGGACAAGCGGAT
ATTAAAACAGATGTGCCGTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAVRSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQV
IRQAIENIREYHERQLQSSWFYHRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG
LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREVFGDVDIDMIAGPSEIVVLADET
AIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVSAEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAP
EHLEIITQSPEALLGSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQSAFEEHAE
SIAAFARLEGLEAHARSIEARERRISK

Sequences:

>Translated_427_residues
MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAVRSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQV
IRQAIENIREYHERQLQSSWFYHRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG
LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREVFGDVDIDMIAGPSEIVVLADET
AIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVSAEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAP
EHLEIITQSPEALLGSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQSAFEEHAE
SIAAFARLEGLEAHARSIEARERRISK
>Mature_427_residues
MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAVRSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQV
IRQAIENIREYHERQLQSSWFYHRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG
LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREVFGDVDIDMIAGPSEIVVLADET
AIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVSAEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAP
EHLEIITQSPEALLGSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQSAFEEHAE
SIAAFARLEGLEAHARSIEARERRISK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=415, Percent_Identity=39.7590361445783, Blast_Score=288, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=421, Percent_Identity=36.8171021377672, Blast_Score=255, Evalue=9e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_BACSU (O34651)

Other databases:

- EMBL:   AF017113
- EMBL:   AL009126
- PIR:   A69641
- RefSeq:   NP_391371.1
- ProteinModelPortal:   O34651
- SMR:   O34651
- EnsemblBacteria:   EBBACT00000002743
- GeneID:   936584
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU34910
- NMPDR:   fig|224308.1.peg.3497
- GenoList:   BSU34910
- GeneTree:   EBGT00050000002843
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- PhylomeDB:   O34651
- ProtClustDB:   PRK00877
- BioCyc:   BSUB:BSU34910-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46257; Mature: 46257

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 321-321 ACT_SITE 322-322 BINDING 123-123 BINDING 185-185 BINDING 208-208 BINDING 231-231 BINDING 253-253 BINDING 256-256 BINDING 322-322 BINDING 355-355 BINDING 409-409 BINDING 414-414

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAVRSYTAKFDCIEIDSPL
CEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCC
VTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFYHRKDGTMLGQKVTALDSA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHCCCC
GVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDGLLSPGVLVAAAELGIKDIYK
CEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
MGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREVFGDVDIDMIAGPSEIVVLADET
CCCHHHHHHHHHCCCHHCHHHHCCCCCCEEEEEECHHHCCCCCEEEECCCCEEEEEECCC
AIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVSAEVNKQLETLPRREIAEASVRDYG
CCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
CIYVAETMVEAIETVNTLAPEHLEIITQSPEALLGSIKHAGAIFLGRYSPEPVGDYFAGP
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCEEEEECCCCCCCCHHCCCC
NHVLPTNGTARFSSPLNVTDFQKKSSIISYSQSAFEEHAESIAAFARLEGLEAHARSIEA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RERRISK
HHHHCCC
>Mature Secondary Structure
MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAVRSYTAKFDCIEIDSPL
CEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCC
VTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFYHRKDGTMLGQKVTALDSA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHCCCC
GVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDGLLSPGVLVAAAELGIKDIYK
CEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
MGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREVFGDVDIDMIAGPSEIVVLADET
CCCHHHHHHHHHCCCHHCHHHHCCCCCCEEEEEECHHHCCCCCEEEECCCCEEEEEECCC
AIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVSAEVNKQLETLPRREIAEASVRDYG
CCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
CIYVAETMVEAIETVNTLAPEHLEIITQSPEALLGSIKHAGAIFLGRYSPEPVGDYFAGP
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCEEEEECCCCCCCCHHCCCC
NHVLPTNGTARFSSPLNVTDFQKKSSIISYSQSAFEEHAESIAAFARLEGLEAHARSIEA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RERRISK
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377