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The map label for this gene is gcvPB

Identifier: 16079511

GI number: 16079511

Start: 2545410

End: 2546876

Strand: Reverse

Name: gcvPB

Synonym: BSU24550

Alternate gene names: 16079511

Gene position: 2546876-2545410 (Counterclockwise)

Preceding gene: 255767551

Following gene: 16079509

Centisome position: 60.42

GC content: 47.92

Gene sequence:

>1467_bases
ATGAGTAATCAGGACCAGGCACTTATTTTTGAACTTTCAAGAGAAGGCCGAATCGGCTATAGTCTGCCGGAGCTCGATGT
ACCGGAAATCGAATTGGGGGACCTCTTGTCAGACACCTATATTCGTGACGAAGACGCAGCGCTGCCGGAGGTTTCAGAGC
TGGACATCATGCGCCATTATACAGCGCTGTCCAAACGCAATCACGGGGTGGATTCCGGTTTTTATCCTCTCGGTTCTTGC
ACGATGAAATATAATCCGAAAATCAATGAAAAAATCGCACGTATTCCTGGTTTTGCTGCGATTCATCCTCTTCAGGATGA
AGACACGGTGCAAGGCGCATTAGAGCTTTTATATGATTTAAGCAAACACCTTGAAGAAATAACGGGAATGGATGAGGTTA
CGCTTCAGCCTGCTGCCGGAGCGCACGGCGAATGGACGGGGCTGATGATGATCCGTGCCTATCATGAAGCTCGCGGGGAT
TTCAAGCGGACGAAGGTCATTGTCCCTGATTCCGCGCATGGGACGAATCCTGCATCAGCAACAGTAGCAGGCTTTGAAAC
CGTTACGGTGAAATCGAATGAAAAAGGGCTTGTTGATTTAGAGGATTTAAAAAGAGCAGTGAATGAAGAAACTGCAGCTC
TTATGCTGACGAATCCGAACACGCTCGGCTTGTTTGAGGAGCAGATTACAGAGATGGCGGAAATTGTACACCAAGCGGGG
GGGAAACTGTATTATGACGGCGCTAATTTAAATGCCGTTTTAAGCAAGGCGAGACCTGGTGATATGGGATTTGACGTGGT
GCACCTCAACCTGCATAAAACATTCACAGGCCCTCATGGCGGCGGAGGCCCCGGCTCAGGCCCTGTCGGCGTAAAACAAG
ATCTGATTCCTTATTTGCCAAAGCCAGTTTTAGTCAAAAAAGAAGGGCGCTTTACGTTTGATTATGACCGCCCTCATGCG
ATCGGCCGTGTGAAGCCGTATTACGGCAACTTTGGCATTAATGTGAGAGCGTATACGTATATTCGCTCCATGGGGCCTGA
CGGATTAAAGGCTGTTACTGAGAACGCAGTGTTAAACGCCAATTATATGATGAGAAAACTCGCGCCTTATTACGATCTTC
CGTTTGACCGCCATTGCAAGCATGAATTTGTATTATCAGGGAAGCGGCAGAAAAAGCTGGGAGTGCGTACGCTTGATATT
GCAAAACGGCTCCTTGATTTCGGCTATCATCCGCCGACGATTTATTTCCCGCTTAATGTTGAAGAATGCATCATGATCGA
GCCGACAGAGACCGAATCAAAGGAAACACTGGACGCGTTTATTGATGCTATGATTCAAATCGCAAAAGAAGCGGAGGAGA
ATCCGGAGCTTGTTCAGGAGGCCCCGCATACAACGATTGTAAAAAGAATGGATGAAACAAAAGCGGCGAGACACCCAGTG
CTCAGATACGAGGCGGAAGAAAGATAA

Upstream 100 bases:

>100_bases
TTGACGTATCCAGAGCTGGACTGCCATATGCTGATTGCTGTAACAGAGCTGAGAACAAAAGAAGAAATTGACGCACTCAT
TCAGGAATTGGGGGATCGCC

Downstream 100 bases:

>100_bases
ATAAAAACAGCTGTCTACCAGACAGCTGTTTGCTTTATTTCTTCGCTTTAATCTTTCCGCCCCATTTTTTAAAGCCGCCT
TTTAGGTTGTAAATCTCAGT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDEDAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSC
TMKYNPKINEKIARIPGFAAIHPLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD
FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTNPNTLGLFEEQITEMAEIVHQAG
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHA
IGRVKPYYGNFGINVRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKKLGVRTLDI
AKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKEAEENPELVQEAPHTTIVKRMDETKAARHPV
LRYEAEER

Sequences:

>Translated_488_residues
MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDEDAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSC
TMKYNPKINEKIARIPGFAAIHPLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD
FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTNPNTLGLFEEQITEMAEIVHQAG
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHA
IGRVKPYYGNFGINVRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKKLGVRTLDI
AKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKEAEENPELVQEAPHTTIVKRMDETKAARHPV
LRYEAEER
>Mature_487_residues
SNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDEDAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCT
MKYNPKINEKIARIPGFAAIHPLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGDF
KRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTNPNTLGLFEEQITEMAEIVHQAGG
KLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAI
GRVKPYYGNFGINVRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKKLGVRTLDIA
KRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKEAEENPELVQEAPHTTIVKRMDETKAARHPVL
RYEAEER

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=408, Percent_Identity=44.1176470588235, Blast_Score=292, Evalue=5e-79,
Organism=Escherichia coli, GI1789269, Length=409, Percent_Identity=42.2982885085575, Blast_Score=293, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17535605, Length=428, Percent_Identity=41.3551401869159, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI32564013, Length=384, Percent_Identity=42.7083333333333, Blast_Score=269, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6323843, Length=435, Percent_Identity=43.448275862069, Blast_Score=323, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24645648, Length=411, Percent_Identity=41.8491484184915, Blast_Score=284, Evalue=8e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 54428; Mature: 54296

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDEDAALPEVSELDIMRHY
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHCEECCCCCCCCCHHHHHHHHHH
TALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIHPLQDEDTVQGALELLYDL
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHH
SKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGDFKRTKVIVPDSAHGTNPASA
HHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCE
TVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTNPNTLGLFEEQITEMAEIVHQAG
EEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKQDLIPYLP
CEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCC
KPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGINVRAYTYIRSMGPDGLKAVTENAVLNA
CCEEEEECCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEHHCCCCHHHHHHHCCEECH
NYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKKLGVRTLDIAKRLLDFGYHPPTIYFPLNV
HHHHHHHCCCCCCCCCCCCCHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCC
EECIMIEPTETESKETLDAFIDAMIQIAKEAEENPELVQEAPHTTIVKRMDETKAARHPV
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHCCC
LRYEAEER
EEECCCCC
>Mature Secondary Structure 
SNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDEDAALPEVSELDIMRHY
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHCEECCCCCCCCCHHHHHHHHHH
TALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIHPLQDEDTVQGALELLYDL
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHH
SKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGDFKRTKVIVPDSAHGTNPASA
HHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCE
TVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTNPNTLGLFEEQITEMAEIVHQAG
EEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKQDLIPYLP
CEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCC
KPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGINVRAYTYIRSMGPDGLKAVTENAVLNA
CCEEEEECCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEHHCCCCHHHHHHHCCEECH
NYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKKLGVRTLDIAKRLLDFGYHPPTIYFPLNV
HHHHHHHCCCCCCCCCCCCCHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCC
EECIMIEPTETESKETLDAFIDAMIQIAKEAEENPELVQEAPHTTIVKRMDETKAARHPV
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHCCC
LRYEAEER
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA