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The map label for this gene is gcvPA

Identifier: 255767551

GI number: 255767551

Start: 2546869

End: 2548215

Strand: Reverse

Name: gcvPA

Synonym: BSU24560

Alternate gene names: 255767551

Gene position: 2548215-2546869 (Counterclockwise)

Preceding gene: 255767552

Following gene: 16079511

Centisome position: 60.45

GC content: 46.4

Gene sequence:

>1347_bases
ATGAAGCACCGTTATTTGCCCGCAACAGAAAAGGATAAACAGGAGATGCTTGCTACTATCGGCGTAAGCAGCATCGATGA
TTTATTTGCTGATATACCGGAAAACGTCAAATATAAAAAAGAGCATCAAATCAAAAAAGCGAAATCAGAGACAGAATTAA
CAAGAGAACTGACAAAGCTGGCCTCTAAAAATCGTGATACCGTACAATACGCTTCTTTCTTAGGAGCGGGTGTATATGAC
CACTATCAGCCTGTCATTGTGGATCATGTCATTTCGCGCTCTGAGTTTTATACCGCATATACGCCTTATCAGCCAGAGAT
TTCACAAGGAGAGCTCCAGGCTATTTTTGAATTCCAAACGATGATCTGTGAACTGACAGGCATGGATATCGCCAACTCCT
CGATGTATGACGGCGGAACAGCCTTGGCAGAAGCAGCAATGCTTGCTTCAGGCCACACGAAAAAGAAAAAAATTGTTGTG
TCAAAAACCGTGCATCCTGAATCGCGAGAGGTGCTGAAAACTTACGCAAAAGGTCAGTATATTGATGTTGTTGAAGTACC
CGCTGCGGATGGCGTTACGGATCTTGATGCATTGCGCCAAACCGTTTGCGAGAACACAGCCGCAGTGATCGTTCAGTACC
CGAATTTTTTCGGCAGGATCGAGCCGCTAAAGGATATTGAGCCTATCGCTCATCAAGGGAAATCCATGTTTATTGTTTCA
GCCAACCCGCTGGCGCTAGGTCTTCTCACTCCGCCGGGCAAGTTTCAGTCTGATATCGTCGTCGGTGATGCGCAGCCTTT
CGGCATTCCTTCAGCATACGGCGGCCCGCATTGCGGCTTTTTTGCCGTTACTAAAAAATTAATGAGAAAGGTGCCGGGCC
GTCTCGTCGGACAAACGGAAGACGAAAACGGAAAAAGAGGCTTTGTGCTTACCCTGCAAGCCAGGGAGCAGCATATCCGC
CGGGATAAAGCAACATCAAATATATGCTCGAACCAAGCTTTAAATGCGCTGGCAGCATCAGTGGCCATGACTGCTCTCGG
AAAAAACGGCGTAAAAGATATAGCCCGCCAAAATCTCTTAAAAGCCAACTATGCAAAGCAAGAAGCAAAAAAAGCAGGCC
TTACTGTTATGTTTGACGGGCCGATGTTTAATGAATTTGTCATCAAACTGGATGAGCCGGTGAGAGCTGTGAACAAGCGT
TTGCTGGCAAAAGGCATGATTGGCGGATATGATCTTGGGTTGACGTATCCAGAGCTGGACTGCCATATGCTGATTGCTGT
AACAGAGCTGAGAACAAAAGAAGAAATTGACGCACTCATTCAGGAATTGGGGGATCGCCATGAGTAA

Upstream 100 bases:

>100_bases
TTGTAGATGTAGAGATACGCAAAAAATTAGTGAAAGCAAAGGTTGTCAAAACACCATTTTATAAACGCTAATATTTTTTC
TTGGAGAGAGGAGACAACAC

Downstream 100 bases:

>100_bases
TCAGGACCAGGCACTTATTTTTGAACTTTCAAGAGAAGGCCGAATCGGCTATAGTCTGCCGGAGCTCGATGTACCGGAAA
TCGAATTGGGGGACCTCTTG

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQIKKAKSETELTRELTKLASKNRDTVQYASFLGAGVYD
HYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV
SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFGRIEPLKDIEPIAHQGKSMFIVS
ANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGPHCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDEPVRAVNKR
LLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE

Sequences:

>Translated_448_residues
MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQIKKAKSETELTRELTKLASKNRDTVQYASFLGAGVYD
HYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV
SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFGRIEPLKDIEPIAHQGKSMFIVS
ANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGPHCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDEPVRAVNKR
LLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE
>Mature_448_residues
MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQIKKAKSETELTRELTKLASKNRDTVQYASFLGAGVYD
HYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV
SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFGRIEPLKDIEPIAHQGKSMFIVS
ANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGPHCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDEPVRAVNKR
LLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=416, Percent_Identity=37.7403846153846, Blast_Score=279, Evalue=4e-75,
Organism=Escherichia coli, GI1789269, Length=360, Percent_Identity=36.6666666666667, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17535605, Length=396, Percent_Identity=38.3838383838384, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=364, Percent_Identity=40.9340659340659, Blast_Score=270, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24645648, Length=358, Percent_Identity=38.8268156424581, Blast_Score=262, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_BACSU (P54376)

Other databases:

- EMBL:   D84432
- EMBL:   AL009126
- PIR:   A69959
- RefSeq:   NP_390336.2
- ProteinModelPortal:   P54376
- SMR:   P54376
- EnsemblBacteria:   EBBACT00000002280
- GeneID:   938546
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU24560
- NMPDR:   fig|224308.1.peg.2460
- GenoList:   BSU24560
- GeneTree:   EBGT00050000001780
- HOGENOM:   HBG288345
- ProtClustDB:   PRK00451
- BioCyc:   BSUB:BSU24560-MONOMER
- BRENDA:   1.4.4.2
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 49429; Mature: 49429

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQIKKAKSETELTRELTKL
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHCHHEEEEECCCCCCCCCCHHHHHHHHHH
MICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVVSKTVHPESREVLKTYAKGQY
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCE
IDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFGRIEPLKDIEPIAHQGKSMFIVS
EEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHCCCCCHHHCCHHHHCCCEEEEEE
ANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGPHCGFFAVTKKLMRKVPGRLVGQTE
CCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
DENGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVAMTALGKNGVKDIARQNLL
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KANYAKQEAKKAGLTVMFDGPMFNEFVIKLDEPVRAVNKRLLAKGMIGGYDLGLTYPELD
HHHHHHHHHHHCCCEEEECCCCCCHHHEECCHHHHHHHHHHHHHCCCCCEECCCCCCCCC
CHMLIAVTELRTKEEIDALIQELGDRHE
CEEEEHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQIKKAKSETELTRELTKL
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHCHHEEEEECCCCCCCCCCHHHHHHHHHH
MICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVVSKTVHPESREVLKTYAKGQY
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCE
IDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFGRIEPLKDIEPIAHQGKSMFIVS
EEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHCCCCCHHHCCHHHHCCCEEEEEE
ANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGPHCGFFAVTKKLMRKVPGRLVGQTE
CCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
DENGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVAMTALGKNGVKDIARQNLL
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KANYAKQEAKKAGLTVMFDGPMFNEFVIKLDEPVRAVNKRLLAKGMIGGYDLGLTYPELD
HHHHHHHHHHHCCCEEEECCCCCCHHHEECCHHHHHHHHHHHHHCCCCCEECCCCCCCCC
CHMLIAVTELRTKEEIDALIQELGDRHE
CEEEEHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377