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The map label for this gene is nprB

Identifier: 16078174

GI number: 16078174

Start: 1186037

End: 1187653

Strand: Direct

Name: nprB

Synonym: BSU11100

Alternate gene names: 16078174

Gene position: 1186037-1187653 (Clockwise)

Preceding gene: 16078173

Following gene: 16078176

Centisome position: 28.13

GC content: 45.58

Gene sequence:

>1617_bases
TTGCGCAACTTGACCAAGACATCTCTATTACTGGCCGGCTTATGCACAGCGGCCCAAATGGTTTTTGTAACACATGCCTC
AGCTGAAGAAAGCATCGAATACGACCATACGTATCAAACCCCTTCATACATCATCGAAAAGTCACCGCAGAAGCCGGTAC
AAAACACAACCCAGAAAGAATCGCTATTTTCCTATCTTGACAAGCATCAAACGCAGTTTAAGCTCAAAGGGAATGCGAAC
AGCCATTTTCGCGTTTCGAAAACCATAAAGGATCCAAAGACAAAACAAACGTTTTTTAAATTAACGGAGGTTTACAAAGG
AATTCCGATTTACGGCTTTGAACAAGCGGTCGCGATGAAGGAAAACAAACAAGTGAAAAGTTTCTTTGGAAAGGTGCATC
CGCAAATCAAGGACGTCTCCGTCACACCGTCTATTTCTGAGAAAAAAGCAATACATACAGCAAGGCGTGAGCTCGAGGCT
TCCATTGGAAAAATCGAATATCTTGATGGGGAACCAAAAGGCGAATTATATATCTATCCACACGACGGTGAATATGATCT
CGCCTACCTTGTGAGACTCTCGACATCTGAACCTGAGCCTGGCTATTGGCATTATTTCATCGATGCCAAAAACGGAAAGG
TCATCGAGTCCTTTAATGCCATTCATGAAGCGGCAGGTACAGGAATCGGCGTGTCAGGTGATGAAAAAAGCTTTGACGTC
ACAGAACAAAATGGGCGCTTTTATTTGGCTGACGAAACAAGGGGAAAAGGGATCAATACATTTGACGCGAAGAACCTGAA
CGAAACCTTGTTTACGCTTTTGTCTCAACTGATCGGGTATACGGGCAAAGAAATAGTCAGCGGCACGTCCGTATTTAATG
AACCTGCGGCTGTAGACGCACACGCAAATGCGCAAGCCGTTTACGATTATTACAGCAAGACATTTGGCCGTGATTCTTTT
GATCAAAACGGAGCAAGGATTACGTCTACCGTGCATGTCGGCAAACAATGGAACAATGCTGCGTGGAACGGTGTCCAGAT
GGTATACGGGGATGGAGACGGTTCGAAATTTAAGCCGCTGTCTGGATCGCTCGACATTGTCGCGCATGAAATCACACACG
CAGTCACACAGTATTCCGCCGGTCTTTTATATCAAGGAGAACCCGGTGCATTAAATGAGTCCATTTCTGACATTATGGGC
GCGATGGCTGACCGTGATGATTGGGAGATCGGCGAAGATGTCTATACTCCTGGTATTGCAGGAGATTCATTGCGGTCATT
GGAGGACCCATCTAAGCAGGGAAATCCAGATCATTACTCGAACCGCTACACAGGAACAGAGGATTATGGCGGAGTCCATA
TCAATTCGTCCATTCACAATAAAGCAGCTTATCTTCTTGCAGAAGGAGGCGTGCACCACGGTGTACAGGTTGAAGGGATT
GGGCGTGAAGCAAGTGAACAAATTTACTATCGGGCTTTAACATATTATGTAACGGCATCTACAGATTTCAGCATGATGAA
GCAAGCGGCGATTGAAGCTGCCAATGATTTATACGGTGAAGGCTCGAAGCAATCAGCTTCAGTCGAAAAGGCGTATGAGG
CTGTCGGCATTCTATGA

Upstream 100 bases:

>100_bases
TTTTTTGGGAAAATAAGAACGAAGCACCACATACAAGTTTTTGTATTTTTGATAGGATGAAGAAAAATGGTAGATTCCAA
AATAGGAAGGATGTGGTGTT

Downstream 100 bases:

>100_bases
GCAAACAAAAACAGTCAGGACACAGAGTCTGACTGTTTTTGTTTGCTCATTTTCTTAAAAAGAATATCGCCAATGTACCT
GGACCGGCATGCGAGCCGAT

Product: extracellular neutral protease B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYIIEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNAN
SHFRVSKTIKDPKTKQTFFKLTEVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA
SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESFNAIHEAAGTGIGVSGDEKSFDV
TEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQLIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSF
DQNGARITSTVHVGKQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALNESISDIMG
AMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYGGVHINSSIHNKAAYLLAEGGVHHGVQVEGI
GREASEQIYYRALTYYVTASTDFSMMKQAAIEAANDLYGEGSKQSASVEKAYEAVGIL

Sequences:

>Translated_538_residues
MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYIIEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNAN
SHFRVSKTIKDPKTKQTFFKLTEVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA
SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESFNAIHEAAGTGIGVSGDEKSFDV
TEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQLIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSF
DQNGARITSTVHVGKQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALNESISDIMG
AMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYGGVHINSSIHNKAAYLLAEGGVHHGVQVEGI
GREASEQIYYRALTYYVTASTDFSMMKQAAIEAANDLYGEGSKQSASVEKAYEAVGIL
>Mature_538_residues
MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYIIEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNAN
SHFRVSKTIKDPKTKQTFFKLTEVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA
SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESFNAIHEAAGTGIGVSGDEKSFDV
TEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQLIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSF
DQNGARITSTVHVGKQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALNESISDIMG
AMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYGGVHINSSIHNKAAYLLAEGGVHHGVQVEGI
GREASEQIYYRALTYYVTASTDFSMMKQAAIEAANDLYGEGSKQSASVEKAYEAVGIL

Specific function: Unknown

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPRB_BACSU (P39899)

Other databases:

- EMBL:   M62845
- EMBL:   Z79580
- EMBL:   Y09476
- EMBL:   AL009126
- PIR:   A41042
- RefSeq:   NP_388991.1
- ProteinModelPortal:   P39899
- SMR:   P39899
- MEROPS:   M04.012
- EnsemblBacteria:   EBBACT00000001379
- GeneID:   936384
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU11100
- NMPDR:   fig|224308.1.peg.1110
- GenoList:   BSU11100
- GeneTree:   EBGT00070000032112
- HOGENOM:   HBG753113
- OMA:   GHNEELM
- ProtClustDB:   CLSK887046
- BioCyc:   BSUB:BSU11100-MONOMER
- GO:   GO:0006508
- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096
- Gene3D:   G3DSA:3.10.170.10
- Gene3D:   G3DSA:1.10.390.10
- PRINTS:   PR00730

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C

EC number: NA

Molecular weight: Translated: 59336; Mature: 59336

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 370-370 ACT_SITE 453-453

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYIIEKSPQKPVQNTTQKE
CCCCHHHHHHHHHHHHHHHEEEEEECCCHHCCCCCCCCCCCHHHCCCCCCCCHHCCHHHH
SLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLTEVYKGIPIYGFEQAVAMK
HHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
ENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEASIGKIEYLDGEPKGELYIYP
HCHHHHHHHHHHCCCEECEEECCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEE
HDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESFNAIHEAAGTGIGVSGDEKSFDV
CCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCE
TEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQLIGYTGKEIVSGTSVFNEPAAVDA
EECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCHHCCCCCCCCC
HANAQAVYDYYSKTFGRDSFDQNGARITSTVHVGKQWNNAAWNGVQMVYGDGDGSKFKPL
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCC
SGSLDIVAHEITHAVTQYSAGLLYQGEPGALNESISDIMGAMADRDDWEIGEDVYTPGIA
CCCHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCC
GDSLRSLEDPSKQGNPDHYSNRYTGTEDYGGVHINSSIHNKAAYLLAEGGVHHGVQVEGI
CCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEEECCCCCCCEEEEEC
GREASEQIYYRALTYYVTASTDFSMMKQAAIEAANDLYGEGSKQSASVEKAYEAVGIL
CCHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYIIEKSPQKPVQNTTQKE
CCCCHHHHHHHHHHHHHHHEEEEEECCCHHCCCCCCCCCCCHHHCCCCCCCCHHCCHHHH
SLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLTEVYKGIPIYGFEQAVAMK
HHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
ENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEASIGKIEYLDGEPKGELYIYP
HCHHHHHHHHHHCCCEECEEECCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEE
HDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESFNAIHEAAGTGIGVSGDEKSFDV
CCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCE
TEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQLIGYTGKEIVSGTSVFNEPAAVDA
EECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCHHCCCCCCCCC
HANAQAVYDYYSKTFGRDSFDQNGARITSTVHVGKQWNNAAWNGVQMVYGDGDGSKFKPL
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCC
SGSLDIVAHEITHAVTQYSAGLLYQGEPGALNESISDIMGAMADRDDWEIGEDVYTPGIA
CCCHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCC
GDSLRSLEDPSKQGNPDHYSNRYTGTEDYGGVHINSSIHNKAAYLLAEGGVHHGVQVEGI
CCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEEECCCCCCCEEEEEC
GREASEQIYYRALTYYVTASTDFSMMKQAAIEAANDLYGEGSKQSASVEKAYEAVGIL
CCHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1917867; 9025291; 9353931; 9384377