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The map label for this gene is treR

Identifier: 16077849

GI number: 16077849

Start: 853556

End: 854272

Strand: Direct

Name: treR

Synonym: BSU07820

Alternate gene names: 16077849

Gene position: 853556-854272 (Clockwise)

Preceding gene: 16077848

Following gene: 16077850

Centisome position: 20.25

GC content: 46.58

Gene sequence:

>717_bases
ATGAAGGTGAATAAATTCATCACAATTTATAAAGACATCGCACAGCAAATTGAAGGCGGCCGATGGAAAGCGGAGGAGAT
TCTTCCGTCTGAACATGAGTTGACCGCACAGTACGGTACATCAAGAGAAACGGTCCGAAAGGCGCTTCATATGCTCGCGC
AAAACGGTTATATCCAGAAAATCAGGGGAAAAGGCTCCGTCGTGCTCAATCGTGAAAAAATGCAGTTTCCCGTTTCGGGC
CTTGTCAGCTTCAAGGAGCTCGCGCAAACGCTTGGCAAAGAAACGAAAACAACTGTACACAAATTCGGGCTGGAGCCTCC
GTCAGAGCTGATCCAAAAACAGCTCCGGGCCAATCTGGATGACGACATCTGGGAAGTCATCAGGTCTAGAAAGATTGACG
GGGAACATGTGATTTTGGACAAGGATTACTTTTTCAGAAAGCATGTCCCTCACCTGACGAAAGAAATTTGTGAAAACTCC
ATATATGAATATATAGAAGGAGAGCTCGGTCTTTCGATCAGTTACGCCCAAAAAGAAATTGTAGCCGAGCCGTGTACGGA
CGAGGACAGAGAGCTGCTCGATTTACGCGGCTATGACCATATGGTCGTGGTGAGAAACTACGTCTTTTTGGAGGATACCA
GTTTGTTTCAATATACGGAAAGCAGACACCGTCTCGACAAATTCCGATTTGTTGATTTTGCGCGGCGGGGGAAATGA

Upstream 100 bases:

>100_bases
ATGAAGCAAGGGAAGGGCTTCAGAACATGACGCTTCGCCCATATGAGTCCATTGTTTATCGTTTAACGAAACCGTGTTAA
ACTAAGCTGGGTGGTCCATA

Downstream 100 bases:

>100_bases
GAGAGGCGCCTGCCTGCGGCAGCGCGCTTTTTTGTTTGGTATCAAAATTGATACTATCCAACAAAAATGTGCGTACTTTT
ACTTTTTATCATAATGGCTA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRETVRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSG
LVSFKELAQTLGKETKTTVHKFGLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS
IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQYTESRHRLDKFRFVDFARRGK

Sequences:

>Translated_238_residues
MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRETVRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSG
LVSFKELAQTLGKETKTTVHKFGLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS
IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQYTESRHRLDKFRFVDFARRGK
>Mature_238_residues
MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRETVRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSG
LVSFKELAQTLGKETKTTVHKFGLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS
IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQYTESRHRLDKFRFVDFARRGK

Specific function: Repressor for the trehalose operon (treP and treA). Binds trehalose-6-phosphate, which probably acts as an inducer

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1786950, Length=232, Percent_Identity=28.448275862069, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1790118, Length=169, Percent_Identity=27.810650887574, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790540, Length=232, Percent_Identity=20.6896551724138, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRER_BACSU (P39796)

Other databases:

- EMBL:   Z54245
- EMBL:   D83967
- EMBL:   AL009126
- EMBL:   X80203
- PIR:   JC5038
- RefSeq:   NP_388663.1
- PDB:   2OGG
- PDBsum:   2OGG
- ProteinModelPortal:   P39796
- SMR:   P39796
- EnsemblBacteria:   EBBACT00000003852
- GeneID:   936133
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU07820
- NMPDR:   fig|224308.1.peg.782
- GenoList:   BSU07820
- GeneTree:   EBGT00050000000778
- HOGENOM:   HBG696565
- OMA:   HELVESY
- ProtClustDB:   CLSK2752339
- BioCyc:   BSUB:BSU07820-MONOMER
- GO:   GO:0005622
- InterPro:   IPR000524
- InterPro:   IPR012770
- InterPro:   IPR011663
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00345
- SMART:   SM00866
- TIGRFAMs:   TIGR02404

Pfam domain/function: PF00392 GntR; PF07702 UTRA

EC number: NA

Molecular weight: Translated: 27842; Mature: 27842

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRETVRKALHMLAQNGYIQK
CCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCEEE
IRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKFGLEPPSELIQKQLRANLD
ECCCCCEEEEHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCC
DDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENSIYEYIEGELGLSISYAQKEI
HHHHHHHHHCCCCCCEEEECCCHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQYTESRHRLDKFRFVDFARRGK
HCCCCCCCHHHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRETVRKALHMLAQNGYIQK
CCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCEEE
IRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKFGLEPPSELIQKQLRANLD
ECCCCCEEEEHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCC
DDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENSIYEYIEGELGLSISYAQKEI
HHHHHHHHHCCCCCCEEEECCCHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQYTESRHRLDKFRFVDFARRGK
HCCCCCCCHHHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8917076; 8969503; 9384377; 7651129; 8755887