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The map label for this gene is lpxB

Identifier: 15618872

GI number: 15618872

Start: 1104922

End: 1106736

Strand: Reverse

Name: lpxB

Synonym: CPn0965

Alternate gene names: 15618872

Gene position: 1106736-1104922 (Counterclockwise)

Preceding gene: 15618873

Following gene: 15618871

Centisome position: 89.96

GC content: 41.1

Gene sequence:

>1815_bases
ATGATCCCTTCTGGCCTAGTTTATCTGCTTTATCCCCTAGGATTTCTTGCTAGTCTTTTTTTTGGGAGTGCCTTCTCAAT
ACAGTGGTGGCTGAGTAAAAAGCGCAAAGAGGTCTATGCTCCTCGAAGCTTTTGGATTCTCTCTTCAATAGGAGCCACTT
TGATGATTGTCCACGGGACAATTCAAAGCCAATTTCCTGTGACTGTACTTCATGTCATTAACTTAATTATCTACCTCAGA
AACCTAAATATTACTTCCTCTCGACCGATTTCCTTTCGAGCGACCTTAGTTCTGATGGCTCTGAGCGTGGTGTTCGTGAC
TCTGCCTTTCCTCTATGTGAACATGGAATGGATGGCCTCTCCTAATATCTTCCATCTTCCTCTTCCTCCTGCACAACTTT
CTTGGCATCTTATAGGCTGTTTAGGGCTTGCTATTTTTTCGGGTCGTTTTTTAATCCAATGGTTCTACATAGAATCGAAT
AATACTAAAGATTTCCCCTTACTATTTTGGAAAATTGGACTTCTTGGGGGATTGCTGGCGCTGGTGTACTTCATTCGCAT
CGGAGATCCTATAAACATCCTGTGCTATGGCTGTGGATTATTCCCGTCCATCGCAAATTTACGTCTCTTTTATAAAGAAC
AACGTTCGACTCCTTATTTGGATACACACTGCTTTCTCTCTGCTGGAGAAGCTAGCGGTGACATTTTGGGGGGTAAGTTA
ATCCAATCCATAAAGTCTCTCTATCCAAACATACGGTTCTGGGGTGTTGGAGGTCCTGCAATGCGACAAGAAGGTCTCCA
GCCCATTCTAAACATGGAGGAGTTTCAAGTTTCAGGATTTGCTGAAGTTCTGGGGTCATTATTTAGATTATATCGAAATT
ACCGCAAAATCCTAAAAACGATACTCAAACACAAGCCAGCGACTCTTATCTTCATTGATTTCCCCGATTTTCACCTTCTC
TTAATTAAAAAGCTGAGAAAACATGGGTATCGAGGAAAAATCATCCATTACGTTTGCCCGAGTATTTGGGCATGGCGCCC
CAAAAGAAAACGCATACTAGAGCAACATCTTGATATGCTCCTACTGATCCTTCCTTTTGAAGAAGGCCTTTTCAAAAACA
CATCTCTTGAGACTGTGTATTTAGGACACCCCCTAGTTGAGGAGATCTCTGACTACAAAGAACAGGCCTCTTGGAAAGAG
AAATTCCTTAATTCTGACCGTCCTATTGTTGCTGCGTTTCCTGGAAGTCGTCGTGGTGACATCAGCCGAAATTTACGGAT
CCAGGTACAAGCTTTTCTAAATTCATCGCTATCTCAAACACATCAATTTGTGGTTTCCTCATCAAGCGCTAAGTACGACG
AAATCATTGAAGATACTCTAAAAGCAGAAGGATGTCAGCATAGTCAAATCATCCCCATGAATTTCCGCTATGAGCTCATG
AGAAGCTGTGATTGTGCACTAGCAAAATGTGGCACTATAGTCTTAGAAACTGCCTTAAATCAAACACCCACAATAGTCAT
GTGTCGACTTCGACCTTTTGACACATTCTTAGCAAAATATATTTTTAAAATTCTTTTGCCCGCGTATTCCTTACCAAATA
TCATTATGAACTCCGTGATTTTTCCAGAGTTCATTGGAGGGAAAAAAGATTTTCATCCAGAAGAAATCGCTACCGCTTTA
GATTTGCTAAATCAACATGGCTCTAAAGAAAAACAAAAGGAGGACTGCCGCAAATTATGTAAAGTGATGACGACAGGGCA
AATAGCTTCTGAAGAGTTTTTAAAAAGAATTTTTGACACACTTCCCGCTGTATGA

Upstream 100 bases:

>100_bases
TAGTGTATCCTAAGCTCGATAAAGTGTATGTTGCTTGGATACGTCATCATCAAACACTTAAGTGTAAAAAGGATTCTCAT
TCTCAAAAGTAGGTCTAAAC

Downstream 100 bases:

>100_bases
ATATTTAGGTTTCTTAAAACAAGTTCTTTAAGAACTCATAAATAAGTATAAAACAATTCGTTTTGAGCTACTTTTTTATA
GTATTTCTAAATAAAAATTA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MIPSGLVYLLYPLGFLASLFFGSAFSIQWWLSKKRKEVYAPRSFWILSSIGATLMIVHGTIQSQFPVTVLHVINLIIYLR
NLNITSSRPISFRATLVLMALSVVFVTLPFLYVNMEWMASPNIFHLPLPPAQLSWHLIGCLGLAIFSGRFLIQWFYIESN
NTKDFPLLFWKIGLLGGLLALVYFIRIGDPINILCYGCGLFPSIANLRLFYKEQRSTPYLDTHCFLSAGEASGDILGGKL
IQSIKSLYPNIRFWGVGGPAMRQEGLQPILNMEEFQVSGFAEVLGSLFRLYRNYRKILKTILKHKPATLIFIDFPDFHLL
LIKKLRKHGYRGKIIHYVCPSIWAWRPKRKRILEQHLDMLLLILPFEEGLFKNTSLETVYLGHPLVEEISDYKEQASWKE
KFLNSDRPIVAAFPGSRRGDISRNLRIQVQAFLNSSLSQTHQFVVSSSSAKYDEIIEDTLKAEGCQHSQIIPMNFRYELM
RSCDCALAKCGTIVLETALNQTPTIVMCRLRPFDTFLAKYIFKILLPAYSLPNIIMNSVIFPEFIGGKKDFHPEEIATAL
DLLNQHGSKEKQKEDCRKLCKVMTTGQIASEEFLKRIFDTLPAV

Sequences:

>Translated_604_residues
MIPSGLVYLLYPLGFLASLFFGSAFSIQWWLSKKRKEVYAPRSFWILSSIGATLMIVHGTIQSQFPVTVLHVINLIIYLR
NLNITSSRPISFRATLVLMALSVVFVTLPFLYVNMEWMASPNIFHLPLPPAQLSWHLIGCLGLAIFSGRFLIQWFYIESN
NTKDFPLLFWKIGLLGGLLALVYFIRIGDPINILCYGCGLFPSIANLRLFYKEQRSTPYLDTHCFLSAGEASGDILGGKL
IQSIKSLYPNIRFWGVGGPAMRQEGLQPILNMEEFQVSGFAEVLGSLFRLYRNYRKILKTILKHKPATLIFIDFPDFHLL
LIKKLRKHGYRGKIIHYVCPSIWAWRPKRKRILEQHLDMLLLILPFEEGLFKNTSLETVYLGHPLVEEISDYKEQASWKE
KFLNSDRPIVAAFPGSRRGDISRNLRIQVQAFLNSSLSQTHQFVVSSSSAKYDEIIEDTLKAEGCQHSQIIPMNFRYELM
RSCDCALAKCGTIVLETALNQTPTIVMCRLRPFDTFLAKYIFKILLPAYSLPNIIMNSVIFPEFIGGKKDFHPEEIATAL
DLLNQHGSKEKQKEDCRKLCKVMTTGQIASEEFLKRIFDTLPAV
>Mature_604_residues
MIPSGLVYLLYPLGFLASLFFGSAFSIQWWLSKKRKEVYAPRSFWILSSIGATLMIVHGTIQSQFPVTVLHVINLIIYLR
NLNITSSRPISFRATLVLMALSVVFVTLPFLYVNMEWMASPNIFHLPLPPAQLSWHLIGCLGLAIFSGRFLIQWFYIESN
NTKDFPLLFWKIGLLGGLLALVYFIRIGDPINILCYGCGLFPSIANLRLFYKEQRSTPYLDTHCFLSAGEASGDILGGKL
IQSIKSLYPNIRFWGVGGPAMRQEGLQPILNMEEFQVSGFAEVLGSLFRLYRNYRKILKTILKHKPATLIFIDFPDFHLL
LIKKLRKHGYRGKIIHYVCPSIWAWRPKRKRILEQHLDMLLLILPFEEGLFKNTSLETVYLGHPLVEEISDYKEQASWKE
KFLNSDRPIVAAFPGSRRGDISRNLRIQVQAFLNSSLSQTHQFVVSSSSAKYDEIIEDTLKAEGCQHSQIIPMNFRYELM
RSCDCALAKCGTIVLETALNQTPTIVMCRLRPFDTFLAKYIFKILLPAYSLPNIIMNSVIFPEFIGGKKDFHPEEIATAL
DLLNQHGSKEKQKEDCRKLCKVMTTGQIASEEFLKRIFDTLPAV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=327, Percent_Identity=35.1681957186544, Blast_Score=166, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_CHLPN (Q9Z6U3)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B72014
- PIR:   C86611
- RefSeq:   NP_225158.1
- RefSeq:   NP_301022.1
- RefSeq:   NP_445433.1
- RefSeq:   NP_877274.1
- ProteinModelPortal:   Q9Z6U3
- GeneID:   1467681
- GeneID:   895627
- GeneID:   919726
- GeneID:   963352
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0895
- KEGG:   cpn:CPn0965
- KEGG:   cpt:CpB1002
- TIGR:   CP_0895
- HOGENOM:   HBG414066
- OMA:   CALAKCG
- PhylomeDB:   Q9Z6U3
- ProtClustDB:   PRK01021
- BioCyc:   CPNE115711:CP_0895-MONOMER
- BioCyc:   CPNE115713:CPN0965-MONOMER
- BioCyc:   CPNE138677:CPJ0965-MONOMER
- BioCyc:   CPNE182082:CPB1002-MONOMER
- BRENDA:   2.4.1.182
- HAMAP:   MF_00392
- InterPro:   IPR003835
- InterPro:   IPR011499
- ProDom:   PD339292
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF07578 LAB_N; PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 69015; Mature: 69015

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPSGLVYLLYPLGFLASLFFGSAFSIQWWLSKKRKEVYAPRSFWILSSIGATLMIVHGT
CCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEC
IQSQFPVTVLHVINLIIYLRNLNITSSRPISFRATLVLMALSVVFVTLPFLYVNMEWMAS
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEHHEECC
PNIFHLPLPPAQLSWHLIGCLGLAIFSGRFLIQWFYIESNNTKDFPLLFWKIGLLGGLLA
CCEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
LVYFIRIGDPINILCYGCGLFPSIANLRLFYKEQRSTPYLDTHCFLSAGEASGDILGGKL
HHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCCHHHHH
IQSIKSLYPNIRFWGVGGPAMRQEGLQPILNMEEFQVSGFAEVLGSLFRLYRNYRKILKT
HHHHHHHCCCCEEEECCCHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKHKPATLIFIDFPDFHLLLIKKLRKHGYRGKIIHYVCPSIWAWRPKRKRILEQHLDML
HHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHE
LLILPFEEGLFKNTSLETVYLGHPLVEEISDYKEQASWKEKFLNSDRPIVAAFPGSRRGD
EEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
ISRNLRIQVQAFLNSSLSQTHQFVVSSSSAKYDEIIEDTLKAEGCQHSQIIPMNFRYELM
CCCCCEEEEHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEECCCHHHHHH
RSCDCALAKCGTIVLETALNQTPTIVMCRLRPFDTFLAKYIFKILLPAYSLPNIIMNSVI
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FPEFIGGKKDFHPEEIATALDLLNQHGSKEKQKEDCRKLCKVMTTGQIASEEFLKRIFDT
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LPAV
HCCC
>Mature Secondary Structure
MIPSGLVYLLYPLGFLASLFFGSAFSIQWWLSKKRKEVYAPRSFWILSSIGATLMIVHGT
CCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEC
IQSQFPVTVLHVINLIIYLRNLNITSSRPISFRATLVLMALSVVFVTLPFLYVNMEWMAS
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEHHEECC
PNIFHLPLPPAQLSWHLIGCLGLAIFSGRFLIQWFYIESNNTKDFPLLFWKIGLLGGLLA
CCEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
LVYFIRIGDPINILCYGCGLFPSIANLRLFYKEQRSTPYLDTHCFLSAGEASGDILGGKL
HHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCCHHHHH
IQSIKSLYPNIRFWGVGGPAMRQEGLQPILNMEEFQVSGFAEVLGSLFRLYRNYRKILKT
HHHHHHHCCCCEEEECCCHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKHKPATLIFIDFPDFHLLLIKKLRKHGYRGKIIHYVCPSIWAWRPKRKRILEQHLDML
HHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHE
LLILPFEEGLFKNTSLETVYLGHPLVEEISDYKEQASWKEKFLNSDRPIVAAFPGSRRGD
EEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
ISRNLRIQVQAFLNSSLSQTHQFVVSSSSAKYDEIIEDTLKAEGCQHSQIIPMNFRYELM
CCCCCEEEEHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEECCCHHHHHH
RSCDCALAKCGTIVLETALNQTPTIVMCRLRPFDTFLAKYIFKILLPAYSLPNIIMNSVI
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FPEFIGGKKDFHPEEIATALDLLNQHGSKEKQKEDCRKLCKVMTTGQIASEEFLKRIFDT
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LPAV
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362