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The map label for this gene is gpsA

Identifier: 15618764

GI number: 15618764

Start: 972991

End: 973995

Strand: Reverse

Name: gpsA

Synonym: CPn0855

Alternate gene names: 15618764

Gene position: 973995-972991 (Counterclockwise)

Preceding gene: 15618765

Following gene: 15618763

Centisome position: 79.17

GC content: 45.27

Gene sequence:

>1005_bases
ATGAAACAACACATCGGCTACTTAGGTATGGGAATTTGGGGGTTTTGTCTAGCCTCCCTACTTGCGAATAAGGGATATCC
TGTTGTGGCATGGTCCCGGAACCCTGACCTAATCAAGCAATTACAAGAAGAACGACGTCATCCTTTAGCTCCCAATGTTG
TCATCTCTCCAAACCTTTCATTCACTACAGACATGAAAGAAGCGATCCACAATGCTTTCATGATTGTAGAAGGAGTGACC
TCCGCAGGAATCCGTCCCGTAGCAGAGCAATTAAAACAAATCACTGACCTCTCGGTCCCCTTTGTAATTACCTCTAAGGG
AATCGAGCAAAATACAGGACTCCTCCTCAGTGAAATCATGCTCGAAGTGCTTGGAGATTCCGTGACTCCATATTTAGGGT
ATCTCAGTGGTCCTTCCATCGCTAAAGAGGTCCTAAACGGTTCTCCCTGTTCTGTCGTAGTCAGCGCTTACGATTCACAA
ACTCTCAAACAAATCCACGAAGCTTTTTCCCTCCCCACCTTCCGAGTCTACCCTAATACCGATATTAAAGGTGCTGCTCT
CGGAGGAGCTTTGAAAAATGTGATTGCTATTGCCTGTGGGATTGCTGAGGGATTATCGTTTGGAAACAATGCAAAAGCAG
GCCTTGTGACCCGGGGATTGCATGAAATGCGTAAACTCGCCGCTATCATGGATTGTAAACCAGAAACTCTAAATGGCCTT
GCAGGTCTTGGAGATCTTTGTGTTACCTGCTTCTCAGAGTCGAGTCGGAATTTACGGTTCGGGCACCTTCTTGCTCAAGG
TCTTACTTTCGAACAAGCAAAAGCAAAAATTGGGATGGTAGTCGAAGGAGCCTACACAGCACTTTCTGCATACCAAGTCG
CCAAACATCATAAAATCGATATGCCCATCACTACGGGAATCTATCGCGTTCTCTATGAAAATCTTGATCTCAAAGAGGGC
ATTGCTCTCCTCTTACAGAGAAATACAAAAGAAGAGTTCCTATAA

Upstream 100 bases:

>100_bases
CAACATTTGAATTAGAAGCTGATTTTTATTATCCTTCAACATCAACTTCCCTACATTGGGAAAACAAAGCATTTTTCGAG
GAACCATTTTTTGAGGCCTC

Downstream 100 bases:

>100_bases
TCTTTCAGAAAATTAAAGAATCCAGGTGAAAAAAAGACCCGAGACCTACAACATTCTAAGATCCTACCCGTCACTTGTCT
TTTCATTTGTACATTTTTTA

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKQHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRHPLAPNVVISPNLSFTTDMKEAIHNAFMIVEGVT
SAGIRPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIMLEVLGDSVTPYLGYLSGPSIAKEVLNGSPCSVVVSAYDSQ
TLKQIHEAFSLPTFRVYPNTDIKGAALGGALKNVIAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPETLNGL
AGLGDLCVTCFSESSRNLRFGHLLAQGLTFEQAKAKIGMVVEGAYTALSAYQVAKHHKIDMPITTGIYRVLYENLDLKEG
IALLLQRNTKEEFL

Sequences:

>Translated_334_residues
MKQHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRHPLAPNVVISPNLSFTTDMKEAIHNAFMIVEGVT
SAGIRPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIMLEVLGDSVTPYLGYLSGPSIAKEVLNGSPCSVVVSAYDSQ
TLKQIHEAFSLPTFRVYPNTDIKGAALGGALKNVIAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPETLNGL
AGLGDLCVTCFSESSRNLRFGHLLAQGLTFEQAKAKIGMVVEGAYTALSAYQVAKHHKIDMPITTGIYRVLYENLDLKEG
IALLLQRNTKEEFL
>Mature_334_residues
MKQHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRHPLAPNVVISPNLSFTTDMKEAIHNAFMIVEGVT
SAGIRPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIMLEVLGDSVTPYLGYLSGPSIAKEVLNGSPCSVVVSAYDSQ
TLKQIHEAFSLPTFRVYPNTDIKGAALGGALKNVIAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPETLNGL
AGLGDLCVTCFSESSRNLRFGHLLAQGLTFEQAKAKIGMVVEGAYTALSAYQVAKHHKIDMPITTGIYRVLYENLDLKEG
IALLLQRNTKEEFL

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=349, Percent_Identity=26.647564469914, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI24307999, Length=347, Percent_Identity=26.8011527377522, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1790037, Length=327, Percent_Identity=37.9204892966361, Blast_Score=217, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17507425, Length=339, Percent_Identity=23.598820058997, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI32564399, Length=335, Percent_Identity=25.0746268656716, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI193210136, Length=344, Percent_Identity=25, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI32564403, Length=344, Percent_Identity=25, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193210134, Length=213, Percent_Identity=28.169014084507, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320181, Length=347, Percent_Identity=27.0893371757925, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324513, Length=292, Percent_Identity=27.3972602739726, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026922, Length=213, Percent_Identity=24.4131455399061, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136202, Length=278, Percent_Identity=25.8992805755396, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136204, Length=278, Percent_Identity=25.8992805755396, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136200, Length=278, Percent_Identity=25.8992805755396, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_CHLPN (Q9Z751)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   E86597
- PIR:   G72024
- RefSeq:   NP_225050.1
- RefSeq:   NP_300912.1
- RefSeq:   NP_445551.1
- RefSeq:   NP_877156.1
- ProteinModelPortal:   Q9Z751
- SMR:   Q9Z751
- GeneID:   1467563
- GeneID:   895211
- GeneID:   919618
- GeneID:   963488
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP1014
- KEGG:   cpn:CPn0855
- KEGG:   cpt:CpB0884
- TIGR:   CP_1014
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- PhylomeDB:   Q9Z751
- ProtClustDB:   PRK00094
- BioCyc:   CPNE115711:CP_1014-MONOMER
- BioCyc:   CPNE115713:CPN0855-MONOMER
- BioCyc:   CPNE138677:CPJ0855-MONOMER
- BioCyc:   CPNE182082:CPB0884-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 36162; Mature: 36162

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 192-192 BINDING 106-106 BINDING 106-106 BINDING 141-141 BINDING 256-256 BINDING 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRHPLAPNVVISPNLS
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCC
FTTDMKEAIHNAFMIVEGVTSAGIRPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIM
CHHHHHHHHHHHHHHEECCHHCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHH
LEVLGDSVTPYLGYLSGPSIAKEVLNGSPCSVVVSAYDSQTLKQIHEAFSLPTFRVYPNT
HHHHCCCCCHHHHHCCCHHHHHHHHCCCCCEEEEEHHCHHHHHHHHHHHCCCEEEECCCC
DIKGAALGGALKNVIAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPETLNGL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
AGLGDLCVTCFSESSRNLRFGHLLAQGLTFEQAKAKIGMVVEGAYTALSAYQVAKHHKID
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHCEEEEHHHHHHHHHHHHHHCCCC
MPITTGIYRVLYENLDLKEGIALLLQRNTKEEFL
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MKQHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRHPLAPNVVISPNLS
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCC
FTTDMKEAIHNAFMIVEGVTSAGIRPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIM
CHHHHHHHHHHHHHHEECCHHCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHH
LEVLGDSVTPYLGYLSGPSIAKEVLNGSPCSVVVSAYDSQTLKQIHEAFSLPTFRVYPNT
HHHHCCCCCHHHHHCCCHHHHHHHHCCCCCEEEEEHHCHHHHHHHHHHHCCCEEEECCCC
DIKGAALGGALKNVIAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPETLNGL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
AGLGDLCVTCFSESSRNLRFGHLLAQGLTFEQAKAKIGMVVEGAYTALSAYQVAKHHKID
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHCEEEEHHHHHHHHHHHHHHCCCC
MPITTGIYRVLYENLDLKEGIALLLQRNTKEEFL
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362