| Definition | Chlamydophila pneumoniae CWL029, complete genome. |
|---|---|
| Accession | NC_000922 |
| Length | 1,230,230 |
Click here to switch to the map view.
The map label for this gene is polA
Identifier: 15618522
GI number: 15618522
Start: 702019
End: 704631
Strand: Reverse
Name: polA
Synonym: CPn0612
Alternate gene names: 15618522
Gene position: 704631-702019 (Counterclockwise)
Preceding gene: 15618523
Following gene: 15618521
Centisome position: 57.28
GC content: 38.08
Gene sequence:
>2613_bases ATGAAGAAACTGTTTGTATTAGATGCCTCAGGATTTATCTTTCGTGCCTACTTTGCTTTGCCAGAAATGAAAAATCATCA AGGACAAGCAACACAAGCAGTTTTTGGATTTATTCGTTCTTTAAATAAACTTATCAAAGAATTCTCTCCAGAATACATGA TCTCCGTCTTTGACGGTCCTAATAATAAACAAAGCCGTCAGGCGATTTATGCTGATTACAAAAGTAATCGACAGAAAAAA TTCGAAGACATCCCTCCACAAATAGCTCTAGTTAAAGAGTACTGCTCTTTAATAGGCCTAGCTTACTTAGAAAAAGAGTC GGTAGAAGCTGACGATGTGATTGCAAGTATTGCTAAGAAGGCTAGAGAAGAGAATTATAAAGTTTACGTATGCACCGCGG ATAAAGATCTGTTGCAGCTTGTAAACGATCATGTTGTAGCTTGGAATCCTTGGGCAGATCAAGGTGTTGTAGGGATCTCT GAGGTGATAGAACGTTATGGGATTCCTCCAGGGAATATCCCTGATTATCTAGCGTTAGTTGGAGACTCTTCTGATAACAT TCCAGGGCTCCCAGGTTGTGGGCCTAAAAAAGCTGCAGCACTTCTTAAACAATTTGGAAGTGTTGAGGGACTTTTAGAAA ATTTAGACGCCGTGAAGGGATTAAGTCAAACTATGCTGAGTGAACGGCAGGAGACTTTAAAGCTTAGTAAACGGCTTGCC CTCTTGGATTCTAATATCCCTATCCCAGTACCAATAGAGTCCCTTACCTTTCCACAACACCCTGTGGATGAAGAGAAACT CATACACTTTTATATACAACAAGGATTTAAAACTCTTGTGCCGTCCAAGCAAACAGAGGCTGCGACAGTCGATGTTCAGA TAATCAAAGATGCGGAAAGCCTCACCAACATTTTAAACCTTGTGCAAGGGGGGGACATTGCCTTTGCTGTAGCATATACA GGAAACCATCTTCTCTCTTTGAAGCTTGAAGGTTTAGCTTTGACACAGGGATCAGGGGTATTTTTTATTGCCTTAGAAGA GGAAGGCACGAAGATACTCCCTATATTAAAAGATTTCTTTTTAAGAGAAGATCTTACTTTCTATGGTTATAATCTAAAAC GCGATTGCCACGCTCTTCTAAATGCAGGAATTGTAATTCGAGAAATTTCTTATGACCTAGCTTTAGCTGAGCACTTGACA AATGGGGGAGGAAAAATCTCCTTTCAATCTCTTTTAGTAAATCACGGATTTACAGAAACTGCTCACCGGTTTGCTAAGGA ATGGGGAAATTCAGGATTGCCTATAGGTCGTCTACCAGAACAACCTGAGCAATATTTTGGTGAATTTGTTGCCTACCTTC CCATAATAAAAGACGCTATTTTAGAAGAAATCAACCGTAAGAATCTCAACCATATCTTAAGTGATATTGAAATGCCCTTG GAGAAGGTTCTTTTCTCTATGGAAAGAGCTGGAGTGCCTTTAGATGTTGAGGAGTTGGCTATTTTAGAAGCCCTCTTTGA AACAGAATTAGCCGTACTGACAGAGGAAATCTATGATCTTTCTGGAAGGCCATTCAATATAAAATCACCAAAACAGTTAT CAGATATTTTATATAACGAATTAGGTCTTCGCCCTATAGATAAGGCAAAATCTACACGTGCAGAGGTGTTAGAGGCTTTA CGTAGTGAGCACCCAATTATCGAAAAACTTTTAGCTTTCCGGACGATTGAAAAATTATTATCCACATATGTAAAAGCATT ACCGAAACAAGTAGATTCCCATACACAGAGAATACACCCCTCTTTTGATCAGACAGGAGCTGTGACAGGAAGATTAGCTT GTCGAGATCCTAATTTACAAAATATTCCTATAAGATCGGAACGAGGAATCTTACTTAGGAAGGCTTTTCGTTTATCTGAG AAAAATAGTTATTTTTTATCTGCCGATTATTCTCAAATTGAGTTAAGATTTTTAGCACATTTAAGCCAAGATAAGTCATT AAAATTTGCTTTTGAGTCAGGAGAAGATATTCATGCTTTTACTGCATCACAAGTGTTTCATGTGCCTTTAGAACAGGTTT CAAAAGAACAAAGAATGCAGGCAAAGACAGTAAATTTTGGTATCGTGTATGGACAACAGGCTTTTGGTTTGGCAAAAGTT TTAAAAATTTCTATTGGCGAAGCTCAAGAGTTAATTCAAGCATATTTCTCTCGTTATCCCGAAATTGCTCATTTTGTTGA AGAAACTATACAACAAGCAGCTAAAGATTTACGGGTGACCACGATGTTAGGTCGAGAAAGAATTATCGATAGTTGGAATG AATTTCCTGGCTCAAGAGCAGCTTCAGGACGTTTTGCTGTAAATACTCGCATTCAGGGAAGTGCTGCTGAATTGATAAAA CTTGCAATGCTAGATATTTCACAAGCAATAAAGCAACAGCAAATGAAGAGTCGTATGTTATTACAAATACATGACGAATT ATTATTTGAGGTTCCTGAAGAAGAAATAGAAGAGATGCAAAGACTAGTGAGAGAGAAGATGGAATCAGCTATGACTTTAT CCGTTCCTATAGTTGTGAATATCTTAATTGGAAAAAATTGGGCAGAATGTTAA
Upstream 100 bases:
>100_bases TTACTGGCATGATTAAACACGATATTCTGCCTTTATCCCATGACGCTGCATACATACCTCCCTACTTGGCACTGTAGAGA GACCTAGAAGGGAATATGCA
Downstream 100 bases:
>100_bases AATTATTAAAAGTTTCCATTACAGGGGATCTCTCTTCTGGGAAGACTGAAGCTTGCCAAGTTTTTCAGGAATTGGGAGCC TATGTAGTTAGTGCTGATGA
Product: DNA polymerase I
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 870; Mature: 870
Protein sequence:
>870_residues MKKLFVLDASGFIFRAYFALPEMKNHQGQATQAVFGFIRSLNKLIKEFSPEYMISVFDGPNNKQSRQAIYADYKSNRQKK FEDIPPQIALVKEYCSLIGLAYLEKESVEADDVIASIAKKAREENYKVYVCTADKDLLQLVNDHVVAWNPWADQGVVGIS EVIERYGIPPGNIPDYLALVGDSSDNIPGLPGCGPKKAAALLKQFGSVEGLLENLDAVKGLSQTMLSERQETLKLSKRLA LLDSNIPIPVPIESLTFPQHPVDEEKLIHFYIQQGFKTLVPSKQTEAATVDVQIIKDAESLTNILNLVQGGDIAFAVAYT GNHLLSLKLEGLALTQGSGVFFIALEEEGTKILPILKDFFLREDLTFYGYNLKRDCHALLNAGIVIREISYDLALAEHLT NGGGKISFQSLLVNHGFTETAHRFAKEWGNSGLPIGRLPEQPEQYFGEFVAYLPIIKDAILEEINRKNLNHILSDIEMPL EKVLFSMERAGVPLDVEELAILEALFETELAVLTEEIYDLSGRPFNIKSPKQLSDILYNELGLRPIDKAKSTRAEVLEAL RSEHPIIEKLLAFRTIEKLLSTYVKALPKQVDSHTQRIHPSFDQTGAVTGRLACRDPNLQNIPIRSERGILLRKAFRLSE KNSYFLSADYSQIELRFLAHLSQDKSLKFAFESGEDIHAFTASQVFHVPLEQVSKEQRMQAKTVNFGIVYGQQAFGLAKV LKISIGEAQELIQAYFSRYPEIAHFVEETIQQAAKDLRVTTMLGRERIIDSWNEFPGSRAASGRFAVNTRIQGSAAELIK LAMLDISQAIKQQQMKSRMLLQIHDELLFEVPEEEIEEMQRLVREKMESAMTLSVPIVVNILIGKNWAEC
Sequences:
>Translated_870_residues MKKLFVLDASGFIFRAYFALPEMKNHQGQATQAVFGFIRSLNKLIKEFSPEYMISVFDGPNNKQSRQAIYADYKSNRQKK FEDIPPQIALVKEYCSLIGLAYLEKESVEADDVIASIAKKAREENYKVYVCTADKDLLQLVNDHVVAWNPWADQGVVGIS EVIERYGIPPGNIPDYLALVGDSSDNIPGLPGCGPKKAAALLKQFGSVEGLLENLDAVKGLSQTMLSERQETLKLSKRLA LLDSNIPIPVPIESLTFPQHPVDEEKLIHFYIQQGFKTLVPSKQTEAATVDVQIIKDAESLTNILNLVQGGDIAFAVAYT GNHLLSLKLEGLALTQGSGVFFIALEEEGTKILPILKDFFLREDLTFYGYNLKRDCHALLNAGIVIREISYDLALAEHLT NGGGKISFQSLLVNHGFTETAHRFAKEWGNSGLPIGRLPEQPEQYFGEFVAYLPIIKDAILEEINRKNLNHILSDIEMPL EKVLFSMERAGVPLDVEELAILEALFETELAVLTEEIYDLSGRPFNIKSPKQLSDILYNELGLRPIDKAKSTRAEVLEAL RSEHPIIEKLLAFRTIEKLLSTYVKALPKQVDSHTQRIHPSFDQTGAVTGRLACRDPNLQNIPIRSERGILLRKAFRLSE KNSYFLSADYSQIELRFLAHLSQDKSLKFAFESGEDIHAFTASQVFHVPLEQVSKEQRMQAKTVNFGIVYGQQAFGLAKV LKISIGEAQELIQAYFSRYPEIAHFVEETIQQAAKDLRVTTMLGRERIIDSWNEFPGSRAASGRFAVNTRIQGSAAELIK LAMLDISQAIKQQQMKSRMLLQIHDELLFEVPEEEIEEMQRLVREKMESAMTLSVPIVVNILIGKNWAEC >Mature_870_residues MKKLFVLDASGFIFRAYFALPEMKNHQGQATQAVFGFIRSLNKLIKEFSPEYMISVFDGPNNKQSRQAIYADYKSNRQKK FEDIPPQIALVKEYCSLIGLAYLEKESVEADDVIASIAKKAREENYKVYVCTADKDLLQLVNDHVVAWNPWADQGVVGIS EVIERYGIPPGNIPDYLALVGDSSDNIPGLPGCGPKKAAALLKQFGSVEGLLENLDAVKGLSQTMLSERQETLKLSKRLA LLDSNIPIPVPIESLTFPQHPVDEEKLIHFYIQQGFKTLVPSKQTEAATVDVQIIKDAESLTNILNLVQGGDIAFAVAYT GNHLLSLKLEGLALTQGSGVFFIALEEEGTKILPILKDFFLREDLTFYGYNLKRDCHALLNAGIVIREISYDLALAEHLT NGGGKISFQSLLVNHGFTETAHRFAKEWGNSGLPIGRLPEQPEQYFGEFVAYLPIIKDAILEEINRKNLNHILSDIEMPL EKVLFSMERAGVPLDVEELAILEALFETELAVLTEEIYDLSGRPFNIKSPKQLSDILYNELGLRPIDKAKSTRAEVLEAL RSEHPIIEKLLAFRTIEKLLSTYVKALPKQVDSHTQRIHPSFDQTGAVTGRLACRDPNLQNIPIRSERGILLRKAFRLSE KNSYFLSADYSQIELRFLAHLSQDKSLKFAFESGEDIHAFTASQVFHVPLEQVSKEQRMQAKTVNFGIVYGQQAFGLAKV LKISIGEAQELIQAYFSRYPEIAHFVEETIQQAAKDLRVTTMLGRERIIDSWNEFPGSRAASGRFAVNTRIQGSAAELIK LAMLDISQAIKQQQMKSRMLLQIHDELLFEVPEEEIEEMQRLVREKMESAMTLSVPIVVNILIGKNWAEC
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=436, Percent_Identity=34.8623853211009, Blast_Score=216, Evalue=1e-55, Organism=Homo sapiens, GI139394648, Length=522, Percent_Identity=27.2030651340996, Blast_Score=180, Evalue=4e-45, Organism=Escherichia coli, GI1790294, Length=934, Percent_Identity=34.1541755888651, Blast_Score=464, Evalue=1e-132, Organism=Escherichia coli, GI226510970, Length=250, Percent_Identity=28, Blast_Score=100, Evalue=7e-22, Organism=Caenorhabditis elegans, GI86563272, Length=368, Percent_Identity=32.3369565217391, Blast_Score=185, Evalue=9e-47, Organism=Drosophila melanogaster, GI17933644, Length=453, Percent_Identity=30.6843267108168, Blast_Score=177, Evalue=3e-44,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR003583 - InterPro: IPR012337 [H]
Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 97717; Mature: 97717
Theoretical pI: Translated: 5.52; Mature: 5.52
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKLFVLDASGFIFRAYFALPEMKNHQGQATQAVFGFIRSLNKLIKEFSPEYMISVFDGP CCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC NNKQSRQAIYADYKSNRQKKFEDIPPQIALVKEYCSLIGLAYLEKESVEADDVIASIAKK CCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH AREENYKVYVCTADKDLLQLVNDHVVAWNPWADQGVVGISEVIERYGIPPGNIPDYLALV HHHCCCEEEEEECCHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCHHEEE GDSSDNIPGLPGCGPKKAAALLKQFGSVEGLLENLDAVKGLSQTMLSERQETLKLSKRLA CCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LLDSNIPIPVPIESLTFPQHPVDEEKLIHFYIQQGFKTLVPSKQTEAATVDVQIIKDAES HHCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHH LTNILNLVQGGDIAFAVAYTGNHLLSLKLEGLALTQGSGVFFIALEEEGTKILPILKDFF HHHHHHHHCCCCEEEEEEECCCEEEEEEECCEEEECCCCEEEEEECCCCCEEHHHHHHHH LREDLTFYGYNLKRDCHALLNAGIVIREISYDLALAEHLTNGGGKISFQSLLVNHGFTET HHCCCHHCCCCCHHHHHHHHHCCEEEEHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCHHH AHRFAKEWGNSGLPIGRLPEQPEQYFGEFVAYLPIIKDAILEEINRKNLNHILSDIEMPL HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EKVLFSMERAGVPLDVEELAILEALFETELAVLTEEIYDLSGRPFNIKSPKQLSDILYNE HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH LGLRPIDKAKSTRAEVLEALRSEHPIIEKLLAFRTIEKLLSTYVKALPKQVDSHTQRIHP HCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC SFDQTGAVTGRLACRDPNLQNIPIRSERGILLRKAFRLSEKNSYFLSADYSQIELRFLAH CCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHH LSQDKSLKFAFESGEDIHAFTASQVFHVPLEQVSKEQRMQAKTVNFGIVYGQQAFGLAKV CCCCCCEEEEECCCCCEEEEHHHHHEECCHHHHHHHHHHHHHHEEEEEEECCHHHHHHHH LKISIGEAQELIQAYFSRYPEIAHFVEETIQQAAKDLRVTTMLGRERIIDSWNEFPGSRA HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC ASGRFAVNTRIQGSAAELIKLAMLDISQAIKQQQMKSRMLLQIHDELLFEVPEEEIEEMQ CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH RLVREKMESAMTLSVPIVVNILIGKNWAEC HHHHHHHHHHEEEEHHHEEEEEECCCCCCC >Mature Secondary Structure MKKLFVLDASGFIFRAYFALPEMKNHQGQATQAVFGFIRSLNKLIKEFSPEYMISVFDGP CCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC NNKQSRQAIYADYKSNRQKKFEDIPPQIALVKEYCSLIGLAYLEKESVEADDVIASIAKK CCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH AREENYKVYVCTADKDLLQLVNDHVVAWNPWADQGVVGISEVIERYGIPPGNIPDYLALV HHHCCCEEEEEECCHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCHHEEE GDSSDNIPGLPGCGPKKAAALLKQFGSVEGLLENLDAVKGLSQTMLSERQETLKLSKRLA CCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LLDSNIPIPVPIESLTFPQHPVDEEKLIHFYIQQGFKTLVPSKQTEAATVDVQIIKDAES HHCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHH LTNILNLVQGGDIAFAVAYTGNHLLSLKLEGLALTQGSGVFFIALEEEGTKILPILKDFF HHHHHHHHCCCCEEEEEEECCCEEEEEEECCEEEECCCCEEEEEECCCCCEEHHHHHHHH LREDLTFYGYNLKRDCHALLNAGIVIREISYDLALAEHLTNGGGKISFQSLLVNHGFTET HHCCCHHCCCCCHHHHHHHHHCCEEEEHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCHHH AHRFAKEWGNSGLPIGRLPEQPEQYFGEFVAYLPIIKDAILEEINRKNLNHILSDIEMPL HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EKVLFSMERAGVPLDVEELAILEALFETELAVLTEEIYDLSGRPFNIKSPKQLSDILYNE HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH LGLRPIDKAKSTRAEVLEALRSEHPIIEKLLAFRTIEKLLSTYVKALPKQVDSHTQRIHP HCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC SFDQTGAVTGRLACRDPNLQNIPIRSERGILLRKAFRLSEKNSYFLSADYSQIELRFLAH CCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHH LSQDKSLKFAFESGEDIHAFTASQVFHVPLEQVSKEQRMQAKTVNFGIVYGQQAFGLAKV CCCCCCEEEEECCCCCEEEEHHHHHEECCHHHHHHHHHHHHHHEEEEEEECCHHHHHHHH LKISIGEAQELIQAYFSRYPEIAHFVEETIQQAAKDLRVTTMLGRERIIDSWNEFPGSRA HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC ASGRFAVNTRIQGSAAELIKLAMLDISQAIKQQQMKSRMLLQIHDELLFEVPEEEIEEMQ CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH RLVREKMESAMTLSVPIVVNILIGKNWAEC HHHHHHHHHHEEEEHHHEEEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]