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The map label for this gene is coaE

Identifier: 15618521

GI number: 15618521

Start: 701417

End: 702025

Strand: Reverse

Name: coaE

Synonym: CPn0611

Alternate gene names: 15618521

Gene position: 702025-701417 (Counterclockwise)

Preceding gene: 15618522

Following gene: 15618520

Centisome position: 57.06

GC content: 37.77

Gene sequence:

>609_bases
ATGTTAAAATTATTAAAAGTTTCCATTACAGGGGATCTCTCTTCTGGGAAGACTGAAGCTTGCCAAGTTTTTCAGGAATT
GGGAGCCTATGTAGTTAGTGCTGATGAAATTTCGCATAGTTTCCTTATCCCTCATACACGCATAGGTCGTCGTGTTATAG
ATCTTTTAGGATCGGATGTTGTAGTTGATGGGGCGTTTGATGCGCAAGCCATAGCAGCCAAAGTTTTTTACAATTCCGTT
CTATTACAAGGTCTGGAAGCCATTCTACATCCAGAAGTTTGTCGAATTATTGAGGAACAATATCATCAAAGTATTCAAGA
TGGGAACTATCCGTTATTTGTCGCAGAAGTGCCTTTATTATACGAAATACACTATGCTAAGTGGTTTGATTCAGTGATCC
TTGTTATGGCAAACGAAGATATTCGACGCGAGAGATTCATGAAGAAAACAGGGCGTTCCTCTGAAGACTTTGATCAAAGG
TGTTCGCGTTTTCTAAATGTCGAAGAAAAGTTAGCACAAGCAGATGTTGTTGTTGAAAACAACGGAACTAAAAAAGAATT
ACATCAAAAAATTGAAGAATATTTTTACGCTTTAAAGGGAGCATTATGA

Upstream 100 bases:

>100_bases
TAGAAGAGATGCAAAGACTAGTGAGAGAGAAGATGGAATCAGCTATGACTTTATCCGTTCCTATAGTTGTGAATATCTTA
ATTGGAAAAAATTGGGCAGA

Downstream 100 bases:

>100_bases
AAGAAGAGCGTTCTTCAGAAATCTTGCCTAGGGTGAAGGAAACGAAAAAACATGCTTACGTTTCTATGCAGGAAAAATCT
TGTGTAGGGGAGTGTGCTGT

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MLKLLKVSITGDLSSGKTEACQVFQELGAYVVSADEISHSFLIPHTRIGRRVIDLLGSDVVVDGAFDAQAIAAKVFYNSV
LLQGLEAILHPEVCRIIEEQYHQSIQDGNYPLFVAEVPLLYEIHYAKWFDSVILVMANEDIRRERFMKKTGRSSEDFDQR
CSRFLNVEEKLAQADVVVENNGTKKELHQKIEEYFYALKGAL

Sequences:

>Translated_202_residues
MLKLLKVSITGDLSSGKTEACQVFQELGAYVVSADEISHSFLIPHTRIGRRVIDLLGSDVVVDGAFDAQAIAAKVFYNSV
LLQGLEAILHPEVCRIIEEQYHQSIQDGNYPLFVAEVPLLYEIHYAKWFDSVILVMANEDIRRERFMKKTGRSSEDFDQR
CSRFLNVEEKLAQADVVVENNGTKKELHQKIEEYFYALKGAL
>Mature_202_residues
MLKLLKVSITGDLSSGKTEACQVFQELGAYVVSADEISHSFLIPHTRIGRRVIDLLGSDVVVDGAFDAQAIAAKVFYNSV
LLQGLEAILHPEVCRIIEEQYHQSIQDGNYPLFVAEVPLLYEIHYAKWFDSVILVMANEDIRRERFMKKTGRSSEDFDQR
CSRFLNVEEKLAQADVVVENNGTKKELHQKIEEYFYALKGAL

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=196, Percent_Identity=26.530612244898, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI191252795, Length=196, Percent_Identity=26.530612244898, Blast_Score=81, Evalue=8e-16,
Organism=Escherichia coli, GI1786292, Length=182, Percent_Identity=28.021978021978, Blast_Score=70, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17554944, Length=194, Percent_Identity=25.7731958762887, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320402, Length=195, Percent_Identity=25.1282051282051, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24644728, Length=182, Percent_Identity=24.7252747252747, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_CHLPN (Q9Z7U3)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   E72058
- PIR:   H86566
- RefSeq:   NP_224807.1
- RefSeq:   NP_300667.1
- RefSeq:   NP_444688.1
- RefSeq:   NP_876907.1
- ProteinModelPortal:   Q9Z7U3
- SMR:   Q9Z7U3
- PHCI-2DPAGE:   Q9Z7U3
- GeneID:   1467314
- GeneID:   895469
- GeneID:   919373
- GeneID:   963837
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0136
- KEGG:   cpn:CPn0611
- KEGG:   cpt:CpB0635
- TIGR:   CP_0136
- HOGENOM:   HBG650290
- OMA:   RIIEEQY
- ProtClustDB:   PRK00081
- BioCyc:   CPNE115711:CP_0136-MONOMER
- BioCyc:   CPNE115713:CPN0611-MONOMER
- BioCyc:   CPNE138677:CPJ0611-MONOMER
- BioCyc:   CPNE182082:CPB0635-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 22913; Mature: 22913

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLLKVSITGDLSSGKTEACQVFQELGAYVVSADEISHSFLIPHTRIGRRVIDLLGSDV
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHEEEHHHHCCCEECCHHHHHHHHHHHHCCCE
VVDGAFDAQAIAAKVFYNSVLLQGLEAILHPEVCRIIEEQYHQSIQDGNYPLFVAEVPLL
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEECCCHH
YEIHYAKWFDSVILVMANEDIRRERFMKKTGRSSEDFDQRCSRFLNVEEKLAQADVVVEN
HHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHCEEEEC
NGTKKELHQKIEEYFYALKGAL
CCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKLLKVSITGDLSSGKTEACQVFQELGAYVVSADEISHSFLIPHTRIGRRVIDLLGSDV
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHEEEHHHHCCCEECCHHHHHHHHHHHHCCCE
VVDGAFDAQAIAAKVFYNSVLLQGLEAILHPEVCRIIEEQYHQSIQDGNYPLFVAEVPLL
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEECCCHH
YEIHYAKWFDSVILVMANEDIRRERFMKKTGRSSEDFDQRCSRFLNVEEKLAQADVVVEN
HHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHCEEEEC
NGTKKELHQKIEEYFYALKGAL
CCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362