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The map label for this gene is lsp

Identifier: 15606879

GI number: 15606879

Start: 1291521

End: 1292024

Strand: Direct

Name: lsp

Synonym: aq_1837

Alternate gene names: 15606879

Gene position: 1291521-1292024 (Clockwise)

Preceding gene: 15606878

Following gene: 15606881

Centisome position: 83.25

GC content: 42.46

Gene sequence:

>504_bases
ATGGAGAACTTCCTTAGAAAAACTGCTTGGCTCTACTTAAGTATAGCAGTAAGCGTCTTTTTACTCGACATAATTACCAA
AAATCTAGCGGAGAAGTTATTTACAACTCACGTTGAAGTGTTTCCCTTTCTGGAGTTTTACCTGATATACAACAAAGGCG
TAGCCTTCGGTCTCCTTTCCGAACTTCCTGATCCTTTGAGGCTTCCTTTGCTCTTGATAACTCCCGTTATAGCCCTGATA
ATTACGTTCCTTTACGCGCTATACAGCGGAGACAGGATTGTTGCAATCTCCATGGGATTAATAGGAGGAGGTGCACTCGG
AAACCTCTACGACAGGTTATTTCTCGGAATGGTGAGAGACTTTATACACCTACATATAGGGGAGTATTACTGGCCAGCCT
TTAACATCGCAGACGCTTCCATAAGTATAGGTATTGCTCTCTTAATACTCAAGTACTTCTTCACTAAGCCTGCCCTCAAA
AACCTTGTAAACAGAACCCGTTAG

Upstream 100 bases:

>100_bases
AGTGGATGTACATAGGAAAAACGACGGAAGAGAAAAAGATAAAAGTAACCTTCAACGGAGATACTCTCTTAGAGGACGAG
CTTGAGGAGTACGAAAAGTT

Downstream 100 bases:

>100_bases
GAAGACTTCTTTTAAATCCTCCGAAAAATCTATCGTGAGTACCTCACCGCTTCTAGTTAGAACGTTTACGGGCTTTTTCT
TCACTAGACCCTTTAAGTAA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MENFLRKTAWLYLSIAVSVFLLDIITKNLAEKLFTTHVEVFPFLEFYLIYNKGVAFGLLSELPDPLRLPLLLITPVIALI
ITFLYALYSGDRIVAISMGLIGGGALGNLYDRLFLGMVRDFIHLHIGEYYWPAFNIADASISIGIALLILKYFFTKPALK
NLVNRTR

Sequences:

>Translated_167_residues
MENFLRKTAWLYLSIAVSVFLLDIITKNLAEKLFTTHVEVFPFLEFYLIYNKGVAFGLLSELPDPLRLPLLLITPVIALI
ITFLYALYSGDRIVAISMGLIGGGALGNLYDRLFLGMVRDFIHLHIGEYYWPAFNIADASISIGIALLILKYFFTKPALK
NLVNRTR
>Mature_167_residues
MENFLRKTAWLYLSIAVSVFLLDIITKNLAEKLFTTHVEVFPFLEFYLIYNKGVAFGLLSELPDPLRLPLLLITPVIALI
ITFLYALYSGDRIVAISMGLIGGGALGNLYDRLFLGMVRDFIHLHIGEYYWPAFNIADASISIGIALLILKYFFTKPALK
NLVNRTR

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=164, Percent_Identity=32.3170731707317, Blast_Score=78, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_AQUAE (O67692)

Other databases:

- EMBL:   AE000657
- PIR:   B70458
- RefSeq:   NP_214259.1
- MEROPS:   A08.001
- GeneID:   1193499
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1837
- NMPDR:   fig|224324.1.peg.1274
- HOGENOM:   HBG724422
- OMA:   EYYWPAF
- PhylomeDB:   O67692
- ProtClustDB:   PRK14779
- BioCyc:   AAEO224324:AQ_1837-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18919; Mature: 18919

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 111-111 ACT_SITE 138-138

Signals:

None

Transmembrane regions:

HASH(0xd6e07f8)-; HASH(0xde91b68)-; HASH(0xdf251c0)-; HASH(0xd568244)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENFLRKTAWLYLSIAVSVFLLDIITKNLAEKLFTTHVEVFPFLEFYLIYNKGVAFGLLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ELPDPLRLPLLLITPVIALIITFLYALYSGDRIVAISMGLIGGGALGNLYDRLFLGMVRD
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECHHCCCHHHHHHHHHHHHHHHH
FIHLHIGEYYWPAFNIADASISIGIALLILKYFFTKPALKNLVNRTR
HHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCH
>Mature Secondary Structure
MENFLRKTAWLYLSIAVSVFLLDIITKNLAEKLFTTHVEVFPFLEFYLIYNKGVAFGLLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ELPDPLRLPLLLITPVIALIITFLYALYSGDRIVAISMGLIGGGALGNLYDRLFLGMVRD
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECHHCCCHHHHHHHHHHHHHHHH
FIHLHIGEYYWPAFNIADASISIGIALLILKYFFTKPALKNLVNRTR
HHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9537320