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The map label for this gene is purL

Identifier: 15606878

GI number: 15606878

Start: 1289323

End: 1291560

Strand: Direct

Name: purL

Synonym: aq_1836

Alternate gene names: 15606878

Gene position: 1289323-1291560 (Clockwise)

Preceding gene: 15606873

Following gene: 15606879

Centisome position: 83.11

GC content: 46.69

Gene sequence:

>2238_bases
ATGGAAAGGGTTTGGGAAGCCTACGGATTGACCGAAGAAGAATACAGAAAAATACTAAAAACCTTAAAAAGGGAGCCCAA
CCACGTTGAACTCGGCGTTTTAGGAGCTCTGTGGTCGGAACACTGCTCTTACAAGTCCAGCAAAAAGCACCTGAAAAAGT
TTCCCACAAAAGCGGAATGGGTTGTTCAGGGACCGGGTGAAAACGCCGGGGTTGTAAAAATTGACGAAAAGGTTTGGGTA
GCCTTTAAAGTCGAGAGCCACAACCACCCCTCTTACATAGAGCCCTTTCACGGTGCGGCTACAGGAGTTGGCGGTATTAT
CAGAGACGTACTGTCCATGGGAGCGAGACCCATAGCCCTCGCGGACAGCCTGAGGTTCGGCGAGTTTAATTACCATGAAA
CGAAGAGGCTCGTTAAAGGAGTAGTAAGCGGTATCAGTTTCTACGGAAACTGCATAGGAGTTCCCACGGTTGCCGGAGAA
ACGGTTTTCGAACCTTCTTATAAAACGAACCCGTTGGTAAACGCCTTTTGTCTTGGAGTTATACCCGCAGGGAGGATGTA
CAGGGCAAGGGCTACTAGGGAAGGACAGCTCCTCTTTTTAATAGGTTCTTCCACGGGAAGGGACGGGATTTTTGGAGCCG
TAATGGCCTCGGGAGAGTTTTCCGAAGACGTGGAAGAAAAGAGACCTAACGTACAGATAGGGGATCCGTACTTTGGGAAG
AAGCTCGTGGAAGCAATAATGGAGATAGTGGAGAAGGATTTAATCGTCGGAATGCAGGATCTGGGAGCTGCAGGGCTTGC
AGGCTCTGCTTCCGAAATAGCTGCAAAGTCCGAAAAGGGTGTGGAACTTTACCTAGAAAACGTCCCCTTAAGGGAAAAGG
ATATGAACCCCTACGAGATACTCCTTTCAGAGAGTCAGGAGAGGATGCTTCTCGTTGTGGAAGAAGAAAACGTTGAAAAG
GTCAAAGAGATAGCCAATAAGTGGCACCTTGAGGGTGCGGTAGTAGGAAAGATAACCGATGACGATACATTCAGGGCTTA
CTACAAAGGAGAACTGGTTGCAGAACTACCCGTTTCACTTATAGTAGACGAAGCTCCCGTTTACGATAGACCCTACAAAG
AACCCGAATACATGAAGGAAGTGAGGAATTTCAATCAAGAGGAGCTTCCTCAAACAGATGTAAAAGAAGCCCTCAAAAAA
CTCCTATCTTCGCCAAACATTTCGTGCAAGGAGTGGGTTTACACTCAGTACGACTATCAAGTAGGAACGAACACCCTCCT
TATCCCCGGGCACGACGCAGCGGTTTTAAGACTCAAGTGGGTTCTAAGACCGGAGCTCACAACAGAAAAAGGAATAGCCA
TATCTTCCGAAGGAAACGGCAGGATGGTTTACCTCAATCCCTACGAAGGGGGGAAGTTCGTAGTCGCGGAAGTTTGCAGA
AACCTCGCGTGTGTAGGAGCAAAACCCTTAGCCATAACGGACTGTCTTAACTTCGGAAATCCAGAAAGACCGGAGATAAT
GTGGCAGTTCGTAAAGGCTGTAGAGGGAATGGCAGAAGCGTGTGAGGAACTCGGTATTCCGGTAGTGAGCGGGAACGTAT
CCCTTTACAATGAAACCGTTGAGAAAAACGAAATCAGGAACGTATTTCCTACTCCCATAGTCGTAGGTGTGGGTGTCTTA
GAAAAGGCGGAGAAGTATACGCCTTCAAAAGTAGAAAAGGAAAGTGAGCTGTACCTCGTTGGAAACCTTGAGGAGAACTT
AAGACTTGACGGAAGTGAGTACCTCAAAGTAATCCACGGACTTATAAAGGGAGATGTGCCTCCTGTAGACCTTGAAAAGG
AAAAGATACTTATAAACCTTCTCATCTCTTTTAACAACAAGGAATTGATAACCTGTGCCCACGACGTTTCCGTAGGAGGA
CTGTTAATCGCACTCCTTGAAATGGTCTTTAGAACACCCTACGGTCTTGAAGTGGAAGTTTACACCGATGAAAGACCGGA
TGTGTTCTTCTTCTCGGAAAACCCCACAAGGGTGATTATAGGCGTGGAAAGTGATAAGGCGGAAGAGGTAAAGAACGCCG
TTGAAAAGGCTGGACTTGAGTGGATGTACATAGGAAAAACGACGGAAGAGAAAAAGATAAAAGTAACCTTCAACGGAGAT
ACTCTCTTAGAGGACGAGCTTGAGGAGTACGAAAAGTTATGGAGAACTTCCTTAGAAAAACTGCTTGGCTCTACTTAA

Upstream 100 bases:

>100_bases
CTTCCTCTTTTCCCTTCCGTACTTAACTAACTGGTTGAACGTCGGCATTCGCTTCCTCCTTCGGTAAGTAAAATTATAAG
GTTAAAATAAAAACTCTAAA

Downstream 100 bases:

>100_bases
GTATAGCAGTAAGCGTCTTTTTACTCGACATAATTACCAAAAATCTAGCGGAGAAGTTATTTACAACTCACGTTGAAGTG
TTTCCCTTTCTGGAGTTTTA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 745; Mature: 745

Protein sequence:

>745_residues
MERVWEAYGLTEEEYRKILKTLKREPNHVELGVLGALWSEHCSYKSSKKHLKKFPTKAEWVVQGPGENAGVVKIDEKVWV
AFKVESHNHPSYIEPFHGAATGVGGIIRDVLSMGARPIALADSLRFGEFNYHETKRLVKGVVSGISFYGNCIGVPTVAGE
TVFEPSYKTNPLVNAFCLGVIPAGRMYRARATREGQLLFLIGSSTGRDGIFGAVMASGEFSEDVEEKRPNVQIGDPYFGK
KLVEAIMEIVEKDLIVGMQDLGAAGLAGSASEIAAKSEKGVELYLENVPLREKDMNPYEILLSESQERMLLVVEEENVEK
VKEIANKWHLEGAVVGKITDDDTFRAYYKGELVAELPVSLIVDEAPVYDRPYKEPEYMKEVRNFNQEELPQTDVKEALKK
LLSSPNISCKEWVYTQYDYQVGTNTLLIPGHDAAVLRLKWVLRPELTTEKGIAISSEGNGRMVYLNPYEGGKFVVAEVCR
NLACVGAKPLAITDCLNFGNPERPEIMWQFVKAVEGMAEACEELGIPVVSGNVSLYNETVEKNEIRNVFPTPIVVGVGVL
EKAEKYTPSKVEKESELYLVGNLEENLRLDGSEYLKVIHGLIKGDVPPVDLEKEKILINLLISFNNKELITCAHDVSVGG
LLIALLEMVFRTPYGLEVEVYTDERPDVFFFSENPTRVIIGVESDKAEEVKNAVEKAGLEWMYIGKTTEEKKIKVTFNGD
TLLEDELEEYEKLWRTSLEKLLGST

Sequences:

>Translated_745_residues
MERVWEAYGLTEEEYRKILKTLKREPNHVELGVLGALWSEHCSYKSSKKHLKKFPTKAEWVVQGPGENAGVVKIDEKVWV
AFKVESHNHPSYIEPFHGAATGVGGIIRDVLSMGARPIALADSLRFGEFNYHETKRLVKGVVSGISFYGNCIGVPTVAGE
TVFEPSYKTNPLVNAFCLGVIPAGRMYRARATREGQLLFLIGSSTGRDGIFGAVMASGEFSEDVEEKRPNVQIGDPYFGK
KLVEAIMEIVEKDLIVGMQDLGAAGLAGSASEIAAKSEKGVELYLENVPLREKDMNPYEILLSESQERMLLVVEEENVEK
VKEIANKWHLEGAVVGKITDDDTFRAYYKGELVAELPVSLIVDEAPVYDRPYKEPEYMKEVRNFNQEELPQTDVKEALKK
LLSSPNISCKEWVYTQYDYQVGTNTLLIPGHDAAVLRLKWVLRPELTTEKGIAISSEGNGRMVYLNPYEGGKFVVAEVCR
NLACVGAKPLAITDCLNFGNPERPEIMWQFVKAVEGMAEACEELGIPVVSGNVSLYNETVEKNEIRNVFPTPIVVGVGVL
EKAEKYTPSKVEKESELYLVGNLEENLRLDGSEYLKVIHGLIKGDVPPVDLEKEKILINLLISFNNKELITCAHDVSVGG
LLIALLEMVFRTPYGLEVEVYTDERPDVFFFSENPTRVIIGVESDKAEEVKNAVEKAGLEWMYIGKTTEEKKIKVTFNGD
TLLEDELEEYEKLWRTSLEKLLGST
>Mature_745_residues
MERVWEAYGLTEEEYRKILKTLKREPNHVELGVLGALWSEHCSYKSSKKHLKKFPTKAEWVVQGPGENAGVVKIDEKVWV
AFKVESHNHPSYIEPFHGAATGVGGIIRDVLSMGARPIALADSLRFGEFNYHETKRLVKGVVSGISFYGNCIGVPTVAGE
TVFEPSYKTNPLVNAFCLGVIPAGRMYRARATREGQLLFLIGSSTGRDGIFGAVMASGEFSEDVEEKRPNVQIGDPYFGK
KLVEAIMEIVEKDLIVGMQDLGAAGLAGSASEIAAKSEKGVELYLENVPLREKDMNPYEILLSESQERMLLVVEEENVEK
VKEIANKWHLEGAVVGKITDDDTFRAYYKGELVAELPVSLIVDEAPVYDRPYKEPEYMKEVRNFNQEELPQTDVKEALKK
LLSSPNISCKEWVYTQYDYQVGTNTLLIPGHDAAVLRLKWVLRPELTTEKGIAISSEGNGRMVYLNPYEGGKFVVAEVCR
NLACVGAKPLAITDCLNFGNPERPEIMWQFVKAVEGMAEACEELGIPVVSGNVSLYNETVEKNEIRNVFPTPIVVGVGVL
EKAEKYTPSKVEKESELYLVGNLEENLRLDGSEYLKVIHGLIKGDVPPVDLEKEKILINLLISFNNKELITCAHDVSVGG
LLIALLEMVFRTPYGLEVEVYTDERPDVFFFSENPTRVIIGVESDKAEEVKNAVEKAGLEWMYIGKTTEEKKIKVTFNGD
TLLEDELEEYEKLWRTSLEKLLGST

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=736, Percent_Identity=25.4076086956522, Blast_Score=119, Evalue=8e-27,
Organism=Escherichia coli, GI48994899, Length=811, Percent_Identity=23.921085080148, Blast_Score=137, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17553022, Length=748, Percent_Identity=23.1283422459893, Blast_Score=113, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321498, Length=836, Percent_Identity=23.8038277511962, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24582111, Length=760, Percent_Identity=26.4473684210526, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24582109, Length=760, Percent_Identity=26.4473684210526, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17137292, Length=760, Percent_Identity=26.4473684210526, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_AQUAE (O67691)

Other databases:

- EMBL:   AE000657
- PIR:   A70458
- RefSeq:   NP_214258.1
- ProteinModelPortal:   O67691
- GeneID:   1193498
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1836
- NMPDR:   fig|224324.1.peg.1273
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- PhylomeDB:   O67691
- ProtClustDB:   PRK01213
- BioCyc:   AAEO224324:AQ_1836-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 83214; Mature: 83214

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERVWEAYGLTEEEYRKILKTLKREPNHVELGVLGALWSEHCSYKSSKKHLKKFPTKAEW
CCCHHHHHCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCE
VVQGPGENAGVVKIDEKVWVAFKVESHNHPSYIEPFHGAATGVGGIIRDVLSMGARPIAL
EEECCCCCCCEEEECCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEE
ADSLRFGEFNYHETKRLVKGVVSGISFYGNCIGVPTVAGETVFEPSYKTNPLVNAFCLGV
ECCCCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCEECCCCCCCCHHHHHHHHH
IPAGRMYRARATREGQLLFLIGSSTGRDGIFGAVMASGEFSEDVEEKRPNVQIGDPYFGK
CCCCCEEECCCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHCCCCEEECCCHHHH
KLVEAIMEIVEKDLIVGMQDLGAAGLAGSASEIAAKSEKGVELYLENVPLREKDMNPYEI
HHHHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCHHHH
LLSESQERMLLVVEEENVEKVKEIANKWHLEGAVVGKITDDDTFRAYYKGELVAELPVSL
HCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCHHHCCEEE
IVDEAPVYDRPYKEPEYMKEVRNFNQEELPQTDVKEALKKLLSSPNISCKEWVYTQYDYQ
EEECCCCCCCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCHHHEEEEEEEEE
VGTNTLLIPGHDAAVLRLKWVLRPELTTEKGIAISSEGNGRMVYLNPYEGGKFVVAEVCR
ECCCEEEECCCCCEEEEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCEEHHHHHH
NLACVGAKPLAITDCLNFGNPERPEIMWQFVKAVEGMAEACEELGIPVVSGNVSLYNETV
HHHHCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEHHHH
EKNEIRNVFPTPIVVGVGVLEKAEKYTPSKVEKESELYLVGNLEENLRLDGSEYLKVIHG
HHHHHHCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCEEEEECCHHCCCCCHHHHHHHHHH
LIKGDVPPVDLEKEKILINLLISFNNKELITCAHDVSVGGLLIALLEMVFRTPYGLEVEV
HHHCCCCCCCCCHHEEEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEE
YTDERPDVFFFSENPTRVIIGVESDKAEEVKNAVEKAGLEWMYIGKTTEEKKIKVTFNGD
EECCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCC
TLLEDELEEYEKLWRTSLEKLLGST
CCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERVWEAYGLTEEEYRKILKTLKREPNHVELGVLGALWSEHCSYKSSKKHLKKFPTKAEW
CCCHHHHHCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCE
VVQGPGENAGVVKIDEKVWVAFKVESHNHPSYIEPFHGAATGVGGIIRDVLSMGARPIAL
EEECCCCCCCEEEECCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEE
ADSLRFGEFNYHETKRLVKGVVSGISFYGNCIGVPTVAGETVFEPSYKTNPLVNAFCLGV
ECCCCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCEECCCCCCCCHHHHHHHHH
IPAGRMYRARATREGQLLFLIGSSTGRDGIFGAVMASGEFSEDVEEKRPNVQIGDPYFGK
CCCCCEEECCCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHCCCCEEECCCHHHH
KLVEAIMEIVEKDLIVGMQDLGAAGLAGSASEIAAKSEKGVELYLENVPLREKDMNPYEI
HHHHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCHHHH
LLSESQERMLLVVEEENVEKVKEIANKWHLEGAVVGKITDDDTFRAYYKGELVAELPVSL
HCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCHHHCCEEE
IVDEAPVYDRPYKEPEYMKEVRNFNQEELPQTDVKEALKKLLSSPNISCKEWVYTQYDYQ
EEECCCCCCCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCHHHEEEEEEEEE
VGTNTLLIPGHDAAVLRLKWVLRPELTTEKGIAISSEGNGRMVYLNPYEGGKFVVAEVCR
ECCCEEEECCCCCEEEEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCEEHHHHHH
NLACVGAKPLAITDCLNFGNPERPEIMWQFVKAVEGMAEACEELGIPVVSGNVSLYNETV
HHHHCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEHHHH
EKNEIRNVFPTPIVVGVGVLEKAEKYTPSKVEKESELYLVGNLEENLRLDGSEYLKVIHG
HHHHHHCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCEEEEECCHHCCCCCHHHHHHHHHH
LIKGDVPPVDLEKEKILINLLISFNNKELITCAHDVSVGGLLIALLEMVFRTPYGLEVEV
HHHCCCCCCCCCHHEEEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEE
YTDERPDVFFFSENPTRVIIGVESDKAEEVKNAVEKAGLEWMYIGKTTEEKKIKVTFNGD
EECCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCC
TLLEDELEEYEKLWRTSLEKLLGST
CCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320