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The map label for this gene is nox [C]

Identifier: 15606191

GI number: 15606191

Start: 575881

End: 577305

Strand: Direct

Name: nox [C]

Synonym: aq_835

Alternate gene names: 15606191

Gene position: 575881-577305 (Clockwise)

Preceding gene: 15606187

Following gene: 15606193

Centisome position: 37.12

GC content: 44.98

Gene sequence:

>1425_bases
ATGAAAGTTGTAATAGTAGGAAACGGTCCCGCAGCTGCAAGCGCAGTGGAAGCCTTCAGAAAGGTAGACAGAGACAGTGA
GATTATAATCCTTTCCGACGAAGAGTTCCCAACCTACGCTCCAAACTGCATGGAAAACGTGATAAGGGACGACATATCAA
AGGAAGCTCTCTTTTACAAAGGCGGAGAAAAGTTCTACGAAAAGTACAGGGTTGATTTCAGGCCGAAAACCGAGGTTGTA
GGCATAGATAACAAAAGGAAAGTAGTTATCACTAAAAAAGGAGAGGAAATATCCTACGATAAATGTTTGCTCGCCGCTGG
AGCTTACTCCTTTATCCCTCCCATAGACGGGGTTGACTTGGAAAGGGTCACGACCGCTAAAAACCTTTACGACGCTTACA
AGATAAGGAGCTGGATACTTTCAGGAAAAATAACAAAAGCTGTAATAATAGGTGCGGGGCCCATAGGCATAGAGGATGCG
GAAACACTCAGACACATGGGGATAGACGTTACAGTAATAGAGGTCTTTGACAGGATACTCCCGAGGATGCTGGACCGCCA
GATGGGAAAGCTGTACCAAAAGCCTCTAGAAGAGGAAGGTATTGAATTCCTGCTTGAACATCAGGTGGTAGCAATACACG
GAAAGAATGGAGAAGTTGAAGCGGTAGAGGTAAAAAAGAGGGGAACGGATAAGACCTTTTTCATAAAAACGGATATGGTA
ATAATTTCCACCGGAGTAAGACCGAGGACTTACCTCGTTGAAGGAACGGACATTGAAATACACATGGACAAAAAGCTCAA
CAAACCAATAGGCGGTATTCTGGTGAACGAGTATCAGCAAACGAGCGACCCGGACGTTTACGCCGCGGGAGACATAGCCT
CAGGAGTGGACATGTGGGGAAACCACAGGTGGATAGCCCTTTTCCCTCCTGCACAGCAAGCCGGGTACGTGGCGGGCTTT
AATATGGCTGGACTAAAAGTAAGGAATAACGGTCTGGTTGATTACAACGCAGTAAAGACCCGTTCCGTAACTGCCGGAAG
CGGAGGATTGTTTGAAGACGCGGACGAGAGCTTCTTTCTCGAGTATAAAGAATACCTCGTAAAAGTTTTCCTAAAAGACG
GAAAAGTAAGGGGATACCAGTTCGTAGGAGTGCCAAAGTATCCAAAACTCAATCCTAGAAATCCTTTAATAAGAGTTTTA
AACAAGATAAATACGTGGGAGGAAAAGGTTTTATTGGATAAAGGGCTCGGTTTGGAGGCTTCAGGAGCTCTCTTTCACTT
CTTTGTAAAGTTAAACAGGGAGTTCAAGGAAGTTCACAGAAGATTGGTGGAAGAAATGTTCGTGAGGGCGATGGCAAACC
CCTCACGAGAAATACCACTTTTCACAGTACAGGAAGGAGAAGTCCTAAAAACAGTAGGAAAGTAA

Upstream 100 bases:

>100_bases
AAGGTTTGTCTGCTGAGCCGTCATTCCGGAAGCTGAGGTCCAGAGAGCTCTAAACATAACCACCTCCCTCTAGGTACTTA
TTTTAAAATTTAAGCTTAAC

Downstream 100 bases:

>100_bases
GGGGAAACACCTCGGAAAAGTCCAGATCTTCGTACTTTGGTGCTTCTGCCTTCTCTTCAAAGAATACGGGGGAGAACATC
TTAAATCCTACCCAGAGCCA

Product: NADH oxidase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MKVVIVGNGPAAASAVEAFRKVDRDSEIIILSDEEFPTYAPNCMENVIRDDISKEALFYKGGEKFYEKYRVDFRPKTEVV
GIDNKRKVVITKKGEEISYDKCLLAAGAYSFIPPIDGVDLERVTTAKNLYDAYKIRSWILSGKITKAVIIGAGPIGIEDA
ETLRHMGIDVTVIEVFDRILPRMLDRQMGKLYQKPLEEEGIEFLLEHQVVAIHGKNGEVEAVEVKKRGTDKTFFIKTDMV
IISTGVRPRTYLVEGTDIEIHMDKKLNKPIGGILVNEYQQTSDPDVYAAGDIASGVDMWGNHRWIALFPPAQQAGYVAGF
NMAGLKVRNNGLVDYNAVKTRSVTAGSGGLFEDADESFFLEYKEYLVKVFLKDGKVRGYQFVGVPKYPKLNPRNPLIRVL
NKINTWEEKVLLDKGLGLEASGALFHFFVKLNREFKEVHRRLVEEMFVRAMANPSREIPLFTVQEGEVLKTVGK

Sequences:

>Translated_474_residues
MKVVIVGNGPAAASAVEAFRKVDRDSEIIILSDEEFPTYAPNCMENVIRDDISKEALFYKGGEKFYEKYRVDFRPKTEVV
GIDNKRKVVITKKGEEISYDKCLLAAGAYSFIPPIDGVDLERVTTAKNLYDAYKIRSWILSGKITKAVIIGAGPIGIEDA
ETLRHMGIDVTVIEVFDRILPRMLDRQMGKLYQKPLEEEGIEFLLEHQVVAIHGKNGEVEAVEVKKRGTDKTFFIKTDMV
IISTGVRPRTYLVEGTDIEIHMDKKLNKPIGGILVNEYQQTSDPDVYAAGDIASGVDMWGNHRWIALFPPAQQAGYVAGF
NMAGLKVRNNGLVDYNAVKTRSVTAGSGGLFEDADESFFLEYKEYLVKVFLKDGKVRGYQFVGVPKYPKLNPRNPLIRVL
NKINTWEEKVLLDKGLGLEASGALFHFFVKLNREFKEVHRRLVEEMFVRAMANPSREIPLFTVQEGEVLKTVGK
>Mature_474_residues
MKVVIVGNGPAAASAVEAFRKVDRDSEIIILSDEEFPTYAPNCMENVIRDDISKEALFYKGGEKFYEKYRVDFRPKTEVV
GIDNKRKVVITKKGEEISYDKCLLAAGAYSFIPPIDGVDLERVTTAKNLYDAYKIRSWILSGKITKAVIIGAGPIGIEDA
ETLRHMGIDVTVIEVFDRILPRMLDRQMGKLYQKPLEEEGIEFLLEHQVVAIHGKNGEVEAVEVKKRGTDKTFFIKTDMV
IISTGVRPRTYLVEGTDIEIHMDKKLNKPIGGILVNEYQQTSDPDVYAAGDIASGVDMWGNHRWIALFPPAQQAGYVAGF
NMAGLKVRNNGLVDYNAVKTRSVTAGSGGLFEDADESFFLEYKEYLVKVFLKDGKVRGYQFVGVPKYPKLNPRNPLIRVL
NKINTWEEKVLLDKGLGLEASGALFHFFVKLNREFKEVHRRLVEEMFVRAMANPSREIPLFTVQEGEVLKTVGK

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=323, Percent_Identity=26.625386996904, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI65787454, Length=323, Percent_Identity=26.625386996904, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI226437568, Length=323, Percent_Identity=26.625386996904, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI91199540, Length=263, Percent_Identity=26.9961977186312, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789065, Length=322, Percent_Identity=27.3291925465839, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1789765, Length=322, Percent_Identity=27.9503105590062, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788892, Length=293, Percent_Identity=24.2320819112628, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17559934, Length=325, Percent_Identity=28.6153846153846, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32565766, Length=202, Percent_Identity=28.7128712871287, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24585130, Length=324, Percent_Identity=25.9259259259259, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24639257, Length=324, Percent_Identity=26.5432098765432, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281359715, Length=324, Percent_Identity=26.8518518518519, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281359713, Length=324, Percent_Identity=26.8518518518519, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24639250, Length=324, Percent_Identity=26.8518518518519, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18543267, Length=324, Percent_Identity=26.8518518518519, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24639252, Length=324, Percent_Identity=26.8518518518519, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24581020, Length=361, Percent_Identity=24.6537396121884, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573993, Length=361, Percent_Identity=24.6537396121884, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21358499, Length=148, Percent_Identity=34.4594594594595, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 53327; Mature: 53327

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVIVGNGPAAASAVEAFRKVDRDSEIIILSDEEFPTYAPNCMENVIRDDISKEALFYK
CEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEC
GGEKFYEKYRVDFRPKTEVVGIDNKRKVVITKKGEEISYDKCLLAAGAYSFIPPIDGVDL
CCHHHHHHHCCCCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCH
ERVTTAKNLYDAYKIRSWILSGKITKAVIIGAGPIGIEDAETLRHMGIDVTVIEVFDRIL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCEEHHHHHHHHH
PRMLDRQMGKLYQKPLEEEGIEFLLEHQVVAIHGKNGEVEAVEVKKRGTDKTFFIKTDMV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCEEEEEEEEE
IISTGVRPRTYLVEGTDIEIHMDKKLNKPIGGILVNEYQQTSDPDVYAAGDIASGVDMWG
EEECCCCCCEEEEECCEEEEEECCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCHHHCC
NHRWIALFPPAQQAGYVAGFNMAGLKVRNNGLVDYNAVKTRSVTAGSGGLFEDADESFFL
CCEEEEEECCCCCCCEEECCCCCCEEEECCCEEEECCEEEEEEECCCCCCCCCCCHHHHH
EYKEYLVKVFLKDGKVRGYQFVGVPKYPKLNPRNPLIRVLNKINTWEEKVLLDKGLGLEA
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCC
SGALFHFFVKLNREFKEVHRRLVEEMFVRAMANPSREIPLFTVQEGEVLKTVGK
CCHHEEHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHCCC
>Mature Secondary Structure
MKVVIVGNGPAAASAVEAFRKVDRDSEIIILSDEEFPTYAPNCMENVIRDDISKEALFYK
CEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEC
GGEKFYEKYRVDFRPKTEVVGIDNKRKVVITKKGEEISYDKCLLAAGAYSFIPPIDGVDL
CCHHHHHHHCCCCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCH
ERVTTAKNLYDAYKIRSWILSGKITKAVIIGAGPIGIEDAETLRHMGIDVTVIEVFDRIL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCEEHHHHHHHHH
PRMLDRQMGKLYQKPLEEEGIEFLLEHQVVAIHGKNGEVEAVEVKKRGTDKTFFIKTDMV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCEEEEEEEEE
IISTGVRPRTYLVEGTDIEIHMDKKLNKPIGGILVNEYQQTSDPDVYAAGDIASGVDMWG
EEECCCCCCEEEEECCEEEEEECCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCHHHCC
NHRWIALFPPAQQAGYVAGFNMAGLKVRNNGLVDYNAVKTRSVTAGSGGLFEDADESFFL
CCEEEEEECCCCCCCEEECCCCCCEEEECCCEEEECCEEEEEEECCCCCCCCCCCHHHHH
EYKEYLVKVFLKDGKVRGYQFVGVPKYPKLNPRNPLIRVLNKINTWEEKVLLDKGLGLEA
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCC
SGALFHFFVKLNREFKEVHRRLVEEMFVRAMANPSREIPLFTVQEGEVLKTVGK
CCHHEEHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]