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The map label for this gene is ilvD

Identifier: 15606193

GI number: 15606193

Start: 578040

End: 579707

Strand: Direct

Name: ilvD

Synonym: aq_837

Alternate gene names: 15606193

Gene position: 578040-579707 (Clockwise)

Preceding gene: 15606191

Following gene: 15606195

Centisome position: 37.26

GC content: 49.1

Gene sequence:

>1668_bases
ATGAAATTCAGGAGTGATAAGGTAAAAAAAGGAATAGAAAGGGCTCCTCACAGGGCGCTTTTGAGGGCCTGCGGACTTTC
TGATGAGGACTTTGACAAGCCACTTATAGGGATAGCAAACTCATACATAGACATAATTCCGGGGCACGTTCACCTGAGGG
AGTTCGTAGAACCTATAAAGGAAGAAGTCAGGAAACTGGGCGGAGTTCCTATAGAGTTCAACGTAATCGGAGTTGACGAC
GGAATAGCCATGGGACACGAAGGTATGCATTACTCCCTCCCCTCCAGAGAACTCATAGCTGACAGCATAGAAACGGTTGT
AAACGCGCACCAGCTGGACGCACTCATATGCATTCCCAATTGTGACAAAATAGTTCCGGGAATGCTCATGGGAGCTTTGA
GGGTAAACGTCCCCACCGTTTTCATAAGCGGGGGACCCATGCTCGCGGGAGAGGTAAACGGTCAAAAGGTGGATCTCATC
AGCGTCTTTGAAGGTATAGGTAAGGTAAAGAGGGGAGAGATTTCAGAGCAGGAACTAAAAGTTATAGAAGCATCCGCCTG
TCCCACATGCGGTAGCTGTTCTGGAATGTTTACTGCAAATTCTATGAACTGCTTAACGGAAGTACTCGGTCTTGCACTTC
CCGGAAACGGAACTATCCTCGCCATAGACCCGAGGCGTGAAATACTGGCGAGAAACGCGGTAAAAGCCCTCTTTGAACTT
CTAGAAAAGGATGTAAAACCGAGGGATATAGTCACGGAAGAAGCCCTGGACGACGCCTTCACCGTGGACATAGCGATGGG
AGGCTCTTCAAACACCATACTTCACTTACTTGCGATCGCGAGGGAGGCCGGAATAGAGTACAACCTTGCCAAGATAAACG
AGATATCTAAGAGAACACCCACTATATGTAAGATTTCACCCGCATCACACTACCACATTGAGGATCTAGATCGCGTTGGT
GGAATACCCACTATTATGAAGGAGCTCTCAAAACTCGGACTCCTTCACACGGAAAGGAAAACCGTAAGCGGTAAAACGAT
AGGGGAAATAATAAGCGATGCTCCGGACGCCGACGGCGAGGTAGTGAGAACCATTGAGAACCCTTATTCCAAGGACGGAG
GTATAGCAATACTCTTTGGAAACCTCGCCCCCGAGGGAGCTGTTGTAAAGACCGCGGGAGTTGATCCCAAGATGCTCACC
TTTAAGGGTAAAGCCATATGCTTTGATTCGGAAGAGGAGGCTATAGAGGGAATTCTCGGAGGAAAGGTAAAGCCCGGACA
CGTGGTCGTGATAAGGTACGAGGGGCCTAAGGGAGGGCCCGGTATGAGGGAGATGCTCTCACCCACTTCCGCAATAATGG
GAATGGGACTGGGAGACAAAGTGGCACTCATTACGGATGGAAGGTTCTCCGGCGGAACGAGAGGGGCGTGCGTGGGACAC
ATTTCTCCCGAAGCGGCGGCAGGAGGACCGATAGGAATAGTAAAAGACGGAGACGAGATATTAATAGATATACCGAACAG
AAGGATAGAGCTCCTGATTTCCGAAGAAGAGTTCAATGAAAGGATGAAGAACTTCAAACCTAAGCAAAAGGAGATAAAGA
GTTCCTGGCTAAGGCGGTACGCAAAACTCGTGACTTCCGCCTCAAAAGGTGCTATCCTCGAGGCTTAA

Upstream 100 bases:

>100_bases
CACACCGAGGAGTTTTATCATTCCCTTGCCTCCTTTGAGGTTTATAACGTTTTTTATTATACTTGACCCAAAAGTTCCAA
AAACCTTACCTTAATACATT

Downstream 100 bases:

>100_bases
CCCTGTTTCTTTTTTTCCAAAAACTCCTTCTGTTTCTCCTTTAGTTCTTCCATTTTTTTCATTACTTCTTCAAAGGAAAG
GTTTGTCCTGAAGCCGTCAC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MKFRSDKVKKGIERAPHRALLRACGLSDEDFDKPLIGIANSYIDIIPGHVHLREFVEPIKEEVRKLGGVPIEFNVIGVDD
GIAMGHEGMHYSLPSRELIADSIETVVNAHQLDALICIPNCDKIVPGMLMGALRVNVPTVFISGGPMLAGEVNGQKVDLI
SVFEGIGKVKRGEISEQELKVIEASACPTCGSCSGMFTANSMNCLTEVLGLALPGNGTILAIDPRREILARNAVKALFEL
LEKDVKPRDIVTEEALDDAFTVDIAMGGSSNTILHLLAIAREAGIEYNLAKINEISKRTPTICKISPASHYHIEDLDRVG
GIPTIMKELSKLGLLHTERKTVSGKTIGEIISDAPDADGEVVRTIENPYSKDGGIAILFGNLAPEGAVVKTAGVDPKMLT
FKGKAICFDSEEEAIEGILGGKVKPGHVVVIRYEGPKGGPGMREMLSPTSAIMGMGLGDKVALITDGRFSGGTRGACVGH
ISPEAAAGGPIGIVKDGDEILIDIPNRRIELLISEEEFNERMKNFKPKQKEIKSSWLRRYAKLVTSASKGAILEA

Sequences:

>Translated_555_residues
MKFRSDKVKKGIERAPHRALLRACGLSDEDFDKPLIGIANSYIDIIPGHVHLREFVEPIKEEVRKLGGVPIEFNVIGVDD
GIAMGHEGMHYSLPSRELIADSIETVVNAHQLDALICIPNCDKIVPGMLMGALRVNVPTVFISGGPMLAGEVNGQKVDLI
SVFEGIGKVKRGEISEQELKVIEASACPTCGSCSGMFTANSMNCLTEVLGLALPGNGTILAIDPRREILARNAVKALFEL
LEKDVKPRDIVTEEALDDAFTVDIAMGGSSNTILHLLAIAREAGIEYNLAKINEISKRTPTICKISPASHYHIEDLDRVG
GIPTIMKELSKLGLLHTERKTVSGKTIGEIISDAPDADGEVVRTIENPYSKDGGIAILFGNLAPEGAVVKTAGVDPKMLT
FKGKAICFDSEEEAIEGILGGKVKPGHVVVIRYEGPKGGPGMREMLSPTSAIMGMGLGDKVALITDGRFSGGTRGACVGH
ISPEAAAGGPIGIVKDGDEILIDIPNRRIELLISEEEFNERMKNFKPKQKEIKSSWLRRYAKLVTSASKGAILEA
>Mature_555_residues
MKFRSDKVKKGIERAPHRALLRACGLSDEDFDKPLIGIANSYIDIIPGHVHLREFVEPIKEEVRKLGGVPIEFNVIGVDD
GIAMGHEGMHYSLPSRELIADSIETVVNAHQLDALICIPNCDKIVPGMLMGALRVNVPTVFISGGPMLAGEVNGQKVDLI
SVFEGIGKVKRGEISEQELKVIEASACPTCGSCSGMFTANSMNCLTEVLGLALPGNGTILAIDPRREILARNAVKALFEL
LEKDVKPRDIVTEEALDDAFTVDIAMGGSSNTILHLLAIAREAGIEYNLAKINEISKRTPTICKISPASHYHIEDLDRVG
GIPTIMKELSKLGLLHTERKTVSGKTIGEIISDAPDADGEVVRTIENPYSKDGGIAILFGNLAPEGAVVKTAGVDPKMLT
FKGKAICFDSEEEAIEGILGGKVKPGHVVVIRYEGPKGGPGMREMLSPTSAIMGMGLGDKVALITDGRFSGGTRGACVGH
ISPEAAAGGPIGIVKDGDEILIDIPNRRIELLISEEEFNERMKNFKPKQKEIKSSWLRRYAKLVTSASKGAILEA

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=48.8524590163934, Blast_Score=573, Evalue=1e-164,
Organism=Escherichia coli, GI1788157, Length=508, Percent_Identity=30.3149606299213, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI2367371, Length=532, Percent_Identity=32.8947368421053, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1786464, Length=492, Percent_Identity=31.9105691056911, Blast_Score=204, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6322476, Length=548, Percent_Identity=41.6058394160584, Blast_Score=431, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_AQUAE (O67009)

Other databases:

- EMBL:   AE000657
- PIR:   F70372
- RefSeq:   NP_213570.1
- ProteinModelPortal:   O67009
- SMR:   O67009
- GeneID:   1193459
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_837
- NMPDR:   fig|224324.1.peg.585
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   O67009
- ProtClustDB:   PRK00911
- BioCyc:   AAEO224324:AQ_837-MONOMER
- BRENDA:   4.2.1.9
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59548; Mature: 59548

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRSDKVKKGIERAPHRALLRACGLSDEDFDKPLIGIANSYIDIIPGHVHLREFVEPIK
CCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHCCCHHHHHHHHHHHH
EEVRKLGGVPIEFNVIGVDDGIAMGHEGMHYSLPSRELIADSIETVVNAHQLDALICIPN
HHHHHHCCCCEEEEEEECCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCEEEECCC
CDKIVPGMLMGALRVNVPTVFISGGPMLAGEVNGQKVDLISVFEGIGKVKRGEISEQELK
CCHHHHHHHHHHHEECCCEEEEECCCEEEECCCCCEEHHHHHHHHHCCCCCCCCCHHHHH
VIEASACPTCGSCSGMFTANSMNCLTEVLGLALPGNGTILAIDPRREILARNAVKALFEL
EEECCCCCCCCCCCCCEECCHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHHHHHHH
LEKDVKPRDIVTEEALDDAFTVDIAMGGSSNTILHLLAIAREAGIEYNLAKINEISKRTP
HHHCCCCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEHHHHHHHHCCCC
TICKISPASHYHIEDLDRVGGIPTIMKELSKLGLLHTERKTVSGKTIGEIISDAPDADGE
CEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCCEECCCHHCCCCHHHHHHHCCCCCCCC
VVRTIENPYSKDGGIAILFGNLAPEGAVVKTAGVDPKMLTFKGKAICFDSEEEAIEGILG
EEHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCEEEEECCEEEECCHHHHHHHHHC
GKVKPGHVVVIRYEGPKGGPGMREMLSPTSAIMGMGLGDKVALITDGRFSGGTRGACVGH
CCCCCCEEEEEEECCCCCCCCHHHHHCHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEEC
ISPEAAAGGPIGIVKDGDEILIDIPNRRIELLISEEEFNERMKNFKPKQKEIKSSWLRRY
CCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHH
AKLVTSASKGAILEA
HHHHHCCCCCCEECC
>Mature Secondary Structure
MKFRSDKVKKGIERAPHRALLRACGLSDEDFDKPLIGIANSYIDIIPGHVHLREFVEPIK
CCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHCCCHHHHHHHHHHHH
EEVRKLGGVPIEFNVIGVDDGIAMGHEGMHYSLPSRELIADSIETVVNAHQLDALICIPN
HHHHHHCCCCEEEEEEECCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCEEEECCC
CDKIVPGMLMGALRVNVPTVFISGGPMLAGEVNGQKVDLISVFEGIGKVKRGEISEQELK
CCHHHHHHHHHHHEECCCEEEEECCCEEEECCCCCEEHHHHHHHHHCCCCCCCCCHHHHH
VIEASACPTCGSCSGMFTANSMNCLTEVLGLALPGNGTILAIDPRREILARNAVKALFEL
EEECCCCCCCCCCCCCEECCHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHHHHHHH
LEKDVKPRDIVTEEALDDAFTVDIAMGGSSNTILHLLAIAREAGIEYNLAKINEISKRTP
HHHCCCCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEHHHHHHHHCCCC
TICKISPASHYHIEDLDRVGGIPTIMKELSKLGLLHTERKTVSGKTIGEIISDAPDADGE
CEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCCEECCCHHCCCCHHHHHHHCCCCCCCC
VVRTIENPYSKDGGIAILFGNLAPEGAVVKTAGVDPKMLTFKGKAICFDSEEEAIEGILG
EEHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCEEEEECCEEEECCHHHHHHHHHC
GKVKPGHVVVIRYEGPKGGPGMREMLSPTSAIMGMGLGDKVALITDGRFSGGTRGACVGH
CCCCCCEEEEEEECCCCCCCCHHHHHCHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEEC
ISPEAAAGGPIGIVKDGDEILIDIPNRRIELLISEEEFNERMKNFKPKQKEIKSSWLRRY
CCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHH
AKLVTSASKGAILEA
HHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320