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The map label for this gene is trpB1

Identifier: 15606106

GI number: 15606106

Start: 482374

End: 483567

Strand: Direct

Name: trpB1

Synonym: aq_706

Alternate gene names: 15606106

Gene position: 482374-483567 (Clockwise)

Preceding gene: 15606097

Following gene: 15606107

Centisome position: 31.09

GC content: 49.92

Gene sequence:

>1194_bases
ATGTACAACTATCCAGACGAGAGAGGTTATTTCGGGCCCTTCGGGGGAAAATTCGTCCCCGAAACCTTGATGTACGCCCT
GGAAGAACTTGAAGAAAAATACAGGGAATTGAAGAGCGACCCTGAATTCCAGAAAGAACTCGATTACTACCTGAGGGAGT
ACGCCGGAAGACCCACTCCCCTTTACTTTGCGGAGAAACTAACGAAGTACGTGGGCGGTGCGAAGATATATCTGAAGAGG
GAGGATCTTCTCCATACCGGTGCCCATAAGATAAACAACACCATAGGTCAATGTCTTTTGACCAAGAGAATGGGAAAGAA
AAGGGTTATAGCGGAAACGGGGGCGGGACAGCACGGGGTCGCAACCGCAACCGCCTCAGCACTTTTCGGCTTGGAGTGCG
TCGTTTACATGGGTGAAGAAGACGCGGAAAGGCAGGCTCTTAACGTTTTCAGGATGAAACTCCTCGGAGCAAAAGTGGAA
ATAGTAAAGAGCGGAAGCAGGACCCTAAAGGATGCCATAAACGAAGCACTGAGAGACTGGGTGACAAACGTTGAAAGTAC
CCACTACGTGATAGGTTCTGTGGTTGGTCCTCATCCTTTTCCCATGATAGTGAGGGATTTTCAGAGTGTAATTGGAAGGG
AGACTAAGGAGCAGATACTGCAGAAGGAAGGAAGGCTTCCCGACGCTATAGTCGCGTGCGTGGGAGGCGGTTCAAACGCT
ATGGGGATATTCTACCCCTTCGTTGAAGACAAAGGAGTTCAGCTAATAGGCGTGGAAGCGGGAGGATACGGACTGGAAAC
TGGACAGCACGCTGCTTCCATATGCGGGGGAAGTGTAGGAATCCTTCACGGTATGAAGAGTTACTTCCTTCAGGACGAGG
AAGGACAAATTCAGCCAACTCACTCCATTTCAGCTGGACTAGACTACCCAGGAGTTGGACCCGAACACGCTCTCTTTCAC
GAGATAAAACGGGCAAAGTACACCACAGCAACCGATGAGGAGGCGCTTGAAGGTTTCAAACTCCTCGCACGTACGGAAGG
TATAATCCCTGCCCTCGAAAGTGCCCACGCGGTAATAAAGGCGGTTGAAGTGGCAAGAGAATTGGGAAAGGACGGGATAG
TTGTTATTAACCTCTCAGGAAGGGGAGACAAGGATATGGCACACGTTATGAAACACCTTTCACTCGAAGGCTAA

Upstream 100 bases:

>100_bases
CCTTTACCCTTTCCACTACTTCCGTGGAGGTTATTCCCTTTGGCTTGTCTATCAGAAGTGCTCCGTCCATACACAAAATT
ATCAATTTAAAATAAGGCTT

Downstream 100 bases:

>100_bases
TATCATTAAAGTATTATGGAAATCCTTGTAATAGGCGGTGGGGTAATAGGACTATCCATCGGGGTAGAACTGCTCCTTGC
GGGACACGATGTAAGACTCC

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MYNYPDERGYFGPFGGKFVPETLMYALEELEEKYRELKSDPEFQKELDYYLREYAGRPTPLYFAEKLTKYVGGAKIYLKR
EDLLHTGAHKINNTIGQCLLTKRMGKKRVIAETGAGQHGVATATASALFGLECVVYMGEEDAERQALNVFRMKLLGAKVE
IVKSGSRTLKDAINEALRDWVTNVESTHYVIGSVVGPHPFPMIVRDFQSVIGRETKEQILQKEGRLPDAIVACVGGGSNA
MGIFYPFVEDKGVQLIGVEAGGYGLETGQHAASICGGSVGILHGMKSYFLQDEEGQIQPTHSISAGLDYPGVGPEHALFH
EIKRAKYTTATDEEALEGFKLLARTEGIIPALESAHAVIKAVEVARELGKDGIVVINLSGRGDKDMAHVMKHLSLEG

Sequences:

>Translated_397_residues
MYNYPDERGYFGPFGGKFVPETLMYALEELEEKYRELKSDPEFQKELDYYLREYAGRPTPLYFAEKLTKYVGGAKIYLKR
EDLLHTGAHKINNTIGQCLLTKRMGKKRVIAETGAGQHGVATATASALFGLECVVYMGEEDAERQALNVFRMKLLGAKVE
IVKSGSRTLKDAINEALRDWVTNVESTHYVIGSVVGPHPFPMIVRDFQSVIGRETKEQILQKEGRLPDAIVACVGGGSNA
MGIFYPFVEDKGVQLIGVEAGGYGLETGQHAASICGGSVGILHGMKSYFLQDEEGQIQPTHSISAGLDYPGVGPEHALFH
EIKRAKYTTATDEEALEGFKLLARTEGIIPALESAHAVIKAVEVARELGKDGIVVINLSGRGDKDMAHVMKHLSLEG
>Mature_397_residues
MYNYPDERGYFGPFGGKFVPETLMYALEELEEKYRELKSDPEFQKELDYYLREYAGRPTPLYFAEKLTKYVGGAKIYLKR
EDLLHTGAHKINNTIGQCLLTKRMGKKRVIAETGAGQHGVATATASALFGLECVVYMGEEDAERQALNVFRMKLLGAKVE
IVKSGSRTLKDAINEALRDWVTNVESTHYVIGSVVGPHPFPMIVRDFQSVIGRETKEQILQKEGRLPDAIVACVGGGSNA
MGIFYPFVEDKGVQLIGVEAGGYGLETGQHAASICGGSVGILHGMKSYFLQDEEGQIQPTHSISAGLDYPGVGPEHALFH
EIKRAKYTTATDEEALEGFKLLARTEGIIPALESAHAVIKAVEVARELGKDGIVVINLSGRGDKDMAHVMKHLSLEG

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=389, Percent_Identity=57.5835475578406, Blast_Score=456, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6321412, Length=384, Percent_Identity=59.1145833333333, Blast_Score=469, Evalue=1e-133,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB1_AQUAE (O66923)

Other databases:

- EMBL:   AE000657
- PIR:   G70361
- RefSeq:   NP_213483.1
- ProteinModelPortal:   O66923
- SMR:   O66923
- GeneID:   1193372
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_706
- NMPDR:   fig|224324.1.peg.498
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- PhylomeDB:   O66923
- ProtClustDB:   PRK04346
- BioCyc:   AAEO224324:AQ_706-MONOMER
- BRENDA:   4.2.1.20
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 43543; Mature: 43543

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNYPDERGYFGPFGGKFVPETLMYALEELEEKYRELKSDPEFQKELDYYLREYAGRPTP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
LYFAEKLTKYVGGAKIYLKREDLLHTGAHKINNTIGQCLLTKRMGKKRVIAETGAGQHGV
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCH
ATATASALFGLECVVYMGEEDAERQALNVFRMKLLGAKVEIVKSGSRTLKDAINEALRDW
HHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHCCHHEEHHCCHHHHHHHHHHHHHHH
VTNVESTHYVIGSVVGPHPFPMIVRDFQSVIGRETKEQILQKEGRLPDAIVACVGGGSNA
HHCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHEEEECCCCCC
MGIFYPFVEDKGVQLIGVEAGGYGLETGQHAASICGGSVGILHGMKSYFLQDEEGQIQPT
CEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCC
HSISAGLDYPGVGPEHALFHEIKRAKYTTATDEEALEGFKLLARTEGIIPALESAHAVIK
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AVEVARELGKDGIVVINLSGRGDKDMAHVMKHLSLEG
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MYNYPDERGYFGPFGGKFVPETLMYALEELEEKYRELKSDPEFQKELDYYLREYAGRPTP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
LYFAEKLTKYVGGAKIYLKREDLLHTGAHKINNTIGQCLLTKRMGKKRVIAETGAGQHGV
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCH
ATATASALFGLECVVYMGEEDAERQALNVFRMKLLGAKVEIVKSGSRTLKDAINEALRDW
HHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHCCHHEEHHCCHHHHHHHHHHHHHHH
VTNVESTHYVIGSVVGPHPFPMIVRDFQSVIGRETKEQILQKEGRLPDAIVACVGGGSNA
HHCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHEEEECCCCCC
MGIFYPFVEDKGVQLIGVEAGGYGLETGQHAASICGGSVGILHGMKSYFLQDEEGQIQPT
CEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCC
HSISAGLDYPGVGPEHALFHEIKRAKYTTATDEEALEGFKLLARTEGIIPALESAHAVIK
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AVEVARELGKDGIVVINLSGRGDKDMAHVMKHLSLEG
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320