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The map label for this gene is aroD

Identifier: 11497844

GI number: 11497844

Start: 205650

End: 206240

Strand: Reverse

Name: aroD

Synonym: AF0228

Alternate gene names: 11497844

Gene position: 206240-205650 (Counterclockwise)

Preceding gene: 11497845

Following gene: 11497843

Centisome position: 9.47

GC content: 50.42

Gene sequence:

>591_bases
ATGAAGCTTGTTGCAACGCTTTCAAGTCCGGAGGAGCTCGAATTAGCTGAGAAGGCTGATGTTGTCGAGCTAAGAATCGA
CCTTTTCGATTTTAGCGGTGCCAGAGTTGATAAAGAGAAAATTCTGACGTGCAGAAGGGTTTCGGACGGAGGGAAGTTCG
AGGGTGATGAGAGGGAGAGGATTGAAAAGATGAAGAGAGCCTTTGATTCGCTCAACCCCGATTACGTTGACCTCGAAAGC
GACCTCCCGGACTCGGCCTTTGACTTCAACTGCAGAATAATCGAATCCTACCACAACTTTATCCGCACTCCAGACTACTC
CGAGCTCAAAGGCATCGTTGAGGGCAGGAGGGGGGATTTGGTGAAAATAGCCACGATGGGAAAAAGCAAGAGGGACGTTG
AGACCATCGTCCGAATCCTCACGAATTACGATGACGTTGTAGCTTTCCTCATGGGGGAGAGGTTTAGCTTCACGCGCGTC
CTCGCAGCTTACTTAGGCTCTCCATTCATTTACTGCTATGTTGGAAGCCCAAAGGCGCCTGGGCAGATAAGCCTGGATGA
TGCGAGGGAAATAATCAGCAGGCTGGGGTGA

Upstream 100 bases:

>100_bases
GTTGCCGAGCTGAAGCCCGGAGACGAGATTCTTGTCTGGCTGGGAAAGAAGGCCAGGCACTTCGGAGTTGAGGTTGACGA
GTTTATCGTGGAAAGATAGC

Downstream 100 bases:

>100_bases
TTTCTGTGAAGATTCTTATCTACGGCGTTGGAAACATGGGAAAGCTTTTCAGAGACATCTTCTACGGCAAGGGATACTAC
GTCAGGGGATACGACATAGA

Product: 3-dehydroquinate dehydratase (aroD)

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MKLVATLSSPEELELAEKADVVELRIDLFDFSGARVDKEKILTCRRVSDGGKFEGDERERIEKMKRAFDSLNPDYVDLES
DLPDSAFDFNCRIIESYHNFIRTPDYSELKGIVEGRRGDLVKIATMGKSKRDVETIVRILTNYDDVVAFLMGERFSFTRV
LAAYLGSPFIYCYVGSPKAPGQISLDDAREIISRLG

Sequences:

>Translated_196_residues
MKLVATLSSPEELELAEKADVVELRIDLFDFSGARVDKEKILTCRRVSDGGKFEGDERERIEKMKRAFDSLNPDYVDLES
DLPDSAFDFNCRIIESYHNFIRTPDYSELKGIVEGRRGDLVKIATMGKSKRDVETIVRILTNYDDVVAFLMGERFSFTRV
LAAYLGSPFIYCYVGSPKAPGQISLDDAREIISRLG
>Mature_196_residues
MKLVATLSSPEELELAEKADVVELRIDLFDFSGARVDKEKILTCRRVSDGGKFEGDERERIEKMKRAFDSLNPDYVDLES
DLPDSAFDFNCRIIESYHNFIRTPDYSELKGIVEGRRGDLVKIATMGKSKRDVETIVRILTNYDDVVAFLMGERFSFTRV
LAAYLGSPFIYCYVGSPKAPGQISLDDAREIISRLG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROD_ARCFU (O30011)

Other databases:

- EMBL:   AE000782
- PIR:   D69278
- RefSeq:   NP_069066.1
- PDB:   2OX1
- PDBsum:   2OX1
- ProteinModelPortal:   O30011
- SMR:   O30011
- GeneID:   1483439
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0228
- NMPDR:   fig|224325.1.peg.225
- TIGR:   AF_0228
- HOGENOM:   HBG732926
- OMA:   CENTIAI
- ProtClustDB:   CLSK2746348
- BioCyc:   AFUL224325:AF_0228-MONOMER
- BRENDA:   4.2.1.10
- HAMAP:   MF_00214
- InterPro:   IPR013785
- InterPro:   IPR001381
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01093

Pfam domain/function: PF01487 DHquinase_I

EC number: =4.2.1.10

Molecular weight: Translated: 22208; Mature: 22208

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: ACT_SITE 98-98 ACT_SITE 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVATLSSPEELELAEKADVVELRIDLFDFSGARVDKEKILTCRRVSDGGKFEGDERER
CCEEEECCCCHHHHHHHHCCEEEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHH
IEKMKRAFDSLNPDYVDLESDLPDSAFDFNCRIIESYHNFIRTPDYSELKGIVEGRRGDL
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEHHHHHHHHCCCCHHHHHHHHCCCCCCE
VKIATMGKSKRDVETIVRILTNYDDVVAFLMGERFSFTRVLAAYLGSPFIYCYVGSPKAP
EEEEECCCCCHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCC
GQISLDDAREIISRLG
CEECHHHHHHHHHHCC
>Mature Secondary Structure
MKLVATLSSPEELELAEKADVVELRIDLFDFSGARVDKEKILTCRRVSDGGKFEGDERER
CCEEEECCCCHHHHHHHHCCEEEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHH
IEKMKRAFDSLNPDYVDLESDLPDSAFDFNCRIIESYHNFIRTPDYSELKGIVEGRRGDL
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEHHHHHHHHCCCCHHHHHHHHCCCCCCE
VKIATMGKSKRDVETIVRILTNYDDVVAFLMGERFSFTRVLAAYLGSPFIYCYVGSPKAP
EEEEECCCCCHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCC
GQISLDDAREIISRLG
CEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475