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Identifier: 11497845

GI number: 11497845

Start: 206242

End: 207213

Strand: Reverse

Name: Not Available

Synonym: AF0229

Alternate gene names: NA

Gene position: 207213-206242 (Counterclockwise)

Preceding gene: 11497846

Following gene: 11497844

Centisome position: 9.51

GC content: 52.16

Gene sequence:

>972_bases
ATGAAGGAAATATGGTTGTTGGCTGAAAGCGAAAGCTGGGATGAAGCGAAGGAGATGCTGAAGGATGCGATAGAAATCGG
ATTCGACGGGGCGCTCGTGAGGAGGGATTTTCTTGAGAGAGCTGAGAAGCTCGGAAGAATGAAAATTGTACCAATTGAGG
ATGCAGTCGTTAAAATCTCCTCCGCAGAGGATCAGGAAAGGGCGCTGCAAAGGGAAGTGGTCGTTCTGAAGTTCGAGGAC
TGGAAGGTGATTCCTCTCGAGAACATCGTGGCAATGAAGAAAAGCGGGAAGGTCATCGCTGCGGTCGATACGATCGAGGA
TGCGAAGCTTGCCCTGACCACCCTCGAAAGGGGGGCTGATGGAATAGCGGTTAGCGGGGACAGAGAGACGCTGAGGAAGT
TCTACGAGGTTGTTAAGGAAGAAGGGGAGAGGGTTGAGCTCGTGAGGGCAAGAGTTAAGGAAATCAGACCTCTCGGAGTT
GGGGAGAGGGTTTGCATAGACACCGTCACCCTAATGACTCCGGGAGAGGGTATGCTCGTCGGGAACCAGGCATCATTCAT
GTTTCTCGTCGCCAGCGAGAGCGAGGAGAGCGAGTACGTTGCTTCGAGACCTTTCAGAGTTAATGCAGGCAGCGTTAACG
CCTACCTGAAGGTTGGGGATAAAACCAGATATCTGGCTGAGCTTAAGGCTGGAGATGAGGTTGAGGTTGTAAAATTCGAT
GGAGCGGTGAGGAAGAGCTACGTTGGGAGAGTAAAAATTGAGAGGAGGCCGTTGATTCTAATCAGGGCTGAGGTCGACGG
CGTTGAGGGGAGCGTAATTCTGCAGAATGCCGAAACCATAAAGCTTGTTGCCCCGGACGGAAAGCACGTTTCAGTTGCCG
AGCTGAAGCCCGGAGACGAGATTCTTGTCTGGCTGGGAAAGAAGGCCAGGCACTTCGGAGTTGAGGTTGACGAGTTTATC
GTGGAAAGATAG

Upstream 100 bases:

>100_bases
GCGGGGAGAAACGTATTTAACAGCGACCATCCAGTGAGAATTGCCAAAGCACTGCACATGATAGTCCATGGCAATATGCA
TATGGAGGAAGTGATGGAGT

Downstream 100 bases:

>100_bases
CATGAAGCTTGTTGCAACGCTTTCAAGTCCGGAGGAGCTCGAATTAGCTGAGAAGGCTGATGTTGTCGAGCTAAGAATCG
ACCTTTTCGATTTTAGCGGT

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: DHQ synthase

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKEIWLLAESESWDEAKEMLKDAIEIGFDGALVRRDFLERAEKLGRMKIVPIEDAVVKISSAEDQERALQREVVVLKFED
WKVIPLENIVAMKKSGKVIAAVDTIEDAKLALTTLERGADGIAVSGDRETLRKFYEVVKEEGERVELVRARVKEIRPLGV
GERVCIDTVTLMTPGEGMLVGNQASFMFLVASESEESEYVASRPFRVNAGSVNAYLKVGDKTRYLAELKAGDEVEVVKFD
GAVRKSYVGRVKIERRPLILIRAEVDGVEGSVILQNAETIKLVAPDGKHVSVAELKPGDEILVWLGKKARHFGVEVDEFI
VER

Sequences:

>Translated_323_residues
MKEIWLLAESESWDEAKEMLKDAIEIGFDGALVRRDFLERAEKLGRMKIVPIEDAVVKISSAEDQERALQREVVVLKFED
WKVIPLENIVAMKKSGKVIAAVDTIEDAKLALTTLERGADGIAVSGDRETLRKFYEVVKEEGERVELVRARVKEIRPLGV
GERVCIDTVTLMTPGEGMLVGNQASFMFLVASESEESEYVASRPFRVNAGSVNAYLKVGDKTRYLAELKAGDEVEVVKFD
GAVRKSYVGRVKIERRPLILIRAEVDGVEGSVILQNAETIKLVAPDGKHVSVAELKPGDEILVWLGKKARHFGVEVDEFI
VER
>Mature_323_residues
MKEIWLLAESESWDEAKEMLKDAIEIGFDGALVRRDFLERAEKLGRMKIVPIEDAVVKISSAEDQERALQREVVVLKFED
WKVIPLENIVAMKKSGKVIAAVDTIEDAKLALTTLERGADGIAVSGDRETLRKFYEVVKEEGERVELVRARVKEIRPLGV
GERVCIDTVTLMTPGEGMLVGNQASFMFLVASESEESEYVASRPFRVNAGSVNAYLKVGDKTRYLAELKAGDEVEVVKFD
GAVRKSYVGRVKIERRPLILIRAEVDGVEGSVILQNAETIKLVAPDGKHVSVAELKPGDEILVWLGKKARHFGVEVDEFI
VER

Specific function: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis

COG id: COG1465

COG function: function code E; Predicted alternative 3-dehydroquinate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type DHQ synthase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHQS_ARCFU (O30010)

Other databases:

- EMBL:   AE000782
- PIR:   E69278
- RefSeq:   NP_069067.1
- GeneID:   1483440
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0229
- NMPDR:   fig|224325.1.peg.226
- TIGR:   AF_0229
- HOGENOM:   HBG670179
- OMA:   DRVCIDT
- ProtClustDB:   PRK02290
- BioCyc:   AFUL224325:AF_0229-MONOMER
- HAMAP:   MF_01244
- InterPro:   IPR002812
- PIRSF:   PIRSF006655
- ProDom:   PD017907

Pfam domain/function: PF01959 DHQS

EC number: NA

Molecular weight: Translated: 36010; Mature: 36010

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIWLLAESESWDEAKEMLKDAIEIGFDGALVRRDFLERAEKLGRMKIVPIEDAVVKIS
CCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEHHEEEEEC
SAEDQERALQREVVVLKFEDWKVIPLENIVAMKKSGKVIAAVDTIEDAKLALTTLERGAD
CCCHHHHHHHCEEEEEEECCEEEEEHHHHEEECCCCCEEEEEECCCCCCEEEEEHHCCCC
GIAVSGDRETLRKFYEVVKEEGERVELVRARVKEIRPLGVGERVCIDTVTLMTPGEGMLV
CEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCEEE
GNQASFMFLVASESEESEYVASRPFRVNAGSVNAYLKVGDKTRYLAELKAGDEVEVVKFD
ECCCEEEEEEECCCCCCCHHHCCCEEEECCCEEEEEEECCCCEEEEECCCCCEEEEEEEC
GAVRKSYVGRVKIERRPLILIRAEVDGVEGSVILQNAETIKLVAPDGKHVSVAELKPGDE
CHHHHHHCCEEEEECCCEEEEEEECCCCCCEEEEECCCEEEEECCCCCEEEEEECCCCCE
ILVWLGKKARHFGVEVDEFIVER
EEEEECCCCHHCCCCHHHHHHCC
>Mature Secondary Structure
MKEIWLLAESESWDEAKEMLKDAIEIGFDGALVRRDFLERAEKLGRMKIVPIEDAVVKIS
CCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEHHEEEEEC
SAEDQERALQREVVVLKFEDWKVIPLENIVAMKKSGKVIAAVDTIEDAKLALTTLERGAD
CCCHHHHHHHCEEEEEEECCEEEEEHHHHEEECCCCCEEEEEECCCCCCEEEEEHHCCCC
GIAVSGDRETLRKFYEVVKEEGERVELVRARVKEIRPLGVGERVCIDTVTLMTPGEGMLV
CEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCEEE
GNQASFMFLVASESEESEYVASRPFRVNAGSVNAYLKVGDKTRYLAELKAGDEVEVVKFD
ECCCEEEEEEECCCCCCCHHHCCCEEEECCCEEEEEEECCCCEEEEECCCCCEEEEEEEC
GAVRKSYVGRVKIERRPLILIRAEVDGVEGSVILQNAETIKLVAPDGKHVSVAELKPGDE
CHHHHHHCCEEEEECCCEEEEEEECCCCCCEEEEECCCEEEEECCCCCEEEEEECCCCCE
ILVWLGKKARHFGVEVDEFIVER
EEEEECCCCHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475