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Identifier: 15678736

GI number: 15678736

Start: 632455

End: 633015

Strand: Direct

Name: Not Available

Synonym: MTH709

Alternate gene names: 15678736

Gene position: 632455-633015 (Clockwise)

Preceding gene: 15678735

Following gene: 15678737

Centisome position: 36.11

GC content: 52.05

Gene sequence:

>561_bases
ATGTTTATGATACTCATCATCAACAATCACGGGCAGTACAATCACAGGATACACAGGACACTCAGGTACCTCCAGATACC
CTCCGAGCTTGTACCCAACACCACACCACTTGATGAGATCATCTCAAGGGACCCCGAGGGCCTCATACTCGGTGGTGGAC
CATCACTTGAGAGGTCCGGTAACTGTGTGGAGTACATACAGAAGCTTGAAATACCCATCCTCGGCATATGCCTGGGCCAC
CAGCTGATAGCAAAGGCCTACGGTGGAGAAGTTGCAACGGCAGAGGCGGAGAGCTACGCCCAGATCGAACTTGAGATACT
CGACGAGGACGACATATTCAGGGGACTCGGGCCAAGGATGAGTGTATGGGCCTCCCACAAGGACGAGGTTAAGAAGCTAC
CTGACGAGTTTGACGTCCTCGCAACATCAAGCATATGTGAAGTGGAGGCCATGAAACACCATGATAAACCTGTGTATGGT
ATACAGTTCCACCCCGAGGTCCACCATACGAGGGAGGGCCACAGGGTCTTCGAGAACTTCTATGATGTCTGCAGGTCATG
A

Upstream 100 bases:

>100_bases
CAAGGACGAGTGCAACCAGAATGTAAATTATATCCACTGCCTCCATAATATTTAATTATTCGGTAAAATATAAATAGCTT
TTCAGAATCAGAAGAGGAGA

Downstream 100 bases:

>100_bases
ACTGGGACCTGAAGGTACCCACCCTAACACGGGTCAGAACACCGTCCATCCTTAACATTAAATAGATGTCCTGCAAGATA
ATAAATCAATCATTTTTATT

Product: GMP synthase subunit A

Products: NA

Alternate protein names: Glutamine amidotransferase

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MFMILIINNHGQYNHRIHRTLRYLQIPSELVPNTTPLDEIISRDPEGLILGGGPSLERSGNCVEYIQKLEIPILGICLGH
QLIAKAYGGEVATAEAESYAQIELEILDEDDIFRGLGPRMSVWASHKDEVKKLPDEFDVLATSSICEVEAMKHHDKPVYG
IQFHPEVHHTREGHRVFENFYDVCRS

Sequences:

>Translated_186_residues
MFMILIINNHGQYNHRIHRTLRYLQIPSELVPNTTPLDEIISRDPEGLILGGGPSLERSGNCVEYIQKLEIPILGICLGH
QLIAKAYGGEVATAEAESYAQIELEILDEDDIFRGLGPRMSVWASHKDEVKKLPDEFDVLATSSICEVEAMKHHDKPVYG
IQFHPEVHHTREGHRVFENFYDVCRS
>Mature_186_residues
MFMILIINNHGQYNHRIHRTLRYLQIPSELVPNTTPLDEIISRDPEGLILGGGPSLERSGNCVEYIQKLEIPILGICLGH
QLIAKAYGGEVATAEAESYAQIELEILDEDDIFRGLGPRMSVWASHKDEVKKLPDEFDVLATSSICEVEAMKHHDKPVYG
IQFHPEVHHTREGHRVFENFYDVCRS

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=185, Percent_Identity=31.8918918918919, Blast_Score=95, Evalue=4e-20,
Organism=Escherichia coli, GI1788854, Length=194, Percent_Identity=32.4742268041237, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1789760, Length=184, Percent_Identity=29.8913043478261, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787517, Length=185, Percent_Identity=29.1891891891892, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133901714, Length=183, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71992710, Length=183, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71992717, Length=183, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323873, Length=192, Percent_Identity=36.4583333333333, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322638, Length=188, Percent_Identity=26.063829787234, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281365319, Length=185, Percent_Identity=32.972972972973, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAA_METTH (O26805)

Other databases:

- EMBL:   AE000666
- PIR:   F69194
- RefSeq:   NP_275852.1
- ProteinModelPortal:   O26805
- SMR:   O26805
- STRING:   O26805
- GeneID:   1470670
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH709
- NMPDR:   fig|187420.1.peg.707
- eggNOG:   arNOG05587
- HOGENOM:   HBG292341
- OMA:   GQYVHRI
- ProtClustDB:   PRK00758
- BioCyc:   MTHE187420:MTH709-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_01510
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR004739
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.2

Molecular weight: Translated: 21130; Mature: 21130

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 77-77 ACT_SITE 164-164 ACT_SITE 166-166

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMILIINNHGQYNHRIHRTLRYLQIPSELVPNTTPLDEIISRDPEGLILGGGPSLERSG
CEEEEEECCCCCHHHHHHHHHHHHHCCHHHCCCCCCHHHHHCCCCCEEEECCCCCCCCCC
NCVEYIQKLEIPILGICLGHQLIAKAYGGEVATAEAESYAQIELEILDEDDIFRGLGPRM
CHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEEEECCCCHHHCCCCCC
SVWASHKDEVKKLPDEFDVLATSSICEVEAMKHHDKPVYGIQFHPEVHHTREGHRVFENF
EECCCCHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHH
YDVCRS
HHHHCC
>Mature Secondary Structure
MFMILIINNHGQYNHRIHRTLRYLQIPSELVPNTTPLDEIISRDPEGLILGGGPSLERSG
CEEEEEECCCCCHHHHHHHHHHHHHCCHHHCCCCCCHHHHHCCCCCEEEECCCCCCCCCC
NCVEYIQKLEIPILGICLGHQLIAKAYGGEVATAEAESYAQIELEILDEDDIFRGLGPRM
CHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEEEECCCCHHHCCCCCC
SVWASHKDEVKKLPDEFDVLATSSICEVEAMKHHDKPVYGIQFHPEVHHTREGHRVFENF
EECCCCHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHH
YDVCRS
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463