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Identifier: 15678735

GI number: 15678735

Start: 631240

End: 632151

Strand: Direct

Name: Not Available

Synonym: MTH708

Alternate gene names: 15678735

Gene position: 631240-632151 (Clockwise)

Preceding gene: 15678734

Following gene: 15678736

Centisome position: 36.04

GC content: 54.5

Gene sequence:

>912_bases
ATGATGACTGATTATGACATGATAGTTATAGGGGCTGGCCCTGCAGGGCTCACAGCCGGTATCTATGGTGGAAGGCAGGG
AAGCAGCGTCCTGATGCTGGATAAGGGCCCGGCCGGTGGACTGGGCCTCGAGGTGCCCATGATGGAGAACTACCCGGGAT
TCGAGATGATCGCGGGAATGAGCCTCGTTACAAAGATGAAGAAACAGGCCACCGCTGTTGCAGAGCTGAGGGAAATGGAG
GAGGTTAAGGAGATAGAGAAAGGTGATGTGTTCACGGTCAAGACATCAAGGGACACCTACACCGCCTCGGCAATCATCTT
TGCAACCGGCAGCAAACACAGGCAGCTTGGAGTCCCAGGTGAGAACGACCTTCTGGGGCGGGGTGTCTGCTACTGTGCAA
CCTGCGATGGCCCCCTATACAAGGGTCGAAAGGTCCTGATGGTTGGAGGTGGTAACAGCGCAGCCCAGGAGGCCGTTTTC
CTAAAGAACATAGGCTGTGATGTGAGTATAGTCCATCGGAGGGATGAGCTGAGGGCTGATAAGTACCTCCAGGACAAGCT
TCGTGAGATGGAGATCCCTGTGATCTGGAACTCTGTGGTTAAGGAGATAGGGGGTGATGAGAGGGTTGAGGAGGTCATCA
TCCACAACCGTGTAACCGGCAGGGACGAGACCCTCAAGGTTGACGGTGTATTCATAGCAATCGGCGAAGAGCCCCTCAAC
CAGCTTGCAGTTGACCTCGGTGTTGAGGTGGATAAAGGAGGCTACATCATCACAGACAAATTCCAGAGGACAAACGTGCC
CCTCGTTTATGCCGCAGGGGATATAACAGGGGGTCTGAACCAGTGGGTAACGGCATGTGCAGAGGGTGCCATCGCAGCAA
CCTACGCCTACCGTGAAATACAGAGCTACTGA

Upstream 100 bases:

>100_bases
TCAGCAGACCCTAAAGCTCCACCTCCTTTTTAATATGAACCGGTTAACTGAATGTGAAATCTTTATCTCCACCGGTGACC
AAGATAATGATTAAGGTGGT

Downstream 100 bases:

>100_bases
AAGTCACTTACCTACTAATTCTTTTTATGAAATGAGTTTAAATCAGGTTGCGCATCTGCTACTCTCCAGATATGATTATT
CAGGATAGCATCAGCTTGAG

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MMTDYDMIVIGAGPAGLTAGIYGGRQGSSVLMLDKGPAGGLGLEVPMMENYPGFEMIAGMSLVTKMKKQATAVAELREME
EVKEIEKGDVFTVKTSRDTYTASAIIFATGSKHRQLGVPGENDLLGRGVCYCATCDGPLYKGRKVLMVGGGNSAAQEAVF
LKNIGCDVSIVHRRDELRADKYLQDKLREMEIPVIWNSVVKEIGGDERVEEVIIHNRVTGRDETLKVDGVFIAIGEEPLN
QLAVDLGVEVDKGGYIITDKFQRTNVPLVYAAGDITGGLNQWVTACAEGAIAATYAYREIQSY

Sequences:

>Translated_303_residues
MMTDYDMIVIGAGPAGLTAGIYGGRQGSSVLMLDKGPAGGLGLEVPMMENYPGFEMIAGMSLVTKMKKQATAVAELREME
EVKEIEKGDVFTVKTSRDTYTASAIIFATGSKHRQLGVPGENDLLGRGVCYCATCDGPLYKGRKVLMVGGGNSAAQEAVF
LKNIGCDVSIVHRRDELRADKYLQDKLREMEIPVIWNSVVKEIGGDERVEEVIIHNRVTGRDETLKVDGVFIAIGEEPLN
QLAVDLGVEVDKGGYIITDKFQRTNVPLVYAAGDITGGLNQWVTACAEGAIAATYAYREIQSY
>Mature_303_residues
MMTDYDMIVIGAGPAGLTAGIYGGRQGSSVLMLDKGPAGGLGLEVPMMENYPGFEMIAGMSLVTKMKKQATAVAELREME
EVKEIEKGDVFTVKTSRDTYTASAIIFATGSKHRQLGVPGENDLLGRGVCYCATCDGPLYKGRKVLMVGGGNSAAQEAVF
LKNIGCDVSIVHRRDELRADKYLQDKLREMEIPVIWNSVVKEIGGDERVEEVIIHNRVTGRDETLKVDGVFIAIGEEPLN
QLAVDLGVEVDKGGYIITDKFQRTNVPLVYAAGDITGGLNQWVTACAEGAIAATYAYREIQSY

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=306, Percent_Identity=33.6601307189542, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87081763, Length=303, Percent_Identity=34.6534653465347, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789915, Length=218, Percent_Identity=31.1926605504587, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320560, Length=318, Percent_Identity=32.0754716981132, Blast_Score=139, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321898, Length=318, Percent_Identity=32.0754716981132, Blast_Score=139, Evalue=5e-34,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 32769; Mature: 32769

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTDYDMIVIGAGPAGLTAGIYGGRQGSSVLMLDKGPAGGLGLEVPMMENYPGFEMIAGM
CCCCCCEEEEECCCCCCEEECCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCHHHHHHH
SLVTKMKKQATAVAELREMEEVKEIEKGDVFTVKTSRDTYTASAIIFATGSKHRQLGVPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEEECCCCCEECCCC
ENDLLGRGVCYCATCDGPLYKGRKVLMVGGGNSAAQEAVFLKNIGCDVSIVHRRDELRAD
CCCCCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCHHHHHH
KYLQDKLREMEIPVIWNSVVKEIGGDERVEEVIIHNRVTGRDETLKVDGVFIAIGEEPLN
HHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCHH
QLAVDLGVEVDKGGYIITDKFQRTNVPLVYAAGDITGGLNQWVTACAEGAIAATYAYREI
HHHHHHCCEECCCCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEHHHHHHHH
QSY
HCC
>Mature Secondary Structure
MMTDYDMIVIGAGPAGLTAGIYGGRQGSSVLMLDKGPAGGLGLEVPMMENYPGFEMIAGM
CCCCCCEEEEECCCCCCEEECCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCHHHHHHH
SLVTKMKKQATAVAELREMEEVKEIEKGDVFTVKTSRDTYTASAIIFATGSKHRQLGVPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEEECCCCCEECCCC
ENDLLGRGVCYCATCDGPLYKGRKVLMVGGGNSAAQEAVFLKNIGCDVSIVHRRDELRAD
CCCCCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCHHHHHH
KYLQDKLREMEIPVIWNSVVKEIGGDERVEEVIIHNRVTGRDETLKVDGVFIAIGEEPLN
HHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCHH
QLAVDLGVEVDKGGYIITDKFQRTNVPLVYAAGDITGGLNQWVTACAEGAIAATYAYREI
HHHHHHCCEECCCCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEHHHHHHHH
QSY
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]