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Identifier: 15678737

GI number: 15678737

Start: 633118

End: 634053

Strand: Direct

Name: Not Available

Synonym: MTH710

Alternate gene names: 15678737

Gene position: 633118-634053 (Clockwise)

Preceding gene: 15678736

Following gene: 15678738

Centisome position: 36.15

GC content: 50.75

Gene sequence:

>936_bases
GTGATGCTTATGCTGAATCCATCTGATTTTATTGAAGAAGCAGTTGAAGAGATAAGAAGTACCGTTGGTAACGAAAAGGC
CATAATAGCACTATCAGGAGGAGTTGACAGTTCCGTGGCATCTGTTCTTGCCGGTAGGGCCATCGGAGATAACCTCACAG
CGGTATTTGTTGACCATGGACTCCTCAGGGAGGGAGAAGCAGAGTACGTGAGAAAAACATTCAGTGAACGCCTGAACTTC
CGCTACATTGACGCCTCAGAGGAGTTCCTGAAGGAACTTGAGGGTGTCACAGACCCTGAGGAGAAGCGTAAGATAATCGG
AAGGGTGTTCATTGAGGTCTTTGAAAGGGTAGCCGAGGAGATAGGTGCCAGGTACCTGGTGCAGGGCACAATAGCCCCTG
ACTGGATTGAAAGTGAGGGTCAGATAAAGTCCCACCACAACGTCGCACTCCCACACGGACTTGTACTCGAGATAGTTGAA
CCAATAAGGGAGCTCTACAAGGATGAGGTACGTGAAATTGGCCTTGAACTGGGTCTTCCACGTGAGATGATCCAGAGGCA
ACCCTTCCCGGGTCCAGGACTTGCAGTGAGGATAGTCGGGGAGATAACCCGGGAGAAGATTGAGATATGCCGAAGGGCCA
ACGCCATCGTCGAGGAGGAGGTCGTTGAAAGCGGCCTCCACGAGAGTCTCTGGCAGTACTTCGCTGTACTTACTGACACC
ATGGTCACCGGGGTCAAGGGGGACGTGAGGGACTTCGGATACCTCGTGGTTATAAGGATGGTTGAATCTCTTGACGCAAT
GACAGCAAGTGTCCCTGAACTTCCATGGGATCTCATAAAGAGGATATCAAAGCGCATAACCGCCGAGATACCTGAGGTAA
CCCATGTGGCTCTTTCTGTAAGTGATAAGCCGCCAAGCACCATTGAATTTGCCTGA

Upstream 100 bases:

>100_bases
TGGGACCTGAAGGTACCCACCCTAACACGGGTCAGAACACCGTCCATCCTTAACATTAAATAGATGTCCTGCAAGATAAT
AAATCAATCATTTTTATTCG

Downstream 100 bases:

>100_bases
AAAGCCACGAAATCTTTTTTTCTGAATATCAGACCACAGAAAAAAACAAAACCCTTTTTTTCTTAAGATGCTTGAAAAAA
CACCAGCAGTTCCCCTTCAA

Product: GMP synthase subunit B

Products: NA

Alternate protein names: GMP synthetase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MMLMLNPSDFIEEAVEEIRSTVGNEKAIIALSGGVDSSVASVLAGRAIGDNLTAVFVDHGLLREGEAEYVRKTFSERLNF
RYIDASEEFLKELEGVTDPEEKRKIIGRVFIEVFERVAEEIGARYLVQGTIAPDWIESEGQIKSHHNVALPHGLVLEIVE
PIRELYKDEVREIGLELGLPREMIQRQPFPGPGLAVRIVGEITREKIEICRRANAIVEEEVVESGLHESLWQYFAVLTDT
MVTGVKGDVRDFGYLVVIRMVESLDAMTASVPELPWDLIKRISKRITAEIPEVTHVALSVSDKPPSTIEFA

Sequences:

>Translated_311_residues
MMLMLNPSDFIEEAVEEIRSTVGNEKAIIALSGGVDSSVASVLAGRAIGDNLTAVFVDHGLLREGEAEYVRKTFSERLNF
RYIDASEEFLKELEGVTDPEEKRKIIGRVFIEVFERVAEEIGARYLVQGTIAPDWIESEGQIKSHHNVALPHGLVLEIVE
PIRELYKDEVREIGLELGLPREMIQRQPFPGPGLAVRIVGEITREKIEICRRANAIVEEEVVESGLHESLWQYFAVLTDT
MVTGVKGDVRDFGYLVVIRMVESLDAMTASVPELPWDLIKRISKRITAEIPEVTHVALSVSDKPPSTIEFA
>Mature_311_residues
MMLMLNPSDFIEEAVEEIRSTVGNEKAIIALSGGVDSSVASVLAGRAIGDNLTAVFVDHGLLREGEAEYVRKTFSERLNF
RYIDASEEFLKELEGVTDPEEKRKIIGRVFIEVFERVAEEIGARYLVQGTIAPDWIESEGQIKSHHNVALPHGLVLEIVE
PIRELYKDEVREIGLELGLPREMIQRQPFPGPGLAVRIVGEITREKIEICRRANAIVEEEVVESGLHESLWQYFAVLTDT
MVTGVKGDVRDFGYLVVIRMVESLDAMTASVPELPWDLIKRISKRITAEIPEVTHVALSVSDKPPSTIEFA

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=364, Percent_Identity=30.7692307692308, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1788854, Length=318, Percent_Identity=48.4276729559748, Blast_Score=290, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71992710, Length=370, Percent_Identity=31.0810810810811, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71992717, Length=218, Percent_Identity=40.3669724770642, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI133901714, Length=370, Percent_Identity=31.0810810810811, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323873, Length=318, Percent_Identity=45.2830188679245, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI281365319, Length=307, Percent_Identity=32.2475570032573, Blast_Score=137, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 34779; Mature: 34779

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLMLNPSDFIEEAVEEIRSTVGNEKAIIALSGGVDSSVASVLAGRAIGDNLTAVFVDHG
CEEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHEEEECCC
LLREGEAEYVRKTFSERLNFRYIDASEEFLKELEGVTDPEEKRKIIGRVFIEVFERVAEE
HHCCCHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IGARYLVQGTIAPDWIESEGQIKSHHNVALPHGLVLEIVEPIRELYKDEVREIGLELGLP
HCCCEEEECCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
REMIQRQPFPGPGLAVRIVGEITREKIEICRRANAIVEEEVVESGLHESLWQYFAVLTDT
HHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVTGVKGDVRDFGYLVVIRMVESLDAMTASVPELPWDLIKRISKRITAEIPEVTHVALSV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHEEEEEE
SDKPPSTIEFA
CCCCCCCCCCC
>Mature Secondary Structure
MMLMLNPSDFIEEAVEEIRSTVGNEKAIIALSGGVDSSVASVLAGRAIGDNLTAVFVDHG
CEEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHEEEECCC
LLREGEAEYVRKTFSERLNFRYIDASEEFLKELEGVTDPEEKRKIIGRVFIEVFERVAEE
HHCCCHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IGARYLVQGTIAPDWIESEGQIKSHHNVALPHGLVLEIVEPIRELYKDEVREIGLELGLP
HCCCEEEECCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
REMIQRQPFPGPGLAVRIVGEITREKIEICRRANAIVEEEVVESGLHESLWQYFAVLTDT
HHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVTGVKGDVRDFGYLVVIRMVESLDAMTASVPELPWDLIKRISKRITAEIPEVTHVALSV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHEEEEEE
SDKPPSTIEFA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]