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Identifier: 15678523

GI number: 15678523

Start: 434774

End: 436015

Strand: Direct

Name: Not Available

Synonym: MTH495

Alternate gene names: 15678523

Gene position: 434774-436015 (Clockwise)

Preceding gene: 15678522

Following gene: 15678524

Centisome position: 24.82

GC content: 48.47

Gene sequence:

>1242_bases
ATGTCAGATGTTGTGTTGATTGACATATTTGCAGGTGCGGGGGGGCTTACTGAAGGTTTCCTTCGGAGTGATTATACATT
CGTTTCACATATTGAGATGGACAGGGATGCGATTCAGACACTGGAGACAAGGGGACTCTATCATCACCTGCAGAGCGATG
GTGACCCCGAGGATTACACCGAATACGTTAATGGTGAGATAGGACGTGAAGAACTATTCAGAAGATATCCTGACTTTGAC
AGTGAACTGTACATGAACCTTGAACTCACAGAGGAAAACGTGGACAGGGTCATAGAGACCATCAGGTCAAAGATGAATGA
TATGGGGACAGTTTCTGTTGATGGCATAATAGGTGGGCCTCCATGTCAGGCGTACTCATATGCTGGCAGATCCCGGAAGA
ACATGGAAAAGGACAGGAGAAACTACCTCTACCTCCTGTACATTAAATTCCTGAAAGAATTCCAGCCGGAATTCTTTGTA
TTCGAGAACGTCCCCGGGATGAAGTCAGCGCAAAGGGGCCACATACTATCTGATTTCCAGAGGAAGGTAACAGACCTGGA
ATATAAACTTGACTTTGAAGTGCGTGATGCATATAACTTCGGGGTCCCTCAGAGGAGAAGGAGGATCATAGTCATCGGCC
ACCGCATGGAAGATAAAAGGATACAGTTTGATGAGGAGAGGTATGCCGGTACAGTGAATGACATCCTATGTGATCTGCCC
GCCCTTGAACCCGGCCAGGGCACAGACGGGCCCCAGGAATATAGATCCAGACCATCACGCCTCCTGAATGAGATGGGTAT
AAGGACAGAGAATGATATTCTCCGACATCACCAGGCGCGAAGACACAACCCGCGGGACCGCGAAATTTACAGGAGAACAA
TTGACGCATGGAACTCAGAGAGGAGAAGATTAAAATATACAGAACTTCCACCGGAACTCAGGACACACAGGAACACCAGG
AGCTTCCTTGACCGTTACAAGGTGGTTGCAGGGGACCTCCCCTATTCCCATACCATTGTCGCGCATATATCAAAGGATGG
ACACTACTACATCCACCCCGACAGAGAACAGGCCCGTTCTCTGACCGTAAGGGAAGCTGCAAGGATCCAGTCCTTCCCGG
ATAACTACATATTTGAAGGATCCATGACCTCAAAGTACCGGCAGATAGGAAACGCCGTGCCTCCACTAATGTCTGAGAAG
ATTGCCCGCAAACTTTATGAAATCTACAGGGGGGACCTCTGA

Upstream 100 bases:

>100_bases
CACCCTCTGAGTTTAACCCATATGGGTGGACATAACAAAAAATAATTTAATGTGGTTAAGATAAATCATCAATGACAGGT
AACCAGAGGCAGGTTCGGCG

Downstream 100 bases:

>100_bases
TTTCTGAAAAGGATCTGCTGCTTGATATTCATACCAGAATCTGCGAATGGGGAAAAAAGAATTTAAGGAAATTTCCCTGG
CGCGAAAGAAGAGATGACTA

Product: modification methyltransferase, cytosine-specific

Products: NA

Alternate protein names: M.DdeI; Cytosine-specific methyltransferase DdeI [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSDVVLIDIFAGAGGLTEGFLRSDYTFVSHIEMDRDAIQTLETRGLYHHLQSDGDPEDYTEYVNGEIGREELFRRYPDFD
SELYMNLELTEENVDRVIETIRSKMNDMGTVSVDGIIGGPPCQAYSYAGRSRKNMEKDRRNYLYLLYIKFLKEFQPEFFV
FENVPGMKSAQRGHILSDFQRKVTDLEYKLDFEVRDAYNFGVPQRRRRIIVIGHRMEDKRIQFDEERYAGTVNDILCDLP
ALEPGQGTDGPQEYRSRPSRLLNEMGIRTENDILRHHQARRHNPRDREIYRRTIDAWNSERRRLKYTELPPELRTHRNTR
SFLDRYKVVAGDLPYSHTIVAHISKDGHYYIHPDREQARSLTVREAARIQSFPDNYIFEGSMTSKYRQIGNAVPPLMSEK
IARKLYEIYRGDL

Sequences:

>Translated_413_residues
MSDVVLIDIFAGAGGLTEGFLRSDYTFVSHIEMDRDAIQTLETRGLYHHLQSDGDPEDYTEYVNGEIGREELFRRYPDFD
SELYMNLELTEENVDRVIETIRSKMNDMGTVSVDGIIGGPPCQAYSYAGRSRKNMEKDRRNYLYLLYIKFLKEFQPEFFV
FENVPGMKSAQRGHILSDFQRKVTDLEYKLDFEVRDAYNFGVPQRRRRIIVIGHRMEDKRIQFDEERYAGTVNDILCDLP
ALEPGQGTDGPQEYRSRPSRLLNEMGIRTENDILRHHQARRHNPRDREIYRRTIDAWNSERRRLKYTELPPELRTHRNTR
SFLDRYKVVAGDLPYSHTIVAHISKDGHYYIHPDREQARSLTVREAARIQSFPDNYIFEGSMTSKYRQIGNAVPPLMSEK
IARKLYEIYRGDL
>Mature_412_residues
SDVVLIDIFAGAGGLTEGFLRSDYTFVSHIEMDRDAIQTLETRGLYHHLQSDGDPEDYTEYVNGEIGREELFRRYPDFDS
ELYMNLELTEENVDRVIETIRSKMNDMGTVSVDGIIGGPPCQAYSYAGRSRKNMEKDRRNYLYLLYIKFLKEFQPEFFVF
ENVPGMKSAQRGHILSDFQRKVTDLEYKLDFEVRDAYNFGVPQRRRRIIVIGHRMEDKRIQFDEERYAGTVNDILCDLPA
LEPGQGTDGPQEYRSRPSRLLNEMGIRTENDILRHHQARRHNPRDREIYRRTIDAWNSERRRLKYTELPPELRTHRNTRS
FLDRYKVVAGDLPYSHTIVAHISKDGHYYIHPDREQARSLTVREAARIQSFPDNYIFEGSMTSKYRQIGNAVPPLMSEKI
ARKLYEIYRGDL

Specific function: This methylase recognizes the double-stranded sequence CTNAG, causes specific methylation on C-1 on both strands, and protects the DNA from cleavage by the DdeI endonuclease [H]

COG id: COG0270

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C5-methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018117
- InterPro:   IPR001525 [H]

Pfam domain/function: PF00145 DNA_methylase [H]

EC number: =2.1.1.37 [H]

Molecular weight: Translated: 48577; Mature: 48446

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00094 C5_MTASE_1 ; PS00095 C5_MTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVVLIDIFAGAGGLTEGFLRSDYTFVSHIEMDRDAIQTLETRGLYHHLQSDGDPEDYT
CCCEEEEEEECCCCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
EYVNGEIGREELFRRYPDFDSELYMNLELTEENVDRVIETIRSKMNDMGTVSVDGIIGGP
HHHCCCCCHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
PCQAYSYAGRSRKNMEKDRRNYLYLLYIKFLKEFQPEFFVFENVPGMKSAQRGHILSDFQ
CCHHHHHCCCCHHHHHHHHHCEEHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHH
RKVTDLEYKLDFEVRDAYNFGVPQRRRRIIVIGHRMEDKRIQFDEERYAGTVNDILCDLP
HHHHCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHCCCHHHHHHCCC
ALEPGQGTDGPQEYRSRPSRLLNEMGIRTENDILRHHQARRHNPRDREIYRRTIDAWNSE
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCH
RRRLKYTELPPELRTHRNTRSFLDRYKVVAGDLPYSHTIVAHISKDGHYYIHPDREQARS
HHCEECCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEECCCHHHHHH
LTVREAARIQSFPDNYIFEGSMTSKYRQIGNAVPPLMSEKIARKLYEIYRGDL
HHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDVVLIDIFAGAGGLTEGFLRSDYTFVSHIEMDRDAIQTLETRGLYHHLQSDGDPEDYT
CCEEEEEEECCCCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
EYVNGEIGREELFRRYPDFDSELYMNLELTEENVDRVIETIRSKMNDMGTVSVDGIIGGP
HHHCCCCCHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
PCQAYSYAGRSRKNMEKDRRNYLYLLYIKFLKEFQPEFFVFENVPGMKSAQRGHILSDFQ
CCHHHHHCCCCHHHHHHHHHCEEHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHH
RKVTDLEYKLDFEVRDAYNFGVPQRRRRIIVIGHRMEDKRIQFDEERYAGTVNDILCDLP
HHHHCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHCCCHHHHHHCCC
ALEPGQGTDGPQEYRSRPSRLLNEMGIRTENDILRHHQARRHNPRDREIYRRTIDAWNSE
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCH
RRRLKYTELPPELRTHRNTRSFLDRYKVVAGDLPYSHTIVAHISKDGHYYIHPDREQARS
HHCEECCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEECCCHHHHHH
LTVREAARIQSFPDNYIFEGSMTSKYRQIGNAVPPLMSEKIARKLYEIYRGDL
HHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2823226 [H]