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Identifier: 15678522

GI number: 15678522

Start: 434187

End: 434708

Strand: Direct

Name: Not Available

Synonym: MTH494

Alternate gene names: 15678522

Gene position: 434187-434708 (Clockwise)

Preceding gene: 15678521

Following gene: 15678523

Centisome position: 24.79

GC content: 50.57

Gene sequence:

>522_bases
ATGAGGTGTGCATTCATGAAGAAGTATATTTTAATTGTGATGCTTGCCCTGATGGTTGCGGGCTGCGTCTCTGAGGATGG
TAACTACACATACAATGAGGGTGTCCAGGACAGCAATGTGGACAATCCTGTTAATGATTCATGGACCAGCGACTCCCAGG
ATAAGGTTAACGATACTGCTGAGAAAAAATCCAGTTATGAGGCATCAGGCAGCTGTTACCATGTGGTTGACGGTGACACC
ATAGACGTTGAGGGCGTCGGGAGGATACGCCTGGTAGGGGTTAACACCCCTGAACGTGGACAGCCAGGCTACAGGGAGGC
GAAGGACTTCGTGAAGTCCATGTGCCTTGGAAGAACAGTCCAGCTGGACATCGATGATGCTAAAAGACACGACAGGTATG
GGAGGGTCCTTGCAGTTGTCTACGTCGACGGTGTCAACCTCAACAGGGAGCTTCTCAGGCGCGGCTATGCCGAGGTAATG
TACATACCACCCTCTGAGTTTAACCCATATGGGTGGACATAA

Upstream 100 bases:

>100_bases
CGTGAAGGGTGACGTCGTGGTTTCAGGGAGGATTGTAACGGTACCCGCCCCTGAATCCGCCTAAACTGAGGGATACCCTC
AGGGAGATGATCAGGAAGAG

Downstream 100 bases:

>100_bases
CAAAAAATAATTTAATGTGGTTAAGATAAATCATCAATGACAGGTAACCAGAGGCAGGTTCGGCGATGTCAGATGTTGTG
TTGATTGACATATTTGCAGG

Product: thermonuclease precursor

Products: NA

Alternate protein names: TNase; Micrococcal nuclease; Staphylococcal nuclease [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MRCAFMKKYILIVMLALMVAGCVSEDGNYTYNEGVQDSNVDNPVNDSWTSDSQDKVNDTAEKKSSYEASGSCYHVVDGDT
IDVEGVGRIRLVGVNTPERGQPGYREAKDFVKSMCLGRTVQLDIDDAKRHDRYGRVLAVVYVDGVNLNRELLRRGYAEVM
YIPPSEFNPYGWT

Sequences:

>Translated_173_residues
MRCAFMKKYILIVMLALMVAGCVSEDGNYTYNEGVQDSNVDNPVNDSWTSDSQDKVNDTAEKKSSYEASGSCYHVVDGDT
IDVEGVGRIRLVGVNTPERGQPGYREAKDFVKSMCLGRTVQLDIDDAKRHDRYGRVLAVVYVDGVNLNRELLRRGYAEVM
YIPPSEFNPYGWT
>Mature_173_residues
MRCAFMKKYILIVMLALMVAGCVSEDGNYTYNEGVQDSNVDNPVNDSWTSDSQDKVNDTAEKKSSYEASGSCYHVVDGDT
IDVEGVGRIRLVGVNTPERGQPGYREAKDFVKSMCLGRTVQLDIDDAKRHDRYGRVLAVVYVDGVNLNRELLRRGYAEVM
YIPPSEFNPYGWT

Specific function: Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond [H]

COG id: COG1525

COG function: function code L; Micrococcal nuclease (thermonuclease) homologs

Gene ontology:

Cell location: Nuclease B:Membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thermonuclease family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016071
- InterPro:   IPR006021
- InterPro:   IPR002071 [H]

Pfam domain/function: PF00565 SNase [H]

EC number: =3.1.31.1 [H]

Molecular weight: Translated: 19423; Mature: 19423

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01284 TNASE_2 ; PS50830 TNASE_3 ; PS01095 CHITINASE_18

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCAFMKKYILIVMLALMVAGCVSEDGNYTYNEGVQDSNVDNPVNDSWTSDSQDKVNDTA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EKKSSYEASGSCYHVVDGDTIDVEGVGRIRLVGVNTPERGQPGYREAKDFVKSMCLGRTV
HHHCCCCCCCCEEEEECCCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEE
QLDIDDAKRHDRYGRVLAVVYVDGVNLNRELLRRGYAEVMYIPPSEFNPYGWT
EEECCHHHHCCCCCCEEEEEEECCCCCCHHHHHCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRCAFMKKYILIVMLALMVAGCVSEDGNYTYNEGVQDSNVDNPVNDSWTSDSQDKVNDTA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EKKSSYEASGSCYHVVDGDTIDVEGVGRIRLVGVNTPERGQPGYREAKDFVKSMCLGRTV
HHHCCCCCCCCEEEEECCCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEE
QLDIDDAKRHDRYGRVLAVVYVDGVNLNRELLRRGYAEVMYIPPSEFNPYGWT
EEECCHHHHCCCCCCEEEEEEECCCCCCHHHHHCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6307819; 3921523; 3112123; 893427; 4324890; 4339720; 288045; 1896431; 1731948; 8069625 [H]