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Identifier: 15678446

GI number: 15678446

Start: 353983

End: 355191

Strand: Direct

Name: Not Available

Synonym: MTH418

Alternate gene names: 15678446

Gene position: 353983-355191 (Clockwise)

Preceding gene: 15678445

Following gene: 15678447

Centisome position: 20.21

GC content: 56.08

Gene sequence:

>1209_bases
GTGATAACCATGAAACATGTTATTCTTGTTGGAGACGGAATGGCGGATTACCCCCTTGATGAACTCGACGGTAAAACGCC
ACTGCAGGTGGCAGATAAGCCCAACATGGACCAGCTTGCAGGGATGGGTGCGTGCGGTCTTCTCAGGACAGTCCCGGAGG
GGATGGAGGCGGGTTCAGATGTTGCAAACCTCAGTATAATGGGCTACGACCCCCGCAGGTACTACACCGGGAGGGGCCCC
CTTGAGGCTGCAAGCATAGGTGTTGAGCTGGGCGATGATGATGTGGCATTCAGATGCAACCTCATAAACGCTGATGAGAG
GATCGTGGACTTCAACGCCGGACACATAGAAACAGCTGAGGCGTCAAGCCTCATAGATGCCCTCAATCATGAACTTGAAA
CCAGGGGGAGGTTCTATGCCGGTGTGAGCTACAGGAACCTCTTTGTTATAGAGGGGAGGGGCTACACCTCGGTGAGGGTT
GAGCCACCCCACGACATAGTGGGGGAGTCTGTGGCCGCACACCTCCCCTCAGGCTCGGAGGAGGCAGACCATATAAGGGA
GCTGATGCTGGAATCAGCAGGCGTCCTCAGATCCCATGAGGTGAACCTCAAAAGGGAATCCATGGGTAAGAGGCCGGCCA
CCATGATCTGGCTCTGGGGACAGGGTTTAAGGCCATCAATGGAGCCCTTCAGTGAAAGGTACGGTATTAGAGGTGCCACA
ATAACTGCAGTGGACCTGATAAAGGGCCTGGGCGTATATGCGGGTCTTGAAAACATCCATGTCCCGGGCGCCACAGGTTA
CCTGGACACAGACTACAGGGCCAAGGGCAGATACGCTGCCGGGGCCCTTGAGGAATATGACTTCCTCTACGTCCATGTTG
AGGCACCCGATGAGGCAGGGCATGCCGGTGACGCTGAGGAGAAGATAAGGGCCATAGAGAATATAGACCGCTTCGTCCTC
GGCAGGTTACTTGATGCGCTCTCAGACCATGAGCACAGGATAGCGGTCCTCCCGGATCACCCCACACCCATTGAGATCAG
GACCCATGTACCCGACCCCGTACCATGCATCCTTGCAGGTGACGGCGTGGATGCTGATCAGGTGAAATCCTATGACGAGT
TCACAGTCAGGGAGGGGTCCCTGGGCACATGGGAGGCCCACAGGCTCATGGAAATCATGATGGACCCGGCTGCCCGGTTA
AGGCAATGA

Upstream 100 bases:

>100_bases
TGGCGCAGGATCCCTTGAGACGGCCTCGGCCATGCTCACAGACACCATCACCATATGGAGGAAGTCTGGAGGGCGTTAAA
CCCCTTTACGGTTCTTTTCA

Downstream 100 bases:

>100_bases
GTTTTTAACATCCTAATCACATATATTGACCCATCAAACTAATCTGAGGAGTTGGTTCATCTGGCCAAGTACATCGTTGT
AACGGGAGGAGTTGTAAGCT

Product: cofactor-independent phosphoglycerate mutase

Products: NA

Alternate protein names: BPG-independent PGAM 2; Phosphoglyceromutase 2; aPGAM 2

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MITMKHVILVGDGMADYPLDELDGKTPLQVADKPNMDQLAGMGACGLLRTVPEGMEAGSDVANLSIMGYDPRRYYTGRGP
LEAASIGVELGDDDVAFRCNLINADERIVDFNAGHIETAEASSLIDALNHELETRGRFYAGVSYRNLFVIEGRGYTSVRV
EPPHDIVGESVAAHLPSGSEEADHIRELMLESAGVLRSHEVNLKRESMGKRPATMIWLWGQGLRPSMEPFSERYGIRGAT
ITAVDLIKGLGVYAGLENIHVPGATGYLDTDYRAKGRYAAGALEEYDFLYVHVEAPDEAGHAGDAEEKIRAIENIDRFVL
GRLLDALSDHEHRIAVLPDHPTPIEIRTHVPDPVPCILAGDGVDADQVKSYDEFTVREGSLGTWEAHRLMEIMMDPAARL
RQ

Sequences:

>Translated_402_residues
MITMKHVILVGDGMADYPLDELDGKTPLQVADKPNMDQLAGMGACGLLRTVPEGMEAGSDVANLSIMGYDPRRYYTGRGP
LEAASIGVELGDDDVAFRCNLINADERIVDFNAGHIETAEASSLIDALNHELETRGRFYAGVSYRNLFVIEGRGYTSVRV
EPPHDIVGESVAAHLPSGSEEADHIRELMLESAGVLRSHEVNLKRESMGKRPATMIWLWGQGLRPSMEPFSERYGIRGAT
ITAVDLIKGLGVYAGLENIHVPGATGYLDTDYRAKGRYAAGALEEYDFLYVHVEAPDEAGHAGDAEEKIRAIENIDRFVL
GRLLDALSDHEHRIAVLPDHPTPIEIRTHVPDPVPCILAGDGVDADQVKSYDEFTVREGSLGTWEAHRLMEIMMDPAARL
RQ
>Mature_402_residues
MITMKHVILVGDGMADYPLDELDGKTPLQVADKPNMDQLAGMGACGLLRTVPEGMEAGSDVANLSIMGYDPRRYYTGRGP
LEAASIGVELGDDDVAFRCNLINADERIVDFNAGHIETAEASSLIDALNHELETRGRFYAGVSYRNLFVIEGRGYTSVRV
EPPHDIVGESVAAHLPSGSEEADHIRELMLESAGVLRSHEVNLKRESMGKRPATMIWLWGQGLRPSMEPFSERYGIRGAT
ITAVDLIKGLGVYAGLENIHVPGATGYLDTDYRAKGRYAAGALEEYDFLYVHVEAPDEAGHAGDAEEKIRAIENIDRFVL
GRLLDALSDHEHRIAVLPDHPTPIEIRTHVPDPVPCILAGDGVDADQVKSYDEFTVREGSLGTWEAHRLMEIMMDPAARL
RQ

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG3635

COG function: function code G; Predicted phosphoglycerate mutase, AP superfamily

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APGM2_METTH (O26518)

Other databases:

- EMBL:   AE000666
- PIR:   D69154
- RefSeq:   NP_275561.1
- ProteinModelPortal:   O26518
- SMR:   O26518
- STRING:   O26518
- GeneID:   1470379
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH418
- NMPDR:   fig|187420.1.peg.416
- eggNOG:   arNOG04733
- HOGENOM:   HBG463247
- OMA:   DYSAGHI
- ProtClustDB:   PRK04200
- BioCyc:   MetaCyc:MONOMER-14535
- BioCyc:   MTHE187420:MTH418-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01402_A
- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR004456
- InterPro:   IPR013371
- InterPro:   IPR006124
- Gene3D:   G3DSA:3.40.720.10
- PIRSF:   PIRSF006392
- TIGRFAMs:   TIGR00306
- TIGRFAMs:   TIGR02535

Pfam domain/function: PF01676 Metalloenzyme; PF10143 PhosphMutase; SSF53649 Alkaline_phosphatase_core

EC number: =5.4.2.1

Molecular weight: Translated: 44100; Mature: 44100

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITMKHVILVGDGMADYPLDELDGKTPLQVADKPNMDQLAGMGACGLLRTVPEGMEAGSD
CEEEEEEEEEECCCCCCCHHHCCCCCCEEECCCCCHHHHHCCCHHHHHHHCHHHHHCCCC
VANLSIMGYDPRRYYTGRGPLEAASIGVELGDDDVAFRCNLINADERIVDFNAGHIETAE
EEEEEEEECCCCEEECCCCCCCHHEEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCHH
ASSLIDALNHELETRGRFYAGVSYRNLFVIEGRGYTSVRVEPPHDIVGESVAAHLPSGSE
HHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCCEEEEECCCHHHHHCHHHHHCCCCCH
EADHIRELMLESAGVLRSHEVNLKRESMGKRPATMIWLWGQGLRPSMEPFSERYGIRGAT
HHHHHHHHHHHHCCCHHHCCCCCCHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCE
ITAVDLIKGLGVYAGLENIHVPGATGYLDTDYRAKGRYAAGALEEYDFLYVHVEAPDEAG
EHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCEECCCCCCCEEEEEEEECCCCCC
HAGDAEEKIRAIENIDRFVLGRLLDALSDHEHRIAVLPDHPTPIEIRTHVPDPVPCILAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCEEEEC
DGVDADQVKSYDEFTVREGSLGTWEAHRLMEIMMDPAARLRQ
CCCCHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MITMKHVILVGDGMADYPLDELDGKTPLQVADKPNMDQLAGMGACGLLRTVPEGMEAGSD
CEEEEEEEEEECCCCCCCHHHCCCCCCEEECCCCCHHHHHCCCHHHHHHHCHHHHHCCCC
VANLSIMGYDPRRYYTGRGPLEAASIGVELGDDDVAFRCNLINADERIVDFNAGHIETAE
EEEEEEEECCCCEEECCCCCCCHHEEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCHH
ASSLIDALNHELETRGRFYAGVSYRNLFVIEGRGYTSVRVEPPHDIVGESVAAHLPSGSE
HHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCCEEEEECCCHHHHHCHHHHHCCCCCH
EADHIRELMLESAGVLRSHEVNLKRESMGKRPATMIWLWGQGLRPSMEPFSERYGIRGAT
HHHHHHHHHHHHCCCHHHCCCCCCHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCE
ITAVDLIKGLGVYAGLENIHVPGATGYLDTDYRAKGRYAAGALEEYDFLYVHVEAPDEAG
EHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCEECCCCCCCEEEEEEEECCCCCC
HAGDAEEKIRAIENIDRFVLGRLLDALSDHEHRIAVLPDHPTPIEIRTHVPDPVPCILAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCEEEEC
DGVDADQVKSYDEFTVREGSLGTWEAHRLMEIMMDPAARLRQ
CCCCHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463