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Identifier: 15678445

GI number: 15678445

Start: 352939

End: 353961

Strand: Direct

Name: Not Available

Synonym: MTH417

Alternate gene names: 15678445

Gene position: 352939-353961 (Clockwise)

Preceding gene: 15678444

Following gene: 15678446

Centisome position: 20.15

GC content: 56.89

Gene sequence:

>1023_bases
GTGAGGGTTATGAGGATATGTCTTGTTGGACTGGGAGCTGTTGGTCAGGGATTCCTCAGGGCCGTTCAGATGAAGGGCGA
GTATCTGAGGGAAAGGTATGGCCTCGATATAAGGTTCACGGGAGTCGCGGATTCATCAGGAGCCCTCCACGACCCGGATG
GCCTTGACATCAGGGGGGTACTTGAGCACAAGAAGCGGGCCGGCCTGGGGTCACATCCCTCAGGATACGAGGGGATGACC
GGAGATGAACTCCTTGATGAGGCAGAATATGACTGCCTGGTGGAGGCAACACCAACAAATATAGAGGACGGCGAACCCGG
CAGGTCACTGGTCCTGAAGGCCATGGGTGACGGGAAGCACGTTGTAACATCAAACAAGGGGCACCTGGCCCTTTTCTACT
CTGAACTCATGGAGGCGGCCTCTGAGGCAGGTGTTGAGTTCATGTTCGAGGCATCTGTGGGGGGTGCCATGCCCATAATA
AACCTTGCAAGGGAGACCCTAGCATCATGCACCATAGAATCTGTGATCGGTATCCTGAACGGTACCACCAACTTCATACT
CTCCAGGATGGCCTCTGAGGGATCATCCTACAGGCAGGCCCTCATTGAGGCCCAGGAGCTGGGCATTGCAGAGACAAATC
CCGCCCAGGACGTTGAAGGTACTGATGCGGCCTGCAAGGCTGTGATAATCGCCAATTCAATCCTCGGAAGGCCATGCACC
CTCAGGGATGTCAGGGTCGAGGGGATCACCGGTATAACCCAGGGGGCCATTGAACTGGCAGCCCAGGAGGGGTACCTCAT
AAAACTCATTGCAGAGATCTCAGGGGACAGGCTGGAGGTCGGACCCAGGCTGGTGAGGATGGGGTCACCCTACGCCGTGG
ACGGGACACTGAACATGGCCACCCTCAGGACAGACCTTGCAGGTGAGGTGACAGCTGTTGGACGTGGCGCAGGATCCCTT
GAGACGGCCTCGGCCATGCTCACAGACACCATCACCATATGGAGGAAGTCTGGAGGGCGTTAA

Upstream 100 bases:

>100_bases
GATAACCTTTGAAGCAGAACACGGCAGCAGGGATGAGGTCCTGAGGAGGATCAATGAAGCCGCCATGGAGAGGAACCTCC
TGCTTGTAAGCGAGGTCTAG

Downstream 100 bases:

>100_bases
ACCCCTTTACGGTTCTTTTCAGTGATAACCATGAAACATGTTATTCTTGTTGGAGACGGAATGGCGGATTACCCCCTTGA
TGAACTCGACGGTAAAACGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MRVMRICLVGLGAVGQGFLRAVQMKGEYLRERYGLDIRFTGVADSSGALHDPDGLDIRGVLEHKKRAGLGSHPSGYEGMT
GDELLDEAEYDCLVEATPTNIEDGEPGRSLVLKAMGDGKHVVTSNKGHLALFYSELMEAASEAGVEFMFEASVGGAMPII
NLARETLASCTIESVIGILNGTTNFILSRMASEGSSYRQALIEAQELGIAETNPAQDVEGTDAACKAVIIANSILGRPCT
LRDVRVEGITGITQGAIELAAQEGYLIKLIAEISGDRLEVGPRLVRMGSPYAVDGTLNMATLRTDLAGEVTAVGRGAGSL
ETASAMLTDTITIWRKSGGR

Sequences:

>Translated_340_residues
MRVMRICLVGLGAVGQGFLRAVQMKGEYLRERYGLDIRFTGVADSSGALHDPDGLDIRGVLEHKKRAGLGSHPSGYEGMT
GDELLDEAEYDCLVEATPTNIEDGEPGRSLVLKAMGDGKHVVTSNKGHLALFYSELMEAASEAGVEFMFEASVGGAMPII
NLARETLASCTIESVIGILNGTTNFILSRMASEGSSYRQALIEAQELGIAETNPAQDVEGTDAACKAVIIANSILGRPCT
LRDVRVEGITGITQGAIELAAQEGYLIKLIAEISGDRLEVGPRLVRMGSPYAVDGTLNMATLRTDLAGEVTAVGRGAGSL
ETASAMLTDTITIWRKSGGR
>Mature_340_residues
MRVMRICLVGLGAVGQGFLRAVQMKGEYLRERYGLDIRFTGVADSSGALHDPDGLDIRGVLEHKKRAGLGSHPSGYEGMT
GDELLDEAEYDCLVEATPTNIEDGEPGRSLVLKAMGDGKHVVTSNKGHLALFYSELMEAASEAGVEFMFEASVGGAMPII
NLARETLASCTIESVIGILNGTTNFILSRMASEGSSYRQALIEAQELGIAETNPAQDVEGTDAACKAVIIANSILGRPCT
LRDVRVEGITGITQGAIELAAQEGYLIKLIAEISGDRLEVGPRLVRMGSPYAVDGTLNMATLRTDLAGEVTAVGRGAGSL
ETASAMLTDTITIWRKSGGR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=239, Percent_Identity=26.7782426778243, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 35952; Mature: 35952

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVMRICLVGLGAVGQGFLRAVQMKGEYLRERYGLDIRFTGVADSSGALHDPDGLDIRGV
CHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHH
LEHKKRAGLGSHPSGYEGMTGDELLDEAEYDCLVEATPTNIEDGEPGRSLVLKAMGDGKH
HHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHEEEEECCCCCE
VVTSNKGHLALFYSELMEAASEAGVEFMFEASVGGAMPIINLARETLASCTIESVIGILN
EEECCCCCEEHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GTTNFILSRMASEGSSYRQALIEAQELGIAETNPAQDVEGTDAACKAVIIANSILGRPCT
CHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHEEEHHHHCCCCC
LRDVRVEGITGITQGAIELAAQEGYLIKLIAEISGDRLEVGPRLVRMGSPYAVDGTLNMA
EEEEEECCCCCHHHHHHHHHHCCCEEEEEEEHHCCCEEECCCEEEECCCCEEECCCEEHH
TLRTDLAGEVTAVGRGAGSLETASAMLTDTITIWRKSGGR
HHHHCCCCCEEEECCCCCCHHHHHHHHHHHHEEEECCCCC
>Mature Secondary Structure
MRVMRICLVGLGAVGQGFLRAVQMKGEYLRERYGLDIRFTGVADSSGALHDPDGLDIRGV
CHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHH
LEHKKRAGLGSHPSGYEGMTGDELLDEAEYDCLVEATPTNIEDGEPGRSLVLKAMGDGKH
HHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHEEEEECCCCCE
VVTSNKGHLALFYSELMEAASEAGVEFMFEASVGGAMPIINLARETLASCTIESVIGILN
EEECCCCCEEHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GTTNFILSRMASEGSSYRQALIEAQELGIAETNPAQDVEGTDAACKAVIIANSILGRPCT
CHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHEEEHHHHCCCCC
LRDVRVEGITGITQGAIELAAQEGYLIKLIAEISGDRLEVGPRLVRMGSPYAVDGTLNMA
EEEEEECCCCCHHHHHHHHHHCCCEEEEEEEHHCCCEEECCCEEEECCCCEEECCCEEHH
TLRTDLAGEVTAVGRGAGSLETASAMLTDTITIWRKSGGR
HHHHCCCCCEEEECCCCCCHHHHHHHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]