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The map label for this gene is cbiC

Identifier: 15678255

GI number: 15678255

Start: 169994

End: 170614

Strand: Direct

Name: cbiC

Synonym: MTH227

Alternate gene names: 15678255

Gene position: 169994-170614 (Clockwise)

Preceding gene: 15678254

Following gene: 15678256

Centisome position: 9.71

GC content: 54.27

Gene sequence:

>621_bases
TTGATGGGAGCATCCACAGGCCAGGGCTATGAAATAGCAAGGAAGAGCAGGGAGATAGTGAGGGAACTCATCTCCGAGGA
TATATCCTCGCTGGGTCCCGCTGAGGTGGCCATAGTTGAAAGGATAGTCCACTCCACCGCCGACCCGGAATATGCACGTA
TAACAGAATTCAGCCAGGGCTTTGTTGATGAGGCACTCAGATCCCTCAGGAGTTCAGGCGGGATACTCACAGACATTGAA
ATGGTCCGCGCAGGCATATCACATCCCTCCCGGTGCTACATAAGGGAACCCGCTGTGAGGGAGCTTGCAGAGAAAAGGGA
CATCACAAGGGCCGCTGCTTCAATGGAGTACGCCGCCAGCCAGGGATTCCGGGGGATCGTTGTCATAGGCAACGCACCGA
CAGCCCTCATGAAGGTGATTGAACTAACCCTTGAAGGCCTGATGGATGCCAGGGCCGTTATAGGTGTGCCTGTGGGCTTT
GTAGGTGCTGCAGAGTCTAAAGAGGCCCTCAGAGGTACAGAAATACCTCATATGATAACCAGGGGTCCCAAGGGGGGCAC
ACCAGTCGCAGTGGCGGCTGCAAACGCACTCATAGCATTATCCAAGGATAAAGAGGTTTAG

Upstream 100 bases:

>100_bases
GTGCTGAGAGGTTCAACATGACCCTCACAGGACTTAAAAACATAAGGGAGACGGTCCTCTTCCCGAGGGACAGGAGGAGG
CTCACGCCGTAGGTGATAAT

Downstream 100 bases:

>100_bases
AGGTTTTAAAAATGAAGTCAGAGGAACTCTTCAGAAGGGCCAGTAACGTCCTCCCGGGGGGTGTGAGTTCACCTGTGAGG
AGGTTCGACCCCCACCCATT

Product: precorrin-8X methylmutase

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MMGASTGQGYEIARKSREIVRELISEDISSLGPAEVAIVERIVHSTADPEYARITEFSQGFVDEALRSLRSSGGILTDIE
MVRAGISHPSRCYIREPAVRELAEKRDITRAAASMEYAASQGFRGIVVIGNAPTALMKVIELTLEGLMDARAVIGVPVGF
VGAAESKEALRGTEIPHMITRGPKGGTPVAVAAANALIALSKDKEV

Sequences:

>Translated_206_residues
MMGASTGQGYEIARKSREIVRELISEDISSLGPAEVAIVERIVHSTADPEYARITEFSQGFVDEALRSLRSSGGILTDIE
MVRAGISHPSRCYIREPAVRELAEKRDITRAAASMEYAASQGFRGIVVIGNAPTALMKVIELTLEGLMDARAVIGVPVGF
VGAAESKEALRGTEIPHMITRGPKGGTPVAVAAANALIALSKDKEV
>Mature_206_residues
MMGASTGQGYEIARKSREIVRELISEDISSLGPAEVAIVERIVHSTADPEYARITEFSQGFVDEALRSLRSSGGILTDIE
MVRAGISHPSRCYIREPAVRELAEKRDITRAAASMEYAASQGFRGIVVIGNAPTALMKVIELTLEGLMDARAVIGVPVGF
VGAAESKEALRGTEIPHMITRGPKGGTPVAVAAANALIALSKDKEV

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CBIC_METTH (O26329)

Other databases:

- EMBL:   AE000666
- PIR:   B69128
- RefSeq:   NP_275370.1
- ProteinModelPortal:   O26329
- SMR:   O26329
- STRING:   O26329
- GeneID:   1470188
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH227
- NMPDR:   fig|187420.1.peg.225
- eggNOG:   arNOG05874
- HOGENOM:   HBG553498
- OMA:   ACGMVDL
- ProtClustDB:   PRK06264
- BioCyc:   MTHE187420:MTH227-MONOMER
- InterPro:   IPR003722
- Gene3D:   G3DSA:3.40.50.10230

Pfam domain/function: PF02570 CbiC; SSF63965 CbiC

EC number: 5.4.1.2

Molecular weight: Translated: 21904; Mature: 21904

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: ACT_SITE 44-44

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGASTGQGYEIARKSREIVRELISEDISSLGPAEVAIVERIVHSTADPEYARITEFSQG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
FVDEALRSLRSSGGILTDIEMVRAGISHPSRCYIREPAVRELAEKRDITRAAASMEYAAS
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
QGFRGIVVIGNAPTALMKVIELTLEGLMDARAVIGVPVGFVGAAESKEALRGTEIPHMIT
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHH
RGPKGGTPVAVAAANALIALSKDKEV
CCCCCCCCHHHHHHHHHEEECCCCCC
>Mature Secondary Structure
MMGASTGQGYEIARKSREIVRELISEDISSLGPAEVAIVERIVHSTADPEYARITEFSQG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
FVDEALRSLRSSGGILTDIEMVRAGISHPSRCYIREPAVRELAEKRDITRAAASMEYAAS
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
QGFRGIVVIGNAPTALMKVIELTLEGLMDARAVIGVPVGFVGAAESKEALRGTEIPHMIT
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHH
RGPKGGTPVAVAAANALIALSKDKEV
CCCCCCCCHHHHHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463