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Identifier: 15678077

GI number: 15678077

Start: 26230

End: 27279

Strand: Direct

Name: Not Available

Synonym: MTH48

Alternate gene names: 15678077

Gene position: 26230-27279 (Clockwise)

Preceding gene: 15678076

Following gene: 15678078

Centisome position: 1.5

GC content: 52.0

Gene sequence:

>1050_bases
ATGATTTCGGATAGGAAACTGGAGCATCTGATCCTGTGCGCCAGCTGTGATGTTGAGTACAGGAAGAAGACAGGCTTCGA
GGATATTGAGATAGTTCACAGAGCCATACCTGAAATAAACAAGGAAAAGATAGATATAAGCCTTGATTTTCTCGGCAGGG
AATTATCATCTCCTGTAATGATAAGTGCAATCACAGGCGGCCACCCGGCCTCCATGAAGATAAACAGGGAACTTGCCAGG
GCGGCAGAGAAACTTGGAATAGCACTTGGACTTGGAAGTCAGAGGGCCGGGGTGGAGCACCCTGAACTTGAGGGGACCTA
CACCATCGCAAGGGAGGAGGCACCCTCAGCAATGCTCATAGGTAACATTGGAAGTTCACATATCGAATACGCTGAAAGGG
CCGTGGAGATGATAGATGCAGACGCCCTGGCAGTGCACCTCAACCCACTCCAGGAGTCCATACAGCCCGGAGGAGACGTT
GACTCATCAGGGGCCCTCGAGTCCATATCAGCAATAGTTGAGTCAGTGGACGTCCCGGTAATGGTGAAGGAGACAGGGGC
AGGTATATGCTCAGAGGATGCCATTGAACTTGAATCCTGTGGTGTATCAGCCATAGATGTTGCAGGTGCAGGCGGCACCA
GCTGGGCTGCCGTGGAAACATACCGGGCGGATGACAGGTACCTCGGAGAACTCTTCTGGGACTGGGGCATACCAACCGCT
GCAAGCACCGTGGAGGTCGTGGAATCTGTCAGCATCCCGGTAATAGCATCAGGGGGTATCAGGAGCGGGATCGACGCCGC
CAAGGCAATATCCCTCGGTGCAGAAATGGTGGGGATTGCACTCCCGGTCCTTGAAGCAGCGGGGCATGGCTACAGGGAAG
TTATTAAGGTAATTGAGGGATTCAATGAGGCCCTCAGGACTGCAATGTACCTGGCAGGTGCAGAGACACTTGACGATCTT
AAAAAATCACCAGTCATAATAACAGGCCATACAGGAGAATGGCTGAACCAAAGGGGCTTTGAAACTAAAAAATACGCCAG
GAGGTCATAA

Upstream 100 bases:

>100_bases
GGCACAAGAATCACAGGGAAACATTGAGGACATTCACGATTATCAATCAACATTCAAAGGAATTTATAGGGTGATGGAAA
ATTTTTAAGGGCGTTAAAAT

Downstream 100 bases:

>100_bases
TTTGAGCGTAGAAGTAATTGCGATCGGCGGATACGAGGAAGTTGGTAAGAACATGTCCGCCGTTAAGGTAGGAGATGACG
TTGTAATATTTGATATGGGG

Product: isopentenyl pyrophosphate isomerase

Products: NA

Alternate protein names: IPP isomerase; Isopentenyl pyrophosphate isomerase

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MISDRKLEHLILCASCDVEYRKKTGFEDIEIVHRAIPEINKEKIDISLDFLGRELSSPVMISAITGGHPASMKINRELAR
AAEKLGIALGLGSQRAGVEHPELEGTYTIAREEAPSAMLIGNIGSSHIEYAERAVEMIDADALAVHLNPLQESIQPGGDV
DSSGALESISAIVESVDVPVMVKETGAGICSEDAIELESCGVSAIDVAGAGGTSWAAVETYRADDRYLGELFWDWGIPTA
ASTVEVVESVSIPVIASGGIRSGIDAAKAISLGAEMVGIALPVLEAAGHGYREVIKVIEGFNEALRTAMYLAGAETLDDL
KKSPVIITGHTGEWLNQRGFETKKYARRS

Sequences:

>Translated_349_residues
MISDRKLEHLILCASCDVEYRKKTGFEDIEIVHRAIPEINKEKIDISLDFLGRELSSPVMISAITGGHPASMKINRELAR
AAEKLGIALGLGSQRAGVEHPELEGTYTIAREEAPSAMLIGNIGSSHIEYAERAVEMIDADALAVHLNPLQESIQPGGDV
DSSGALESISAIVESVDVPVMVKETGAGICSEDAIELESCGVSAIDVAGAGGTSWAAVETYRADDRYLGELFWDWGIPTA
ASTVEVVESVSIPVIASGGIRSGIDAAKAISLGAEMVGIALPVLEAAGHGYREVIKVIEGFNEALRTAMYLAGAETLDDL
KKSPVIITGHTGEWLNQRGFETKKYARRS
>Mature_349_residues
MISDRKLEHLILCASCDVEYRKKTGFEDIEIVHRAIPEINKEKIDISLDFLGRELSSPVMISAITGGHPASMKINRELAR
AAEKLGIALGLGSQRAGVEHPELEGTYTIAREEAPSAMLIGNIGSSHIEYAERAVEMIDADALAVHLNPLQESIQPGGDV
DSSGALESISAIVESVDVPVMVKETGAGICSEDAIELESCGVSAIDVAGAGGTSWAAVETYRADDRYLGELFWDWGIPTA
ASTVEVVESVSIPVIASGGIRSGIDAAKAISLGAEMVGIALPVLEAAGHGYREVIKVIEGFNEALRTAMYLAGAETLDDL
KKSPVIITGHTGEWLNQRGFETKKYARRS

Specific function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IPP isomerase type 2 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IDI2_METTH (O26154)

Other databases:

- EMBL:   AE000666
- PIR:   H69162
- RefSeq:   NP_275191.1
- ProteinModelPortal:   O26154
- SMR:   O26154
- STRING:   O26154
- GeneID:   1470010
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH48
- NMPDR:   fig|187420.1.peg.46
- eggNOG:   arNOG04310
- HOGENOM:   HBG354479
- OMA:   GSQRAAI
- ProtClustDB:   PRK05437
- BioCyc:   MTHE187420:MTH48-MONOMER
- BRENDA:   5.3.3.2
- GO:   GO:0005737
- HAMAP:   MF_00354
- InterPro:   IPR013785
- InterPro:   IPR000262
- InterPro:   IPR011179
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR10578:SF3
- PIRSF:   PIRSF003314
- TIGRFAMs:   TIGR02151

Pfam domain/function: PF01070 FMN_dh

EC number: =5.3.3.2

Molecular weight: Translated: 37143; Mature: 37143

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISDRKLEHLILCASCDVEYRKKTGFEDIEIVHRAIPEINKEKIDISLDFLGRELSSPVM
CCCCCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCEE
ISAITGGHPASMKINRELARAAEKLGIALGLGSQRAGVEHPELEGTYTIAREEAPSAMLI
EEEECCCCCCCEEEHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEE
GNIGSSHIEYAERAVEMIDADALAVHLNPLQESIQPGGDVDSSGALESISAIVESVDVPV
ECCCCHHHHHHHHHHHHHCCCEEEEEECHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCE
MVKETGAGICSEDAIELESCGVSAIDVAGAGGTSWAAVETYRADDRYLGELFWDWGIPTA
EEECCCCCCCCCCCHHHHHCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCH
ASTVEVVESVSIPVIASGGIRSGIDAAKAISLGAEMVGIALPVLEAAGHGYREVIKVIEG
HHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FNEALRTAMYLAGAETLDDLKKSPVIITGHTGEWLNQRGFETKKYARRS
HHHHHHHHHHHHCHHHHHHHHCCCEEEECCCCHHHHHCCCCHHHHHCCC
>Mature Secondary Structure
MISDRKLEHLILCASCDVEYRKKTGFEDIEIVHRAIPEINKEKIDISLDFLGRELSSPVM
CCCCCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCEE
ISAITGGHPASMKINRELARAAEKLGIALGLGSQRAGVEHPELEGTYTIAREEAPSAMLI
EEEECCCCCCCEEEHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEE
GNIGSSHIEYAERAVEMIDADALAVHLNPLQESIQPGGDVDSSGALESISAIVESVDVPV
ECCCCHHHHHHHHHHHHHCCCEEEEEECHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCE
MVKETGAGICSEDAIELESCGVSAIDVAGAGGTSWAAVETYRADDRYLGELFWDWGIPTA
EEECCCCCCCCCCCHHHHHCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCH
ASTVEVVESVSIPVIASGGIRSGIDAAKAISLGAEMVGIALPVLEAAGHGYREVIKVIEG
HHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FNEALRTAMYLAGAETLDDLKKSPVIITGHTGEWLNQRGFETKKYARRS
HHHHHHHHHHHHCHHHHHHHHCCCEEEECCCCHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463