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Identifier: 15678078

GI number: 15678078

Start: 27281

End: 28633

Strand: Direct

Name: Not Available

Synonym: MTH49

Alternate gene names: NA

Gene position: 27281-28633 (Clockwise)

Preceding gene: 15678077

Following gene: 15678079

Centisome position: 1.56

GC content: 52.62

Gene sequence:

>1353_bases
TTGAGCGTAGAAGTAATTGCGATCGGCGGATACGAGGAAGTTGGTAAGAACATGTCCGCCGTTAAGGTAGGAGATGACGT
TGTAATATTTGATATGGGGATTCACCTTGACAGGGTTCACATACATGAGGACACAGATATAGCAAGGATGCACAGCCTCG
ACCTCATTGAGAGGGGGGTCATCCCCGACGATACCCTCATGAAGGACGTTGACGGGAAGGTCAGGGCCATAGTATTCACC
CATGGGCACCTTGACCATATAGGGGCAGTTGCAAAACTCGCCCACAGGTACCAGGCGCCCATAATAGCAACACCCTACAC
CATAGCACTCATAGAGAGAACAATAAAGGCTGAGAGGAAGTTCAACGTCCTCAACACACTCCAGGTACTGAACGCCGGGG
AGAAGTGTCAGATATCACCGGGTATAACCCTGGAGTTCATCCAGTCAACCCACAGCATACCCCAGTCAGTGATAGCAGCC
CTGCACACACCGGAGGGCATAATAGTCTATGCACTGGACTTCAAATTCGACGACCACCAGAAGATATCCCCACCACCAGA
CTACCACCGTCTCAGGGAACTTGGAAGGAAGGGCGTCCTCGCCATGATAGTCGAGACAACAAGGGCCAATGAGAAGCAGG
AGGTCAAGACCCACTCAGAGAAGGTTGCAAGGATAGTCCTGGAGGACATAATGAAGAACCCCCTGGAGGAGAAGACCGGG
ATGATCGTGACAACCTTCTCATCCCACATGGAACGTATACAGGCCATAAGTGACATAGCATCAAAGAGCGACAGGCAGAT
GCTTCTCCTGGGAAGGTCAATGGAGCGCTACTGTGGACTCGCAGAGGCAATGGGGATCCTGAAACTCCCTGAGAATGCGA
GCATATATGGAAGTCCCAAGGCAGTTAACAGGGCCCTTGCACGTGCAGAGGCAAAGCGCGAGGACTACCTCCTCATAACC
ACGGGACATCAGGGGGAACCCGACGCACTGCTCCCAAGGATAGCCAATGCAAAGACCCAGTTCAGGATACAGAGGGGTGA
TAATGTTGTGATATCAGCCCCGGTCATCCCGAACCCCATGAACGTTGCCAACAGGAACCTGATGGAGAGGCGTCTGGCAT
CAAGCGGTGCCAGGATCTACACCAACGCCCATGTGTCAGGGCATGCTGGAAGGGAGGACCACAGGGACTTCATAAGAATG
CTGAACCCCATGCACATAATACCTGCCCACGGTGACCTGAGCATGCTCTCGGCCTACGCAGAGATAGCAGAGGAGGAGGG
CTACAAGCTGGGTAACGATATACATATCCTAAGGAATGGACAGGCACAGGTCTTTAATGGAGGTATCCGATGA

Upstream 100 bases:

>100_bases
GACGATCTTAAAAAATCACCAGTCATAATAACAGGCCATACAGGAGAATGGCTGAACCAAAGGGGCTTTGAAACTAAAAA
ATACGCCAGGAGGTCATAAT

Downstream 100 bases:

>100_bases
TGGAAGTAATGGATATTCTAAGGAAGTACTCTGAAATGGCTGATGAGAGGATAAGGGAGTCCATCAGTGACATAACACCC
GAGACGTTACTCAGAGCATC

Product: hypothetical protein

Products: NA

Alternate protein names: RNase J [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSVEVIAIGGYEEVGKNMSAVKVGDDVVIFDMGIHLDRVHIHEDTDIARMHSLDLIERGVIPDDTLMKDVDGKVRAIVFT
HGHLDHIGAVAKLAHRYQAPIIATPYTIALIERTIKAERKFNVLNTLQVLNAGEKCQISPGITLEFIQSTHSIPQSVIAA
LHTPEGIIVYALDFKFDDHQKISPPPDYHRLRELGRKGVLAMIVETTRANEKQEVKTHSEKVARIVLEDIMKNPLEEKTG
MIVTTFSSHMERIQAISDIASKSDRQMLLLGRSMERYCGLAEAMGILKLPENASIYGSPKAVNRALARAEAKREDYLLIT
TGHQGEPDALLPRIANAKTQFRIQRGDNVVISAPVIPNPMNVANRNLMERRLASSGARIYTNAHVSGHAGREDHRDFIRM
LNPMHIIPAHGDLSMLSAYAEIAEEEGYKLGNDIHILRNGQAQVFNGGIR

Sequences:

>Translated_450_residues
MSVEVIAIGGYEEVGKNMSAVKVGDDVVIFDMGIHLDRVHIHEDTDIARMHSLDLIERGVIPDDTLMKDVDGKVRAIVFT
HGHLDHIGAVAKLAHRYQAPIIATPYTIALIERTIKAERKFNVLNTLQVLNAGEKCQISPGITLEFIQSTHSIPQSVIAA
LHTPEGIIVYALDFKFDDHQKISPPPDYHRLRELGRKGVLAMIVETTRANEKQEVKTHSEKVARIVLEDIMKNPLEEKTG
MIVTTFSSHMERIQAISDIASKSDRQMLLLGRSMERYCGLAEAMGILKLPENASIYGSPKAVNRALARAEAKREDYLLIT
TGHQGEPDALLPRIANAKTQFRIQRGDNVVISAPVIPNPMNVANRNLMERRLASSGARIYTNAHVSGHAGREDHRDFIRM
LNPMHIIPAHGDLSMLSAYAEIAEEEGYKLGNDIHILRNGQAQVFNGGIR
>Mature_449_residues
SVEVIAIGGYEEVGKNMSAVKVGDDVVIFDMGIHLDRVHIHEDTDIARMHSLDLIERGVIPDDTLMKDVDGKVRAIVFTH
GHLDHIGAVAKLAHRYQAPIIATPYTIALIERTIKAERKFNVLNTLQVLNAGEKCQISPGITLEFIQSTHSIPQSVIAAL
HTPEGIIVYALDFKFDDHQKISPPPDYHRLRELGRKGVLAMIVETTRANEKQEVKTHSEKVARIVLEDIMKNPLEEKTGM
IVTTFSSHMERIQAISDIASKSDRQMLLLGRSMERYCGLAEAMGILKLPENASIYGSPKAVNRALARAEAKREDYLLITT
GHQGEPDALLPRIANAKTQFRIQRGDNVVISAPVIPNPMNVANRNLMERRLASSGARIYTNAHVSGHAGREDHRDFIRML
NPMHIIPAHGDLSMLSAYAEIAEEEGYKLGNDIHILRNGQAQVFNGGIR

Specific function: Unknown

COG id: COG0595

COG function: function code R; Predicted hydrolase of the metallo-beta-lactamase superfamily

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. RNase J subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR011108
- InterPro:   IPR004613
- InterPro:   IPR001587 [H]

Pfam domain/function: PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 49984; Mature: 49853

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEVIAIGGYEEVGKNMSAVKVGDDVVIFDMGIHLDRVHIHEDTDIARMHSLDLIERGV
CCEEEEEECCHHHHCCCCEEEEECCCEEEEEECCEEEEEEEECCCCHHHHHHHHHHHCCC
IPDDTLMKDVDGKVRAIVFTHGHLDHIGAVAKLAHRYQAPIIATPYTIALIERTIKAERK
CCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHH
FNVLNTLQVLNAGEKCQISPGITLEFIQSTHSIPQSVIAALHTPEGIIVYALDFKFDDHQ
HHHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCHHHHHHHHCCCCCEEEEEEEEEECCCC
KISPPPDYHRLRELGRKGVLAMIVETTRANEKQEVKTHSEKVARIVLEDIMKNPLEEKTG
CCCCCCCHHHHHHHCCCCEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
MIVTTFSSHMERIQAISDIASKSDRQMLLLGRSMERYCGLAEAMGILKLPENASIYGSPK
EEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCHHHHCCEEECCCCCCCCCCHH
AVNRALARAEAKREDYLLITTGHQGEPDALLPRIANAKTQFRIQRGDNVVISAPVIPNPM
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCC
NVANRNLMERRLASSGARIYTNAHVSGHAGREDHRDFIRMLNPMHIIPAHGDLSMLSAYA
CHHHHHHHHHHHHCCCCEEEEECEECCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHH
EIAEEEGYKLGNDIHILRNGQAQVFNGGIR
HHHHHCCCCCCCEEEEEECCCEEEECCCCC
>Mature Secondary Structure 
SVEVIAIGGYEEVGKNMSAVKVGDDVVIFDMGIHLDRVHIHEDTDIARMHSLDLIERGV
CEEEEEECCHHHHCCCCEEEEECCCEEEEEECCEEEEEEEECCCCHHHHHHHHHHHCCC
IPDDTLMKDVDGKVRAIVFTHGHLDHIGAVAKLAHRYQAPIIATPYTIALIERTIKAERK
CCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHH
FNVLNTLQVLNAGEKCQISPGITLEFIQSTHSIPQSVIAALHTPEGIIVYALDFKFDDHQ
HHHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCHHHHHHHHCCCCCEEEEEEEEEECCCC
KISPPPDYHRLRELGRKGVLAMIVETTRANEKQEVKTHSEKVARIVLEDIMKNPLEEKTG
CCCCCCCHHHHHHHCCCCEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
MIVTTFSSHMERIQAISDIASKSDRQMLLLGRSMERYCGLAEAMGILKLPENASIYGSPK
EEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCHHHHCCEEECCCCCCCCCCHH
AVNRALARAEAKREDYLLITTGHQGEPDALLPRIANAKTQFRIQRGDNVVISAPVIPNPM
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCC
NVANRNLMERRLASSGARIYTNAHVSGHAGREDHRDFIRMLNPMHIIPAHGDLSMLSAYA
CHHHHHHHHHHHHCCCCEEEEECEECCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHH
EIAEEEGYKLGNDIHILRNGQAQVFNGGIR
HHHHHCCCCCCCEEEEEECCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]