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The map label for this gene is ubiE

Identifier: 15646092

GI number: 15646092

Start: 1556519

End: 1557259

Strand: Reverse

Name: ubiE

Synonym: HP1483

Alternate gene names: 15646092

Gene position: 1557259-1556519 (Counterclockwise)

Preceding gene: 15646093

Following gene: 15646091

Centisome position: 93.37

GC content: 39.27

Gene sequence:

>741_bases
ATGAAAAAAGAAAAGCATCTCAAGCAAGAAAAAATCATCAACATGTTTGATGATATAGCCAGCTCTTACGATCAAGCCAA
CCGCTTGATGAGTTTTGGCTTAGACGTTAAATGGCGAGAAAGGGCTTGCGAGCATGCGTTTTTATTTTTAGAAAACAAGA
AAGCGTTAAGGCTTGTGGATGTGGCATGCGGGACGGGGGATATGCTTGTGGCTTGGCAAAAAAGCGCTCTCAATTGCGGT
ATAGAGTTTAAGGAATGTTTGGGGATTGACCCCTCTAATAACATGCTTGAATTAGCCATCAAAAAATGTGAAGAGCTTGA
AAACAAAGCTTCTTTCATCCAAGCTCAAGCCAAAGATTTAAAAGGCGTTGAAAATAACAGCGTGGATATCCTCTCTATTG
CGTATGGCTTGCGTAATGTCGTGGAAAGACAAGAGGCCTTAAAAGAGTTTTTTAGGGTGTTAAAACCCAGGGGCGTTTTA
GTGATTTTAGAATTTTTAAAAAAAGACAACCCCACATGGCTGGATAAAATCTCAGGGTTTTACACGAATAAGGTTTTGCC
TTTAGTGGGAGGGGCTATCAGTAAGAATTATGGTGCTTATTCTTATTTACCGCAATCCATTGAGGGGTTTTTGAGTTTAG
AGGGTTTGAAGCATGAATTAAGAAACGCAGGGTTTGAGATTTTAAGGACTGAAGATTCTATCGCTCAAATTTCAACGACC
ATGCTTGTTAAAAAAAACTAA

Upstream 100 bases:

>100_bases
ATCGCGTGTTTAATGAGGCGCCAACGATTTTAATGATCCTCATTGTGATTTTAGTGGTTGTCAAGCCTTTTTAAAGACAA
GCCATGAAAAAAGAAAAGTC

Downstream 100 bases:

>100_bases
AGGAATGTTATGCAAGATGAATTATTTGAAACCGAAAAAATCCCCCCAAAAAACACTAAAAATACTAAAAACGCCCCTAA
AAAAAGTTTTGAAGAGCATG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKKEKHLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVDVACGTGDMLVAWQKSALNCG
IEFKECLGIDPSNNMLELAIKKCEELENKASFIQAQAKDLKGVENNSVDILSIAYGLRNVVERQEALKEFFRVLKPRGVL
VILEFLKKDNPTWLDKISGFYTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLEGLKHELRNAGFEILRTEDSIAQISTT
MLVKKN

Sequences:

>Translated_246_residues
MKKEKHLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVDVACGTGDMLVAWQKSALNCG
IEFKECLGIDPSNNMLELAIKKCEELENKASFIQAQAKDLKGVENNSVDILSIAYGLRNVVERQEALKEFFRVLKPRGVL
VILEFLKKDNPTWLDKISGFYTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLEGLKHELRNAGFEILRTEDSIAQISTT
MLVKKN
>Mature_246_residues
MKKEKHLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVDVACGTGDMLVAWQKSALNCG
IEFKECLGIDPSNNMLELAIKKCEELENKASFIQAQAKDLKGVENNSVDILSIAYGLRNVVERQEALKEFFRVLKPRGVL
VILEFLKKDNPTWLDKISGFYTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLEGLKHELRNAGFEILRTEDSIAQISTT
MLVKKN

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=265, Percent_Identity=28.3018867924528, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI48994983, Length=226, Percent_Identity=30.5309734513274, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17557039, Length=229, Percent_Identity=27.0742358078603, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6323526, Length=232, Percent_Identity=30.1724137931034, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24641702, Length=238, Percent_Identity=28.1512605042017, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27872; Mature: 27872

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEKHLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCEEEEE
VACGTGDMLVAWQKSALNCGIEFKECLGIDPSNNMLELAIKKCEELENKASFIQAQAKDL
EECCCCCEEEEEEHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KGVENNSVDILSIAYGLRNVVERQEALKEFFRVLKPRGVLVILEFLKKDNPTWLDKISGF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
YTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLEGLKHELRNAGFEILRTEDSIAQISTT
HHCCHHHHHCCHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
MLVKKN
HEEECC
>Mature Secondary Structure
MKKEKHLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCEEEEE
VACGTGDMLVAWQKSALNCGIEFKECLGIDPSNNMLELAIKKCEELENKASFIQAQAKDL
EECCCCCEEEEEEHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KGVENNSVDILSIAYGLRNVVERQEALKEFFRVLKPRGVLVILEFLKKDNPTWLDKISGF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
YTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLEGLKHELRNAGFEILRTEDSIAQISTT
HHCCHHHHHCCHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
MLVKKN
HEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA