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Identifier: 15646037

GI number: 15646037

Start: 1497367

End: 1498440

Strand: Reverse

Name: Not Available

Synonym: HP1428

Alternate gene names: 15646037

Gene position: 1498440-1497367 (Counterclockwise)

Preceding gene: 15646038

Following gene: 15646036

Centisome position: 89.84

GC content: 38.83

Gene sequence:

>1074_bases
ATGAAAGCTAGTATTTATGATTTCACTCTAAAGGAATTGAGCCAGCTTTTAAAACCAAGCTTTAGGGCTAAACAGCTTTA
TTTGTGGCTCTATGCGAAGTATAAAACAAGCTTTAAGGACATGCAAAATAATTTTTCAAAAGATTTTATCGCTTATTTGG
AGCGAGAATTTGCTTTGCGCACGATAGAAATCACGCATGTGAGGGAGAGCGTTGATGGCTCTAAAAAATACCTTTTTAAA
TCTTTAAGAGACAACCACACTTTTGAAGCGGTGTTGTTGAAAATGAAGGATAAAAAGATTGATGCAGAAACGAACGCTAT
TTTAGAGAGGGAAAAATACACCGTATGCGTGTCTTGTCAAATCGGCTGTCAAGTGGGTTGCTCGTTTTGTTTCACTCAAA
AAGGCGGTTTTGTAAGGAACTTAAAAGCGAGCGAGATCATCCAACAAGCCCTACTCATTAAAGAAGACAACAACCTCCCC
CTTGAAAAAGCGCTCAACATTGTTTTTATGGGAATGGGCGAGCCTTTAAACAATTTAGATGAGGTGTGTAAAGCGATTGA
GATTTTCAATACCGGCATGCAAATTTCGCCTAAAAGAATCACCATTTCCACTAGCGGCGTAGCCGATAAAATCCCTATTT
TAGCGGGCAAAAACTTAGGCGTGCAATTAGCCATATCCTTACACGCCGTAGATGACAAAACGCGCTCGTCTTTAATGCCC
TTGAATAAAAAATACAATATTGAATGCGTTTTGAATGAAGTGAGGAAATGGCCTTTAGAGCAGCGCAAAAGAGTGATGTT
TGAATACCTTTTGATCAAAGATTTGAACGATAGCCTAGACTGCGCTAAAAAACTTTTAAAACTTTTAAACGGCATTAAAT
CCAAAGTGAATTTGATCTTATTCAACCCGCATGAAGGCTCTAAGTTTGAACGCCCTAGCTTAGAGAACGCTAGAATGTTT
GCGGATTTTTTAAACTCTAAAGGCTTATTATGCACCATTAGAGAGTCTAAAGCCTTGGATATTGAAGCGGCTTGCGGGCA
GTTGAGGGAGAAAAAACTCTCTCAGCAAATTTGA

Upstream 100 bases:

>100_bases
TAGAGCGCCATAAGATCCAGCTTTTAGTGTGCGTAGATGATCATAATAAGGTTTTAGGGGTCTTGCACTTGCACCAACTT
TTAGAATTAGGGCTTAAAGC

Downstream 100 bases:

>100_bases
AAACTTTTTTGTGGTGTTTGTCTTTTTTCTAATGGGGGGTGTTGGTTTTAGTCAAGCGATAATTCAAAATTTAGGGAATA
TGGATTAAAAATTAGCACTA

Product: ribosomal RNA large subunit methyltransferase N

Products: NA

Alternate protein names: 23S rRNA m2A2503 methyltransferase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKASIYDFTLKELSQLLKPSFRAKQLYLWLYAKYKTSFKDMQNNFSKDFIAYLEREFALRTIEITHVRESVDGSKKYLFK
SLRDNHTFEAVLLKMKDKKIDAETNAILEREKYTVCVSCQIGCQVGCSFCFTQKGGFVRNLKASEIIQQALLIKEDNNLP
LEKALNIVFMGMGEPLNNLDEVCKAIEIFNTGMQISPKRITISTSGVADKIPILAGKNLGVQLAISLHAVDDKTRSSLMP
LNKKYNIECVLNEVRKWPLEQRKRVMFEYLLIKDLNDSLDCAKKLLKLLNGIKSKVNLILFNPHEGSKFERPSLENARMF
ADFLNSKGLLCTIRESKALDIEAACGQLREKKLSQQI

Sequences:

>Translated_357_residues
MKASIYDFTLKELSQLLKPSFRAKQLYLWLYAKYKTSFKDMQNNFSKDFIAYLEREFALRTIEITHVRESVDGSKKYLFK
SLRDNHTFEAVLLKMKDKKIDAETNAILEREKYTVCVSCQIGCQVGCSFCFTQKGGFVRNLKASEIIQQALLIKEDNNLP
LEKALNIVFMGMGEPLNNLDEVCKAIEIFNTGMQISPKRITISTSGVADKIPILAGKNLGVQLAISLHAVDDKTRSSLMP
LNKKYNIECVLNEVRKWPLEQRKRVMFEYLLIKDLNDSLDCAKKLLKLLNGIKSKVNLILFNPHEGSKFERPSLENARMF
ADFLNSKGLLCTIRESKALDIEAACGQLREKKLSQQI
>Mature_357_residues
MKASIYDFTLKELSQLLKPSFRAKQLYLWLYAKYKTSFKDMQNNFSKDFIAYLEREFALRTIEITHVRESVDGSKKYLFK
SLRDNHTFEAVLLKMKDKKIDAETNAILEREKYTVCVSCQIGCQVGCSFCFTQKGGFVRNLKASEIIQQALLIKEDNNLP
LEKALNIVFMGMGEPLNNLDEVCKAIEIFNTGMQISPKRITISTSGVADKIPILAGKNLGVQLAISLHAVDDKTRSSLMP
LNKKYNIECVLNEVRKWPLEQRKRVMFEYLLIKDLNDSLDCAKKLLKLLNGIKSKVNLILFNPHEGSKFERPSLENARMF
ADFLNSKGLLCTIRESKALDIEAACGQLREKKLSQQI

Specific function: Specifically methylates position 2 of adenine 2503 in 23S rRNA [H]

COG id: COG0820

COG function: function code R; Predicted Fe-S-cluster redox enzyme

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. RlmN family [H]

Homologues:

Organism=Escherichia coli, GI1788865, Length=361, Percent_Identity=35.1800554016621, Blast_Score=199, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007197
- InterPro:   IPR004383 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =2.1.1.192 [H]

Molecular weight: Translated: 40814; Mature: 40814

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKASIYDFTLKELSQLLKPSFRAKQLYLWLYAKYKTSFKDMQNNFSKDFIAYLEREFALR
CCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHE
TIEITHVRESVDGSKKYLFKSLRDNHTFEAVLLKMKDKKIDAETNAILEREKYTVCVSCQ
EEEEEHHHHHCCCHHHHHHHHHCCCCCCHHHHEEHHCCCCCCHHHHHHCCCCEEEEEEEE
IGCQVGCSFCFTQKGGFVRNLKASEIIQQALLIKEDNNLPLEKALNIVFMGMGEPLNNLD
ECCCCCCCEEEECCCCCEECCCHHHHHHHHHHEECCCCCCHHHCCCEEEEECCCCCHHHH
EVCKAIEIFNTGMQISPKRITISTSGVADKIPILAGKNLGVQLAISLHAVDDKTRSSLMP
HHHHHHHHHCCCCEECCCEEEEEECCCCCCCCEEECCCCCEEEEEEEEECCCHHHHHCCC
LNKKYNIECVLNEVRKWPLEQRKRVMFEYLLIKDLNDSLDCAKKLLKLLNGIKSKVNLIL
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEE
FNPHEGSKFERPSLENARMFADFLNSKGLLCTIRESKALDIEAACGQLREKKLSQQI
ECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKASIYDFTLKELSQLLKPSFRAKQLYLWLYAKYKTSFKDMQNNFSKDFIAYLEREFALR
CCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHE
TIEITHVRESVDGSKKYLFKSLRDNHTFEAVLLKMKDKKIDAETNAILEREKYTVCVSCQ
EEEEEHHHHHCCCHHHHHHHHHCCCCCCHHHHEEHHCCCCCCHHHHHHCCCCEEEEEEEE
IGCQVGCSFCFTQKGGFVRNLKASEIIQQALLIKEDNNLPLEKALNIVFMGMGEPLNNLD
ECCCCCCCEEEECCCCCEECCCHHHHHHHHHHEECCCCCCHHHCCCEEEEECCCCCHHHH
EVCKAIEIFNTGMQISPKRITISTSGVADKIPILAGKNLGVQLAISLHAVDDKTRSSLMP
HHHHHHHHHCCCCEECCCEEEEEECCCCCCCCEEECCCCCEEEEEEEEECCCHHHHHCCC
LNKKYNIECVLNEVRKWPLEQRKRVMFEYLLIKDLNDSLDCAKKLLKLLNGIKSKVNLIL
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEE
FNPHEGSKFERPSLENARMFADFLNSKGLLCTIRESKALDIEAACGQLREKKLSQQI
ECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA