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Identifier: 15646038

GI number: 15646038

Start: 1498437

End: 1499426

Strand: Reverse

Name: Not Available

Synonym: HP1429

Alternate gene names: 15646038

Gene position: 1499426-1498437 (Counterclockwise)

Preceding gene: 15646039

Following gene: 15646037

Centisome position: 89.9

GC content: 42.22

Gene sequence:

>990_bases
ATGCCCATTCTTTTTGATTGTAACGCTATTGCTTCACAAGTTTTAAAAGATGAAGCGAGCGCGCTTTTAGAAAGCGTTGG
ACAATTCCAAAAACCCAACGATTTAGAAGCGATTGTCAAACTCATTTTAAAAAGCCAAGAAAATGGGGGTAAGCTTGTGA
TAGTGGGTGTGGGTAAGAGCGCTTTAGTGGCGCAAAAAATCGTTGCTTCCATGCTAAGCACCGGTAACAGGAGCGCGTTT
TTACACCCCACAGAAGCCATGCATGGGGATTTGGGCATGGTGGAAAAAAACGATGTGGTTTTAATGATTAGCTATGGGGG
CGAGTCTTTAGAATTATTGAATCTGGTGAGCCATTTAAAACGCTTGAGCCATAAAATCATCACTTTCACTAAAAGCCCTA
ATAGCTCGCTCTCTAAACTCGGCGATTATTATTTGAGCTTGAAAATTCAAAAAGAAGCTTGCCCGATTAACACCGCTCCA
ACGACTTCTACCACCCTAACTCTAGCGTTAGGCGATGTTTTAATGGCATGCTTGATGCGAGCGAAAAACTTTAGCCAAGA
AGATTTTGCCTCCTTTCATCCGGGCGGGCTTTTAGGCAAAAAACTTTTTGTCAAGGTTAAAGATTTACTGCAAACCACGA
ACCTCCCCCTAATCGCTCCTAGCACAAGTTTTAAAGACGCGCTCATAGAAATGAGTGAAAAACGCTTAGGCAGCGCGATT
TTAGTCAATGAAGCTAACGAGCTTGTGGGGGTGTTAAGCGATGGCGATGTCCGTAGGGCGTTATTAAAAGGGGTGAGTTT
AAAGAGCGAAGTGAGGCATTTTGCCACTTTAAAACCTAAAAGCTTTAAGAATTTAGACGCTCTTCTTTTAGAAGCGTTGG
AATTTTTAGAGCGCCATAAGATCCAGCTTTTAGTGTGCGTAGATGATCATAATAAGGTTTTAGGGGTCTTGCACTTGCAC
CAACTTTTAGAATTAGGGCTTAAAGCATGA

Upstream 100 bases:

>100_bases
GAAATTTTGAATAACCCTAAAAAATTAGAAGATCACACTCGTAATTTCATCAGAAAAGCGCTCTTTAAAAAGTTTAGAAA
ATACCCGGCTATCATTTGTC

Downstream 100 bases:

>100_bases
AAGCTAGTATTTATGATTTCACTCTAAAGGAATTGAGCCAGCTTTTAAAACCAAGCTTTAGGGCTAAACAGCTTTATTTG
TGGCTCTATGCGAAGTATAA

Product: polysialic acid capsule expression protein (kpsF)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MPILFDCNAIASQVLKDEASALLESVGQFQKPNDLEAIVKLILKSQENGGKLVIVGVGKSALVAQKIVASMLSTGNRSAF
LHPTEAMHGDLGMVEKNDVVLMISYGGESLELLNLVSHLKRLSHKIITFTKSPNSSLSKLGDYYLSLKIQKEACPINTAP
TTSTTLTLALGDVLMACLMRAKNFSQEDFASFHPGGLLGKKLFVKVKDLLQTTNLPLIAPSTSFKDALIEMSEKRLGSAI
LVNEANELVGVLSDGDVRRALLKGVSLKSEVRHFATLKPKSFKNLDALLLEALEFLERHKIQLLVCVDDHNKVLGVLHLH
QLLELGLKA

Sequences:

>Translated_329_residues
MPILFDCNAIASQVLKDEASALLESVGQFQKPNDLEAIVKLILKSQENGGKLVIVGVGKSALVAQKIVASMLSTGNRSAF
LHPTEAMHGDLGMVEKNDVVLMISYGGESLELLNLVSHLKRLSHKIITFTKSPNSSLSKLGDYYLSLKIQKEACPINTAP
TTSTTLTLALGDVLMACLMRAKNFSQEDFASFHPGGLLGKKLFVKVKDLLQTTNLPLIAPSTSFKDALIEMSEKRLGSAI
LVNEANELVGVLSDGDVRRALLKGVSLKSEVRHFATLKPKSFKNLDALLLEALEFLERHKIQLLVCVDDHNKVLGVLHLH
QLLELGLKA
>Mature_328_residues
PILFDCNAIASQVLKDEASALLESVGQFQKPNDLEAIVKLILKSQENGGKLVIVGVGKSALVAQKIVASMLSTGNRSAFL
HPTEAMHGDLGMVEKNDVVLMISYGGESLELLNLVSHLKRLSHKIITFTKSPNSSLSKLGDYYLSLKIQKEACPINTAPT
TSTTLTLALGDVLMACLMRAKNFSQEDFASFHPGGLLGKKLFVKVKDLLQTTNLPLIAPSTSFKDALIEMSEKRLGSAIL
VNEANELVGVLSDGDVRRALLKGVSLKSEVRHFATLKPKSFKNLDALLLEALEFLERHKIQLLVCVDDHNKVLGVLHLHQ
LLELGLKA

Specific function: Unknown

COG id: COG0794

COG function: function code M; Predicted sugar phosphate isomerase involved in capsule formation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1789588, Length=326, Percent_Identity=39.2638036809816, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082151, Length=311, Percent_Identity=36.0128617363344, Blast_Score=200, Evalue=9e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1429_HELPY (O25971)

Other databases:

- EMBL:   AE000511
- PIR:   E64698
- RefSeq:   NP_208220.1
- ProteinModelPortal:   O25971
- GeneID:   899866
- GenomeReviews:   AE000511_GR
- KEGG:   hpy:HP1429
- NMPDR:   fig|85962.1.peg.1416
- TIGR:   HP_1429
- HOGENOM:   HBG754974
- OMA:   MLAMGDA
- ProtClustDB:   CLSK496485
- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR004800
- InterPro:   IPR001347
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00116
- TIGRFAMs:   TIGR00393

Pfam domain/function: PF00571 CBS; PF01380 SIS

EC number: NA

Molecular weight: Translated: 35785; Mature: 35653

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS51371 CBS; PS51464 SIS; PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPILFDCNAIASQVLKDEASALLESVGQFQKPNDLEAIVKLILKSQENGGKLVIVGVGKS
CCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCH
ALVAQKIVASMLSTGNRSAFLHPTEAMHGDLGMVEKNDVVLMISYGGESLELLNLVSHLK
HHHHHHHHHHHHCCCCCCEEECCHHHHCCCCCCEECCCEEEEEECCCCHHHHHHHHHHHH
RLSHKIITFTKSPNSSLSKLGDYYLSLKIQKEACPINTAPTTSTTLTLALGDVLMACLMR
HHHHHEEEEECCCCHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AKNFSQEDFASFHPGGLLGKKLFVKVKDLLQTTNLPLIAPSTSFKDALIEMSEKRLGSAI
HCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCEE
LVNEANELVGVLSDGDVRRALLKGVSLKSEVRHFATLKPKSFKNLDALLLEALEFLERHK
EEECHHHHEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
IQLLVCVDDHNKVLGVLHLHQLLELGLKA
EEEEEEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PILFDCNAIASQVLKDEASALLESVGQFQKPNDLEAIVKLILKSQENGGKLVIVGVGKS
CEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCH
ALVAQKIVASMLSTGNRSAFLHPTEAMHGDLGMVEKNDVVLMISYGGESLELLNLVSHLK
HHHHHHHHHHHHCCCCCCEEECCHHHHCCCCCCEECCCEEEEEECCCCHHHHHHHHHHHH
RLSHKIITFTKSPNSSLSKLGDYYLSLKIQKEACPINTAPTTSTTLTLALGDVLMACLMR
HHHHHEEEEECCCCHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AKNFSQEDFASFHPGGLLGKKLFVKVKDLLQTTNLPLIAPSTSFKDALIEMSEKRLGSAI
HCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCEE
LVNEANELVGVLSDGDVRRALLKGVSLKSEVRHFATLKPKSFKNLDALLLEALEFLERHK
EEECHHHHEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
IQLLVCVDDHNKVLGVLHLHQLLELGLKA
EEEEEEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185