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Identifier: 15645977

GI number: 15645977

Start: 1426963

End: 1427604

Strand: Reverse

Name: Not Available

Synonym: HP1365

Alternate gene names: 15645977

Gene position: 1427604-1426963 (Counterclockwise)

Preceding gene: 15645978

Following gene: 15645976

Centisome position: 85.59

GC content: 38.79

Gene sequence:

>642_bases
ATGCAAAAAAAGATTTTTTTACTAGAAGACGATTACCTTTTAAGCGAGAGCGTTAAGGAGTTTTTGGAGCATTTGGGCTA
TGAAGTGTTTTGTGCTTTTAACGGAAAAGAAGCTTATGAAAGGCTCTCTGTTGAGCGCTTCAACCTCTTGCTTTTAGACG
TGCAAGTGCCTGAAATGAATAGCTTGGAATTGTTTAAGCGCATCAAAAACGATTTTTTAATCTCTACGCCTGTGATTTTT
ATCACCGCCTTACAGGATAACGCTACCTTAAAAAACGCTTTTAATTTAGGAGCGAGCGATTATTTGAAAAAGCCTTTTGA
TTTAGACGAATTGGAAGCACGCATTAAAAGGTTTTTCAATGATGATCCCATAGAAATCATGCCTAACATTTTTTACCACC
AAAATTGCTTGAGTGTCAGGGGCAAAAAAGAGATCTTGCCGCCCAAAACCGCCCAACTTTTAGAATACTTTTTGGAGCAT
AAAGGGCAAATCATTAGCTCTCAAGCGCTAGAAAATAACCTATGGGAGCAAGCGATTGATGATTCCACCTTGCGCACTTA
TATTAAAGTGTTGCGCAAGCTTTTGGGTAAAAATTGCATAGAAACGCATAAGGGGGTTGGCTATCGCTTTAACCCACTAT
GA

Upstream 100 bases:

>100_bases
ATTCTAAAAACGGCTGATAAAATAAAGCGGTGTCTTTTTTAAGGGAGTGTTTTTTTATAACCGCTTTTAGTATAAAGGCA
ATTAGCGCTACAATACCCCC

Downstream 100 bases:

>100_bases
AAAAAAATCCCTTAAACTCTTTTTAGGGATTTATTTAGGCTCTTCGTTTGTGTTGATGCTAGTGATTAGCGTTTTAGCGT
TTAACTATGAAAAAAACGAA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MQKKIFLLEDDYLLSESVKEFLEHLGYEVFCAFNGKEAYERLSVERFNLLLLDVQVPEMNSLELFKRIKNDFLISTPVIF
ITALQDNATLKNAFNLGASDYLKKPFDLDELEARIKRFFNDDPIEIMPNIFYHQNCLSVRGKKEILPPKTAQLLEYFLEH
KGQIISSQALENNLWEQAIDDSTLRTYIKVLRKLLGKNCIETHKGVGYRFNPL

Sequences:

>Translated_213_residues
MQKKIFLLEDDYLLSESVKEFLEHLGYEVFCAFNGKEAYERLSVERFNLLLLDVQVPEMNSLELFKRIKNDFLISTPVIF
ITALQDNATLKNAFNLGASDYLKKPFDLDELEARIKRFFNDDPIEIMPNIFYHQNCLSVRGKKEILPPKTAQLLEYFLEH
KGQIISSQALENNLWEQAIDDSTLRTYIKVLRKLLGKNCIETHKGVGYRFNPL
>Mature_213_residues
MQKKIFLLEDDYLLSESVKEFLEHLGYEVFCAFNGKEAYERLSVERFNLLLLDVQVPEMNSLELFKRIKNDFLISTPVIF
ITALQDNATLKNAFNLGASDYLKKPFDLDELEARIKRFFNDDPIEIMPNIFYHQNCLSVRGKKEILPPKTAQLLEYFLEH
KGQIISSQALENNLWEQAIDDSTLRTYIKVLRKLLGKNCIETHKGVGYRFNPL

Specific function: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by phoB and phoR when phosphate is limited [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=27.0642201834862, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=26.3636363636364, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1790552, Length=215, Percent_Identity=32.093023255814, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=27.8761061946903, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=26.1261261261261, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790860, Length=237, Percent_Identity=27.0042194092827, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=24, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=26.2222222222222, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790299, Length=124, Percent_Identity=36.2903225806452, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=114, Percent_Identity=31.5789473684211, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790437, Length=115, Percent_Identity=33.0434782608696, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1789809, Length=236, Percent_Identity=24.5762711864407, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=25.1101321585903, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=24.3589743589744, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=29.004329004329, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=24.4343891402715, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=121, Percent_Identity=28.099173553719, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR011879
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24872; Mature: 24872

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKIFLLEDDYLLSESVKEFLEHLGYEVFCAFNGKEAYERLSVERFNLLLLDVQVPEMN
CCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHEEEEEEEECCCCC
SLELFKRIKNDFLISTPVIFITALQDNATLKNAFNLGASDYLKKPFDLDELEARIKRFFN
HHHHHHHHHHCEEEECCEEEEEEECCCCHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHCC
DDPIEIMPNIFYHQNCLSVRGKKEILPPKTAQLLEYFLEHKGQIISSQALENNLWEQAID
CCCHHHHCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
DSTLRTYIKVLRKLLGKNCIETHKGVGYRFNPL
HHHHHHHHHHHHHHHCCHHHHHHCCCCEECCCC
>Mature Secondary Structure
MQKKIFLLEDDYLLSESVKEFLEHLGYEVFCAFNGKEAYERLSVERFNLLLLDVQVPEMN
CCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHEEEEEEEECCCCC
SLELFKRIKNDFLISTPVIFITALQDNATLKNAFNLGASDYLKKPFDLDELEARIKRFFN
HHHHHHHHHHCEEEECCEEEEEEECCCCHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHCC
DDPIEIMPNIFYHQNCLSVRGKKEILPPKTAQLLEYFLEHKGQIISSQALENNLWEQAID
CCCHHHHCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
DSTLRTYIKVLRKLLGKNCIETHKGVGYRFNPL
HHHHHHHHHHHHHHHCCHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2115874; 10984043 [H]