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Identifier: 15645967

GI number: 15645967

Start: 1417068

End: 1417889

Strand: Reverse

Name: Not Available

Synonym: HP1355

Alternate gene names: 15645967

Gene position: 1417889-1417068 (Counterclockwise)

Preceding gene: 15645968

Following gene: 15645966

Centisome position: 85.01

GC content: 41.61

Gene sequence:

>822_bases
ATGGAGATTAGAACCTTTTTAGAACGCGCTTTAAAAGAAGATTTAGGGCATGGGGATTTGTTTGAAAGGGTGTTAGAAAA
AGATTTTAAGGCCACAGCGTTTGTTAGGGCTAAACAAGAGGGCGTGTTTTCAGGCGAAAAATACGCTTTAGAGTTGTTGG
AAATGACCGGCATTGAATGCGTTCAAACGATTAAGGATAAAGAACGCTTCAAGCCTAAAGACGCTTTAATGGAAATTAGG
GGGGATTTTAGCATGCTTTTAAAGGTTGAGCGCACCCTTTTAAACCTTTTGCAACACAGCAGCGGGATTGCTACTTTAAC
GAGCCGTTTTGTAGAGGCTTTAAATTCTCATAAAGTGCGTTTGTTGGACACGAGAAAAACGAGACCCCTTTTAAGGATCT
TTGAAAAATATTCCGTGCTTAATGGGGGAGCGAGCAACCACCGCTTAGGGCTAGATGACGCTTTAATGCTTAAAGACACG
CATTTAAGGCATGTGAAAGATCTCAAAAGCTTTTTAACGCATGCCAGAAAAAACTTGCCTTTCACGGCTAAAATTGAAAT
TGAATGCGAAAGCTTTGAAGAGGCCAAAAACGCCATGAATGCGGGAGCGGATATTGTGATGTGCGATAATTTGAGCGTTT
TAGAGACTAAAGAAATTGCCGCTTATAGAGATGCGCATTATCCCTTTGTTTTACTGGAAGCGAGCGGGAACATTTCACTA
GAGAGCATTAACGCTTACGCTAAAAGCGGCGTGGATGCCATTAGCGTAGGGGCTTTAATCCATCAAGCCACTTTTATTGA
CATGCACATGAAAATGGCTTAA

Upstream 100 bases:

>100_bases
AGGCTTACAAAAACCACAGGGCTTACAATACGATTGAATTAAAAGATGAGGTGGCGCGTTTGGCCAAACTCGCTTTAACT
AAAATGATGGAGTTATCTTA

Downstream 100 bases:

>100_bases
AGACTTTAAAAAGGGGTTATTAACATGCTAAAAGAATATTTAGAAAGCATTAAAGATCTTACGCCTGAAAAGAATGAACT
CACGCACCGCCCTTCTTTAT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MEIRTFLERALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIECVQTIKDKERFKPKDALMEIR
GDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDT
HLRHVKDLKSFLTHARKNLPFTAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISL
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA

Sequences:

>Translated_273_residues
MEIRTFLERALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIECVQTIKDKERFKPKDALMEIR
GDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDT
HLRHVKDLKSFLTHARKNLPFTAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISL
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA
>Mature_273_residues
MEIRTFLERALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIECVQTIKDKERFKPKDALMEIR
GDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDT
HLRHVKDLKSFLTHARKNLPFTAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISL
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=274, Percent_Identity=31.021897810219, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1786299, Length=279, Percent_Identity=34.7670250896057, Blast_Score=147, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6321162, Length=282, Percent_Identity=33.6879432624113, Blast_Score=132, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30803; Mature: 30803

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRTFLERALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIEC
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VQTIKDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVR
HHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLRHVKDLKSFLTHARKNLP
EEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
FTAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISL
EEEEEEEEHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCEEH
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MEIRTFLERALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIEC
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VQTIKDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVR
HHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLRHVKDLKSFLTHARKNLP
EEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
FTAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISL
EEEEEEEEHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCEEH
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]