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The map label for this gene is tmk [H]

Identifier: 13507745

GI number: 13507745

Start: 8579

End: 9211

Strand: Direct

Name: tmk [H]

Synonym: MPN006

Alternate gene names: 13507745

Gene position: 8579-9211 (Clockwise)

Preceding gene: 13507744

Following gene: 13507746

Centisome position: 1.05

GC content: 45.5

Gene sequence:

>633_bases
ATGAAACAAGGCGTGTTTGTGGCCATAGAGGGCGTGGATGGTGCGGGGAAAACCGTCCTCCTAGAAGCTTTTAAACAGCG
CTTTCCCCAAAGCTTTTTGGGCTTTAAAACGCTTTTTAGCAGGGAACCCGGGGGCACACCGTTAGCGGAAAAAATCCGGG
CACTGCTCCTGCATGAAGCAATGGAACCACTTACAGAAGCTTATCTGTTTGCGGCATCGCGCACCGAACACGTGCGCCAG
TTAATCCAACCAGCGTTACAACAAAAACAGTTAGTGATAGTAGACCGCTTTGTGTGATCTAGTTATGCATACCAGGGCTT
AATTAAAAAAGTCGGACTTGATGTGGTCAAAAAGCTCAATGCTGATGCGGTGGGGGATAGTATGCCCGACTTTACCTTTA
TTGTTGATTGTGACTTTGAGACTGCTTTAAACCGGATGGCCAAACGCGGTCAGGACAATTTATTGGACAATACTGTTAAA
AAGCAAGCGGACTTTAATACTATGCGCCAGTATTACCACAGTTTGGTTGATAACAAACGCGTCTTTCTCTTAGACGGGCA
AAACCAAACGGGTTGTCTGGAACAATTTATTGAACAATTAAGCCAATGTTTAACCCAACCCACGCTCTCTTAA

Upstream 100 bases:

>100_bases
ATCTTGGAACACTACCAAACGAAGGCAGGGGAAGTAATGATTCCCCAAGCCTTGTTGAAATACTTAGACTTTGACAAAAT
TACCAAACCAAAATAAACCA

Downstream 100 bases:

>100_bases
TTATTCAAAGACGGGGTAGCTATCTCCAACCAGTTTTAACGGAGTACCTAACCCGGGTCGTTTGTGAACAGCAAACGGGG
TGTCAAACATGTCCGAGTTG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKQGVFVAIEGVDGAGKTVLLEAFKQRFPQSFLGFKTLFSREPGGTPLAEKIRALLLHEAMEPLTEAYLFAASRTEHVRQ
LIQPALQQKQLVIVDRFVWSSYAYQGLIKKVGLDVVKKLNADAVGDSMPDFTFIVDCDFETALNRMAKRGQDNLLDNTVK
KQADFNTMRQYYHSLVDNKRVFLLDGQNQTGCLEQFIEQLSQCLTQPTLS

Sequences:

>Translated_210_residues
MKQGVFVAIEGVDGAGKTVLLEAFKQRFPQSFLGFKTLFSREPGGTPLAEKIRALLLHEAMEPLTEAYLFAASRTEHVRQ
LIQPALQQKQLVIVDRFV*SSYAYQGLIKKVGLDVVKKLNADAVGDSMPDFTFIVDCDFETALNRMAKRGQDNLLDNTVK
KQADFNTMRQYYHSLVDNKRVFLLDGQNQTGCLEQFIEQLSQCLTQPTLS
>Mature_210_residues
MKQGVFVAIEGVDGAGKTVLLEAFKQRFPQSFLGFKTLFSREPGGTPLAEKIRALLLHEAMEPLTEAYLFAASRTEHVRQ
LIQPALQQKQLVIVDRFV*SSYAYQGLIKKVGLDVVKKLNADAVGDSMPDFTFIVDCDFETALNRMAKRGQDNLLDNTVK
KQADFNTMRQYYHSLVDNKRVFLLDGQNQTGCLEQFIEQLSQCLTQPTLS

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=214, Percent_Identity=33.6448598130841, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23507; Mature: 23507

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQGVFVAIEGVDGAGKTVLLEAFKQRFPQSFLGFKTLFSREPGGTPLAEKIRALLLHEA
CCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
MEPLTEAYLFAASRTEHVRQLIQPALQQKQLVIVDRFVSSYAYQGLIKKVGLDVVKKLNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DAVGDSMPDFTFIVDCDFETALNRMAKRGQDNLLDNTVKKQADFNTMRQYYHSLVDNKRV
HHCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
FLLDGQNQTGCLEQFIEQLSQCLTQPTLS
EEEECCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKQGVFVAIEGVDGAGKTVLLEAFKQRFPQSFLGFKTLFSREPGGTPLAEKIRALLLHEA
CCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
MEPLTEAYLFAASRTEHVRQLIQPALQQKQLVIVDRFVSSYAYQGLIKKVGLDVVKKLNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DAVGDSMPDFTFIVDCDFETALNRMAKRGQDNLLDNTVKKQADFNTMRQYYHSLVDNKRV
HHCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
FLLDGQNQTGCLEQFIEQLSQCLTQPTLS
EEEECCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]