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The map label for this gene is serS [H]

Identifier: 13507744

GI number: 13507744

Start: 7312

End: 8574

Strand: Direct

Name: serS [H]

Synonym: MPN005

Alternate gene names: 13507744

Gene position: 7312-8574 (Clockwise)

Preceding gene: 13507743

Following gene: 13507745

Centisome position: 0.9

GC content: 45.37

Gene sequence:

>1263_bases
ATGTTGGATCGAAACAAATTACGCAATAACCTTGACTTCTTTAAAAAGAAGTTAGTTGAACGGGGTGTAAGTGAAAGCCA
GTTCGAGGCGTACGTGCAAGCTGATAAAGCAATGCGCAAACTGTTGCACCAAATTGAACTGGCCAACCAAAAGCAAACCC
TGTTAGCGCAACAGGTTGCCAAGAAGAAGGGTGATCCGAAGTTATTAAAGGAATCCAAGGAGTTAAAGCAAAAACTAGAA
CAGCTCAACATCGCTTTTAAGGAAGCGGAAACCTTAAGCCAAGAGTTACTGTTAAACCTCCCTAACATTGCTGATGAATC
AGTACCAGTTGGACGGGATGAAACTGCTAACTTAGAACTGCTCAAAGAAGGGCGTAAACCGGTGTTTGACTTTACTCCCT
TACCCCACTGGGAGTTGTGTGAACGCTTACAGTTAGTTGCCTTTGATAAGGCCACTAAGCTAACGGGTGCACGGTTTGTC
GCTTACACTGATAAAGCAGCGAAACTGCTCCGCGCCATTGCTAGCTTAATGATTGACCTCAACAAAAACAAATACCAGGA
GTGAAACGTGCCGGTCATTGTGAACGAGACTAGTCTTACTGGTACGGGTCAGCTACCCAAATTTAAGGATGATGTCTTTA
AGTTAGAAAACACGCGTTACTACCTCTCCCCGACCCTAGAGGTGCAACTAGCCAACCTCCATGCCAACGAAATCTTCACG
GAGGGTGAACTCCCCAAATACTATACCGCTACTGGGGTGAACTTTCGCCAGGAAGCGGGCAGTGCTGGTAAACAAACTAA
GGGTACGATTCGCCTACACCAGTTCCAAAAGGTAGAACTAGTGAAGTTTTGTAAACCAAGTGAAGCGATTCACGAACTGG
AAGAAATGACCCGGGACGCTGAGCAAATTTTGTTAGAACTCAAAATTCCCTTTCGCCGTTTGTTACTCTGTAGCGGTGAC
ATGGGTTTTAGTGCCCAGAAAACCTATGACTTGGAAGTGTGGATGGCGGGTTGCAATGAGTACCGCGAAGTTTCGTCCTG
TTCTTCTTGTGGTGACTTTCAAGCACGCAGAGCAATGATCCGCTATAAGGACTTAACCACAGGCAAGAATACCTATGTGG
CTACCTTAAACGGCACCGCTTTAGCGATTGACCGCATCTTTGCAGCCATCTTGGAACACTACCAAACGAAGGCAGGGGAA
GTAATGATTCCCCAAGCCTTGTTGAAATACTTAGACTTTGACAAAATTACCAAACCAAAATAA

Upstream 100 bases:

>100_bases
GTTAAACTAATCAAACTAAAAGAGAAGGAACGCTTAGAGACTGTTACTATCTTTAAAAAGGAAGAAGCCATTAAAACCAC
AACAGCAACCGAGACAGACG

Downstream 100 bases:

>100_bases
ACCAATGAAACAAGGCGTGTTTGTGGCCATAGAGGGCGTGGATGGTGCGGGGAAAACCGTCCTCCTAGAAGCTTTTAAAC
AGCGCTTTCCCCAAAGCTTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MLDRNKLRNNLDFFKKKLVERGVSESQFEAYVQADKAMRKLLHQIELANQKQTLLAQQVAKKKGDPKLLKESKELKQKLE
QLNIAFKEAETLSQELLLNLPNIADESVPVGRDETANLELLKEGRKPVFDFTPLPHWELCERLQLVAFDKATKLTGARFV
AYTDKAAKLLRAIASLMIDLNKNKYQEWNVPVIVNETSLTGTGQLPKFKDDVFKLENTRYYLSPTLEVQLANLHANEIFT
EGELPKYYTATGVNFRQEAGSAGKQTKGTIRLHQFQKVELVKFCKPSEAIHELEEMTRDAEQILLELKIPFRRLLLCSGD
MGFSAQKTYDLEVWMAGCNEYREVSSCSSCGDFQARRAMIRYKDLTTGKNTYVATLNGTALAIDRIFAAILEHYQTKAGE
VMIPQALLKYLDFDKITKPK

Sequences:

>Translated_420_residues
MLDRNKLRNNLDFFKKKLVERGVSESQFEAYVQADKAMRKLLHQIELANQKQTLLAQQVAKKKGDPKLLKESKELKQKLE
QLNIAFKEAETLSQELLLNLPNIADESVPVGRDETANLELLKEGRKPVFDFTPLPHWELCERLQLVAFDKATKLTGARFV
AYTDKAAKLLRAIASLMIDLNKNKYQE*NVPVIVNETSLTGTGQLPKFKDDVFKLENTRYYLSPTLEVQLANLHANEIFT
EGELPKYYTATGVNFRQEAGSAGKQTKGTIRLHQFQKVELVKFCKPSEAIHELEEMTRDAEQILLELKIPFRRLLLCSGD
MGFSAQKTYDLEVWMAGCNEYREVSSCSSCGDFQARRAMIRYKDLTTGKNTYVATLNGTALAIDRIFAAILEHYQTKAGE
VMIPQALLKYLDFDKITKPK
>Mature_420_residues
MLDRNKLRNNLDFFKKKLVERGVSESQFEAYVQADKAMRKLLHQIELANQKQTLLAQQVAKKKGDPKLLKESKELKQKLE
QLNIAFKEAETLSQELLLNLPNIADESVPVGRDETANLELLKEGRKPVFDFTPLPHWELCERLQLVAFDKATKLTGARFV
AYTDKAAKLLRAIASLMIDLNKNKYQE*NVPVIVNETSLTGTGQLPKFKDDVFKLENTRYYLSPTLEVQLANLHANEIFT
EGELPKYYTATGVNFRQEAGSAGKQTKGTIRLHQFQKVELVKFCKPSEAIHELEEMTRDAEQILLELKIPFRRLLLCSGD
MGFSAQKTYDLEVWMAGCNEYREVSSCSSCGDFQARRAMIRYKDLTTGKNTYVATLNGTALAIDRIFAAILEHYQTKAGE
VMIPQALLKYLDFDKITKPK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI8923421, Length=381, Percent_Identity=30.7086614173228, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI225579074, Length=329, Percent_Identity=31.306990881459, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI16306548, Length=236, Percent_Identity=34.3220338983051, Blast_Score=142, Evalue=5e-34,
Organism=Escherichia coli, GI1787120, Length=424, Percent_Identity=39.1509433962264, Blast_Score=295, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17539260, Length=341, Percent_Identity=31.3782991202346, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17542084, Length=195, Percent_Identity=34.3589743589744, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321799, Length=390, Percent_Identity=31.5384615384615, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6320226, Length=364, Percent_Identity=31.3186813186813, Blast_Score=162, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24581334, Length=346, Percent_Identity=30.9248554913295, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI17737985, Length=277, Percent_Identity=34.2960288808664, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47721; Mature: 47721

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRNKLRNNLDFFKKKLVERGVSESQFEAYVQADKAMRKLLHQIELANQKQTLLAQQVA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
KKKGDPKLLKESKELKQKLEQLNIAFKEAETLSQELLLNLPNIADESVPVGRDETANLEL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
LKEGRKPVFDFTPLPHWELCERLQLVAFDKATKLTGARFVAYTDKAAKLLRAIASLMIDL
HHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCEEEEECHHHHHHHHHHHHHHHHC
NKNKYQENVPVIVNETSLTGTGQLPKFKDDVFKLENTRYYLSPTLEVQLANLHANEIFTE
CCCHHCCCCCEEEECCCCCCCCCCCCHHHHHHEECCCEEEECCEEEEEEEEECHHHHCCC
GELPKYYTATGVNFRQEAGSAGKQTKGTIRLHQFQKVELVKFCKPSEAIHELEEMTRDAE
CCCCCEEEECCCCHHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QILLELKIPFRRLLLCSGDMGFSAQKTYDLEVWMAGCNEYREVSSCSSCGDFQARRAMIR
HHHHHHCCCHHHHHHCCCCCCCCCCCEEEHHHEECCHHHHHHHHHHCCCCCHHHHHHHHH
YKDLTTGKNTYVATLNGTALAIDRIFAAILEHYQTKAGEVMIPQALLKYLDFDKITKPK
HHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLDRNKLRNNLDFFKKKLVERGVSESQFEAYVQADKAMRKLLHQIELANQKQTLLAQQVA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
KKKGDPKLLKESKELKQKLEQLNIAFKEAETLSQELLLNLPNIADESVPVGRDETANLEL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
LKEGRKPVFDFTPLPHWELCERLQLVAFDKATKLTGARFVAYTDKAAKLLRAIASLMIDL
HHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCEEEEECHHHHHHHHHHHHHHHHC
NKNKYQENVPVIVNETSLTGTGQLPKFKDDVFKLENTRYYLSPTLEVQLANLHANEIFTE
CCCHHCCCCCEEEECCCCCCCCCCCCHHHHHHEECCCEEEECCEEEEEEEEECHHHHCCC
GELPKYYTATGVNFRQEAGSAGKQTKGTIRLHQFQKVELVKFCKPSEAIHELEEMTRDAE
CCCCCEEEECCCCHHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QILLELKIPFRRLLLCSGDMGFSAQKTYDLEVWMAGCNEYREVSSCSSCGDFQARRAMIR
HHHHHHCCCHHHHHHCCCCCCCCCCCEEEHHHEECCHHHHHHHHHHCCCCCHHHHHHHHH
YKDLTTGKNTYVATLNGTALAIDRIFAAILEHYQTKAGEVMIPQALLKYLDFDKITKPK
HHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]